MNX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description motor neuron and pancreas homeobox 1|This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 3110)
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Genes

316 genes differentially expressed following the MNX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LTF lactotransferrin 2.72992
KNG1 kininogen 1 2.72992
TRIM50 tripartite motif containing 50 2.72992
ADIRF adipogenesis regulatory factor 2.72992
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.72992
GRAPL GRB2-related adaptor protein-like 2.72992
LPAR5 lysophosphatidic acid receptor 5 2.72992
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.72992
GPR78 G protein-coupled receptor 78 2.72992
ITPRID1 ITPR interacting domain containing 1 2.72992
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.72992
AMIGO1 adhesion molecule with Ig-like domain 1 2.72992
SPMIP3 sperm microtubule inner protein 3 2.72992
CD22 CD22 molecule 2.72992
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.72992
WFDC13 WAP four-disulfide core domain 13 2.72992
RHOJ ras homolog family member J 2.72992
NRSN1 neurensin 1 2.72992
PAX7 paired box 7 2.72399
PTH2 parathyroid hormone 2 2.72399
RAX retina and anterior neural fold homeobox 2.72399
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.72399
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.72399
PLIN1 perilipin 1 2.72399
SCGB3A1 secretoglobin, family 3A, member 1 2.72399
MAGEA2 melanoma antigen family A2 2.72399
GLUD2 glutamate dehydrogenase 2 2.72399
CELA3A chymotrypsin-like elastase family, member 3A 2.72399
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.72399
BATF basic leucine zipper transcription factor, ATF-like 2.72399
ARSF arylsulfatase F 2.72399
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.72399
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.72399
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.72399
SLC10A5 solute carrier family 10, member 5 2.72399
LVRN laeverin 2.72399
C1ORF146 chromosome 1 open reading frame 146 2.72399
FBXL12 F-box and leucine-rich repeat protein 12 2.72399
LGALS7 lectin, galactoside-binding, soluble, 7 2.72399
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.72399
DLL4 delta-like 4 (Drosophila) 2.72399
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.72399
CRH corticotropin releasing hormone 2.72399
MROH2B maestro heat-like repeat family member 2B 2.72399
TMEM72 transmembrane protein 72 2.72399
TDRD6 tudor domain containing 6 2.72399
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.72399
SP7 Sp7 transcription factor 2.72399
ANKRD30B ankyrin repeat domain 30B 2.72399
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.72399
GRAP GRB2-related adaptor protein 2.72399
GCSAM germinal center-associated, signaling and motility 2.72399
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.72399
MAGIX MAGI family member, X-linked 2.72399
FAM228A family with sequence similarity 228, member A 2.72399
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.72399
HNF1A HNF1 homeobox A 2.72399
LOC128125816 uncharacterized LOC128125816 2.72399
HR hair growth associated 2.72399
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.72399
ACER1 alkaline ceramidase 1 2.72399
LY6S lymphocyte antigen 6 family member S 2.72399
MDFIC2 MyoD family inhibitor domain containing 2 2.72399
C20ORF204 chromosome 20 open reading frame 204 2.72399
AKR1C8 aldo-keto reductase family 1 member C8 2.72399
PPP4R3C protein phosphatase 4 regulatory subunit 3C 2.72399
CALHM5 calcium homeostasis modulator family member 5 2.72399
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.72399
ZAR1 zygote arrest 1 2.72399
WNT9B wingless-type MMTV integration site family, member 9B 2.72399
GDF9 growth differentiation factor 9 2.72399
CLTA clathrin, light chain A 2.72399
GPR6 G protein-coupled receptor 6 2.72399
