MLN 8237 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/24771867
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Genes

199 proteins with high or low expression in MLN 8237 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.93
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.61
BORA bora, aurora kinase A activator 1.27
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.11
TP53 tumor protein p53 1.1
PRF1 perforin 1 (pore forming protein) 1.06
KIF20A kinesin family member 20A 1.03
TP53I3 tumor protein p53 inducible protein 3 0.88
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.81
SULF2 sulfatase 2 0.77
AURKA aurora kinase A 0.77
HEXD hexosaminidase D 0.76
CCND1 cyclin D1 0.75
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.74
VIM vimentin 0.73
SMTN smoothelin 0.72
CKAP2 cytoskeleton associated protein 2 0.69
GAS2L3 growth arrest-specific 2 like 3 0.68
POLH polymerase (DNA directed), eta 0.67
PRR11 proline rich 11 0.67
TROAP trophinin associated protein 0.66
TDG thymine-DNA glycosylase 0.61
CCNB1 cyclin B1 0.61
CDCA3 cell division cycle associated 3 0.61
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.6
INCENP inner centromere protein antigens 135/155kDa 0.6
AKT1S1 AKT1 substrate 1 (proline-rich) 0.6
CCNG1 cyclin G1 0.59
SHCBP1 SHC SH2-domain binding protein 1 0.57
LIPT1 lipoyltransferase 1 0.56
KIF14 kinesin family member 14 0.55
SEMG1 semenogelin I 0.55
HJURP Holliday junction recognition protein 0.55
KIF2C kinesin family member 2C 0.54
FGFR1OP2 FGFR1 oncogene partner 2 0.54
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.53
CKAP2L cytoskeleton associated protein 2-like 0.52
PTTG1 pituitary tumor-transforming 1 0.52
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.52
CDCA8 cell division cycle associated 8 0.51
FAS Fas cell surface death receptor 0.51
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.5
AURKB aurora kinase B 0.5
TOB1 transducer of ERBB2, 1 0.49
BRSK2 BR serine/threonine kinase 2 0.49
MED10 mediator complex subunit 10 0.48
CEBPZOS CEBPZ opposite strand 0.48
ZNF276 zinc finger protein 276 0.48
GDF15 growth differentiation factor 15 0.47
PLK1 polo-like kinase 1 0.47
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.46
SGO2 shugoshin 2 0.45
CLU clusterin 0.45
SYN2 synapsin II 0.45
PRC1 protein regulator of cytokinesis 1 0.45
ZC3H6 zinc finger CCCH-type containing 6 0.45
HSP90AB3P heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene 0.44
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.44
SRD5A3 steroid 5 alpha-reductase 3 0.44
SACK1D scaffolding CK1 anchoring protein D 0.43
GTSE1 G-2 and S-phase expressed 1 0.43
UNC13C unc-13 homolog C (C. elegans) 0.43
ZNF444 zinc finger protein 444 0.43
LAMA3 laminin, alpha 3 0.43
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.43
RBL2 retinoblastoma-like 2 0.42
KIF23 kinesin family member 23 0.42
CCDC90B coiled-coil domain containing 90B 0.41
CDCA2 cell division cycle associated 2 0.41
FRMPD1 FERM and PDZ domain containing 1 0.41
ELL3 elongation factor RNA polymerase II-like 3 0.41
LAMC2 laminin, gamma 2 0.4
KIF16B kinesin family member 16B 0.4
CENPE centromere protein E, 312kDa 0.4
DES desmin 0.39
KNSTRN kinetochore-localized astrin/SPAG5 binding protein 0.39
NT5E 5'-nucleotidase, ecto (CD73) 0.39
TOP2A topoisomerase (DNA) II alpha 170kDa 0.39
CENPF centromere protein F, 350/400kDa 0.38
GPR161 G protein-coupled receptor 161 0.38
GAS6 growth arrest-specific 6 0.38
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.38
CLTB clathrin, light chain B 0.37
BIRC5 baculoviral IAP repeat containing 5 0.37
FDXR ferredoxin reductase 0.37
NEU1 sialidase 1 (lysosomal sialidase) 0.37
NUSAP1 nucleolar and spindle associated protein 1 0.37
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.37
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.37
NRXN3 neurexin 3 0.36
YPEL5 yippee-like 5 (Drosophila) 0.36
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.36
SLC25A44 solute carrier family 25, member 44 0.36
BCORL1 BCL6 corepressor-like 1 0.36
DNLZ DNL-type zinc finger 0.36
LMO7 LIM domain 7 0.35
ERCC6 excision repair cross-complementation group 6 0.35
FAT4 FAT atypical cadherin 4 0.35
RINL Ras and Rab interactor-like 0.35

