MOGS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mannosyl-oligosaccharide glucosidase|This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 7841)
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Genes

287 genes differentially expressed following the MOGS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SAMD5 sterile alpha motif domain containing 5 2.37716
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 2.37716
COL6A5 collagen, type VI, alpha 5 2.37716
NECTIN4 nectin cell adhesion molecule 4 2.37716
NOD2 nucleotide-binding oligomerization domain containing 2 2.37716
SH2D7 SH2 domain containing 7 2.37716
F5 coagulation factor V (proaccelerin, labile factor) 2.37716
ASB15 ankyrin repeat and SOCS box containing 15 2.37716
C10ORF90 chromosome 10 open reading frame 90 2.37716
GPR179 G protein-coupled receptor 179 2.37716
GFRA3 GDNF family receptor alpha 3 2.37716
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.37716
CARMIL3 capping protein regulator and myosin 1 linker 3 2.37716
MINAR2 membrane integral NOTCH2 associated receptor 2 2.37716
KIRREL2 kin of IRRE like 2 (Drosophila) 2.37716
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.37716
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.37716
DES desmin 2.37716
ARL5C ADP-ribosylation factor-like 5C 2.37716
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.37716
NRN1 neuritin 1 2.30721
CCDC110 coiled-coil domain containing 110 2.30721
LAPTM5 lysosomal protein transmembrane 5 2.30721
IL22RA1 interleukin 22 receptor, alpha 1 2.30721
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.30721
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.30721
CD274 CD274 molecule 2.30721
AGTR1 angiotensin II receptor, type 1 2.30721
SOX1 SRY (sex determining region Y)-box 1 2.30721
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.30721
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.30721
BTC betacellulin 2.30721
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.30721
UBA7 ubiquitin-like modifier activating enzyme 7 2.30721
TJP2 tight junction protein 2 2.30721
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.30721
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.30721
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.30721
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 2.30721
PECAM1 platelet/endothelial cell adhesion molecule 1 2.30721
TUBB1 tubulin, beta 1 class VI 2.30721
FOXR1 forkhead box R1 2.30721
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.30721
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.30721
LRRC55 leucine rich repeat containing 55 2.30721
OSR2 odd-skipped related transciption factor 2 2.30721
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.30721
RNF166 ring finger protein 166 2.30721
TUBB4B tubulin, beta 4B class IVb 2.30721
SSTR1 somatostatin receptor 1 2.30721
RGPD4 RANBP2-like and GRIP domain containing 4 2.30721
SLC22A10 solute carrier family 22, member 10 2.30721
SCARA5 scavenger receptor class A, member 5 2.30721
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.30721
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.30721
DENND11 DENN domain containing 11 2.30721
TMPRSS6 transmembrane protease, serine 6 2.30721
GRAP GRB2-related adaptor protein 2.30721
CLEC6A C-type lectin domain family 6, member A 2.30721
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.30721
ROPN1 rhophilin associated tail protein 1 2.30721
TEX13C TEX13 family member C 2.30721
CLEC20A C-type lectin domain containing 20A 2.30721
DNAAF19 dynein axonemal assembly factor 19 2.30721
C3ORF85 chromosome 3 open reading frame 85 2.30721
FAM240C family with sequence similarity 240 member C 2.30721
ANKRD42-DT ANKRD42 divergent transcript 2.30721
NPIPA6 nuclear pore complex interacting protein family, member A6 2.30721
C20ORF204 chromosome 20 open reading frame 204 2.30721
CALHM4 calcium homeostasis modulator family member 4 2.30721
LHFPL7 LHFPL tetraspan subfamily member 7 2.30721
PNPLA1 patatin-like phospholipase domain containing 1 2.30721
ZAR1L zygote arrest 1-like 2.30721
NPIPB9 nuclear pore complex interacting protein family, member B9 2.30721
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.30721
PCDHA1 protocadherin alpha 1 2.30721
SLC35D3 solute carrier family 35, member D3 2.30721
FOXD1 forkhead box D1 2.30721
ACTL10 actin-like 10 2.30721
ZNF436 zinc finger protein 436 2.30721
NKX3-1 NK3 homeobox 1 2.30721
SIM2 single-minded family bHLH transcription factor 2 2.30721