SIX6 SIX homeobox 6 2.72399
FAM187B family with sequence similarity 187, member B 2.72399
RELL2 RELT-like 2 2.72399
CARD18 caspase recruitment domain family, member 18 2.72399
MAP3K7CL MAP3K7 C-terminal like 2.72399
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.72399
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.72399
PCDHA2 protocadherin alpha 2 2.72399
JAGN1 jagunal homolog 1 (Drosophila) 2.72399
GPR83 G protein-coupled receptor 83 2.72399
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.72399
TARM1 T cell-interacting, activating receptor on myeloid cells 1 2.72399
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.72399
IL6 interleukin 6 2.72399
MSX2 msh homeobox 2 2.72399
CATSPERD catsper channel auxiliary subunit delta 2.72399
C3ORF80 chromosome 3 open reading frame 80 2.72399
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.72399
PASD1 PAS domain containing 1 2.72399
SMIM22 small integral membrane protein 22 2.72399
RESP18 regulated endocrine-specific protein 18 2.72399
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.72399
GLOD5 glyoxalase domain containing 5 2.72399
PCP2 Purkinje cell protein 2 2.72399
NIPAL4 NIPA-like domain containing 4 2.72399
PRR23A proline rich 23A 2.72399
CCDC73 coiled-coil domain containing 73 2.72399
THBD thrombomodulin 2.72399
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.72399
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 2.72399
APOH apolipoprotein H (beta-2-glycoprotein I) 2.72399
GAL3ST2 galactose-3-O-sulfotransferase 2 2.72399
CCDC154 coiled-coil domain containing 154 2.72399
CUX1 cut-like homeobox 1 2.72399
SHOX2 short stature homeobox 2 2.72399
ERICH4 glutamate-rich 4 2.72399
RAD21L1 RAD21-like 1 (S. pombe) 2.72399
C22ORF42 chromosome 22 open reading frame 42 2.72399
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.72399
SAMD9 sterile alpha motif domain containing 9 2.72399
ITGB7 integrin, beta 7 2.72399
LRRC24 leucine rich repeat containing 24 2.72399
GPR150 G protein-coupled receptor 150 2.72399
SPATA16 spermatogenesis associated 16 2.72399
MGP matrix Gla protein 2.72399
CXORF58 chromosome X open reading frame 58 2.72399
GJC2 gap junction protein, gamma 2, 47kDa 2.72399
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.72399
GOLGA8N golgin A8 family, member N 2.72399
CLEC1A C-type lectin domain family 1, member A 2.72399
CCNI2 cyclin I family, member 2 2.72399
RIPPLY2 ripply transcriptional repressor 2 2.72399
ARL13A ADP-ribosylation factor-like 13A 2.72399
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.72399
PRSS33 protease, serine, 33 2.72399
GPR61 G protein-coupled receptor 61 2.72399
CA5A carbonic anhydrase VA, mitochondrial 2.72399
CLEC4A C-type lectin domain family 4, member A 2.72399
CYTH4 cytohesin 4 2.72399
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.72399
CARD9 caspase recruitment domain family, member 9 2.72399
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.72399
GCM2 glial cells missing homolog 2 (Drosophila) 2.72399
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.72399
ACKR2 atypical chemokine receptor 2 2.72399
NEUROD1 neuronal differentiation 1 2.72399
SYTL4 synaptotagmin-like 4 2.72399
NKPD1 NTPase, KAP family P-loop domain containing 1 2.72399
TEX35 testis expressed 35 2.72399
ACSM6 acyl-CoA synthetase medium-chain family member 6 2.72399
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.72399
PDCD11 programmed cell death 11 2.72399
ICAM2 intercellular adhesion molecule 2 2.72399
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.72399
AQP1 aquaporin 1 (Colton blood group) 2.72399
MMP9 matrix metallopeptidase 9 2.67686
EFCAB5 EF-hand calcium binding domain 5 2.67453
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.66572
SBF2 SET binding factor 2 2.63178
DNAH7 dynein, axonemal, heavy chain 7 2.62144
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 2.59667
