MOCS2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description molybdenum cofactor synthesis 2|Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4338)
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Genes

360 genes differentially expressed following the MOCS2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF99 zinc finger protein 99 2.43707
ANKRD22 ankyrin repeat domain 22 2.43707
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.43707
NANOS2 nanos homolog 2 (Drosophila) 2.43707
GLUD2 glutamate dehydrogenase 2 2.43707
PCDHB1 protocadherin beta 1 2.43707
PKD1L1 polycystic kidney disease 1 like 1 2.43707
RWDD1 RWD domain containing 1 2.43707
CCNB3 cyclin B3 2.43707
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2.43707
MYBPC3 myosin binding protein C, cardiac 2.43707
FAM180A family with sequence similarity 180, member A 2.43707
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.43707
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.43707
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.43707
NDRG1 N-myc downstream regulated 1 2.43707
MYT1L myelin transcription factor 1-like 2.43707
TMPRSS11A transmembrane protease, serine 11A 2.43707
HRH1 histamine receptor H1 2.43707
CFL2 cofilin 2 (muscle) 2.43707
CST11 cystatin 11 2.43707
IL4I1 interleukin 4 induced 1 2.43707
AGTR1 angiotensin II receptor, type 1 2.43707
PDZD9 PDZ domain containing 9 2.43707
PAX4 paired box 4 2.43707
CEP295NL CEP295 N-terminal like 2.43707
LGALS4 lectin, galactoside-binding, soluble, 4 2.43707
LGALS1 lectin, galactoside-binding, soluble, 1 2.43707
TCEAL8 transcription elongation factor A (SII)-like 8 2.43707
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.43707
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.43707
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.43707
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.43707
VENTX VENT homeobox 2.43707
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.43707
SCIN scinderin 2.43707
LBX2 ladybird homeobox 2 2.43707
LRRC63 leucine rich repeat containing 63 2.43707
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.43707
LBP lipopolysaccharide binding protein 2.43707
GPR26 G protein-coupled receptor 26 2.43707
GIMAP1 GTPase, IMAP family member 1 2.43707
ANKRD34A ankyrin repeat domain 34A 2.43707
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 2.43707
PTGFR prostaglandin F receptor (FP) 2.43707
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.43707
ATF1 activating transcription factor 1 2.43707
KYNU kynureninase 2.43707
FAM81B family with sequence similarity 81, member B 2.43707
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.43707
PNMA6F PNMA family member 6F 2.43707
MLN motilin 2.43707
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.43707
PDC phosducin 2.43707
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.43707
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.43707
MYZAP myocardial zonula adherens protein 2.43707
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.43707
BDKRB1 bradykinin receptor B1 2.43707
MIOX myo-inositol oxygenase 2.43707
MYPN myopalladin 2.43707
ZNF726 zinc finger protein 726 2.43707
MCRIP2 MAPK regulated corepressor interacting protein 2 2.43707
FAM240A family with sequence similarity 240 member A 2.43707
CPNE8-AS1 CPNE8 antisense RNA 1 2.43707
DRC3 dynein regulatory complex subunit 3 2.43707
C1ORF232 chromosome 1 open reading frame 230 2.43707
TMA7B translation machinery associated 7 homolog B 2.43707
SMIM45 small integral membrane protein 45 2.43707
GARIN5B golgi associated RAB2 interactor family member 5B 2.43707
CFAP97D1 CFAP97 domain containing 1 2.43707
DUSP29 dual specificity phosphatase 29 2.43707
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 2.43707
RASD2 RASD family, member 2 2.43707
DYNAP dynactin associated protein 2.43707
TMEM119 transmembrane protein 119 2.43707
ZIC4 Zic family member 4 2.43707
CXCL16 chemokine (C-X-C motif) ligand 16 2.43707
CXCL14 chemokine (C-X-C motif) ligand 14 2.43707
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.43707
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.43707
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.43707
IRF9 interferon regulatory factor 9 2.43707
MAGEB3 melanoma antigen family B3 2.43707
CLDN9 claudin 9 2.43707
PCDHA7 protocadherin alpha 7 2.43707
TACSTD2 tumor-associated calcium signal transducer 2 2.43707
IL5 interleukin 5 2.43707
LRRC73 leucine rich repeat containing 73 2.43707