MIP major intrinsic protein of lens fiber 2.30721
FRK fyn-related Src family tyrosine kinase 2.30721
PLEK2 pleckstrin 2 2.30721
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.30721
TACR2 tachykinin receptor 2 2.30721
GSC goosecoid homeobox 2.30721
PRR18 proline rich 18 2.30721
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.30721
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.30721
LRTM3 leucine rich repeat transmembrane protein 3 2.30721
WFDC10A WAP four-disulfide core domain 10A 2.30721
POF1B premature ovarian failure, 1B 2.30721
KLHL1 kelch-like family member 1 2.30721
CXCR6 chemokine (C-X-C motif) receptor 6 2.30721
KLF1 Kruppel-like factor 1 (erythroid) 2.30721
PRM1 protamine 1 2.30721
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.30721
WFDC1 WAP four-disulfide core domain 1 2.30721
GOLGA6D golgin A6 family, member D 2.30721
NIM1K NIM1 serine/threonine protein kinase 2.30721
FNDC9 fibronectin type III domain containing 9 2.30721
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.30721
MT1A metallothionein 1A 2.30721
GH2 growth hormone 2 2.30721
PLGLB2 plasminogen-like B2 2.30721
ECM1 extracellular matrix protein 1 2.30721
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.30721
PRSS53 protease, serine, 53 2.30721
APOH apolipoprotein H (beta-2-glycoprotein I) 2.30721
PCDHGB4 protocadherin gamma subfamily B, 4 2.30721
FAM177B family with sequence similarity 177, member B 2.30721
NPFFR1 neuropeptide FF receptor 1 2.30721
NYX nyctalopin 2.30721
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.30721
MSMP microseminoprotein, prostate associated 2.30721
INSL3 insulin-like 3 (Leydig cell) 2.30721
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.30721
ESPNL espin-like 2.30721
CCDC170 coiled-coil domain containing 170 2.30721
FOXS1 forkhead box S1 2.30721
VAV1 vav 1 guanine nucleotide exchange factor 2.30721
PDCD1LG2 programmed cell death 1 ligand 2 2.30721
SPATA9 spermatogenesis associated 9 2.30721
CLEC4D C-type lectin domain family 4, member D 2.30721
MAB21L1 mab-21-like 1 (C. elegans) 2.30721
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 2.30721
IRGC immunity-related GTPase family, cinema 2.30721
CHI3L2 chitinase 3-like 2 2.30721
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.30721
FBXO47 F-box protein 47 2.30721
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.30721
MZB1 marginal zone B and B1 cell-specific protein 2.30721
OC90 otoconin 90 2.30721
CLEC2B C-type lectin domain family 2, member B 2.30721
MROH2A maestro heat-like repeat family member 2A 2.30721
KIF19 kinesin family member 19 2.30721
KIF11 kinesin family member 11 2.30721
KCNK16 potassium channel, two pore domain subfamily K, member 16 2.30721
MMP12 matrix metallopeptidase 12 2.30721
ANGPTL6 angiopoietin-like 6 2.30721
TMEM52B transmembrane protein 52B 2.30721
VPREB3 pre-B lymphocyte 3 2.30721
PCDHGA11 protocadherin gamma subfamily A, 11 2.30721
ZNF804B zinc finger protein 804B 2.30721
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.30721
FOXJ1 forkhead box J1 2.30721
GNRH2 gonadotropin-releasing hormone 2 2.30721
LGALS2 lectin, galactoside-binding, soluble, 2 2.30721
LDHC lactate dehydrogenase C 2.30721
NMUR1 neuromedin U receptor 1 2.30721
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.30721
CRX cone-rod homeobox 2.30721
PADI4 peptidyl arginine deiminase, type IV 2.30721
ITPKA inositol-trisphosphate 3-kinase A 2.30721
ZBED6 zinc finger, BED-type containing 6 2.30721
RHAG Rh-associated glycoprotein 2.30721
GCM1 glial cells missing homolog 1 (Drosophila) 2.30721
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.30721
MED23 mediator complex subunit 23 2.30721
FBLIM1 filamin binding LIM protein 1 2.30721
TGM2 transglutaminase 2 2.30721
LRRC38 leucine rich repeat containing 38 2.30721
USF1 upstream transcription factor 1 2.28947
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 2.28016
PRAP1 proline-rich acidic protein 1 2.27215
TNS1-AS1 TNS1 antisense RNA 1 2.27215
SLC22A24 solute carrier family 22, member 24 2.27215
CCL27 chemokine (C-C motif) ligand 27 2.26784
H3C7 H3 clustered histone 7 2.25547
MTG1 mitochondrial ribosome-associated GTPase 1 2.24062
ZNF800 zinc finger protein 800 2.2369
ZFP14 ZFP14 zinc finger protein 2.22384
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 2.14682
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 2.14337
SH3PXD2B SH3 and PX domains 2B 2.14337