FADD Fas (TNFRSF6)-associated via death domain 2.55442
PCED1A PC-esterase domain containing 1A 2.54435
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 2.52086
TRUB2 TruB pseudouridine (psi) synthase family member 2 2.50515
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.48576
C10ORF67 chromosome 10 open reading frame 67 2.48576
INHA inhibin, alpha 2.47649
MKI67 marker of proliferation Ki-67 2.47649
MEI1 meiosis inhibitor 1 2.47109
MEGF9 multiple EGF-like-domains 9 2.38233
JUP junction plakoglobin 2.33417
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 2.33261
ACP6 acid phosphatase 6, lysophosphatidic 2.33261
ADAM23 ADAM metallopeptidase domain 23 2.32081
BUB3 BUB3 mitotic checkpoint protein 2.31519
C8ORF58 chromosome 8 open reading frame 58 2.31472
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 2.30396
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.29971
EXOSC3 exosome component 3 2.29841
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.29837
CARD6 caspase recruitment domain family, member 6 2.25802
RHOQ ras homolog family member Q 2.22391
PRDM15 PR domain containing 15 2.21726
TRIM24 tripartite motif containing 24 2.21726
HNRNPM heterogeneous nuclear ribonucleoprotein M 2.18195
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.18195
TMEM254 transmembrane protein 254 2.17242
CZIB CXXC motif containing zinc binding protein 2.17064
STX8 syntaxin 8 2.15517
LRRC40 leucine rich repeat containing 40 2.15141
SLC38A4 solute carrier family 38, member 4 2.11595
TUBA1C tubulin, alpha 1c 2.11541
CDYL chromodomain protein, Y-like 2.09724
ASPH aspartate beta-hydroxylase 2.09366
SH3BP4 SH3-domain binding protein 4 2.0905
ELL2 elongation factor, RNA polymerase II, 2 2.08935
RYK receptor-like tyrosine kinase 2.06022
PEA15 phosphoprotein enriched in astrocytes 15 2.05837
FER fer (fps/fes related) tyrosine kinase 2.05741
GPR107 G protein-coupled receptor 107 2.04188
IL17RA interleukin 17 receptor A 2.04188
ADAM10 ADAM metallopeptidase domain 10 2.04188
LINC02798 long intergenic non-protein coding RNA 2798 2.04188
CFAP97 cilia and flagella associated protein 97 2.03467
GPR173 G protein-coupled receptor 173 2.03408
CSNK2A1 casein kinase 2, alpha 1 polypeptide 2.0229
NUDCD2 NudC domain containing 2 2.0159
PRAF2 PRA1 domain family, member 2 2.0159
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 2.01331

decreased expression

Symbol Name Standardized Value
PSPN persephin -2.72992
NCF2 neutrophil cytosolic factor 2 -2.72992
ZZZ3 zinc finger, ZZ-type containing 3 -2.72992
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -2.72992
OVGP1 oviductal glycoprotein 1, 120kDa -2.72992
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.72992
AHSG alpha-2-HS-glycoprotein -2.72992
CD34 CD34 molecule -2.72399
KIF19 kinesin family member 19 -2.72399
PPP1R3C protein phosphatase 1, regulatory subunit 3C -2.72399
ZNF436 zinc finger protein 436 -2.72399
EPN3 epsin 3 -2.72399
C1ORF167 chromosome 1 open reading frame 167 -2.72399
NPIPB15 nuclear pore complex interacting protein family, member B15 -2.72399
IL17REL interleukin 17 receptor E-like -2.72399
LIPI lipase, member I -2.72399
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -2.72399
GPR20 G protein-coupled receptor 20 -2.72399
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase -2.72399
SCN2B sodium channel, voltage gated, type II beta subunit -2.72399
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.72399
SHISA7 shisa family member 7 -2.72399
LCN12 lipocalin 12 -2.72399
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) -2.72399
LRRC61 leucine rich repeat containing 61 -2.72399
FPR1 formyl peptide receptor 1 -2.72399
HHEX hematopoietically expressed homeobox -2.72399
SPMAP2L sperm microtubule associated protein 2 like -2.72399
ISM2 isthmin 2 -2.72399
TACR2 tachykinin receptor 2 -2.72399
DNAH12 dynein, axonemal, heavy chain 12 -2.72399