ARMC12 armadillo repeat containing 12 2.43707
C6 complement component 6 2.43707
SAA1 serum amyloid A1 2.43707
PLB1 phospholipase B1 2.43707
S100B S100 calcium binding protein B 2.43707
C6ORF118 chromosome 6 open reading frame 118 2.43707
CREB3L3 cAMP responsive element binding protein 3-like 3 2.43707
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.43707
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.43707
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.43707
FXYD3 FXYD domain containing ion transport regulator 3 2.43707
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.43707
FIBIN fin bud initiation factor homolog (zebrafish) 2.43707
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 2.43707
C2CD4B C2 calcium-dependent domain containing 4B 2.43707
PCDHGA4 protocadherin gamma subfamily A, 4 2.43707
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 2.43707
TEKT2 tektin 2 (testicular) 2.43707
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.43707
UTS2B urotensin 2B 2.43707
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.43707
CTXN1 cortexin 1 2.43707
TRIM50 tripartite motif containing 50 2.43707
MAB21L3 mab-21-like 3 (C. elegans) 2.43707
DNAH12 dynein, axonemal, heavy chain 12 2.43707
ZNF541 zinc finger protein 541 2.43707
CLDN34 claudin 34 2.43707
CST1 cystatin SN 2.43707
C11ORF91 chromosome 11 open reading frame 91 2.43707
TMEM60 transmembrane protein 60 2.43707
GOLGA6D golgin A6 family, member D 2.43707
SCT secretin 2.43707
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 2.43707
CCDC170 coiled-coil domain containing 170 2.43707
FGR FGR proto-oncogene, Src family tyrosine kinase 2.43707
COL9A2 collagen, type IX, alpha 2 2.43707
MOG myelin oligodendrocyte glycoprotein 2.43707
FLRT3 fibronectin leucine rich transmembrane protein 3 2.43707
NYX nyctalopin 2.43707
LDLRAD2 low density lipoprotein receptor class A domain containing 2 2.43707
POU4F1 POU class 4 homeobox 1 2.43707
GPR142 G protein-coupled receptor 142 2.43707
C11ORF42 chromosome 11 open reading frame 42 2.43707
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.43707
ADCY4 adenylate cyclase 4 2.43707
IL25 interleukin 25 2.43707
LHX5 LIM homeobox 5 2.43707
IDI2 isopentenyl-diphosphate delta isomerase 2 2.43707
TPPP3 tubulin polymerization-promoting protein family member 3 2.43707
SMIM19 small integral membrane protein 19 2.43707
SMIM17 small integral membrane protein 17 2.43707
GSTA1 glutathione S-transferase alpha 1 2.43707
NTN5 netrin 5 2.43707
GPR62 G protein-coupled receptor 62 2.43707
PENK proenkephalin 2.43707
DAPL1 death associated protein-like 1 2.43707
CA5A carbonic anhydrase VA, mitochondrial 2.43707
DND1 DND microRNA-mediated repression inhibitor 1 2.43707
ETV3L ets variant 3-like 2.43707
SLC51B solute carrier family 51, beta subunit 2.43707
STOML3 stomatin (EPB72)-like 3 2.43707
SDSL serine dehydratase-like 2.43707
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.43707
ZNF676 zinc finger protein 676 2.43707
MAPK11 mitogen-activated protein kinase 11 2.43707
PRR15L proline rich 15-like 2.43707
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.43707
TMEM86B transmembrane protein 86B 2.43707
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.43707
MSLN mesothelin 2.43707
MC5R melanocortin 5 receptor 2.43707
LPAR5 lysophosphatidic acid receptor 5 2.43707
NUTM2A NUT family member 2A 2.43707
LRRC38 leucine rich repeat containing 38 2.43707
LRRC74B leucine rich repeat containing 74B 2.43707
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.43707
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.43707
NEUROD2 neuronal differentiation 2 2.43707
APLNR apelin receptor 2.43707
PDCL2 phosducin-like 2 2.43707
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.43707
GHRH growth hormone releasing hormone 2.43707
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.43707
TSSK1B testis-specific serine kinase 1B 2.43707
PMP2 peripheral myelin protein 2 2.43707
C5ORF46 chromosome 5 open reading frame 46 2.43707
PSD2 pleckstrin and Sec7 domain containing 2 2.43707
PLA2G4B phospholipase A2, group IVB (cytosolic) 2.43707
STBD1 starch binding domain 1 2.41683
TNNI1 troponin I type 1 (skeletal, slow) 2.40111
UNC5CL unc-5 homolog C (C. elegans)-like 2.39821
PIH1D2 PIH1 domain containing 2 2.39332
DYNLT2B dynein light chain Tctex-type 2B 2.38963
GDF11 growth differentiation factor 11 2.37773
H4C14 H4 clustered histone 14 2.37151
