MNK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description MAP kinase interacting serine/threonine kinase 2|This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2872)
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100 substrates of the kinase MNK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
SCAF1 SR-related CTD-associated factor 1
PLXNB1 plexin B1
KMT2A lysine (K)-specific methyltransferase 2A
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
FAM65B family with sequence similarity 65, member B
ZBTB44 zinc finger and BTB domain containing 44
PPP1R10 protein phosphatase 1, regulatory subunit 10
RPTOR regulatory associated protein of MTOR, complex 1
IRS1 insulin receptor substrate 1
KATNA1 katanin p60 (ATPase containing) subunit A 1
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
UBE2O ubiquitin-conjugating enzyme E2O
LEMD2 LEM domain containing 2
LARP1 La ribonucleoprotein domain family, member 1
KIF2A kinesin heavy chain member 2A
KIF2C kinesin family member 2C
SGOL1 shugoshin-like 1 (S. pombe)
KAT5 K(lysine) acetyltransferase 5
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
MKI67 marker of proliferation Ki-67
TRA2A transformer 2 alpha homolog (Drosophila)
TP53RK TP53 regulating kinase
SON SON DNA binding protein
GAS7 growth arrest-specific 7
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
DMXL1 Dmx-like 1
RASAL2 RAS protein activator like 2
MRVI1 murine retrovirus integration site 1 homolog
CASKIN2 CASK interacting protein 2
LTF lactotransferrin
SNUPN snurportin 1
FRMD4B FERM domain containing 4B
PELI1 pellino E3 ubiquitin protein ligase 1
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PRICKLE3 prickle homolog 3 (Drosophila)
FIGNL1 fidgetin-like 1
PALB2 partner and localizer of BRCA2
SACK1E scaffolding CK1 anchoring protein E
MYO7B myosin VIIB
SOX9 SRY (sex determining region Y)-box 9
SRSF2 serine/arginine-rich splicing factor 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
GPR161 G protein-coupled receptor 161
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
SRBD1 S1 RNA binding domain 1
CASC5 cancer susceptibility candidate 5
DSN1 DSN1, MIS12 kinetochore complex component
TP53BP1 tumor protein p53 binding protein 1
GRK7 G protein-coupled receptor kinase 7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HDAC8 histone deacetylase 8
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
RNF111 ring finger protein 111
NOP2 NOP2 nucleolar protein
DUOX1 dual oxidase 1
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
PYGO2 pygopus family PHD finger 2
DOCK5 dedicator of cytokinesis 5
PPHLN1 periphilin 1
CDCA2 cell division cycle associated 2
CHERP calcium homeostasis endoplasmic reticulum protein
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
ANKRD33B ankyrin repeat domain 33B
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
SRRM2 serine/arginine repetitive matrix 2
ARHGAP23 Rho GTPase activating protein 23
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
KCNK12 potassium channel, two pore domain subfamily K, member 12
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
RBM15B RNA binding motif protein 15B
NOLC1 nucleolar and coiled-body phosphoprotein 1
POLR1E polymerase (RNA) I polypeptide E, 53kDa
OSBPL10 oxysterol binding protein-like 10
SETD2 SET domain containing 2
NUMA1 nuclear mitotic apparatus protein 1
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
LIMK2 LIM domain kinase 2
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCNK3 potassium channel, two pore domain subfamily K, member 3
PITPNB phosphatidylinositol transfer protein, beta
CLK3 CDC-like kinase 3
PRPF4B pre-mRNA processing factor 4B
BAG6 BCL2-associated athanogene 6
LOC113230 uncharacterized protein LOC113230
INCENP inner centromere protein antigens 135/155kDa
NOP56 NOP56 ribonucleoprotein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
SPN sialophorin