ML264_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ML264 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ML264_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.214008
ZSWIM6 zinc finger, SWIM-type containing 6 0.106847
TPT1 tumor protein, translationally-controlled 1 0.105048
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0946264
CANX calnexin 0.0854668
FNDC3B fibronectin type III domain containing 3B 0.0751544
INTS6 integrator complex subunit 6 0.0740586
MACF1 microtubule-actin crosslinking factor 1 0.0697186
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0678533
ASPH aspartate beta-hydroxylase 0.0619653
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0604833
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0581386
ENO1 enolase 1, (alpha) 0.0578689
SVIL supervillin 0.0578553
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0566346
ANXA1 annexin A1 0.0565877
EGFR epidermal growth factor receptor 0.0545309
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0528994
ANXA2 annexin A2 0.0523199
N4BP2L2 NEDD4 binding protein 2-like 2 0.0515764
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0514467
FMNL2 formin-like 2 0.0513319
ANGPTL4 angiopoietin-like 4 0.0501317
BICD1 bicaudal D homolog 1 (Drosophila) 0.0479314
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0465159
ASXL1 additional sex combs like transcriptional regulator 1 0.0464013
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0462084
GPC5 glypican 5 0.04499
LMO7 LIM domain 7 0.0445604
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.043758
DST dystonin 0.0435796
AKAP12 A kinase (PRKA) anchor protein 12 0.0432043
IGFBP3 insulin-like growth factor binding protein 3 0.0425176
CALR calreticulin 0.0417347
HSPA8 heat shock 70kDa protein 8 0.0413701
DSCAM Down syndrome cell adhesion molecule 0.0393963
RIGI RNA sensor RIG-I 0.0393595
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0393177
SERINC1 serine incorporator 1 0.0390457
NT5E 5'-nucleotidase, ecto (CD73) 0.0390187
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0379284
SMAD3 SMAD family member 3 0.0369811
SOD2 superoxide dismutase 2, mitochondrial 0.0366454
S100A10 S100 calcium binding protein A10 0.035707
WARS1 tryptophanyl-tRNA synthetase 1 0.03566
EXT1 exostosin glycosyltransferase 1 0.035633
IRAK2 interleukin-1 receptor-associated kinase 2 0.0350963
SH3KBP1 SH3-domain kinase binding protein 1 0.0343824
SDC4 syndecan 4 0.0343144
SEPTIN9 septin 9 0.0339615
SQSTM1 sequestosome 1 0.0334536
OGA O-GlcNAcase 0.0330779
ERBIN erbb2 interacting protein 0.0320935
LDHA lactate dehydrogenase A 0.0316869
CAVIN1 caveolae associated protein 1 0.0308179
SAMD4A sterile alpha motif domain containing 4A 0.0298708
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0296666
CYTH1 cytohesin 1 0.0293029
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290944
ZFAND3 zinc finger, AN1-type domain 3 0.0289719
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0287646
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0283602
RPS3 ribosomal protein S3 0.0283476
ANKHD1 ankyrin repeat and KH domain containing 1 0.0280347
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0278869
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0278159
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0277892
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0274471
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0271456
PRKCA protein kinase C, alpha 0.0270956
B2M beta-2-microglobulin 0.0270755
ZBTB1 zinc finger and BTB domain containing 1 0.0266066
TRAF3 TNF receptor-associated factor 3 0.0263394
PDIA4 protein disulfide isomerase family A, member 4 0.0261751
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0261511
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0261429
UBC ubiquitin C 0.0257745
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0257496
PARD3 par-3 family cell polarity regulator 0.0257324
BIRC3 baculoviral IAP repeat containing 3 0.025619
TM4SF1 transmembrane 4 L six family member 1 0.0255601
PLAUR plasminogen activator, urokinase receptor 0.0253407
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0251192
MYH9 myosin, heavy chain 9, non-muscle 0.0250989
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0250555
LPP LIM domain containing preferred translocation partner in lipoma 0.0250428
EEF2 eukaryotic translation elongation factor 2 0.0247725
SET SET nuclear proto-oncogene 0.0247525
JAK1 Janus kinase 1 0.0247316
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0246261
JMJD1C jumonji domain containing 1C 0.0246218
CTBP2 C-terminal binding protein 2 0.024397
RAI14 retinoic acid induced 14 0.0243183
KDM4B lysine (K)-specific demethylase 4B 0.0241945
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0239453
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0238721
LRRC23 leucine rich repeat containing 23 0.0238423
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0237851
