MM1S Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description Human B lymphoblast multiple myeloma cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003933)
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Genes

692 gene knockdowns changing fitness of MM1S relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
PHF3 PHD finger protein 3 3.19303
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 3.19167
ADPRH ADP-ribosylarginine hydrolase 3.1907
SRRM2 serine/arginine repetitive matrix 2 3.11557
RPL34 ribosomal protein L34 2.90207
EIF5B eukaryotic translation initiation factor 5B 2.86305
HNF1B HNF1 homeobox B 2.47464
GEN1 GEN1 Holliday junction 5' flap endonuclease 2.44374
RNF113A ring finger protein 113A 2.40046
UBQLNL ubiquilin-like 2.36028
USP39 ubiquitin specific peptidase 39 2.35649
PRSS55 protease, serine, 55 2.33521
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.309
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.30847
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 2.30334
RPS19 ribosomal protein S19 2.30134
CD7 CD7 molecule 2.30119
LTK leukocyte receptor tyrosine kinase 2.26069
ETNK1 ethanolamine kinase 1 2.16416
PIAS3 protein inhibitor of activated STAT, 3 2.13115
PAQR8 progestin and adipoQ receptor family member VIII 2.12653
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 2.11653
AQR aquarius intron-binding spliceosomal factor 2.1154
LOC100508408 2.11408
RPL31 ribosomal protein L31 2.10749
SYT11 synaptotagmin XI 2.09619
PMF1-BGLAP PMF1-BGLAP readthrough 2.09602
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 2.08632
FNTA farnesyltransferase, CAAX box, alpha 2.08359
RPS3A ribosomal protein S3A 2.05166
HIST1H4I histone cluster 1, H4i 2.04691
ACTC1 actin, alpha, cardiac muscle 1 2.03569
BPGM 2,3-bisphosphoglycerate mutase 2.02415
E2F3 E2F transcription factor 3 2.01052
RPS15A ribosomal protein S15a 2.00314
BAG2 BCL2-associated athanogene 2 1.99371
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 1.97246
BGLAP bone gamma-carboxyglutamate (gla) protein 1.97103
PFAS phosphoribosylformylglycinamidine synthase 1.96902
NODAL nodal growth differentiation factor 1.96565
CCR7 chemokine (C-C motif) receptor 7 1.95868
PEX3 peroxisomal biogenesis factor 3 1.94945
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 1.94749
SF3B2 splicing factor 3b, subunit 2, 145kDa 1.9307
KLRB1 killer cell lectin-like receptor subfamily B, member 1 1.92351
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 1.90758
CPA1 carboxypeptidase A1 (pancreatic) 1.90429
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 1.8997
BIRC6 baculoviral IAP repeat containing 6 1.8895
ZNF436 zinc finger protein 436 1.87338
GUCA2A guanylate cyclase activator 2A (guanylin) 1.8608
RPS13 ribosomal protein S13 1.8413
EBF2 early B-cell factor 2 1.84116
MSRA methionine sulfoxide reductase A 1.84084
RPS17 ribosomal protein S17 1.83486
ELMO3 engulfment and cell motility 3 1.8338
RPSAP58 ribosomal protein SA pseudogene 58 1.81325
FOXC1 forkhead box C1 1.79013
TRPS1 trichorhinophalangeal syndrome I 1.78818
SLC14A2 solute carrier family 14 (urea transporter), member 2 1.78179
NUCLEOLIN nucleolin multifunctional protein 1.77384
RPS27A ribosomal protein S27a 1.76492
DUXA double homeobox A 1.7496
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.74758
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 1.74529
DUX3 double homeobox 3 1.73969
RPSA ribosomal protein SA 1.69056
MAP3K4 mitogen-activated protein kinase kinase kinase 4 1.68944
RPL23A ribosomal protein L23a 1.68746
PAPPA2 pappalysin 2 1.67295
SUOX sulfite oxidase 1.66169
DHRS4L1 dehydrogenase/reductase (SDR family) member 4 like 1 1.65946
RUNDC3A RUN domain containing 3A 1.65238
GPSM1 G-protein signaling modulator 1 1.64553
ZNF432 zinc finger protein 432 1.6433
GLP1R glucagon-like peptide 1 receptor 1.64231
PXK PX domain containing serine/threonine kinase 1.6387
ACSS1 acyl-CoA synthetase short-chain family member 1 1.63368
RPS18 ribosomal protein S18 1.62824
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 1.62373
OTX2 orthodenticle homeobox 2 1.61969
GDF2 growth differentiation factor 2 1.61497
CRELD1 cysteine-rich with EGF-like domains 1 1.61418
