MMRN2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description multimerin 2|This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012] (NCBI Entrez Gene Database, 79812)
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Genes

367 genes differentially expressed following the MMRN2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD53 CD53 molecule 2.46412
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.46412
PLXNA2 plexin A2 2.46412
LMNTD1 lamin tail domain containing 1 2.46412
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.46412
MRLN myoregulin 2.46412
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.46412
RELN reelin 2.46412
LMO1 LIM domain only 1 (rhombotin 1) 2.46412
SIX3 SIX homeobox 3 2.46412
BBS5 Bardet-Biedl syndrome 5 2.46412
TBX18 T-box 18 2.46412
ANXA8 annexin A8 2.46412
KCTD21 potassium channel tetramerization domain containing 21 2.46412
NPPC natriuretic peptide C 2.46412
HRH4 histamine receptor H4 2.46412
G0S2 G0/G1 switch 2 2.46412
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.46412
LONRF1 LON peptidase N-terminal domain and ring finger 1 2.46412
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.46412
BOLL boule-like RNA-binding protein 2.46412
IER5L immediate early response 5-like 2.46412
IHO1 interactor of HORMAD1 1 2.46412
VWA7 von Willebrand factor A domain containing 7 2.46412
GPR150 G protein-coupled receptor 150 2.46412
ERAS ES cell expressed Ras 2.46412
PRDM16 PR domain containing 16 2.46412
GPR75 G protein-coupled receptor 75 2.46412
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 2.43804
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.40881
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.40881
NDRG1 N-myc downstream regulated 1 2.40881
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.40881
PDILT protein disulfide isomerase-like, testis expressed 2.40881
DUXA double homeobox A 2.40881
SCG2 secretogranin II 2.40881
FER1L6 fer-1-like family member 6 2.40881
USP26 ubiquitin specific peptidase 26 2.40881
CLEC12A C-type lectin domain family 12, member A 2.40881
GJA9 gap junction protein, alpha 9, 59kDa 2.40881
MAPRE2 microtubule-associated protein, RP/EB family, member 2 2.40881
PRELP proline/arginine-rich end leucine-rich repeat protein 2.40881
THAP2 THAP domain containing, apoptosis associated protein 2 2.40881
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.40881
BATF basic leucine zipper transcription factor, ATF-like 2.40881
MUSK muscle, skeletal, receptor tyrosine kinase 2.40881
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.40881
SP7 Sp7 transcription factor 2.40881
AVPR2 arginine vasopressin receptor 2 2.40881
BHLHE40 basic helix-loop-helix family, member e40 2.40881
C1ORF146 chromosome 1 open reading frame 146 2.40881
EDDM3A epididymal protein 3A 2.40881
SHISA7 shisa family member 7 2.40881
TNS4 tensin 4 2.40881
TYRP1 tyrosinase-related protein 1 2.40881
PTH2 parathyroid hormone 2 2.40881
ZEB2 zinc finger E-box binding homeobox 2 2.40881
ADRB2 adrenoceptor beta 2, surface 2.40881
FOXA2 forkhead box A2 2.40881
PKP1 plakophilin 1 2.40881
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.40881
OSGIN1 oxidative stress induced growth inhibitor 1 2.40881
DRICH1 aspartate-rich 1 2.40881
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.40881
LRRC14B leucine rich repeat containing 14B 2.40881
SLC25A47 solute carrier family 25, member 47 2.40881
DSG3 desmoglein 3 2.40881
ACTL7A actin-like 7A 2.40881
PRR20G proline rich 20G 2.40881
GBP2 guanylate binding protein 2, interferon-inducible 2.40881
ZAR1 zygote arrest 1 2.40881
CXCL13 chemokine (C-X-C motif) ligand 13 2.40881
