MMP2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description matrix metallopeptidase 2|This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] (NCBI Entrez Gene Database, 4313)
External Link http://www.ncbi.nlm.nih.gov/gene/4313
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353 interacting proteins for MMP2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
ACAN aggrecan
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTBL2 actin, beta-like 2
AHCY adenosylhomocysteinase
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALB albumin
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDOA aldolase A, fructose-bisphosphate
AMPD1 adenosine monophosphate deaminase 1
ANAPC1 anaphase promoting complex subunit 1
ANGPT1 angiopoietin 1
ANGPT4 angiopoietin 4
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ATG3 autophagy related 3
ATG4B autophagy related 4B, cysteine peptidase
ATG7 autophagy related 7
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
BACE1 beta-site APP-cleaving enzyme 1
BAG4 BCL2-associated athanogene 4
BCAN brevican
BUB3 BUB3 mitotic checkpoint protein
C1QBP complement component 1, q subcomponent binding protein
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAND1 cullin-associated and neddylation-dissociated 1
CAPN3 calpain 3, (p94)
CAPZB capping protein (actin filament) muscle Z-line, beta
CARM1 coactivator-associated arginine methyltransferase 1
CCBL2 cysteine conjugate-beta lyase 2
CCL7 chemokine (C-C motif) ligand 7
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CENPJ centromere protein J
CLDN1 claudin 1
CLINT1 clathrin interactor 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A3 collagen, type VI, alpha 3
COL7A1 collagen, type VII, alpha 1
CORO1C coronin, actin binding protein, 1C
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CUL1 cullin 1
CUL9 cullin 9
CXCL12 chemokine (C-X-C motif) ligand 12
DAP3 death associated protein 3
DAZAP1 DAZ associated protein 1
DCN decorin
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DGAT2L7P diacylglycerol O-acyltransferase 2-like 7, pseudogene
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLAT dihydrolipoamide S-acetyltransferase
DMWD dystrophia myotonica, WD repeat containing
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPP3 dipeptidyl-peptidase 3
DSG1 desmoglein 1
DSP desmoplakin
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EFNB3 ephrin-B3
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPHB6 EPH receptor B6
EWSR1 EWS RNA-binding protein 1
FAM91A1 family with sequence similarity 91, member A1
FASN fatty acid synthase
FGFR1 fibroblast growth factor receptor 1
FLG filaggrin
FLG2 filaggrin family member 2
FLNB filamin B, beta
FLNC filamin C, gamma
FOXK1 forkhead box K1
FOXK2 forkhead box K2
FUS FUS RNA binding protein
FYCO1 FYVE and coiled-coil domain containing 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBAS glioblastoma amplified sequence
GFAP glial fibrillary acidic protein
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLO1 glyoxalase I
GMPS guanine monphosphate synthase
GPI glucose-6-phosphate isomerase
GSTP1 glutathione S-transferase pi 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIST1H1C histone cluster 1, H1c
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90AB2P heat shock protein 90kDa alpha (cytosolic), class B member 2, pseudogene
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IARS isoleucyl-tRNA synthetase
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
IQSEC1 IQ motif and Sec7 domain 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUP junction plakoglobin
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KEAP1 kelch-like ECH-associated protein 1
KISS1 KiSS-1 metastasis-suppressor
KLHL12 kelch-like family member 12
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT2 keratin 2, type II
KRT24 keratin 24, type I
KRT5 keratin 5, type II
KRT71 keratin 71, type II
KRT75 keratin 75, type II
KRT76 keratin 76, type II
KRT77 keratin 77, type II
KRT78 keratin 78, type II
KRT9 keratin 9, type I
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC47 leucine rich repeat containing 47
LUC7L2 LUC7-like 2 (S. cerevisiae)
MAP1A microtubule-associated protein 1A
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP1S microtubule-associated protein 1S
MATR3 matrin 3
MCM3 minichromosome maintenance complex component 3
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUCLEOLIN nucleolin multifunctional protein
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUP160 nucleoporin 160kDa
NUP210 nucleoporin 210kDa
NUP88 nucleoporin 88kDa
OSBPL10 oxysterol binding protein-like 10
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCNA proliferating cell nuclear antigen
PDCD6 programmed cell death 6
PDHB pyruvate dehydrogenase (lipoamide) beta
PDIA6 protein disulfide isomerase family A, member 6
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEF1 penta-EF-hand domain containing 1
PFN1 profilin 1
PGAM5 phosphoglycerate mutase family member 5
PHB prohibitin
PHB2 prohibitin 2
PHGDH phosphoglycerate dehydrogenase
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PKM pyruvate kinase, muscle
PLEC plectin
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRDX3 peroxiredoxin 3
PRKCA protein kinase C, alpha
PRKCI protein kinase C, iota
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF8 pre-mRNA processing factor 8
PTBP1 polypyrimidine tract binding protein 1
PZP pregnancy-zone protein
RAD51AP1 RAD51 associated protein 1
RANBP2 RAN binding protein 2
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RBM39 RNA binding motif protein 39
RBMX RNA binding motif protein, X-linked
RBMXL2 RNA binding motif protein, X-linked-like 2
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL21 ribosomal protein L21
RPL22 ribosomal protein L22
RPL23A ribosomal protein L23a
RPL38 ribosomal protein L38
RPL4 ribosomal protein L4
RPL8 ribosomal protein L8
RPLP0 ribosomal protein, large, P0
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS14 ribosomal protein S14
RPS20 ribosomal protein S20
RPS3 ribosomal protein S3
RPS4X ribosomal protein S4, X-linked
RPS8 ribosomal protein S8
RPTN repetin
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
RUVBL2 RuvB-like AAA ATPase 2
SAFB scaffold attachment factor B
SAFB2 scaffold attachment factor B2
SAMHD1 SAM domain and HD domain 1
SAP18 Sin3A-associated protein, 18kDa
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDF4 stromal cell derived factor 4
SEC23A Sec23 homolog A (S. cerevisiae)
SEC24C SEC24 family member C
SERBP1 SERPINE1 mRNA binding protein 1
SFPQ splicing factor proline/glutamine-rich
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPC small nuclear ribonucleoprotein polypeptide C
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
SSB Sjogren syndrome antigen B (autoantigen La)
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCP1 t-complex 1
TEK TEK tyrosine kinase, endothelial
TFG TRK-fused gene
TGFB1 transforming growth factor, beta 1
TGM3 transglutaminase 3
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM160 transmembrane protein 160
TNRC6B trinucleotide repeat containing 6B
TPM1 tropomyosin 1 (alpha)
TRA2A transformer 2 alpha homolog (Drosophila)
TRAP1 TNF receptor-associated protein 1
TRIM21 tripartite motif containing 21
TRIM28 tripartite motif containing 28
TTN titin
TUBA1C tubulin, alpha 1c
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB1 tubulin, beta 1 class VI
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TUFM Tu translation elongation factor, mitochondrial
TXN thioredoxin
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP12 ubiquitin specific peptidase 12
USP39 ubiquitin specific peptidase 39
VIM vimentin
WDR20 WD repeat domain 20
WDR48 WD repeat domain 48
WRNIP1 Werner helicase interacting protein 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YAE1D1 Yae1 domain containing 1
YBX3 Y box binding protein 3
ZC3H18 zinc finger CCCH-type containing 18
ZNF207 zinc finger protein 207
ZNF326 zinc finger protein 326