MMP11 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description matrix metallopeptidase 11|Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4320)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_MMP11
Similar Terms
Downloads & Tools

Genes

41 co-expressed genes for MMP11 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ALPP alkaline phosphatase, placental
CAPN6 calpain 6
CRH corticotropin releasing hormone
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
EBI3 Epstein-Barr virus induced 3
EGFL6 EGF-like-domain, multiple 6
ENDOU endonuclease, polyU-specific
GCM1 glial cells missing homolog 1 (Drosophila)
GDF15 growth differentiation factor 15
GH2 growth hormone 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IGFBP1 insulin-like growth factor binding protein 1
INSL4 insulin-like 4 (placenta)
KISS1 KiSS-1 metastasis-suppressor
LEP leptin
LGALS14 lectin, galactoside-binding, soluble, 14
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MMP11 matrix metallopeptidase 11
PAGE4 P antigen family, member 4 (prostate associated)
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PLAC1 placenta-specific 1
PSG1 pregnancy specific beta-1-glycoprotein 1
PSG2 pregnancy specific beta-1-glycoprotein 2
PSG3 pregnancy specific beta-1-glycoprotein 3
PSG4 pregnancy specific beta-1-glycoprotein 4
PSG5 pregnancy specific beta-1-glycoprotein 5
PSG6 pregnancy specific beta-1-glycoprotein 6
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
PSG9 pregnancy specific beta-1-glycoprotein 9
RHOBTB1 Rho-related BTB domain containing 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP2 TIMP metallopeptidase inhibitor 2
VGLL1 vestigial-like family member 1