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.37151
ZNF471 zinc finger protein 471 2.33521
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.33433
EIF3F eukaryotic translation initiation factor 3, subunit F 2.3303
METTL9 methyltransferase like 9 2.32286
RAD18 RAD18 E3 ubiquitin protein ligase 2.31041
PAM peptidylglycine alpha-amidating monooxygenase 2.30229
UBXN11 UBX domain protein 11 2.29845
NSMCE3 NSE3 homolog, SMC5-SMC6 complex component 2.29618
MYO5C myosin VC 2.29618
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 2.27659
TMEM35B transmembrane protein 35B 2.22874
GSTM4 glutathione S-transferase mu 4 2.22311
TPT1 tumor protein, translationally-controlled 1 2.22196
MRPS6 mitochondrial ribosomal protein S6 2.22085
DMXL1 Dmx-like 1 2.21548
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.20865
AKR1C3 aldo-keto reductase family 1, member C3 2.19945
SPATA7 spermatogenesis associated 7 2.19182
HDDC2 HD domain containing 2 2.18704
RASL11B RAS-like, family 11, member B 2.18057
CENPC centromere protein C 2.17937
INKA1 inka box actin regulator 1 2.17672
TRIM35 tripartite motif containing 35 2.17451
ZC2HC1A zinc finger, C2HC-type containing 1A 2.17451
ADGRL4 adhesion G protein-coupled receptor L4 2.17121
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.16612
GSTCD glutathione S-transferase, C-terminal domain containing 2.16462
ZBTB20 zinc finger and BTB domain containing 20 2.11896
DVL3 dishevelled segment polarity protein 3 2.11896
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.11896
CASP8AP2 caspase 8 associated protein 2 2.11268
IRAK2 interleukin-1 receptor-associated kinase 2 2.10746
ARGLU1 arginine and glutamate rich 1 2.09318
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.09243
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 2.08829
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.08721
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.07844
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.07844
RAB25 RAB25, member RAS oncogene family 2.07844
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.0699
CCDC33 coiled-coil domain containing 33 2.0699
TRIM9 tripartite motif containing 9 2.06794
MAML1 mastermind-like 1 (Drosophila) 2.06379
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.04176
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.02109
SMAD6 SMAD family member 6 2.01414
EVA1A eva-1 homolog A (C. elegans) 2.01047

decreased expression

Symbol Name Standardized Value
CCDC3 coiled-coil domain containing 3 -2.43707
BTBD10 BTB (POZ) domain containing 10 -2.43707
FNDC3B fibronectin type III domain containing 3B -2.43707
MROH6 maestro heat-like repeat family member 6 -2.43707
TTLL7 tubulin tyrosine ligase-like family member 7 -2.43707
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.43707
GCKR glucokinase (hexokinase 4) regulator -2.43707
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.43707
COL16A1 collagen, type XVI, alpha 1 -2.43707
PGM3 phosphoglucomutase 3 -2.43707
ANXA9 annexin A9 -2.43707
MSL3 male-specific lethal 3 homolog (Drosophila) -2.43707
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -2.43707
RLN1 relaxin 1 -2.43707
DIABLO diablo, IAP-binding mitochondrial protein -2.43707
NAP1L5 nucleosome assembly protein 1-like 5 -2.43707
MAPK15 mitogen-activated protein kinase 15 -2.43707
IFI16 interferon, gamma-inducible protein 16 -2.43707
NOS2 nitric oxide synthase 2, inducible -2.43707
SYTL5 synaptotagmin-like 5 -2.43707
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -2.43707
MBLAC1 metallo-beta-lactamase domain containing 1 -2.43707
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.43707
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.43707
SCIMP SLP adaptor and CSK interacting membrane protein -2.43707
CDKL4 cyclin-dependent kinase-like 4 -2.43707
TMEM190 transmembrane protein 190 -2.43707
BZW1 basic leucine zipper and W2 domains 1 -2.43707
MGAM maltase-glucoamylase -2.43707
ALX3 ALX homeobox 3 -2.43707
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.43707
TMEM17 transmembrane protein 17 -2.43707
NR1I2 nuclear receptor subfamily 1, group I, member 2 -2.43707
ERI3 ERI1 exoribonuclease family member 3 -2.43707
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.43707
PI15 peptidase inhibitor 15 -2.43707
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.43707
EQTN equatorin, sperm acrosome associated -2.43707
OVGP1 oviductal glycoprotein 1, 120kDa -2.43707
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.43707
