MMP11 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description matrix metallopeptidase 11|Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4320)
External Link http://www.ncbi.nlm.nih.gov/gene/4320
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Genes

4 interacting proteins for MMP11 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
FURIN furin (paired basic amino acid cleaving enzyme)
MMP1 matrix metallopeptidase 1
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1