AFG3L1P AFG3-like AAA ATPase 1, pseudogene 1.60408
MET MET proto-oncogene, receptor tyrosine kinase 1.59113
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.58923
OPN5 opsin 5 1.57961
KLK15 kallikrein-related peptidase 15 1.57907
PHKG2 phosphorylase kinase, gamma 2 (testis) 1.57695
OLFML2B olfactomedin-like 2B 1.57313
RABGGTA Rab geranylgeranyltransferase, alpha subunit 1.57121
FZD8 frizzled class receptor 8 1.57073
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 1.56802
DSCAM Down syndrome cell adhesion molecule 1.56341
FNDC3B fibronectin type III domain containing 3B 1.56163
JAG2 jagged 2 1.54043
RPS8 ribosomal protein S8 1.53503
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1.53326
HIST2H2AC histone cluster 2, H2ac 1.53149
TSG101 tumor susceptibility 101 1.5293
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 1.52662
EIF3G eukaryotic translation initiation factor 3, subunit G 1.52488
NME1 NME/NM23 nucleoside diphosphate kinase 1 1.52483
LHX8 LIM homeobox 8 1.51384
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 1.51376
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 1.50294
BTF3 basic transcription factor 3 1.50266
PPP1R9A protein phosphatase 1, regulatory subunit 9A 1.50183
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1.50173
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.49577
SRP9 signal recognition particle 9kDa 1.48762
CCDC71 coiled-coil domain containing 71 1.48064
LAMB3 laminin, beta 3 1.47711
BTF3L4 basic transcription factor 3-like 4 1.47678
ANKRD29 ankyrin repeat domain 29 1.47407
ATXN3 ataxin 3 1.47312
MSL2 male-specific lethal 2 homolog (Drosophila) 1.47001
MCM6 minichromosome maintenance complex component 6 1.46755
CNGB3 cyclic nucleotide gated channel beta 3 1.46383
FADS6 fatty acid desaturase 6 1.46191
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 1.45818
ABLIM1 actin binding LIM protein 1 1.45681
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 1.45105
SCARF1 scavenger receptor class F, member 1 1.44278
HDAC7 histone deacetylase 7 1.4404
SDK1 sidekick cell adhesion molecule 1 1.42836
VARS valyl-tRNA synthetase 1.42162
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 1.4158
CHD9 chromodomain helicase DNA binding protein 9 1.40777
KLF13 Kruppel-like factor 13 1.40455
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 1.40238
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 1.40193
OXSM 3-oxoacyl-ACP synthase, mitochondrial 1.39585
ANXA8 annexin A8 1.39369
MMP2 matrix metallopeptidase 2 1.39245
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 1.39092
NXF1 nuclear RNA export factor 1 1.38774
HIST1H2AI histone cluster 1, H2ai 1.387
SIX6 SIX homeobox 6 1.38511
RPS15 ribosomal protein S15 1.38446
PITRM1 pitrilysin metallopeptidase 1 1.38186
UBB ubiquitin B 1.37638
PLCH1 phospholipase C, eta 1 1.36351
RGSL1 regulator of G-protein signaling like 1 1.36332
DMTF1 cyclin D binding myb-like transcription factor 1 1.36226
GPX3 glutathione peroxidase 3 1.36172
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 1.3614
CXCL11 chemokine (C-X-C motif) ligand 11 1.36047
FTH1P3 ferritin, heavy polypeptide 1 pseudogene 3 1.35835
FAM207A family with sequence similarity 207, member A 1.34839
CDC5L cell division cycle 5-like 1.34697
H1FOO H1 histone family, member O, oocyte-specific 1.34649
GPX1 glutathione peroxidase 1 1.34595
TMOD1 tropomodulin 1 1.34448
POU2F3 POU class 2 homeobox 3 1.33735
CTSB cathepsin B 1.33692
CAPN7 calpain 7 1.33607
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.33555
KCTD7 potassium channel tetramerization domain containing 7 1.33469
IL1R1 interleukin 1 receptor, type I 1.33447
FOXK1 forkhead box K1 1.33441
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 1.33356
ZIC5 Zic family member 5 1.333
CLEC2D C-type lectin domain family 2, member D 1.33171
NFIB nuclear factor I/B 1.33045
PKD2L2 polycystic kidney disease 2-like 2 1.33044
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.32614
ERF Ets2 repressor factor 1.32592
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1.32515
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 1.32458
COL11A1 collagen, type XI, alpha 1 1.32335
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.32196
