MOCS3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description molybdenum cofactor synthesis 3|Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012] (NCBI Entrez Gene Database, 27304)
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Genes

329 genes differentially expressed following the MOCS3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COL20A1 collagen, type XX, alpha 1 2.30584
HORMAD2 HORMA domain containing 2 2.30584
UNC13C unc-13 homolog C (C. elegans) 2.30584
NCF1 neutrophil cytosolic factor 1 2.30584
RIMBP2 RIMS binding protein 2 2.30584
AFM afamin 2.30584
ADTRP androgen-dependent TFPI-regulating protein 2.30584
GSTM5 glutathione S-transferase mu 5 2.30584
TMEM100 transmembrane protein 100 2.30584
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.30584
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.30584
TMEM151A transmembrane protein 151A 2.30584
PCDHB9 protocadherin beta 9 2.30584
CD7 CD7 molecule 2.30584
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 2.30584
GRHL3 grainyhead-like 3 (Drosophila) 2.30584
ZBTB5 zinc finger and BTB domain containing 5 2.30584
FAM167A family with sequence similarity 167, member A 2.30584
GIP gastric inhibitory polypeptide 2.30584
NANOS2 nanos homolog 2 (Drosophila) 2.30584
THAP2 THAP domain containing, apoptosis associated protein 2 2.30584
MUC6 mucin 6, oligomeric mucus/gel-forming 2.30584
EPPIN epididymal peptidase inhibitor 2.30584
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.30584
PTH2 parathyroid hormone 2 2.30584
PLSCR4 phospholipid scramblase 4 2.30584
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.30584
CD69 CD69 molecule 2.30584
SIRPB2 signal-regulatory protein beta 2 2.30584
CLEC5A C-type lectin domain family 5, member A 2.30584
EIF1 eukaryotic translation initiation factor 1 2.30584
TMEM121 transmembrane protein 121 2.30584
COL15A1 collagen, type XV, alpha 1 2.30584
MUC20 mucin 20, cell surface associated 2.30584
TAS2R19 taste receptor, type 2, member 19 2.30584
GADL1 glutamate decarboxylase-like 1 2.30584
IRS2 insulin receptor substrate 2 2.30584
PAX7 paired box 7 2.30584
NPSR1 neuropeptide S receptor 1 2.30584
FAM90A1 family with sequence similarity 90, member A1 2.30584
LCORL ligand dependent nuclear receptor corepressor-like 2.30584
XCL1 chemokine (C motif) ligand 1 2.30584
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.30584
CROT carnitine O-octanoyltransferase 2.30584
TAL2 T-cell acute lymphocytic leukemia 2 2.30584
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.30584
CXCL6 chemokine (C-X-C motif) ligand 6 2.30584
PRDM12 PR domain containing 12 2.30584
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.30584
CCDC187 coiled-coil domain containing 187 2.30584
INKA1 inka box actin regulator 1 2.30584
NSD3 nuclear receptor binding SET domain protein 3 2.30584
MCHR1 melanin-concentrating hormone receptor 1 2.30584
CAPN9 calpain 9 2.30584
PNLIPRP1 pancreatic lipase-related protein 1 2.30584
KRT86 keratin 86, type II 2.30584
TMEM126A transmembrane protein 126A 2.30584
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.30584
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.30584
JAML junction adhesion molecule like 2.30584
RTL5 retrotransposon Gag like 5 2.30584
AKAP19 A-kinase anchoring protein 19 2.30584
THSD8 thrombospondin type 1 domain containing 8 2.30584
EXOC1L exocyst complex component 1 like 2.30584
TNS1-AS1 TNS1 antisense RNA 1 2.30584
CFAP97D2 CFAP97 domain containing 2 2.30584
H4C14 H4 clustered histone 14 2.30584
SERTM2 serine rich and transmembrane domain containing 2 2.30584
CFAP73 cilia and flagella associated protein 73 2.30584
MUCL3 mucin like 3 2.30584
DNAAF6 dynein axonemal assembly factor 6 2.30584
GATA3 GATA binding protein 3 2.30584
MRPS35 mitochondrial ribosomal protein S35 2.30584
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 2.30584
TEX101 testis expressed 101 2.30584
ARL5C ADP-ribosylation factor-like 5C 2.30584
SOX21 SRY (sex determining region Y)-box 21 2.30584
LOC124906892 uncharacterized LOC124906892 2.30584
NDRG1 N-myc downstream regulated 1 2.30584