SRGN serglycin 2.40881
SMLR1 small leucine-rich protein 1 2.40881
TBC1D3L TBC1 domain family, member 3L 2.40881
GTF2B general transcription factor IIB 2.40881
DAP3 death associated protein 3 2.40881
GCSAM germinal center-associated, signaling and motility 2.40881
LRRN4CL LRRN4 C-terminal like 2.40881
DLK1 delta-like 1 homolog (Drosophila) 2.40881
TLE7 TLE family member 7 2.40881
TMEM275 transmembrane protein 275 2.40881
ANKRD42-DT ANKRD42 divergent transcript 2.40881
NPIPA6 nuclear pore complex interacting protein family, member A6 2.40881
CFAP97D2 CFAP97 domain containing 2 2.40881
SMIM31 small integral membrane protein 31 2.40881
LHFPL7 LHFPL tetraspan subfamily member 7 2.40881
SHOC1 shortage in chiasmata 1 2.40881
CFAP276 cilia and flagella associated protein 276 2.40881
DNAAF6 dynein axonemal assembly factor 6 2.40881
ELOA2 elongin A2 2.40881
AJM1 apical junction component 1 homolog 2.40881
MYOCOS myocilin opposite strand 2.40881
LRRC73 leucine rich repeat containing 73 2.40881
TAS1R1 taste receptor, type 1, member 1 2.40881
CLDN9 claudin 9 2.40881
PCDHA2 protocadherin alpha 2 2.40881
IL12RB1 interleukin 12 receptor, beta 1 2.40881
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.40881
LIPK lipase, family member K 2.40881
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.40881
RS1 retinoschisin 1 2.40881
TMEM59L transmembrane protein 59-like 2.40881
FAM153A family with sequence similarity 153, member A 2.40881
FAM3D family with sequence similarity 3, member D 2.40881
HBA2 hemoglobin, alpha 2 2.40881
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.40881
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.40881
STARD6 StAR-related lipid transfer (START) domain containing 6 2.40881
PCDH11X protocadherin 11 X-linked 2.40881
PGA5 pepsinogen 5, group I (pepsinogen A) 2.40881
TACR2 tachykinin receptor 2 2.40881
CCR7 chemokine (C-C motif) receptor 7 2.40881
GJD4 gap junction protein, delta 4, 40.1kDa 2.40881
TBX3 T-box 3 2.40881
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.40881
CENPA centromere protein A 2.40881
IL6 interleukin 6 2.40881
CUL1 cullin 1 2.40881
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.40881
PARP10 poly (ADP-ribose) polymerase family, member 10 2.40881
VTCN1 V-set domain containing T cell activation inhibitor 1 2.40881
THTPA thiamine triphosphatase 2.40881
CXCR2 chemokine (C-X-C motif) receptor 2 2.40881
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.40881
GLT1D1 glycosyltransferase 1 domain containing 1 2.40881
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 2.40881
PAGE4 P antigen family, member 4 (prostate associated) 2.40881
CD248 CD248 molecule, endosialin 2.40881
ZFHX2 zinc finger homeobox 2 2.40881
CGB7 chorionic gonadotropin, beta polypeptide 7 2.40881
COX7B2 cytochrome c oxidase subunit VIIb2 2.40881
S100A14 S100 calcium binding protein A14 2.40881
C18ORF63 chromosome 18 open reading frame 63 2.40881
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 2.40881
POU3F2 POU class 3 homeobox 2 2.40881
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.40881
LIMS3 LIM and senescent cell antigen-like domains 3 2.40881
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.40881
RORC RAR-related orphan receptor C 2.40881
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.40881
HP haptoglobin 2.40881
GAL3ST2 galactose-3-O-sulfotransferase 2 2.40881
GFI1B growth factor independent 1B transcription repressor 2.40881
CCL20 chemokine (C-C motif) ligand 20 2.40881
CER1 cerberus 1, DAN family BMP antagonist 2.40881
C8ORF89 chromosome 8 open reading frame 89 2.40881
NFYC nuclear transcription factor Y, gamma 2.40881
