MLX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description MLX, MAX dimerization protein|The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6945)
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Genes

345 genes differentially expressed following the MLX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KIF19 kinesin family member 19 2.31795
LRRC38 leucine rich repeat containing 38 2.31795
CRYBA1 crystallin, beta A1 2.31795
SYTL4 synaptotagmin-like 4 2.31795
MYH15 myosin, heavy chain 15 2.31795
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.31795
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.31795
PCDH12 protocadherin 12 2.31795
PEX12 peroxisomal biogenesis factor 12 2.31795
TAS1R1 taste receptor, type 1, member 1 2.31795
C5AR2 complement component 5a receptor 2 2.31795
WFDC8 WAP four-disulfide core domain 8 2.31795
OVOL1 ovo-like zinc finger 1 2.31795
GREM1 gremlin 1, DAN family BMP antagonist 2.31795
DMTN dematin actin binding protein 2.31795
GJB3 gap junction protein, beta 3, 31kDa 2.31795
RBM24 RNA binding motif protein 24 2.31795
TLE6 transducin-like enhancer of split 6 2.31795
STING1 stimulator of interferon response cGAMP interactor 1 2.31795
WNT2 wingless-type MMTV integration site family member 2 2.31795
ZNF491 zinc finger protein 491 2.31795
SCRG1 stimulator of chondrogenesis 1 2.31795
LINC02268 long intergenic non-protein coding RNA 2268 2.31795
SCG2 secretogranin II 2.30642
PCDHB6 protocadherin beta 6 2.30642
GJB5 gap junction protein, beta 5, 31.1kDa 2.30642
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.30642
ADGRE3 adhesion G protein-coupled receptor E3 2.30642
TMEM235 transmembrane protein 235 2.30642
SPINK1 serine peptidase inhibitor, Kazal type 1 2.30642
PEAR1 platelet endothelial aggregation receptor 1 2.30642
MAGEA6 melanoma antigen family A6 2.30642
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.30642
RRAD Ras-related associated with diabetes 2.30642
PRODH2 proline dehydrogenase (oxidase) 2 2.30642
ADGRG4 adhesion G protein-coupled receptor G4 2.30642
LRRC59 leucine rich repeat containing 59 2.30642
RGPD4 RANBP2-like and GRIP domain containing 4 2.30642
SLC10A4 solute carrier family 10, member 4 2.30642
OCSTAMP osteoclast stimulatory transmembrane protein 2.30642
MMP20 matrix metallopeptidase 20 2.30642
VSX1 visual system homeobox 1 2.30642
FGL1 fibrinogen-like 1 2.30642
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.30642
LGALS9 lectin, galactoside-binding, soluble, 9 2.30642
PLXNA2 plexin A2 2.30642
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.30642
PAX9 paired box 9 2.30642
CD69 CD69 molecule 2.30642
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.30642
PDE7B phosphodiesterase 7B 2.30642
EIF5B eukaryotic translation initiation factor 5B 2.30642
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.30642
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.30642
NUGGC nuclear GTPase, germinal center associated 2.30642
ARL17B ADP-ribosylation factor-like 17B 2.30642
NCKAP1L NCK-associated protein 1-like 2.30642
RGPD3 RANBP2-like and GRIP domain containing 3 2.30642
TDO2 tryptophan 2,3-dioxygenase 2.30642
SPMAP1 sperm microtubule associated protein 1 2.30642
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.30642
SAG S-antigen; retina and pineal gland (arrestin) 2.30642
TTR transthyretin 2.30642
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.30642
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.30642
LEKR1 leucine, glutamate and lysine rich 1 2.30642
PRDM7 PR domain containing 7 2.30642
DYNAP dynactin associated protein 2.30642
C20ORF202 chromosome 20 open reading frame 202 2.30642
CXCL13 chemokine (C-X-C motif) ligand 13 2.30642
PNLIPRP2 pancreatic lipase-related protein 2 2.30642
LOC124902436 talanin 2.30642
METTL27 methyltransferase like 27 2.30642
TOMT transmembrane O-methyltransferase 2.30642
YJU2 YJU2 splicing factor homolog 2.30642
GBP7 guanylate binding protein 7 2.30642
AVPR1A arginine vasopressin receptor 1A 2.30642
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.30642
HBG2 hemoglobin, gamma G 2.30642
ZNF683 zinc finger protein 683 2.30642
FMR1NB fragile X mental retardation 1 neighbor 2.30642
UTS2 urotensin 2 2.30642