SBK3 SH3 domain binding kinase family, member 3 2.30584
FOXL2 forkhead box L2 2.30584
TMPRSS11D transmembrane protease, serine 11D 2.30584
HLF hepatic leukemia factor 2.30584
ACTA1 actin, alpha 1, skeletal muscle 2.30584
TACSTD2 tumor-associated calcium signal transducer 2 2.30584
HNF1B HNF1 homeobox B 2.30584
NCAPD3 non-SMC condensin II complex, subunit D3 2.30584
LGSN lengsin, lens protein with glutamine synthetase domain 2.30584
GDF9 growth differentiation factor 9 2.30584
MPPED1 metallophosphoesterase domain containing 1 2.30584
CDKN2A cyclin-dependent kinase inhibitor 2A 2.30584
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.30584
PRRT4 proline-rich transmembrane protein 4 2.30584
LEF1 lymphoid enhancer-binding factor 1 2.30584
MYH13 myosin, heavy chain 13, skeletal muscle 2.30584
HRH4 histamine receptor H4 2.30584
TMC3 transmembrane channel-like 3 2.30584
LRRC36 leucine rich repeat containing 36 2.30584
UBQLNL ubiquilin-like 2.30584
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.30584
BTNL9 butyrophilin-like 9 2.30584
RB1 retinoblastoma 1 2.30584
DUOX2 dual oxidase 2 2.30584
CSF1R colony stimulating factor 1 receptor 2.30584
LCN1 lipocalin 1 2.30584
OLFML1 olfactomedin-like 1 2.30584
NLRC5 NLR family, CARD domain containing 5 2.30584
LGALS12 lectin, galactoside-binding, soluble, 12 2.30584
AQP6 aquaporin 6, kidney specific 2.30584
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 2.30584
NGB neuroglobin 2.30584
CABP7 calcium binding protein 7 2.30584
EBF2 early B-cell factor 2 2.30584
MYF6 myogenic factor 6 (herculin) 2.30584
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.30584
CLIC2 chloride intracellular channel 2 2.30584
ADAM7 ADAM metallopeptidase domain 7 2.30584
PLET1 placenta expressed transcript 1 2.30584
FAM177B family with sequence similarity 177, member B 2.30584
SOD1 superoxide dismutase 1, soluble 2.30584
RGCC regulator of cell cycle 2.30584
RBM24 RNA binding motif protein 24 2.30584
CH25H cholesterol 25-hydroxylase 2.30584
CATIP ciliogenesis associated TTC17 interacting protein 2.30584
TBX1 T-box 1 2.30584
FGR FGR proto-oncogene, Src family tyrosine kinase 2.30584
IGSF1 immunoglobulin superfamily, member 1 2.30584
MUC16 mucin 16, cell surface associated 2.30584
NT5DC1 5'-nucleotidase domain containing 1 2.30584
PLCD4 phospholipase C, delta 4 2.30584
TRADD TNFRSF1A-associated via death domain 2.30584
AKNAD1 AKNA domain containing 1 2.30584
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.30584
PRTN3 proteinase 3 2.30584
MRAP melanocortin 2 receptor accessory protein 2.30584
IRGM immunity-related GTPase family, M 2.30584
DLX3 distal-less homeobox 3 2.30584
RRM2 ribonucleotide reductase M2 2.30584
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.30584
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.30584
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.30584
RAB27B RAB27B, member RAS oncogene family 2.30584
FAF1 Fas (TNFRSF6) associated factor 1 2.30584
PADI4 peptidyl arginine deiminase, type IV 2.30584
EIF3K eukaryotic translation initiation factor 3, subunit K 2.30584
C22ORF23 chromosome 22 open reading frame 23 2.30584
TEX35 testis expressed 35 2.30584
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.30584
TMEM215 transmembrane protein 215 2.30584
BIN2 bridging integrator 2 2.30584
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.30584
MYL7 myosin, light chain 7, regulatory 2.30584
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.30584
KRTAP2-1 keratin associated protein 2-1 2.30584
IFITM10 interferon induced transmembrane protein 10 2.30584
ELMOD3 ELMO/CED-12 domain containing 3 2.30584
LOXL4 lysyl oxidase-like 4 2.30584
ASCL3 achaete-scute family bHLH transcription factor 3 2.30584
NLRP6 NLR family, pyrin domain containing 6 2.30584
CCDC166 coiled-coil domain containing 166 2.30584
ADGRF5 adhesion G protein-coupled receptor F5 2.30584
POU3F3 POU class 3 homeobox 3 2.30584
TBC1D26 TBC1 domain family, member 26 2.30584
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.30584
RPL12 ribosomal protein L12 2.30584
ROM1 retinal outer segment membrane protein 1 2.30584