TYR tyrosinase 2.40881
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.40881
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.40881
OPTC opticin 2.40881
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.40881
GBX1 gastrulation brain homeobox 1 2.40881
CCDC78 coiled-coil domain containing 78 2.40881
NPM2 nucleophosmin/nucleoplasmin 2 2.40881
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.40881
FSD1L fibronectin type III and SPRY domain containing 1-like 2.40881
PSG1 pregnancy specific beta-1-glycoprotein 1 2.40881
IGLL1 immunoglobulin lambda-like polypeptide 1 2.40881
FBXO47 F-box protein 47 2.40881
EGR2 early growth response 2 2.40881
ASTL astacin-like metallo-endopeptidase (M12 family) 2.40881
SVOP SV2 related protein homolog (rat) 2.40881
UTS2R urotensin 2 receptor 2.40881
RIPPLY2 ripply transcriptional repressor 2 2.40881
SYNGR4 synaptogyrin 4 2.40881
PRH2 proline-rich protein HaeIII subfamily 2 2.40881
OTOP2 otopetrin 2 2.40881
PENK proenkephalin 2.40881
BCL2A1 BCL2-related protein A1 2.40881
MMP13 matrix metallopeptidase 13 2.40881
TSHZ1 teashirt zinc finger homeobox 1 2.40881
MRC1 mannose receptor, C type 1 2.40881
ICAM5 intercellular adhesion molecule 5, telencephalin 2.40881
NOP9 NOP9 nucleolar protein 2.40881
ICAM1 intercellular adhesion molecule 1 2.40881
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.40881
PRSS22 protease, serine, 22 2.40881
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.40881
SERTM1 serine-rich and transmembrane domain containing 1 2.40881
ANXA2R annexin A2 receptor 2.40881
SPAG8 sperm associated antigen 8 2.40881
FGF7 fibroblast growth factor 7 2.40881
FAM81B family with sequence similarity 81, member B 2.40881
MMEL1 membrane metallo-endopeptidase-like 1 2.40881
SPNS3 spinster homolog 3 (Drosophila) 2.40881
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.40881
TTLL2 tubulin tyrosine ligase-like family member 2 2.40881
CLCA2 chloride channel accessory 2 2.40881
MEIKIN meiotic kinetochore factor 2.40881
PKDREJ polycystin (PKD) family receptor for egg jelly 2.40881
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.40881
MUC20 mucin 20, cell surface associated 2.40881
CCDC83 coiled-coil domain containing 83 2.40881
HARS2 histidyl-tRNA synthetase 2, mitochondrial 2.40881
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.40881
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.40881
GRAP2 GRB2-related adaptor protein 2 2.40881
CEP55 centrosomal protein 55kDa 2.40881
LOXL4 lysyl oxidase-like 4 2.40785
SCAMP3 secretory carrier membrane protein 3 2.40785
ZNF99 zinc finger protein 99 2.38201
FAM216B family with sequence similarity 216, member B 2.38201
UTP11 UTP11 small subunit processome component 2.33954
FOXO6 forkhead box O6 2.3335
SAMD1 sterile alpha motif domain containing 1 2.31812
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 2.29733
GHR growth hormone receptor 2.28305
HYAL3 hyaluronoglucosaminidase 3 2.28305
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.28305
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.27528
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 2.26685
DSE dermatan sulfate epimerase 2.24304
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.22778
ATP5PB ATP synthase peripheral stalk-membrane subunit b 2.22397
SEC62 SEC62 homolog (S. cerevisiae) 2.22356
DEPDC5 DEP domain containing 5 2.18996
TTC9 tetratricopeptide repeat domain 9 2.18964
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.18496
TP53BP2 tumor protein p53 binding protein 2 2.17848
PRXL2A peroxiredoxin like 2A 2.17818
RUFY1 RUN and FYVE domain containing 1 2.1735