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 1.32004
E2F1 E2F transcription factor 1 1.31932
HIST1H2AD histone cluster 1, H2ad 1.31573
MXD3 MAX dimerization protein 3 1.30734
MEF2C myocyte enhancer factor 2C 1.29987
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 1.29625
TSC22D4 TSC22 domain family, member 4 1.29422
PDAP1 PDGFA associated protein 1 1.29236
OR10S1 olfactory receptor, family 10, subfamily S, member 1 1.29075
NUP107 nucleoporin 107kDa 1.29028
TRIM41 tripartite motif containing 41 1.28192
LMNA lamin A/C 1.28024
GTPBP3 GTP binding protein 3 (mitochondrial) 1.27597
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 1.27381
CRX cone-rod homeobox 1.27326
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 1.26949
APAF1 apoptotic peptidase activating factor 1 1.26436
RPS29 ribosomal protein S29 1.26306
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 1.26186
XPOT exportin, tRNA 1.26167
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 1.25469
MCHR2 melanin-concentrating hormone receptor 2 1.2478
PRTN3 proteinase 3 1.24659
RPS11 ribosomal protein S11 1.24408
SYT9 synaptotagmin IX 1.24405
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 1.24159
PLRG1 pleiotropic regulator 1 1.24152
DTX1 deltex 1, E3 ubiquitin ligase 1.24147
NAV3 neuron navigator 3 1.24028
VILL villin-like 1.23874
GPR146 G protein-coupled receptor 146 1.23765
ZNF217 zinc finger protein 217 1.23505
DMAP1 DNA methyltransferase 1 associated protein 1 1.23489
OR2T1 olfactory receptor, family 2, subfamily T, member 1 1.23325
ZNF454 zinc finger protein 454 1.23229
KDM4C lysine (K)-specific demethylase 4C 1.2322
PPP1R7 protein phosphatase 1, regulatory subunit 7 1.23156
CD209 CD209 molecule 1.22604
HIST1H2AC histone cluster 1, H2ac 1.22034
ZNF143 zinc finger protein 143 1.21917
SIM2 single-minded family bHLH transcription factor 2 1.21351
PTPRC protein tyrosine phosphatase, receptor type, C 1.2089
CUL5 cullin 5 1.208
NOG noggin 1.20718
HIST3H2A histone cluster 3, H2a 1.20134
KISS1 KiSS-1 metastasis-suppressor 1.19748
ZSCAN20 zinc finger and SCAN domain containing 20 1.19454
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 1.18774
NUP160 nucleoporin 160kDa 1.18677
SOX14 SRY (sex determining region Y)-box 14 1.18656
RPL7 ribosomal protein L7 1.18566
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 1.18464
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.1832
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 1.18234
ZNF585A zinc finger protein 585A 1.18189
RRM1 ribonucleotide reductase M1 1.17799
HCK HCK proto-oncogene, Src family tyrosine kinase 1.17677
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 1.17491
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 1.17159
HIST1H3D histone cluster 1, H3d 1.16859
INSM1 insulinoma-associated 1 1.1678
NACA nascent polypeptide-associated complex alpha subunit 1.16647
HIST1H2AL histone cluster 1, H2al 1.16615
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.16378
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.16339
VCP valosin containing protein 1.16149
FN3K fructosamine 3 kinase 1.16082
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 1.15782
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 1.1561
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.15358
SCARA3 scavenger receptor class A, member 3 1.14949
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 1.14873
ZRANB2 zinc finger, RAN-binding domain containing 2 1.14828
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 1.14659
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 1.14635
SLCO1B7 solute carrier organic anion transporter family, member 1B7 (non-functional) 1.14581
LEP leptin 1.14529
MAN1A1 mannosidase, alpha, class 1A, member 1 1.14408
OR10J1 olfactory receptor, family 10, subfamily J, member 1 1.14073
ACBD3 acyl-CoA binding domain containing 3 1.13785
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 1.13503
HIST1H2AB histone cluster 1, H2ab 1.12864
CALN1 calneuron 1 1.12497
SLC17A2 solute carrier family 17, member 2 1.12436
PHF11 PHD finger protein 11 1.1236
MFAP1 microfibrillar-associated protein 1 1.12305
POLR1C polymerase (RNA) I polypeptide C, 30kDa 1.11944