BHLHA15 basic helix-loop-helix family, member a15 2.30584
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.30584
TBC1D21 TBC1 domain family, member 21 2.30584
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.30584
APOL4 apolipoprotein L, 4 2.30584
ECM1 extracellular matrix protein 1 2.30584
NOS2 nitric oxide synthase 2, inducible 2.30584
CCDC70 coiled-coil domain containing 70 2.30584
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.30584
MAGEB17 melanoma antigen family B17 2.30584
FUNDC2 FUN14 domain containing 2 2.30584
FAAP100 FA core complex associated protein 100 2.25287
FAM161A family with sequence similarity 161, member A 2.22996
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.22796
RPL10A ribosomal protein L10a 2.22796
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 2.22796
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.22796
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 2.22796
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 2.22796
TTC4 tetratricopeptide repeat domain 4 2.22774
SEC63 SEC63 homolog (S. cerevisiae) 2.22215
NME9 NME/NM23 family member 9 2.2171
MRPL18 mitochondrial ribosomal protein L18 2.21604
FANCC Fanconi anemia, complementation group C 2.20547
KNL1 kinetochore scaffold 1 2.20547
DENND4B DENN/MADD domain containing 4B 2.17424
ADI1 acireductone dioxygenase 1 2.17424
MAP7D3 MAP7 domain containing 3 2.16891
MTFR2 mitochondrial fission regulator 2 2.15766
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 2.1575
ZNF174 zinc finger protein 174 2.15693
TENM1 teneurin transmembrane protein 1 2.15668
IL17RC interleukin 17 receptor C 2.10138
BAK1 BCL2-antagonist/killer 1 2.10138
NISCH nischarin 2.08962
PFN1 profilin 1 2.08504
CLTB clathrin, light chain B 2.0722
ANO7 anoctamin 7 2.06096
HNRNPK heterogeneous nuclear ribonucleoprotein K 2.05284
SPATA6 spermatogenesis associated 6 2.05235
CAV1 caveolin 1, caveolae protein, 22kDa 2.03787
ZNF680 zinc finger protein 680 2.03646
RPL36A ribosomal protein L36a 2.01982
ACTR6 ARP6 actin-related protein 6 homolog (yeast) 2.01839
TTC28 tetratricopeptide repeat domain 28 2.0079
SPATA18 spermatogenesis associated 18 2.0027

decreased expression

Symbol Name Standardized Value
SREBF2 sterol regulatory element binding transcription factor 2 -2.30584
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.30584
ZNF207 zinc finger protein 207 -2.30584
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 -2.30584
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.30584
ZNF431 zinc finger protein 431 -2.30584
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -2.30584
POFUT3 protein O-fucosyltransferase 3 -2.30584
TMEM234 transmembrane protein 234 -2.30584
TLCD1 TLC domain containing 1 -2.30584
ANKRD18B ankyrin repeat domain 18B -2.30584
OLFM3 olfactomedin 3 -2.30584
HEXIM2 hexamethylene bis-acetamide inducible 2 -2.30584
ACAT2 acetyl-CoA acetyltransferase 2 -2.30584
ANG angiogenin, ribonuclease, RNase A family, 5 -2.30584
CENPK centromere protein K -2.30584
ZNF561 zinc finger protein 561 -2.30584
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.30584
C16ORF89 chromosome 16 open reading frame 89 -2.30584
C3 complement component 3 -2.30584
NUP62 nucleoporin 62kDa -2.30584
LOXHD1 lipoxygenase homology domains 1 -2.30584
ZFYVE27 zinc finger, FYVE domain containing 27 -2.30584
STX12 syntaxin 12 -2.30584
TMUB2 transmembrane and ubiquitin-like domain containing 2 -2.30584
MYO15A myosin XVA -2.30584
THBS3 thrombospondin 3 -2.30584
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -2.30584
ZNG1C Zn regulated GTPase metalloprotein activator 1C -2.30584
METTL8 methyltransferase like 8 -2.30584
FKBPL FK506 binding protein like -2.22796
DUSP10 dual specificity phosphatase 10 -2.22796
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.22796
GYPB glycophorin B (MNS blood group) -2.22796
ALDOB aldolase B, fructose-bisphosphate -2.22796
CFAP119 cilia and flagella associated protein 119 -2.22796
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.22796
SMIM47 small integral membrane protein 47 -2.22796