TBX22 T-box 22 2.30642
GPR6 G protein-coupled receptor 6 2.30642
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.30642
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 2.30642
SIX2 SIX homeobox 2 2.30642
MYO7B myosin VIIB 2.30642
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.30642
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.30642
PCDHA2 protocadherin alpha 2 2.30642
FAM43A family with sequence similarity 43, member A 2.30642
RNF183 ring finger protein 183 2.30642
GSC goosecoid homeobox 2.30642
PRR11 proline rich 11 2.30642
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.30642
GREB1 growth regulation by estrogen in breast cancer 1 2.30642
SCRT2 scratch family zinc finger 2 2.30642
NPIPB9 nuclear pore complex interacting protein family, member B9 2.30642
ULBP3 UL16 binding protein 3 2.30642
OLAH oleoyl-ACP hydrolase 2.30642
FGD2 FYVE, RhoGEF and PH domain containing 2 2.30642
CENPN centromere protein N 2.30642
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.30642
S100A14 S100 calcium binding protein A14 2.30642
RESP18 regulated endocrine-specific protein 18 2.30642
NUTM1 NUT midline carcinoma, family member 1 2.30642
CXCR4 chemokine (C-X-C motif) receptor 4 2.30642
GOLGA6A golgin A6 family, member A 2.30642
OAZ3 ornithine decarboxylase antizyme 3 2.30642
CALHM3 calcium homeostasis modulator 3 2.30642
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.30642
CLEC4G C-type lectin domain family 4, member G 2.30642
ADGRA1 adhesion G protein-coupled receptor A1 2.30642
CST7 cystatin F (leukocystatin) 2.30642
PHOSPHO1 phosphatase, orphan 1 2.30642
NPBWR1 neuropeptides B/W receptor 1 2.30642
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 2.30642
IL17REL interleukin 17 receptor E-like 2.30642
MYF5 myogenic factor 5 2.30642
BRD3 bromodomain containing 3 2.30642
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.30642
EDN2 endothelin 2 2.30642
CDC20B cell division cycle 20B 2.30642
EMP1 epithelial membrane protein 1 2.30642
CGB2 chorionic gonadotropin, beta polypeptide 2 2.30642
POGK pogo transposable element with KRAB domain 2.30642
PRTN3 proteinase 3 2.30642
CCNI2 cyclin I family, member 2 2.30642
OPTC opticin 2.30642
IL26 interleukin 26 2.30642
LMX1B LIM homeobox transcription factor 1, beta 2.30642
C1ORF185 chromosome 1 open reading frame 185 2.30642
ADRA2C adrenoceptor alpha 2C 2.30642
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.30642
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.30642
AMN amnion associated transmembrane protein 2.30642
LMOD2 leiomodin 2 (cardiac) 2.30642
IFITM5 interferon induced transmembrane protein 5 2.30642
IL1A interleukin 1, alpha 2.30642
TEX19 testis expressed 19 2.30642
NRIP2 nuclear receptor interacting protein 2 2.30642
COL6A5 collagen, type VI, alpha 5 2.30642
SIRPG signal-regulatory protein gamma 2.30642
ITGB6 integrin, beta 6 2.30642
TH tyrosine hydroxylase 2.30642
LRRC43 leucine rich repeat containing 43 2.30642
ASCL1 achaete-scute family bHLH transcription factor 1 2.30642
LPAR5 lysophosphatidic acid receptor 5 2.30642
ANXA2R annexin A2 receptor 2.30642
CARD9 caspase recruitment domain family, member 9 2.30642
XCR1 chemokine (C motif) receptor 1 2.30642
PLGLB1 plasminogen-like B1 2.30642
AMIGO3 adhesion molecule with Ig-like domain 3 2.30642
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.30642
NUTM2F NUT family member 2F 2.30642
NUTM2A NUT family member 2A 2.30642
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 2.30642
CD226 CD226 molecule 2.30642
DUOXA1 dual oxidase maturation factor 1 2.30642
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.30642
TBC1D26 TBC1 domain family, member 26 2.30642
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.30642
FZD9 frizzled class receptor 9 2.30642
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 2.30642
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.30642
SNAI2 snail family zinc finger 2 2.30642
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.30642
CALML5 calmodulin-like 5 2.30642
TMEM52B transmembrane protein 52B 2.30642
CCDC74A coiled-coil domain containing 74A 2.30642
TRIM26 tripartite motif containing 26 2.30642
HOXB1 homeobox B1 2.30642
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.30642