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 1.11742
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 1.1153
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 1.11519
GALNS galactosamine (N-acetyl)-6-sulfatase 1.11456
ZNF684 zinc finger protein 684 1.11386
SRY sex determining region Y 1.11246
C1QA complement component 1, q subcomponent, A chain 1.11062
COG3 component of oligomeric golgi complex 3 1.10948
NINJ1 ninjurin 1 1.10892
U2AF1 U2 small nuclear RNA auxiliary factor 1 1.10456
DTNB dystrobrevin, beta 1.10424
CALCR calcitonin receptor 1.10324
TMPRSS13 transmembrane protease, serine 13 1.10236
MCM5 minichromosome maintenance complex component 5 1.10168
PCBP1 poly(rC) binding protein 1 1.10104
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 1.10003
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 1.09931
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.09869
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 1.09827
PDHB pyruvate dehydrogenase (lipoamide) beta 1.09603
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1 1.0958
NLN neurolysin (metallopeptidase M3 family) 1.09565
CNGA1 cyclic nucleotide gated channel alpha 1 1.09454
TSLP thymic stromal lymphopoietin 1.09353
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.09096
APOO apolipoprotein O 1.08925
EME1 essential meiotic structure-specific endonuclease 1 1.08919
ASPH aspartate beta-hydroxylase 1.08882
ADCK3 aarF domain containing kinase 3 1.08799
RAB20 RAB20, member RAS oncogene family 1.0874
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 1.08642
AHR aryl hydrocarbon receptor 1.08605
TPTE transmembrane phosphatase with tensin homology 1.08186
TICAM2 toll-like receptor adaptor molecule 2 1.08126
PMM1 phosphomannomutase 1 1.07964
STK3 serine/threonine kinase 3 1.07482
HRK harakiri, BCL2 interacting protein 1.07476
CARD9 caspase recruitment domain family, member 9 1.07451
CABP4 calcium binding protein 4 1.07446
MNX1 motor neuron and pancreas homeobox 1 1.07444
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.07078
EVX1 even-skipped homeobox 1 1.06908
SLAMF1 signaling lymphocytic activation molecule family member 1 1.06898
VEZF1 vascular endothelial zinc finger 1 1.06516
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.05979
PDE1A phosphodiesterase 1A, calmodulin-dependent 1.05969
CFD complement factor D (adipsin) 1.05509
EIF4E eukaryotic translation initiation factor 4E 1.05236
GIMAP4 GTPase, IMAP family member 4 1.05204
FOXH1 forkhead box H1 1.05095
NTF3 neurotrophin 3 1.04804
CDC40 cell division cycle 40 1.04693
HIST1H2AG histone cluster 1, H2ag 1.04592
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 1.04507
CDK11B cyclin-dependent kinase 11B 1.04389
SF3A3 splicing factor 3a, subunit 3, 60kDa 1.04299
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.04182
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 1.04179
HOXB4 homeobox B4 1.04039
OCM oncomodulin 1.03781
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.0366
AHCTF1 AT hook containing transcription factor 1 1.035
GRK7 G protein-coupled receptor kinase 7 1.03412
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 1.03325
LPGAT1 lysophosphatidylglycerol acyltransferase 1 1.03286
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.02895
RPGR retinitis pigmentosa GTPase regulator 1.02851
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) 1.02556
NDOR1 NADPH dependent diflavin oxidoreductase 1 1.02418
PCDHB5 protocadherin beta 5 1.02326
USP32 ubiquitin specific peptidase 32 1.0223
RPS14 ribosomal protein S14 1.02107
IL13 interleukin 13 1.02066
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.0195
IFNA13 interferon, alpha 13 1.01821
TASP1 taspase, threonine aspartase, 1 1.016
EMX1 empty spiracles homeobox 1 1.01523
GCKR glucokinase (hexokinase 4) regulator 1.01512
CSNK2B casein kinase 2, beta polypeptide 1.01373
ZNF329 zinc finger protein 329 1.0129
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 1.01225
PRKCSH protein kinase C substrate 80K-H 1.00949
TCEAL1 transcription elongation factor A (SII)-like 1 1.00948
TRPM1 transient receptor potential cation channel, subfamily M, member 1 1.00864
ZNF461 zinc finger protein 461 1.00782