COL5A1 collagen, type V, alpha 1 0.0237004
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0236556

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0750128
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0482222
SPAG9 sperm associated antigen 9 -0.0447481
DIAPH3 diaphanous-related formin 3 -0.0427434
VIM vimentin -0.0402889
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0399854
DNER delta/notch-like EGF repeat containing -0.0396527
CENPF centromere protein F, 350/400kDa -0.0384115
BSG basigin (Ok blood group) -0.0356945
ECT2 epithelial cell transforming 2 -0.0356356
TPX2 TPX2, microtubule-associated -0.0345366
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0340083
HJURP Holliday junction recognition protein -0.0335959
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0323279
CKAP2 cytoskeleton associated protein 2 -0.0322623
SMC4 structural maintenance of chromosomes 4 -0.0321871
YBX3 Y box binding protein 3 -0.0318305
MBNL1 muscleblind-like splicing regulator 1 -0.0315658
MIS18BP1 MIS18 binding protein 1 -0.0314149
ANKRD28 ankyrin repeat domain 28 -0.0300855
CKAP5 cytoskeleton associated protein 5 -0.0297777
ZNF292 zinc finger protein 292 -0.0292591
KIAA1328 KIAA1328 -0.0290001
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0280934
NALCN sodium leak channel, non selective -0.0277893
MKI67 marker of proliferation Ki-67 -0.0275038
NIPBL Nipped-B homolog (Drosophila) -0.027094
PRPF8 pre-mRNA processing factor 8 -0.0266857
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0265105
PIAS1 protein inhibitor of activated STAT, 1 -0.0256836
RFC3 replication factor C (activator 1) 3, 38kDa -0.0253627
HDAC9 histone deacetylase 9 -0.0251641
NCEH1 neutral cholesterol ester hydrolase 1 -0.0248825
ZNF609 zinc finger protein 609 -0.0245991
LCORL ligand dependent nuclear receptor corepressor-like -0.0245842
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0242924
SKIC3 SKI3 subunit of superkiller complex -0.0239968
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0239543
SNX14 sorting nexin 14 -0.0238204
ATN1 atrophin 1 -0.0235795
RPL32 ribosomal protein L32 -0.0234743
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0232553
SMAP1 small ArfGAP 1 -0.0232137
MCTP1 multiple C2 domains, transmembrane 1 -0.0231177
EVI5 ecotropic viral integration site 5 -0.0230139
NF1 neurofibromin 1 -0.0229323
SPIDR scaffolding protein involved in DNA repair -0.0226773
PFN1 profilin 1 -0.0223238
TTK TTK protein kinase -0.0222517
NLK nemo-like kinase -0.022124
KMT2E lysine (K)-specific methyltransferase 2E -0.0221054
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0218761
GOLGA4 golgin A4 -0.0218394
GAS2L3 growth arrest-specific 2 like 3 -0.0218093
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.021751
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0217045
SGO2 shugoshin 2 -0.021602
CCNI cyclin I -0.0215942
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.021512
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0212187
PTMA prothymosin, alpha -0.0211337
ATRN attractin -0.0210511
NAV3 neuron navigator 3 -0.0210362
TAS2R14 taste receptor, type 2, member 14 -0.0209731
KIF5B kinesin family member 5B -0.0209155
HMGA1 high mobility group AT-hook 1 -0.0208324
PTBP2 polypyrimidine tract binding protein 2 -0.0207813
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0203232
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.0201419
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0201348
PSPC1 paraspeckle component 1 -0.0199277
SMYD3 SET and MYND domain containing 3 -0.0198513
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0197768
RAB6A RAB6A, member RAS oncogene family -0.0197644
NBEAL1 neurobeachin-like 1 -0.0196385
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0195733
DLG1 discs, large homolog 1 (Drosophila) -0.0194192
R3HDM1 R3H domain containing 1 -0.0193983
AKAP9 A kinase (PRKA) anchor protein 9 -0.0192564
GLCCI1 glucocorticoid induced 1 -0.0190863
XPO6 exportin 6 -0.0190185
AUH AU RNA binding protein/enoyl-CoA hydratase -0.018862
KIF23 kinesin family member 23 -0.0187086
GLG1 golgi glycoprotein 1 -0.0185319
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0184734
PCNX4 pecanex 4 -0.0184366
NKTR natural killer cell triggering receptor -0.0183578
RIN2 Ras and Rab interactor 2 -0.0182081
MED17 mediator complex subunit 17 -0.0180349
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0179998
CENPE centromere protein E, 312kDa -0.0179363
OSMR oncostatin M receptor -0.0178422
IGF2 insulin-like growth factor 2 -0.0177873
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0177854
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0177721
ARL8B ADP-ribosylation factor-like 8B -0.017694
TRA2A transformer 2 alpha homolog (Drosophila) -0.0176665
POU2F1 POU class 2 homeobox 1 -0.0176226
UBE2C ubiquitin-conjugating enzyme E2C -0.0176078
CCDC14 coiled-coil domain containing 14 -0.0175462