ML264_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ML264 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ML264_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.234456
AHNAK AHNAK nucleoprotein 0.171207
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0974765
EZR ezrin 0.0962654
HDAC9 histone deacetylase 9 0.0857112
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.083287
ZEB1 zinc finger E-box binding homeobox 1 0.0765108
ANXA1 annexin A1 0.0753884
TMSB4X thymosin beta 4, X-linked 0.0733744
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.073064
PDGFC platelet derived growth factor C 0.0707157
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0647536
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0587313
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0583587
PDE4B phosphodiesterase 4B, cAMP-specific 0.0571413
HSPA8 heat shock 70kDa protein 8 0.0571144
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0569801
EXT1 exostosin glycosyltransferase 1 0.0568403
TM4SF1 transmembrane 4 L six family member 1 0.0555682
ZNF608 zinc finger protein 608 0.0548357
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0511438
EGFR epidermal growth factor receptor 0.0502174
DSCAM Down syndrome cell adhesion molecule 0.0494569
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0479181
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0461279
MYO5C myosin VC 0.0442738
MYOF myoferlin 0.042975
MACF1 microtubule-actin crosslinking factor 1 0.0401671
JUN jun proto-oncogene 0.0393122
NCEH1 neutral cholesterol ester hydrolase 1 0.0370233
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0365595
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0353433
CORO1C coronin, actin binding protein, 1C 0.0353257
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0337451
SQSTM1 sequestosome 1 0.0337391
APLP2 amyloid beta (A4) precursor-like protein 2 0.0336469
EIF4A2 eukaryotic translation initiation factor 4A2 0.033174
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.032649
SGMS2 sphingomyelin synthase 2 0.0316424
RPL7 ribosomal protein L7 0.0316252
FNIP1 folliculin interacting protein 1 0.0314847
KLF6 Kruppel-like factor 6 0.0314371
GLI2 GLI family zinc finger 2 0.0311963
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0311283
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0311058
BMP10 bone morphogenetic protein 10 0.0310812
TACC2 transforming, acidic coiled-coil containing protein 2 0.030951
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0300471
CANX calnexin 0.0295761
FAT1 FAT atypical cadherin 1 0.0294199
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0293029
HSPH1 heat shock 105kDa/110kDa protein 1 0.0290876
CREB5 cAMP responsive element binding protein 5 0.0290761
RPS8 ribosomal protein S8 0.0289786
NAP1L1 nucleosome assembly protein 1-like 1 0.0286278
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0279899
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0279831
CLIP1 CAP-GLY domain containing linker protein 1 0.0277105
ZNF217 zinc finger protein 217 0.0273696
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0271797
ZBTB38 zinc finger and BTB domain containing 38 0.0270512
LMCD1 LIM and cysteine-rich domains 1 0.0270346
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0269477
PUM1 pumilio RNA-binding family member 1 0.0268768
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0267811
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0264906
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0264565
LPP LIM domain containing preferred translocation partner in lipoma 0.0259715
KMT2E lysine (K)-specific methyltransferase 2E 0.0258176
ZFAND3 zinc finger, AN1-type domain 3 0.0255903
ANLN anillin, actin binding protein 0.0254184
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0253803
SOX6 SRY (sex determining region Y)-box 6 0.0252593
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0251698
SMAD3 SMAD family member 3 0.0251178
PGK1 phosphoglycerate kinase 1 0.0248783
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0246865
EEF2 eukaryotic translation elongation factor 2 0.0245415
RPL26 ribosomal protein L26 0.024369
DIAPH1 diaphanous-related formin 1 0.0242509
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0241378
CTBP2 C-terminal binding protein 2 0.0241027
IFI16 interferon, gamma-inducible protein 16 0.0238246
KMT2C lysine (K)-specific methyltransferase 2C 0.0237168
KAT6A K(lysine) acetyltransferase 6A 0.0236103
CUL3 cullin 3 0.0235352
RAB27B RAB27B, member RAS oncogene family 0.0234601
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.023179
CRY1 cryptochrome circadian clock 1 0.0230375
SPAG9 sperm associated antigen 9 0.0228515
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0226842
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.022643
SON SON DNA binding protein 0.0222337
RLF rearranged L-myc fusion 0.0222279
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0217961
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0217831