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.22796
TNC tenascin C -2.22796
EML5 echinoderm microtubule associated protein like 5 -2.22796
ZC3H11C zinc finger CCCH-type containing 11C -2.22796
HID1 HID1 domain containing -2.22796
TRIM17 tripartite motif containing 17 -2.22796
CCR9 chemokine (C-C motif) receptor 9 -2.22796
TBX6 T-box 6 -2.22796
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -2.22796
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.22796
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.22796
C4ORF50 chromosome 4 open reading frame 50 -2.22796
IGSF22 immunoglobulin superfamily, member 22 -2.22796
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.22796
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -2.22796
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) -2.22796
SLC46A2 solute carrier family 46, member 2 -2.22796
RHCE Rh blood group, CcEe antigens -2.22796
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.22796
PRICKLE4 prickle homolog 4 (Drosophila) -2.22796
PRICKLE3 prickle homolog 3 (Drosophila) -2.22796
C11ORF86 chromosome 11 open reading frame 86 -2.22796
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.22796
CARD6 caspase recruitment domain family, member 6 -2.22796
TBCA tubulin folding cofactor A -2.22796
SLC22A31 solute carrier family 22, member 31 -2.22796
NT5C1B 5'-nucleotidase, cytosolic IB -2.22796
NBPF8 neuroblastoma breakpoint family, member 8 -2.22796
PLAC8 placenta-specific 8 -2.22796
ALAS2 5'-aminolevulinate synthase 2 -2.22796
RPA2 replication protein A2, 32kDa -2.22796
LRP2BP LRP2 binding protein -2.22796
KLK14 kallikrein-related peptidase 14 -2.22796
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 -2.22796
TTLL11 tubulin tyrosine ligase-like family member 11 -2.22796
SIT1 signaling threshold regulating transmembrane adaptor 1 -2.22796
NOS3 nitric oxide synthase 3 (endothelial cell) -2.22796
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.22796
C3ORF62 chromosome 3 open reading frame 62 -2.22796
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -2.22796
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.22796
ADAMTSL5 ADAMTS-like 5 -2.22796
EHBP1L1 EH domain binding protein 1-like 1 -2.22796
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -2.22796
RAD21L1 RAD21-like 1 (S. pombe) -2.22796
S100A10 S100 calcium binding protein A10 -2.22796
PM20D1 peptidase M20 domain containing 1 -2.22796
SLC25A34 solute carrier family 25, member 34 -2.22796
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -2.22796
ZFYVE19 zinc finger, FYVE domain containing 19 -2.22796
ZFP41 ZFP41 zinc finger protein -2.22796
ZSWIM5 zinc finger, SWIM-type containing 5 -2.21477
TUBB4B tubulin, beta 4B class IVb -2.1944
KIF21B kinesin family member 21B -2.17424
WWC3 WWC family member 3 -2.17018
MAN1A2 mannosidase, alpha, class 1A, member 2 -2.17001
ARL2 ADP-ribosylation factor-like 2 -2.1699
ZDHHC11 zinc finger, DHHC-type containing 11 -2.16191
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -2.1515
KNOP1 lysine-rich nucleolar protein 1 -2.13986
JAKMIP1 janus kinase and microtubule interacting protein 1 -2.10138
GLB1L galactosidase, beta 1-like -2.10138
IGFBP3 insulin-like growth factor binding protein 3 -2.10138
GZF1 GDNF-inducible zinc finger protein 1 -2.10138
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.08855
MVK mevalonate kinase -2.08855
SERP2 stress-associated endoplasmic reticulum protein family member 2 -2.08855
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -2.08504
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.08504
ASPHD1 aspartate beta-hydroxylase domain containing 1 -2.08075
SKIL SKI-like proto-oncogene -2.05995
CALML4 calmodulin-like 4 -2.05365
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.03646
GPHRB golgi pH regulator B -2.02896
FBXL4 F-box and leucine-rich repeat protein 4 -2.02547
CLCN7 chloride channel, voltage-sensitive 7 -2.02547
STARD8 StAR-related lipid transfer (START) domain containing 8 -2.01982
SNAP91 synaptosomal-associated protein, 91kDa -2.01982
ZNF440 zinc finger protein 440 -2.01254