GCM2 glial cells missing homolog 2 (Drosophila) 2.30642
APOL6 apolipoprotein L, 6 2.30642
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.30642
CDH20 cadherin 20, type 2 2.28452
CFAP46 cilia and flagella associated protein 46 2.26409
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.26409
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 2.26409
FSTL5 follistatin-like 5 2.26409
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2.26409
IGSF3 immunoglobulin superfamily, member 3 2.26409
PRM1 protamine 1 2.26409
DENND2D DENN/MADD domain containing 2D 2.26409
ZNF805 zinc finger protein 805 2.22679
ING3 inhibitor of growth family, member 3 2.20532
FAM234A family with sequence similarity 234 member A 2.19792
CLDN20 claudin 20 2.1801
PRICKLE2 prickle homolog 2 (Drosophila) 2.17737
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 2.15999
MAEA macrophage erythroblast attacher 2.15999
TRIM23 tripartite motif containing 23 2.15153
CEP85L centrosomal protein 85kDa-like 2.14915
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.14275
ARF6 ADP-ribosylation factor 6 2.1394
CATSPERB catsper channel auxiliary subunit beta 2.13667
PRKCA protein kinase C, alpha 2.12815
GATAD1 GATA zinc finger domain containing 1 2.12186
FBLN1 fibulin 1 2.12186
TSNAX translin-associated factor X 2.113
CENPB centromere protein B, 80kDa 2.11271
ZNF862 zinc finger protein 862 2.08399
DRG1 developmentally regulated GTP binding protein 1 2.07663
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 2.0741
SUOX sulfite oxidase 2.07378
RARB retinoic acid receptor, beta 2.06709
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.05993
ERGIC3 ERGIC and golgi 3 2.05986
TBPL1 TBP-like 1 2.05476
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 2.05476
PTCH2 patched 2 2.05476
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.05476
CDH3 cadherin 3, type 1, P-cadherin (placental) 2.04393
ZNG1B Zn regulated GTPase metalloprotein activator 1B 2.04039
PPARD peroxisome proliferator-activated receptor delta 2.04039
AKAP19 A-kinase anchoring protein 19 2.04039
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 2.04039
MFAP1 microfibrillar-associated protein 1 2.03851
RNF130 ring finger protein 130 2.01701
PRDM10 PR domain containing 10 2.01267
ZBTB3 zinc finger and BTB domain containing 3 2.01267
RBM47 RNA binding motif protein 47 2.01267
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 2.00698

decreased expression

Symbol Name Standardized Value
ARFRP1 ADP-ribosylation factor related protein 1 -2.31795
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.31795
DISC1 disrupted in schizophrenia 1 -2.30642
CCDC121 coiled-coil domain containing 121 -2.30642
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.30642
SAP25 Sin3A-associated protein, 25kDa -2.30642
CSPG4 chondroitin sulfate proteoglycan 4 -2.30642
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -2.30642
STAB2 stabilin 2 -2.30642
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.30642
NXNL2 nucleoredoxin-like 2 -2.30642
RPL13 ribosomal protein L13 -2.30642
AGBL1 ATP/GTP binding protein-like 1 -2.30642
SEC61B Sec61 beta subunit -2.30642
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -2.30642
C1ORF116 chromosome 1 open reading frame 116 -2.30642
FAXC failed axon connections homolog (Drosophila) -2.30642
IKZF1 IKAROS family zinc finger 1 (Ikaros) -2.30642
ZFYVE1 zinc finger, FYVE domain containing 1 -2.30642
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.30642
TCP11L1 t-complex 11, testis-specific-like 1 -2.30642
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 -2.30642
RPS16 ribosomal protein S16 -2.30642
RAD51AP1 RAD51 associated protein 1 -2.30642
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.30642
FAXDC2 fatty acid hydroxylase domain containing 2 -2.30642
TMLHE trimethyllysine hydroxylase, epsilon -2.30642
HPCA hippocalcin -2.30642
EPHA6 EPH receptor A6 -2.30642
VSTM5 V-set and transmembrane domain containing 5 -2.30642
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.30642
STIP1 stress-induced phosphoprotein 1 -2.30642
SERP2 stress-associated endoplasmic reticulum protein family member 2 -2.30642
BEX2 brain expressed X-linked 2 -2.30642