CRK v-crk avian sarcoma virus CT10 oncogene homolog 1.00746
FLNB filamin B, beta 1.00611
SLC31A1 solute carrier family 31 (copper transporter), member 1 1.00607
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 1.00528
AKIP1 A kinase (PRKA) interacting protein 1 1.00445
RNASEH2A ribonuclease H2, subunit A 1.00383
ZNF571 zinc finger protein 571 1.00276
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 1.00223
LBR lamin B receptor 1.00211
API5 apoptosis inhibitor 5 1.00162
RND3 Rho family GTPase 3 1.00069

decreased fitness

Symbol Name Standardized Value
SREBF1 sterol regulatory element binding transcription factor 1 -3.50369
TAS2R60 taste receptor, type 2, member 60 -3.1821
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -3.18002
INHBC inhibin, beta C -3.15292
REPIN1 replication initiator 1 -2.99763
PLXNC1 plexin C1 -2.96279
GPR32 G protein-coupled receptor 32 -2.95871
CNTF ciliary neurotrophic factor -2.94936
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.84226
DIDO1 death inducer-obliterator 1 -2.80635
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.74961
EPB41 erythrocyte membrane protein band 4.1 -2.71462
TTLL1 tubulin tyrosine ligase-like family member 1 -2.70703
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -2.64341
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -2.59365
RIMS3 regulating synaptic membrane exocytosis 3 -2.59327
GPR141 G protein-coupled receptor 141 -2.52983
IVD isovaleryl-CoA dehydrogenase -2.5111
MMP19 matrix metallopeptidase 19 -2.50487
TM7SF2 transmembrane 7 superfamily member 2 -2.49186
UGDH UDP-glucose 6-dehydrogenase -2.47631
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.44395
NLGN1 neuroligin 1 -2.44102
FFAR2 free fatty acid receptor 2 -2.43177
ANPEP alanyl (membrane) aminopeptidase -2.43002
ZNF92 zinc finger protein 92 -2.39074
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -2.34056
CD302 CD302 molecule -2.33823
CPNE3 copine III -2.26276
LY75-CD302 LY75-CD302 readthrough -2.24475
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 -2.2224
BAG6 BCL2-associated athanogene 6 -2.21749
CD248 CD248 molecule, endosialin -2.19155
ZNF560 zinc finger protein 560 -2.14856
RORA RAR-related orphan receptor A -2.13011
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.11761
ZNF227 zinc finger protein 227 -2.10594
UBAC2 UBA domain containing 2 -2.09729
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.08441
ZNF568 zinc finger protein 568 -2.05141
CFLAR CASP8 and FADD-like apoptosis regulator -2.00374
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -1.977
DAP death-associated protein -1.97087
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 -1.96818
ZNF254 zinc finger protein 254 -1.9676
PTRH2 peptidyl-tRNA hydrolase 2 -1.96319
CIB4 calcium and integrin binding family member 4 -1.94969
MOCS2 molybdenum cofactor synthesis 2 -1.94604
OPN4 opsin 4 -1.9416
IL1RAP interleukin 1 receptor accessory protein -1.93865
ATP13A2 ATPase type 13A2 -1.93141
STRN4 striatin, calmodulin binding protein 4 -1.93127
ZNF513 zinc finger protein 513 -1.92733
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 -1.91945
ACRBP acrosin binding protein -1.91774
PDCD6IP programmed cell death 6 interacting protein -1.91188
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -1.91185
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase -1.90009
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -1.88951
LYAR Ly1 antibody reactive -1.88689
MC4R melanocortin 4 receptor -1.87779
ADGRG6 adhesion G protein-coupled receptor G6 -1.87369
ZNF160 zinc finger protein 160 -1.8696
HIST1H1C histone cluster 1, H1c -1.86063
SLC35E1 solute carrier family 35, member E1 -1.86
MOCS3 molybdenum cofactor synthesis 3 -1.85641
CST11 cystatin 11 -1.85292
ZNF813 zinc finger protein 813 -1.84398
PTDSS2 phosphatidylserine synthase 2 -1.83845
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 -1.83207
AGBL2 ATP/GTP binding protein-like 2 -1.82064
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -1.81959
ZNF599 zinc finger protein 599 -1.8054
OR10R2 olfactory receptor, family 10, subfamily R, member 2 -1.80371
OR2J2 olfactory receptor, family 2, subfamily J, member 2 -1.79741