XRN2 5'-3' exoribonuclease 2 0.0214946
STK4 serine/threonine kinase 4 0.0214794
CDK13 cyclin-dependent kinase 13 0.021425
EIF3J eukaryotic translation initiation factor 3, subunit J 0.0211713

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.236668
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232624
PKM pyruvate kinase, muscle -0.0991212
POTEF POTE ankyrin domain family, member F -0.0896917
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0691384
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0654175
S100A6 S100 calcium binding protein A6 -0.0646048
PFN1 profilin 1 -0.0614969
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0524931
S100A4 S100 calcium binding protein A4 -0.0518274
ENO2 enolase 2 (gamma, neuronal) -0.0507792
TXNRD1 thioredoxin reductase 1 -0.0499079
RPL35A ribosomal protein L35a -0.0481476
FTL ferritin, light polypeptide -0.046624
GNAS GNAS complex locus -0.0461783
IGF2 insulin-like growth factor 2 -0.0425944
RPS19 ribosomal protein S19 -0.0418168
RPLP1 ribosomal protein, large, P1 -0.0407215
SMC3 structural maintenance of chromosomes 3 -0.0402383
TMSB10 thymosin beta 10 -0.0400814
ACTG1 actin gamma 1 -0.0393012
PTMS parathymosin -0.0392305
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0387136
FAM162A family with sequence similarity 162, member A -0.0382806
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0374223
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0373102
MT2A metallothionein 2A -0.037021
RPS24 ribosomal protein S24 -0.0362484
FOXP1 forkhead box P1 -0.0359124
CCND1 cyclin D1 -0.0353294
PNISR PNN-interacting serine/arginine-rich protein -0.0349039
CBX3 chromobox homolog 3 -0.0338451
HSPB1 heat shock 27kDa protein 1 -0.0318206
RPL31 ribosomal protein L31 -0.0317711
RPL28 ribosomal protein L28 -0.0315928
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0314861
RHOA ras homolog family member A -0.0310811
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.030659
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0306003
HMGA1 high mobility group AT-hook 1 -0.0299657
EVI5 ecotropic viral integration site 5 -0.0298897
RPLP0 ribosomal protein, large, P0 -0.0298772
RPS25 ribosomal protein S25 -0.0294068
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0293892
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.02923
MYL12B myosin, light chain 12B, regulatory -0.0288975
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0282641
RPLP2 ribosomal protein, large, P2 -0.0281548
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0279827
RPS14 ribosomal protein S14 -0.0278998
KPNB1 karyopherin (importin) beta 1 -0.0277898
GCLM glutamate-cysteine ligase, modifier subunit -0.0269118
S100A9 S100 calcium binding protein A9 -0.0261408
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0258736
RPS23 ribosomal protein S23 -0.0254007
RPL9 ribosomal protein L9 -0.0253161
RPL11 ribosomal protein L11 -0.0250149
RPL27A ribosomal protein L27a -0.0248556
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0247877
RPL23 ribosomal protein L23 -0.0247505
RPL37A ribosomal protein L37a -0.024486
GARS1 glycyl-tRNA synthetase 1 -0.0244572
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0244021
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0241958
PRDX2 peroxiredoxin 2 -0.0241159
RPS21 ribosomal protein S21 -0.0239682
HLA-B major histocompatibility complex, class I, B -0.0237563
RBM25 RNA binding motif protein 25 -0.02365
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0236169
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0235962
SBF2 SET binding factor 2 -0.0235214
CCNL1 cyclin L1 -0.0233958
PDIA3 protein disulfide isomerase family A, member 3 -0.0231654
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0230528
UBE2K ubiquitin-conjugating enzyme E2K -0.0230251
RPL36A ribosomal protein L36a -0.0229764
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0224971
DSTN destrin (actin depolymerizing factor) -0.0222704
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0221037
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0220673
VDAC1 voltage-dependent anion channel 1 -0.0218596
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0218352
RPL30 ribosomal protein L30 -0.0218222
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0218073
RYR2 ryanodine receptor 2 (cardiac) -0.0215248
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.021504
IRX2 iroquois homeobox 2 -0.0214261
TPX2 TPX2, microtubule-associated -0.0212915
SRRM2 serine/arginine repetitive matrix 2 -0.0212622
SMIM44 small integral membrane protein 44 -0.0211064
SLC38A2 solute carrier family 38, member 2 -0.0210708
NEBL nebulette -0.0208845
TPI1 triosephosphate isomerase 1 -0.0207959
TOB1 transducer of ERBB2, 1 -0.0207557
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0206558
DGKH diacylglycerol kinase, eta -0.0205769
RPL32 ribosomal protein L32 -0.0204312
LMAN1 lectin, mannose-binding, 1 -0.0202788
CCNI cyclin I -0.0201225
TCERG1 transcription elongation regulator 1 -0.01984