ML264_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ML264 perturbation in SNU-423 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ML264_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.191668
COL6A3 collagen, type VI, alpha 3 0.187021
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.166315
FRMD4A FERM domain containing 4A 0.153792
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.136451
HDAC9 histone deacetylase 9 0.105183
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0998233
MYH9 myosin, heavy chain 9, non-muscle 0.0941133
TRIO trio Rho guanine nucleotide exchange factor 0.0933054
HMGA2 high mobility group AT-hook 2 0.0904605
CANX calnexin 0.0883532
VIM vimentin 0.0880615
EEF2 eukaryotic translation elongation factor 2 0.0849824
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0822305
COL5A1 collagen, type V, alpha 1 0.077752
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0763418
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0757117
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0753059
CALR calreticulin 0.0751219
CDH13 cadherin 13 0.0684526
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0684514
AHNAK AHNAK nucleoprotein 0.0649223
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0632409
MACF1 microtubule-actin crosslinking factor 1 0.0627157
ASPH aspartate beta-hydroxylase 0.0624001
APLP2 amyloid beta (A4) precursor-like protein 2 0.0613237
INTS6 integrator complex subunit 6 0.0603649
PRELID2 PRELI domain containing 2 0.0588712
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0588298
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0577859
COL1A2 collagen, type I, alpha 2 0.0572826
STC1 stanniocalcin 1 0.05625
TPT1 tumor protein, translationally-controlled 1 0.0561357
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0532412
OGA O-GlcNAcase 0.0525499
MYOF myoferlin 0.0522683
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0520242
SEPTIN9 septin 9 0.0515476
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0495842
SQSTM1 sequestosome 1 0.0484231
ENO1 enolase 1, (alpha) 0.0475985
ANXA2 annexin A2 0.0471938
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0470808
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0468839
PPARD peroxisome proliferator-activated receptor delta 0.0466484
CEP250 centrosomal protein 250kDa 0.0451075
FNIP1 folliculin interacting protein 1 0.0436556
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0425318
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.041082
ATXN1 ataxin 1 0.0403579
SMYD3 SET and MYND domain containing 3 0.0403277
AFF3 AF4/FMR2 family, member 3 0.0399795
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0398447
JMJD1C jumonji domain containing 1C 0.0389685
ZSWIM6 zinc finger, SWIM-type containing 6 0.0388155
EFNA5 ephrin-A5 0.0386492
ASXL1 additional sex combs like transcriptional regulator 1 0.0383493
LOXL2 lysyl oxidase-like 2 0.0381224
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0380633
GOLGB1 golgin B1 0.0379344
NAV2 neuron navigator 2 0.0379317
IGFBP3 insulin-like growth factor binding protein 3 0.0378371
WWTR1 WW domain containing transcription regulator 1 0.0362011
CTSB cathepsin B 0.0350643
UBASH3B ubiquitin associated and SH3 domain containing B 0.0348333
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0347769
ZBTB38 zinc finger and BTB domain containing 38 0.0347036
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0342437
EIF4B eukaryotic translation initiation factor 4B 0.0341855
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0331407
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0329867
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0327589
VMP1 vacuole membrane protein 1 0.0325981
SFRP1 secreted frizzled-related protein 1 0.0325915
APP amyloid beta (A4) precursor protein 0.0325396
FBXL7 F-box and leucine-rich repeat protein 7 0.0323706
TLN1 talin 1 0.0321407
MAP1B microtubule-associated protein 1B 0.0317166
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0317043
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0316797
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0313678
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0313367
PGK1 phosphoglycerate kinase 1 0.0310714
DST dystonin 0.030299
BPTF bromodomain PHD finger transcription factor 0.0297357
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0294069
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0290679
SERINC1 serine incorporator 1 0.0289352
CDK13 cyclin-dependent kinase 13 0.028926
VCAN versican 0.0288684
MKI67 marker of proliferation Ki-67 0.028868
ERBIN erbb2 interacting protein 0.0287211
PHF3 PHD finger protein 3 0.0285552
LOX lysyl oxidase 0.0285354
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0285237
ARHGAP22 Rho GTPase activating protein 22 0.0283574
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0281363
