| Dataset | Pathway Commons Protein-Protein Interactions |
| Category | physical interactions |
| Type | interacting protein |
| Description | matrix metallopeptidase 13|Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4322) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/4322 |
| Similar Terms | |
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29 interacting proteins for MMP13 from the Pathway Commons Protein-Protein Interactions dataset.
| Symbol | Name |
|---|---|
| ACAN | aggrecan |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
| BCAN | brevican |
| CCL7 | chemokine (C-C motif) ligand 7 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) |
| COL14A1 | collagen, type XIV, alpha 1 |
| COL15A1 | collagen, type XV, alpha 1 |
| COL18A1 | collagen, type XVIII, alpha 1 |
| COL2A1 | collagen, type II, alpha 1 |
| COL9A1 | collagen, type IX, alpha 1 |
| COL9A2 | collagen, type IX, alpha 2 |
| COL9A3 | collagen, type IX, alpha 3 |
| CTSK | cathepsin K |
| F12 | coagulation factor XII (Hageman factor) |
| HSPG2 | heparan sulfate proteoglycan 2 |
| LAMA3 | laminin, alpha 3 |
| LAMB3 | laminin, beta 3 |
| LAMC2 | laminin, gamma 2 |
| LPA | lipoprotein, Lp(a) |
| LRP1 | low density lipoprotein receptor-related protein 1 |
| MAX | MYC associated factor X |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) |
| MMP3 | matrix metallopeptidase 3 |
| MMP9 | matrix metallopeptidase 9 |
| PLG | plasminogen |
| PRSS1 | protease, serine, 1 (trypsin 1) |
| TIMP3 | TIMP metallopeptidase inhibitor 3 |