PACRG PARK2 co-regulated -2.30642
ZFAND1 zinc finger, AN1-type domain 1 -2.28239
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.26498
TSC1 tuberous sclerosis 1 -2.26409
SKIL SKI-like proto-oncogene -2.26409
ALG10B ALG10B, alpha-1,2-glucosyltransferase -2.26409
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.26409
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.26409
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -2.26409
EBI3 Epstein-Barr virus induced 3 -2.26409
WAS Wiskott-Aldrich syndrome -2.26409
SLC16A11 solute carrier family 16, member 11 -2.26409
LCN15 lipocalin 15 -2.26409
MTTP microsomal triglyceride transfer protein -2.26409
PCDHB4 protocadherin beta 4 -2.26409
RTL5 retrotransposon Gag like 5 -2.26409
HIPK4 homeodomain interacting protein kinase 4 -2.26409
DPPA3 developmental pluripotency associated 3 -2.26409
TRIM73 tripartite motif containing 73 -2.26409
VEGFD vascular endothelial growth factor D -2.26409
ADAM21 ADAM metallopeptidase domain 21 -2.26409
DES desmin -2.26409
C9ORF43 chromosome 9 open reading frame 43 -2.26409
APOH apolipoprotein H (beta-2-glycoprotein I) -2.26409
CCR9 chemokine (C-C motif) receptor 9 -2.26409
PEBP4 phosphatidylethanolamine-binding protein 4 -2.26409
CDH10 cadherin 10, type 2 (T2-cadherin) -2.26409
ZNF541 zinc finger protein 541 -2.26409
XKRX XK, Kell blood group complex subunit-related, X-linked -2.26409
FGFBP1 fibroblast growth factor binding protein 1 -2.26409
F11 coagulation factor XI -2.26409
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.26409
UTS2B urotensin 2B -2.26409
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.26409
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.26409
PRSS53 protease, serine, 53 -2.26409
MGARP mitochondria-localized glutamic acid-rich protein -2.26409
POTEI POTE ankyrin domain family, member I -2.26409
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) -2.26409
FMO3 flavin containing monooxygenase 3 -2.26409
BEAN1 brain expressed, associated with NEDD4, 1 -2.26409
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -2.26398
ZNF696 zinc finger protein 696 -2.26398
CYB5R3 cytochrome b5 reductase 3 -2.26092
TFAM transcription factor A, mitochondrial -2.25155
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.18727
CNR1 cannabinoid receptor 1 (brain) -2.18727
SF3B6 splicing factor 3b, subunit 6, 14kDa -2.18727
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.18386
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 -2.17408
KLKB1 kallikrein B, plasma (Fletcher factor) 1 -2.17271
CARNMT1 carnosine N-methyltransferase 1 -2.16575
ANXA6 annexin A6 -2.15786
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit -2.15089
LAPTM4B lysosomal protein transmembrane 4 beta -2.15037
KIF1B kinesin family member 1B -2.13667
DRC10 dynein regulatory complex subunit 10 -2.12815
KLHDC8A kelch domain containing 8A -2.12815
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.12815
TMEM79 transmembrane protein 79 -2.12815
SHOC1 shortage in chiasmata 1 -2.12186
CSNK2B casein kinase 2, beta polypeptide -2.12186
ZCCHC3 zinc finger, CCHC domain containing 3 -2.12186
CCDC150 coiled-coil domain containing 150 -2.12186
DERL1 derlin 1 -2.1197
BCAR1 breast cancer anti-estrogen resistance 1 -2.11324
ANXA7 annexin A7 -2.1118
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.07663
DVL3 dishevelled segment polarity protein 3 -2.05974
ZNF639 zinc finger protein 639 -2.05974
FRMPD3 FERM and PDZ domain containing 3 -2.05219
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -2.04977
TMEM230 transmembrane protein 230 -2.04804
C1ORF202 chromosome 1 open reading frame 202 -2.04191
CXCL17 chemokine (C-X-C motif) ligand 17 -2.04191
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.04039
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.04039
CA11 carbonic anhydrase XI -2.04039
SUGP1 SURP and G patch domain containing 1 -2.02261
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -2.02201
PDPR pyruvate dehydrogenase phosphatase regulatory subunit -2.01267
SMIM14 small integral membrane protein 14 -2.01267
LYPD1 LY6/PLAUR domain containing 1 -2.01267
DSG2 desmoglein 2 -2.01109
RAB6B RAB6B, member RAS oncogene family -2.00789
FZD2 frizzled class receptor 2 -2.00789