MME membrane metallo-endopeptidase 2.1548
ZBTB26 zinc finger and BTB domain containing 26 2.12606
MBTPS2 membrane-bound transcription factor peptidase, site 2 2.11685
ZNF613 zinc finger protein 613 2.11519
MED22 mediator complex subunit 22 2.10677
LNPK lunapark, ER junction formation factor 2.10677
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 2.10078
ZFR2 zinc finger RNA binding protein 2 2.09901
TAFA1 TAFA chemokine like family member 1 2.09403
PALD1 phosphatase domain containing, paladin 1 2.08749
ZBTB1 zinc finger and BTB domain containing 1 2.08112
OR52A1 olfactory receptor, family 52, subfamily A, member 1 2.07921
CNTNAP1 contactin associated protein 1 2.07921
DMWD dystrophia myotonica, WD repeat containing 2.07557
CLUH clustered mitochondria (cluA/CLU1) homolog 2.06971
DENND6B DENN/MADD domain containing 6B 2.05084
ANKDD1B ankyrin repeat and death domain containing 1B 2.05084
CYSTM1 cysteine-rich transmembrane module containing 1 2.04893
LIPA lipase A, lysosomal acid, cholesterol esterase 2.03163
NCAPG non-SMC condensin I complex, subunit G 2.0251
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 2.02126

decreased expression

Symbol Name Standardized Value
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.46412
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.46412
GREM2 gremlin 2, DAN family BMP antagonist -2.46412
ACTL6B actin-like 6B -2.46412
WNT2B wingless-type MMTV integration site family, member 2B -2.46412
DDIT4L DNA-damage-inducible transcript 4-like -2.46412
DAGLA diacylglycerol lipase, alpha -2.46412
AURKC aurora kinase C -2.46412
C16ORF96 chromosome 16 open reading frame 96 -2.46412
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.46412
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.46412
OTOA otoancorin -2.46412
MYL11 myosin light chain 11 -2.46412
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -2.46412
TMEM171 transmembrane protein 171 -2.40881
NME5 NME/NM23 family member 5 -2.40881
CPTP ceramide-1-phosphate transfer protein -2.40881
TSGA10IP testis specific, 10 interacting protein -2.40881
FANCD2OS FANCD2 opposite strand -2.40881
C19ORF38 chromosome 19 open reading frame 38 -2.40881
MMRN2 multimerin 2 -2.40881
CEP41 centrosomal protein 41kDa -2.40881
PANO1 proapoptotic nucleolar protein 1 -2.40881
ZNF263 zinc finger protein 263 -2.40881
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -2.40881
KIF22 kinesin family member 22 -2.40881
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.40881
ZSCAN22 zinc finger and SCAN domain containing 22 -2.40881
LYNX1 Ly6/neurotoxin 1 -2.40881
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) -2.40881
COLEC10 collectin sub-family member 10 (C-type lectin) -2.40881
C1QL2 complement component 1, q subcomponent-like 2 -2.40881
CELA2A chymotrypsin-like elastase family, member 2A -2.40881
NOXA1 NADPH oxidase activator 1 -2.40881
BAALC brain and acute leukemia, cytoplasmic -2.40881
TAPBP TAP binding protein (tapasin) -2.40881
NEURL4 neuralized E3 ubiquitin protein ligase 4 -2.40881
LPIN3 lipin 3 -2.40881
PLN phospholamban -2.40881
GSTCD glutathione S-transferase, C-terminal domain containing -2.40881
FAM162B family with sequence similarity 162, member B -2.40881
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.40881
GRHL3 grainyhead-like 3 (Drosophila) -2.40881
SYCP1 synaptonemal complex protein 1 -2.40881
ACOT2 acyl-CoA thioesterase 2 -2.40881
CCDC17 coiled-coil domain containing 17 -2.40881
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) -2.40881
AKR1D1 aldo-keto reductase family 1, member D1 -2.40881
OLAH oleoyl-ACP hydrolase -2.40881