low expression

Symbol Name Standardized Value
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.95
H1-2 H1.2 linker histone, cluster member -0.8
H1-3 H1.3 linker histone, cluster member -0.73
C6ORF62 chromosome 6 open reading frame 62 -0.73
H1-4 H1.4 linker histone, cluster member -0.71
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.69
JOSD1 Josephin domain containing 1 -0.67
ATP9A ATPase, class II, type 9A -0.65
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -0.63
CASP2 caspase 2, apoptosis-related cysteine peptidase -0.63
SH2D5 SH2 domain containing 5 -0.62
GREB1 growth regulation by estrogen in breast cancer 1 -0.61
YAF2 YY1 associated factor 2 -0.6
H1-5 H1.5 linker histone, cluster member -0.56
ENDOV endonuclease V -0.54
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.54
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -0.53
PIH1D1 PIH1 domain containing 1 -0.53
ANKRD10 ankyrin repeat domain 10 -0.53
TMCC3 transmembrane and coiled-coil domain family 3 -0.52
LRP4 low density lipoprotein receptor-related protein 4 -0.51
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.51
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -0.49
MIB2 mindbomb E3 ubiquitin protein ligase 2 -0.49
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.48
GLI2 GLI family zinc finger 2 -0.48
EXO1 exonuclease 1 -0.47
DCLRE1A DNA cross-link repair 1A -0.47
TRIM13 tripartite motif containing 13 -0.46
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.45
RPL26 ribosomal protein L26 -0.45
FAR1 fatty acyl CoA reductase 1 -0.45
SDC4 syndecan 4 -0.44
FRMD6 FERM domain containing 6 -0.44
VSIR V-set immunoregulatory receptor -0.43
MAPK14 mitogen-activated protein kinase 14 -0.43
ZNF264 zinc finger protein 264 -0.43
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -0.42
EGR1 early growth response 1 -0.42
PTPRJ protein tyrosine phosphatase, receptor type, J -0.42
BPTF bromodomain PHD finger transcription factor -0.42
INPP5J inositol polyphosphate-5-phosphatase J -0.42
COMMD9 COMM domain containing 9 -0.42
TNK1 tyrosine kinase, non-receptor, 1 -0.41
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -0.41
CEP57 centrosomal protein 57kDa -0.41
E2F2 E2F transcription factor 2 -0.41
JAK1 Janus kinase 1 -0.41
CEP89 centrosomal protein 89kDa -0.4
METTL4 methyltransferase like 4 -0.4
SCARA3 scavenger receptor class A, member 3 -0.4
FAM89A family with sequence similarity 89, member A -0.4
HIST2H2AA3 histone cluster 2, H2aa3 -0.4
BCOR BCL6 corepressor -0.4
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -0.4
UGCG UDP-glucose ceramide glucosyltransferase -0.4
HELLS helicase, lymphoid-specific -0.4
AKAP12 A kinase (PRKA) anchor protein 12 -0.39
IQCE IQ motif containing E -0.39
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -0.39
PCLAF PCNA clamp associated factor -0.39
HDAC5 histone deacetylase 5 -0.38
RAD51AP1 RAD51 associated protein 1 -0.38
HOXA7 homeobox A7 -0.38
ACVR1 activin A receptor, type I -0.38
ZNF624 zinc finger protein 624 -0.38
CREG1 cellular repressor of E1A-stimulated genes 1 -0.38
FAM111B family with sequence similarity 111, member B -0.38
ZNF22 zinc finger protein 22 -0.38
RELT RELT tumor necrosis factor receptor -0.38
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.38
FRRS1 ferric-chelate reductase 1 -0.38
ZNF417 zinc finger protein 417 -0.37
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -0.37
ZNF320 zinc finger protein 320 -0.37
SGMS1 sphingomyelin synthase 1 -0.37
ZNF428 zinc finger protein 428 -0.37
ZNRD1 zinc ribbon domain containing 1 -0.36
ENO1 enolase 1, (alpha) -0.36
WDR76 WD repeat domain 76 -0.36
TSPAN15 tetraspanin 15 -0.36
AGFG2 ArfGAP with FG repeats 2 -0.36
MCOLN1 mucolipin 1 -0.36
TOX2 TOX high mobility group box family member 2 -0.36
RXRG retinoid X receptor, gamma -0.36
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.35
PEX19 peroxisomal biogenesis factor 19 -0.35
CCPG1 cell cycle progression 1 -0.35
PPP4R4 protein phosphatase 4, regulatory subunit 4 -0.35
ACE angiotensin I converting enzyme -0.34
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.34
RGPD8 RANBP2-like and GRIP domain containing 8 -0.34
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -0.34
C12ORF60 chromosome 12 open reading frame 60 -0.34
SCRN3 secernin 3 -0.34
SP4 Sp4 transcription factor -0.34
IFNGR1 interferon gamma receptor 1 -0.34
HM13 histocompatibility (minor) 13 -0.34
DAAM1 dishevelled associated activator of morphogenesis 1 -0.34
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -0.34