STK17B serine/threonine kinase 17b -1.79056
RBKS ribokinase -1.75595
MPG N-methylpurine-DNA glycosylase -1.7408
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -1.73106
ZNF707 zinc finger protein 707 -1.72884
CYB5A cytochrome b5 type A (microsomal) -1.71619
TP53BP1 tumor protein p53 binding protein 1 -1.71416
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -1.71347
HOXC5 homeobox C5 -1.70702
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -1.70541
CCL25 chemokine (C-C motif) ligand 25 -1.69968
ZNF322P1 zinc finger protein 322 pseudogene 1 -1.69937
ZFP91-CNTF ZFP91-CNTF readthrough (NMD candidate) -1.69902
PLXNA3 plexin A3 -1.69628
ZNF493 zinc finger protein 493 -1.69563
AZIN1 antizyme inhibitor 1 -1.68258
MBD3 methyl-CpG binding domain protein 3 -1.67829
ZIK1 zinc finger protein interacting with K protein 1 -1.675
CD72 CD72 molecule -1.6745
CYLD cylindromatosis (turban tumor syndrome) -1.67284
SLK STE20-like kinase -1.66669
CES1 carboxylesterase 1 -1.66624
CBS cystathionine-beta-synthase -1.66372
TGFA transforming growth factor, alpha -1.65825
DPP7 dipeptidyl-peptidase 7 -1.65221
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase -1.65189
MCTP1 multiple C2 domains, transmembrane 1 -1.63757
HESX1 HESX homeobox 1 -1.6375
INSR insulin receptor -1.63168
RASA2 RAS p21 protein activator 2 -1.62936
IL20 interleukin 20 -1.62666
RPH3A rabphilin 3A -1.61627
E4F1 E4F transcription factor 1 -1.61357
ZNF43 zinc finger protein 43 -1.60227
TADA3 transcriptional adaptor 3 -1.59913
PLSCR4 phospholipid scramblase 4 -1.59488
CXCR3 chemokine (C-X-C motif) receptor 3 -1.59457
RAB3A RAB3A, member RAS oncogene family -1.59211
ZNF460 zinc finger protein 460 -1.58898
CASP8 caspase 8, apoptosis-related cysteine peptidase -1.58723
S100A13 S100 calcium binding protein A13 -1.58689
RIOK1 RIO kinase 1 -1.58217
OR2B2 olfactory receptor, family 2, subfamily B, member 2 -1.57221
PROC protein C (inactivator of coagulation factors Va and VIIIa) -1.56957
SSTR2 somatostatin receptor 2 -1.56826
LIMD1 LIM domains containing 1 -1.56613
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -1.56263
TMPO thymopoietin -1.55894
STK17A serine/threonine kinase 17a -1.5557
ZNF792 zinc finger protein 792 -1.55473
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin -1.55147
ZNF681 zinc finger protein 681 -1.54434
ARL1 ADP-ribosylation factor-like 1 -1.54314
CWC15 CWC15 spliceosome-associated protein -1.54282
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -1.54022
R3HDM2 R3H domain containing 2 -1.53804
SEC23B Sec23 homolog B (S. cerevisiae) -1.53671
ZNF322 zinc finger protein 322 -1.53213
TRIM6 tripartite motif containing 6 -1.53014
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H -1.52899
OR2H1 olfactory receptor, family 2, subfamily H, member 1 -1.51023
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -1.50902
ZNF775 zinc finger protein 775 -1.50303
F9 coagulation factor IX -1.49987
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -1.4979
RASD2 RASD family, member 2 -1.49488
ZNF729 zinc finger protein 729 -1.48989
DLX6 distal-less homeobox 6 -1.48721
PNPLA8 patatin-like phospholipase domain containing 8 -1.48422
HSPA4 heat shock 70kDa protein 4 -1.4766
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 -1.46482
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -1.46105
PLA2G4B phospholipase A2, group IVB (cytosolic) -1.46082
TCERG1L transcription elongation regulator 1-like -1.45835
BMP6 bone morphogenetic protein 6 -1.45003
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) -1.44843
OR3A1 olfactory receptor, family 3, subfamily A, member 1 -1.44737
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -1.44402
PDCL phosducin-like -1.43961
BBX bobby sox homolog (Drosophila) -1.43594
HK2 hexokinase 2 -1.43502
EBAG9 estrogen receptor binding site associated, antigen, 9 -1.43249
TLR4 toll-like receptor 4 -1.42437
RAB19 RAB19, member RAS oncogene family -1.42354
IKZF2 IKAROS family zinc finger 2 (Helios) -1.42201
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -1.41886
CIR1 corepressor interacting with RBPJ, 1 -1.41794
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -1.41406
BAAT bile acid CoA:amino acid N-acyltransferase -1.41323