BAHCC1 BAH domain and coiled-coil containing 1 -2.72399
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) -2.72399
GPR146 G protein-coupled receptor 146 -2.72399
MINAR2 membrane integral NOTCH2 associated receptor 2 -2.72399
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.72399
FYB2 FYN binding protein 2 -2.72399
MSMP microseminoprotein, prostate associated -2.72399
TNN tenascin N -2.72399
H3C14 H3 clustered histone 14 -2.72399
TMOD4 tropomodulin 4 (muscle) -2.72399
DMRT1 doublesex and mab-3 related transcription factor 1 -2.72399
ARMC12 armadillo repeat containing 12 -2.72399
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -2.72399
C11ORF91 chromosome 11 open reading frame 91 -2.72399
CTSS cathepsin S -2.72399
F5 coagulation factor V (proaccelerin, labile factor) -2.72399
RTBDN retbindin -2.72399
ZNF831 zinc finger protein 831 -2.72399
SYTL3 synaptotagmin-like 3 -2.71823
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.65156
HPDL 4-hydroxyphenylpyruvate dioxygenase-like -2.62144
NME8 NME/NM23 family member 8 -2.60041
ABLIM3 actin binding LIM protein family, member 3 -2.59438
UPK1A uroplakin 1A -2.59438
MST1 macrophage stimulating 1 -2.59438
EMX1 empty spiracles homeobox 1 -2.55442
CPNE5 copine V -2.54435
CFAP54 cilia and flagella associated 54 -2.54435
KIAA2012 KIAA2012 -2.54435
CRIP2 cysteine-rich protein 2 -2.5178
GIP gastric inhibitory polypeptide -2.5178
RUVBL2 RuvB-like AAA ATPase 2 -2.50711
EXOC5 exocyst complex component 5 -2.50251
TRMT5 tRNA methyltransferase 5 -2.44994
TMEM62 transmembrane protein 62 -2.43392
GALE UDP-galactose-4-epimerase -2.39261
TSHZ2 teashirt zinc finger homeobox 2 -2.38233
PLD3 phospholipase D family, member 3 -2.37848
TUBA1A tubulin, alpha 1a -2.33417
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein -2.3106
CHLSN cholesin -2.29971
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.25554
RAB5C RAB5C, member RAS oncogene family -2.25129
ZFAND6 zinc finger, AN1-type domain 6 -2.24707
ZC3H14 zinc finger CCCH-type containing 14 -2.24707
RPAIN RPA interacting protein -2.21468
RNF122 ring finger protein 122 -2.20637
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -2.19354
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.18876
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.17453
PCDHB5 protocadherin beta 5 -2.17064
CRIP1 cysteine-rich protein 1 (intestinal) -2.16083
CALR3 calreticulin 3 -2.16083
NBPF12 neuroblastoma breakpoint family, member 12 -2.13881
PYCR1 pyrroline-5-carboxylate reductase 1 -2.13873
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -2.13288
H3-3B H3.3 histone B -2.13056
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.11647
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.09724
ARSG arylsulfatase G -2.09724
HM13 histocompatibility (minor) 13 -2.0905
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -2.08766
ZNF24 zinc finger protein 24 -2.08749
PML promyelocytic leukemia -2.08544
UBE2H ubiquitin-conjugating enzyme E2H -2.08323
ZFAND5 zinc finger, AN1-type domain 5 -2.08323
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.07373
PLPP2 phospholipid phosphatase 2 -2.07202
GPR27 G protein-coupled receptor 27 -2.06803
CEP57L1 centrosomal protein 57kDa-like 1 -2.06022
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -2.05837
OGDHL oxoglutarate dehydrogenase-like -2.05741
GRM8 glutamate receptor, metabotropic 8 -2.04367
TRAM1L1 translocation associated membrane protein 1-like 1 -2.04122
NOX4 NADPH oxidase 4 -2.03037
STRBP spermatid perinuclear RNA binding protein -2.03037
CCDC82 coiled-coil domain containing 82 -2.03037
RTRAF RNA transcription, translation and transport factor -2.0159
ZNF345 zinc finger protein 345 -2.0159
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.01113
RUSF1 RUS family member 1 -2.00731
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) -2.00565