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0280072
TMEM132D transmembrane protein 132D 0.0275529
STC2 stanniocalcin 2 0.0272316

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.129615
FTH1 ferritin, heavy polypeptide 1 -0.0875447
FNDC3B fibronectin type III domain containing 3B -0.0742874
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0726789
FN1 fibronectin 1 -0.0687178
UGCG UDP-glucose ceramide glucosyltransferase -0.0669714
BICC1 BicC family RNA binding protein 1 -0.065654
TMSB10 thymosin beta 10 -0.0625368
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.06176
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0484155
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0483626
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0454774
MT2A metallothionein 2A -0.0445596
CADM1 cell adhesion molecule 1 -0.0407553
NDRG1 N-myc downstream regulated 1 -0.0399929
IFI6 interferon, alpha-inducible protein 6 -0.0393485
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0386734
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0379242
HLA-B major histocompatibility complex, class I, B -0.0369094
RIGI RNA sensor RIG-I -0.0368483
PTBP3 polypyrimidine tract binding protein 3 -0.0364562
HMGA1 high mobility group AT-hook 1 -0.034701
FBXO32 F-box protein 32 -0.0346154
MX1 MX dynamin-like GTPase 1 -0.0345455
IFITM3 interferon induced transmembrane protein 3 -0.0337262
PNRC1 proline-rich nuclear receptor coactivator 1 -0.032522
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0323107
PLSCR1 phospholipid scramblase 1 -0.0310649
BASP1 brain abundant, membrane attached signal protein 1 -0.0302836
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0302576
RPL32 ribosomal protein L32 -0.0300894
ZNF292 zinc finger protein 292 -0.0295881
RPS19 ribosomal protein S19 -0.0294108
RPS24 ribosomal protein S24 -0.0286502
RPL35A ribosomal protein L35a -0.0277
IFITM1 interferon induced transmembrane protein 1 -0.0276159
TAPBP TAP binding protein (tapasin) -0.0273401
RPS6 ribosomal protein S6 -0.0269266
IFI16 interferon, gamma-inducible protein 16 -0.0266323
PFN1 profilin 1 -0.0262607
GNAS GNAS complex locus -0.0262573
POTEF POTE ankyrin domain family, member F -0.026133
ASTN2 astrotactin 2 -0.0260368
LOC112694756 uncharaterized LOC112694756 -0.0258387
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0257097
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0256354
EXT1 exostosin glycosyltransferase 1 -0.0254661
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0253354
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0252428
RPL23 ribosomal protein L23 -0.0250974
CCNL1 cyclin L1 -0.0243393
RNF213 ring finger protein 213 -0.0239311
MT1X metallothionein 1X -0.0238382
PMP22 peripheral myelin protein 22 -0.0234926
RAI1 retinoic acid induced 1 -0.0232904
ISG15 ISG15 ubiquitin-like modifier -0.022988
PLPP6 phospholipid phosphatase 6 -0.0229279
SRGN serglycin -0.0228716
ARF4 ADP-ribosylation factor 4 -0.0226494
MARCKS myristoylated alanine-rich protein kinase C substrate -0.022302
TXNRD1 thioredoxin reductase 1 -0.0222141
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0220855
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0216995
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0214075
RPL19 ribosomal protein L19 -0.021393
OSMR oncostatin M receptor -0.0211281
PLIN2 perilipin 2 -0.0209983
DENND5B DENN/MADD domain containing 5B -0.0208366
RNF24 ring finger protein 24 -0.0207468
CTSD cathepsin D -0.0205145
RPLP1 ribosomal protein, large, P1 -0.020184
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0199049
RPLP2 ribosomal protein, large, P2 -0.0197814
CBX3 chromobox homolog 3 -0.0196424
CALD1 caldesmon 1 -0.0192152
NPEPPS aminopeptidase puromycin sensitive -0.0192058
RB1CC1 RB1-inducible coiled-coil 1 -0.0190624
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.019052
FAM162A family with sequence similarity 162, member A -0.0187001
RPL36 ribosomal protein L36 -0.0186043
RPL18 ribosomal protein L18 -0.0184752
NRP1 neuropilin 1 -0.0184182
MX2 MX dynamin-like GTPase 2 -0.0183115
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0181709
S100A9 S100 calcium binding protein A9 -0.0181399
RPS21 ribosomal protein S21 -0.0180534
SYAP1 synapse associated protein 1 -0.0180427
C3 complement component 3 -0.0180038
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0179636
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.017599
DEK DEK proto-oncogene -0.0175831
SOX5 SRY (sex determining region Y)-box 5 -0.0175079
SEPTIN7 septin 7 -0.0173767
RTN4 reticulon 4 -0.0172937
PHIP pleckstrin homology domain interacting protein -0.0172046
GOLGA4 golgin A4 -0.0171623
RPS4X ribosomal protein S4, X-linked -0.0168618
EPSTI1 epithelial stromal interaction 1 (breast) -0.016841
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0167777
IL6 interleukin 6 -0.0167653