ICOS inducible T-cell co-stimulator -1.40963
YBX1 Y box binding protein 1 -1.40731
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1 -1.402
MBNL1 muscleblind-like splicing regulator 1 -1.40157
S100B S100 calcium binding protein B -1.39922
DICER1 dicer 1, ribonuclease type III -1.39268
GDF10 growth differentiation factor 10 -1.391
INPP5F inositol polyphosphate-5-phosphatase F -1.39007
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 -1.38977
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -1.38675
MXD4 MAX dimerization protein 4 -1.38665
ELF5 E74-like factor 5 (ets domain transcription factor) -1.38531
IRF4 interferon regulatory factor 4 -1.38522
ACOX3 acyl-CoA oxidase 3, pristanoyl -1.38402
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) -1.37985
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -1.37664
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -1.37244
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 -1.37117
NR0B2 nuclear receptor subfamily 0, group B, member 2 -1.36496
METRN meteorin, glial cell differentiation regulator -1.3633
PON1 paraoxonase 1 -1.36302
HIST1H2AM histone cluster 1, H2am -1.36135
PCDHA4 protocadherin alpha 4 -1.35864
CELA1 chymotrypsin-like elastase family, member 1 -1.35166
OR2AK2 olfactory receptor, family 2, subfamily AK, member 2 -1.35115
EPHA5 EPH receptor A5 -1.34005
OR1G1 olfactory receptor, family 1, subfamily G, member 1 -1.33826
C14ORF166 chromosome 14 open reading frame 166 -1.32193
FAM131B family with sequence similarity 131, member B -1.31856
BCHE butyrylcholinesterase -1.30431
SPRED2 sprouty-related, EVH1 domain containing 2 -1.30208
PQBP1 polyglutamine binding protein 1 -1.29994
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -1.2928
TMEM130 transmembrane protein 130 -1.29246
CST3 cystatin C -1.28965
SEPHS1 selenophosphate synthetase 1 -1.28285
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -1.28254
IGFBP5 insulin-like growth factor binding protein 5 -1.28033
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma -1.27276
EBP emopamil binding protein (sterol isomerase) -1.26976
NCOA2 nuclear receptor coactivator 2 -1.26715
SLC35E4 solute carrier family 35, member E4 -1.26452
HK3 hexokinase 3 (white cell) -1.25058
APOC3 apolipoprotein C-III -1.2473
EPHB1 EPH receptor B1 -1.24641
CCNI cyclin I -1.23897
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -1.23394
MTA3 metastasis associated 1 family, member 3 -1.23098
NRP2 neuropilin 2 -1.2281
UTRN utrophin -1.22569
ZNF680 zinc finger protein 680 -1.22463
CD8B CD8b molecule -1.22222
PAX9 paired box 9 -1.2084
CNTRL centriolin -1.20502
TGM5 transglutaminase 5 -1.2038
PDCL3 phosducin-like 3 -1.20319
ZBTB26 zinc finger and BTB domain containing 26 -1.20083
CCR8 chemokine (C-C motif) receptor 8 -1.20073
STX1B syntaxin 1B -1.19587
HLA-DMB major histocompatibility complex, class II, DM beta -1.19558
PI4KB phosphatidylinositol 4-kinase, catalytic, beta -1.19481
RAB5B RAB5B, member RAS oncogene family -1.192
ACTL8 actin-like 8 -1.19184
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -1.19141
DGKA diacylglycerol kinase, alpha 80kDa -1.18993
OSGEP O-sialoglycoprotein endopeptidase -1.18795
PCDHAC1 protocadherin alpha subfamily C, 1 -1.18324
DMBT1 deleted in malignant brain tumors 1 -1.18251
PLK2 polo-like kinase 2 -1.18073
PCDHA2 protocadherin alpha 2 -1.1776
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -1.17639
OR7E5P olfactory receptor, family 7, subfamily E, member 5 pseudogene -1.17141
BST2 bone marrow stromal cell antigen 2 -1.17138
IL12RB1 interleukin 12 receptor, beta 1 -1.16837
GPR83 G protein-coupled receptor 83 -1.16694
HILS1 histone linker H1 domain, spermatid-specific 1, pseudogene -1.16055
TEX30 testis expressed 30 -1.16039
TEAD2 TEA domain family member 2 -1.15948
IDI1 isopentenyl-diphosphate delta isomerase 1 -1.15907
CD3G CD3g molecule, gamma (CD3-TCR complex) -1.1529
DLG4 discs, large homolog 4 (Drosophila) -1.14917
GPR174 G protein-coupled receptor 174 -1.14869
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -1.14768
MUSK muscle, skeletal, receptor tyrosine kinase -1.14724
ZNF728 zinc finger protein 728 -1.14653
ZFP36L2 ZFP36 ring finger protein-like 2 -1.14544