TAFA3 TAFA chemokine like family member 3 -2.40881
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -2.40881
ITGA8 integrin, alpha 8 -2.40881
TMEM150B transmembrane protein 150B -2.40881
CLK3 CDC-like kinase 3 -2.40881
CH25H cholesterol 25-hydroxylase -2.40881
ERICH6 glutamate-rich 6 -2.40881
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -2.40881
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -2.40881
DCDC2B doublecortin domain containing 2B -2.40881
SIGLEC10 sialic acid binding Ig-like lectin 10 -2.40881
ZNF449 zinc finger protein 449 -2.40881
MYLK3 myosin light chain kinase 3 -2.40881
ETHE1 ethylmalonic encephalopathy 1 -2.40881
ZNF658 zinc finger protein 658 -2.40881
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.40881
RASA4 RAS p21 protein activator 4 -2.40881
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.40881
HDDC3 HD domain containing 3 -2.40881
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -2.40881
FRS3 fibroblast growth factor receptor substrate 3 -2.40881
DLG3 discs, large homolog 3 (Drosophila) -2.40881
CSPP1 centrosome and spindle pole associated protein 1 -2.40881
TSKS testis-specific serine kinase substrate -2.40881
BLVRB biliverdin reductase B -2.40881
COL12A1 collagen, type XII, alpha 1 -2.40881
GPRC5D G protein-coupled receptor, class C, group 5, member D -2.40881
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -2.40881
WRN Werner syndrome, RecQ helicase-like -2.40881
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -2.40785
NVL nuclear VCP-like -2.38798
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.37226
ZNF480 zinc finger protein 480 -2.35232
GHDC GH3 domain containing -2.35232
ETAA1 Ewing tumor-associated antigen 1 -2.34894
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.34894
RBM39 RNA binding motif protein 39 -2.31062
ITGA1 integrin, alpha 1 -2.26176
FBLN2 fibulin 2 -2.24853
MCM4 minichromosome maintenance complex component 4 -2.23565
TBCE tubulin folding cofactor E -2.23411
MRPS5 mitochondrial ribosomal protein S5 -2.23071
CRIP3 cysteine-rich protein 3 -2.22397
RYR1 ryanodine receptor 1 (skeletal) -2.22356
ICE2 interactor of little elongation complex ELL subunit 2 -2.20868
ANKRD13B ankyrin repeat domain 13B -2.19304
ZNF746 zinc finger protein 746 -2.17848
REEP3 receptor accessory protein 3 -2.17848
GLO1 glyoxalase I -2.17848
FAM204A family with sequence similarity 204, member A -2.17848
C19ORF12 chromosome 19 open reading frame 12 -2.13332
H4C3 H4 clustered histone 3 -2.12301
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.12178
TRA2A transformer 2 alpha homolog (Drosophila) -2.10078
ANKRD6 ankyrin repeat domain 6 -2.09648
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 -2.09154
CIAO3 cytosolic iron-sulfur assembly component 3 -2.09047
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.08749
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.07893
PDZD8 PDZ domain containing 8 -2.07706
TLR3 toll-like receptor 3 -2.0593
MCM9 minichromosome maintenance complex component 9 -2.05093
CCDC107 coiled-coil domain containing 107 -2.05084
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 -2.05084
UBFD1 ubiquitin family domain containing 1 -2.04893
ING3 inhibitor of growth family, member 3 -2.04409
MCFD2 multiple coagulation factor deficiency 2 -2.0403
SH2B3 SH2B adaptor protein 3 -2.02746
TRIM69 tripartite motif containing 69 -2.0243
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.0243
CASKIN1 CASK interacting protein 1 -2.02126
TGFB2 transforming growth factor, beta 2 -2.02126
GDI1 GDP dissociation inhibitor 1 -2.00985
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -2.00426