CFAP99 cilia and flagella associated protein 99 -2.43707
ZBTB16 zinc finger and BTB domain containing 16 -2.43707
EPOP elongin BC and polycomb repressive complex 2 associated protein -2.43707
VAX2 ventral anterior homeobox 2 -2.43707
AQP4 aquaporin 4 -2.43707
ZNF33B zinc finger protein 33B -2.43707
C11ORF96 chromosome 11 open reading frame 96 -2.43707
FBXO47 F-box protein 47 -2.43707
PCDH17 protocadherin 17 -2.43707
CUZD1 CUB and zona pellucida-like domains 1 -2.43707
PLET1 placenta expressed transcript 1 -2.43707
PCDHGA7 protocadherin gamma subfamily A, 7 -2.43707
KIF3A kinesin family member 3A -2.43707
BEAN1 brain expressed, associated with NEDD4, 1 -2.43707
EFCAB3 EF-hand calcium binding domain 3 -2.43707
PLAU plasminogen activator, urokinase -2.43707
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 -2.43707
PLA2G5 phospholipase A2, group V -2.43707
ARHGAP26 Rho GTPase activating protein 26 -2.43707
CDC5L cell division cycle 5-like -2.43707
CCDC71 coiled-coil domain containing 71 -2.43707
PCDHAC1 protocadherin alpha subfamily C, 1 -2.43707
FAM209B family with sequence similarity 209, member B -2.43707
KLC3 kinesin light chain 3 -2.43707
IFI35 interferon-induced protein 35 -2.43707
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.43707
ZYG11B zyg-11 family member B, cell cycle regulator -2.37151
DOCK11 dedicator of cytokinesis 11 -2.35072
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.34571
LZTR1 leucine-zipper-like transcription regulator 1 -2.34306
ATR ATR serine/threonine kinase -2.32652
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -2.32286
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -2.32286
PITRM1 pitrilysin metallopeptidase 1 -2.32193
PHETA2 PH domain containing endocytic trafficking adaptor 2 -2.31082
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.2801
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.27379
FER fer (fps/fes related) tyrosine kinase -2.23154
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.22047
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase -2.19911
SP140L SP140 nuclear body protein-like -2.19093
XKR9 XK, Kell blood group complex subunit-related family, member 9 -2.19093
ZNF565 zinc finger protein 565 -2.18913
FAM78A family with sequence similarity 78, member A -2.18658
DPPA5 developmental pluripotency associated 5 -2.18658
HYLS1 hydrolethalus syndrome 1 -2.18288
IQGAP2 IQ motif containing GTPase activating protein 2 -2.17121
BMERB1 bMERB domain containing 1 -2.16279
INO80 INO80 complex subunit -2.1587
FAM151B family with sequence similarity 151, member B -2.15728
APP amyloid beta (A4) precursor protein -2.15728
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.15441
OMG oligodendrocyte myelin glycoprotein -2.14651
NONO non-POU domain containing, octamer-binding -2.11497
SCUBE1 signal peptide, CUB domain, EGF-like 1 -2.1059
ERVH48-1 endogenous retrovirus group 48, member 1 -2.10571
PCNX1 pecanex 1 -2.10315
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.09396
DOC2B double C2-like domains, beta -2.0933
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -2.0933
PYCR2 pyrroline-5-carboxylate reductase family, member 2 -2.09231
UST uronyl-2-sulfotransferase -2.08985
FRYL FRY-like -2.08666
DENND5B DENN/MADD domain containing 5B -2.07824
PARN poly(A)-specific ribonuclease -2.07061
ZNHIT6 zinc finger, HIT-type containing 6 -2.06533
ZNFX1 zinc finger, NFX1-type containing 1 -2.05596
CAPRIN1 cell cycle associated protein 1 -2.0518
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.0518
FNDC4 fibronectin type III domain containing 4 -2.05055
HMOX1 heme oxygenase 1 -2.04604
SIAH1 siah E3 ubiquitin protein ligase 1 -2.04533
TMEM169 transmembrane protein 169 -2.04533
HUS1 HUS1 checkpoint homolog (S. pombe) -2.02828
CPM carboxypeptidase M -2.02828
KLHL8 kelch-like family member 8 -2.02321
IDUA iduronidase, alpha-L- -2.02285
PCDHGA6 protocadherin gamma subfamily A, 6 -2.02285
METTL24 methyltransferase like 24 -2.02285
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant -2.02137
SNX17 sorting nexin 17 -2.01465
NRIP3 nuclear receptor interacting protein 3 -2.01414
MTMR12 myotubularin related protein 12 -2.01062
PIDD1 p53-induced death domain protein 1 -2.01062
DNAAF5 dynein, axonemal, assembly factor 5 -2.01047
CCDC82 coiled-coil domain containing 82 -2.01047
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 -2.01047
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.00907