DMRT3 doublesex and mab-3 related transcription factor 3 -1.14046
SLC10A4 solute carrier family 10, member 4 -1.1392
OR8G5 olfactory receptor, family 8, subfamily G, member 5 -1.13882
MAPRE2 microtubule-associated protein, RP/EB family, member 2 -1.13706
OR2L13 olfactory receptor, family 2, subfamily L, member 13 -1.13703
MAP2 microtubule-associated protein 2 -1.13315
RGS4 regulator of G-protein signaling 4 -1.12927
CAPN11 calpain 11 -1.12715
KRT1 keratin 1, type II -1.12592
ZNF566 zinc finger protein 566 -1.12448
FBXO3 F-box protein 3 -1.12046
RNF39 ring finger protein 39 -1.1191
DCTN4 dynactin 4 (p62) -1.11708
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -1.11545
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -1.11427
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -1.1142
AKAP3 A kinase (PRKA) anchor protein 3 -1.10933
DCT dopachrome tautomerase -1.10624
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough -1.10488
JDP2 Jun dimerization protein 2 -1.1038
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -1.1038
CPA4 carboxypeptidase A4 -1.09801
GRIA2 glutamate receptor, ionotropic, AMPA 2 -1.09783
OSR1 odd-skipped related transciption factor 1 -1.09742
RHOJ ras homolog family member J -1.09255
ZNF248 zinc finger protein 248 -1.08538
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -1.08434
GUK1 guanylate kinase 1 -1.0815
ZNF525 zinc finger protein 525 -1.07934
PCDH17 protocadherin 17 -1.0791
MEST mesoderm specific transcript -1.07777
ZNF430 zinc finger protein 430 -1.07595
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -1.07368
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -1.07256
TRIM17 tripartite motif containing 17 -1.07236
WFDC5 WAP four-disulfide core domain 5 -1.07114
STS steroid sulfatase (microsomal), isozyme S -1.07065
FMNL1 formin-like 1 -1.06983
ARHGAP20 Rho GTPase activating protein 20 -1.06501
PLSCR2 phospholipid scramblase 2 -1.06248
TAS2R42 taste receptor, type 2, member 42 -1.06185
ZNF239 zinc finger protein 239 -1.06057
LHB luteinizing hormone beta polypeptide -1.05953
SPTAN1 spectrin, alpha, non-erythrocytic 1 -1.05931
IFNA16 interferon, alpha 16 -1.05867
ALG6 ALG6, alpha-1,3-glucosyltransferase -1.05853
COMT catechol-O-methyltransferase -1.05583
URM1 ubiquitin related modifier 1 -1.05527
TRIM49 tripartite motif containing 49 -1.05366
TECTA tectorin alpha -1.05253
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -1.05049
C10ORF10 chromosome 10 open reading frame 10 -1.05026
M6PR mannose-6-phosphate receptor (cation dependent) -1.04944
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -1.0475
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -1.0447
GADD45G growth arrest and DNA-damage-inducible, gamma -1.0378
SSBP2 single-stranded DNA binding protein 2 -1.03693
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -1.03662
PCDHA6 protocadherin alpha 6 -1.0364
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 -1.03351
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -1.0332
WDR11 WD repeat domain 11 -1.03239
BMP2K BMP2 inducible kinase -1.03125
ZNF845 zinc finger protein 845 -1.03076
ABR active BCR-related -1.02884
ZNF766 zinc finger protein 766 -1.02797
MAN2B1 mannosidase, alpha, class 2B, member 1 -1.02681
SIAE sialic acid acetylesterase -1.02609
UIMC1 ubiquitin interaction motif containing 1 -1.02553
ZNF250 zinc finger protein 250 -1.02215
ZNF624 zinc finger protein 624 -1.02173
PLXNA1 plexin A1 -1.02082
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -1.01868
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -1.0155
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -1.01447
TCN2 transcobalamin II -1.01324
TRAF3 TNF receptor-associated factor 3 -1.01092
SCO2 SCO2 cytochrome c oxidase assembly protein -1.01036
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -1.00838
KRT13 keratin 13, type I -1.00677
DIAPH2 diaphanous-related formin 2 -1.00608
ZNF117 zinc finger protein 117 -1.00547
MYL4 myosin, light chain 4, alkali; atrial, embryonic -1.00425
ULBP3 UL16 binding protein 3 -1.00422
LDHB lactate dehydrogenase B -1.0017
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -1.00104
RGS16 regulator of G-protein signaling 16 -1.00084