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 2.14337
DPP4 dipeptidyl-peptidase 4 2.12148
ROR2 receptor tyrosine kinase-like orphan receptor 2 2.11453
C14ORF132 chromosome 14 open reading frame 132 2.10539
HIPK3 homeodomain interacting protein kinase 3 2.09083
TRIM16 tripartite motif containing 16 2.09083
DNHD1 dynein heavy chain domain 1 2.04967
SOX9 SRY (sex determining region Y)-box 9 2.04155
FAM193A family with sequence similarity 193, member A 2.0387
PTGIS prostaglandin I2 (prostacyclin) synthase 2.02134
RFK riboflavin kinase 2.01907
NAT10 N-acetyltransferase 10 (GCN5-related) 2.01183
ITFG1 integrin alpha FG-GAP repeat containing 1 2.01183
RYBP RING1 and YY1 binding protein 2.00507
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.00069

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.37716
CASS4 Cas scaffolding protein family member 4 -2.37716
NOXA1 NADPH oxidase activator 1 -2.37716
ODAD4 outer dynein arm docking complex subunit 4 -2.37716
CNRIP1 cannabinoid receptor interacting protein 1 -2.37716
IL23A interleukin 23, alpha subunit p19 -2.37716
OSBPL7 oxysterol binding protein-like 7 -2.37716
MUC6 mucin 6, oligomeric mucus/gel-forming -2.37716
TMEM97 transmembrane protein 97 -2.33865
WNT3A wingless-type MMTV integration site family, member 3A -2.30721
SERF1B small EDRK-rich factor 1B (centromeric) -2.30721
SCRG1 stimulator of chondrogenesis 1 -2.30721
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.30721
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -2.30721
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 -2.30721
DOT1L DOT1-like histone H3K79 methyltransferase -2.30721
BLACAT1 bladder cancer associated transcript 1 (non-protein coding) -2.30721
ELF4 E74-like factor 4 (ets domain transcription factor) -2.30721
C19ORF38 chromosome 19 open reading frame 38 -2.30721
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.30721
MEI1 meiosis inhibitor 1 -2.30721
SCN2B sodium channel, voltage gated, type II beta subunit -2.30721
FGD3 FYVE, RhoGEF and PH domain containing 3 -2.30721
IZUMO3 IZUMO family member 3 -2.30721
NXPE1 neurexophilin and PC-esterase domain family, member 1 -2.30721
CFAP141 cilia and flagella associated protein 141 -2.30721
TRIR telomerase RNA component interacting RNase -2.30721
OTOA otoancorin -2.30721
PSPH phosphoserine phosphatase -2.30721
YPEL4 yippee-like 4 (Drosophila) -2.30721
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -2.30721
TMT1B thiol methyltransferase 1B -2.30721
DPCD deleted in primary ciliary dyskinesia homolog (mouse) -2.30721
PRDM6 PR domain containing 6 -2.30721
GRIPAP1 GRIP1 associated protein 1 -2.30721
C2CD5 C2 calcium-dependent domain containing 5 -2.30721
NOP16 NOP16 nucleolar protein -2.30721
MYOT myotilin -2.30721
PRRT1 proline-rich transmembrane protein 1 -2.30721
SLC45A3 solute carrier family 45, member 3 -2.30721
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.30721
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 -2.30721
LOC124902694 uncharacterized LOC124902694 -2.30721
PLK3 polo-like kinase 3 -2.30721
MAU2 MAU2 sister chromatid cohesion factor -2.30721
LSMEM2 leucine-rich single-pass membrane protein 2 -2.30721
HLA-DOB major histocompatibility complex, class II, DO beta -2.30721
GPNMB glycoprotein (transmembrane) nmb -2.30721
CATIP ciliogenesis associated TTC17 interacting protein -2.30721
SOD2 superoxide dismutase 2, mitochondrial -2.30721
SKAP1 src kinase associated phosphoprotein 1 -2.30721
MAPK3 mitogen-activated protein kinase 3 -2.30721
BAHCC1 BAH domain and coiled-coil containing 1 -2.30721
TRIM52 tripartite motif containing 52 -2.30721
SYN3 synapsin III -2.30721
SCX scleraxis basic helix-loop-helix transcription factor -2.30721
SRA1 steroid receptor RNA activator 1 -2.30721
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 -2.30721
KLHL26 kelch-like family member 26 -2.30721
GDPGP1 GDP-D-glucose phosphorylase 1 -2.30721
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.30721
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -2.30721
SPHK1 sphingosine kinase 1 -2.30721
CEND1 cell cycle exit and neuronal differentiation 1 -2.30721
ADCY2 adenylate cyclase 2 (brain) -2.30721
RRM2B ribonucleotide reductase M2 B (TP53 inducible) -2.30721
HIGD1C HIG1 hypoxia inducible domain family, member 1C -2.30721
RBP1 retinol binding protein 1, cellular -2.30721
RGS5 regulator of G-protein signaling 5 -2.30721
GTF2H5 general transcription factor IIH, polypeptide 5 -2.30721
CISH cytokine inducible SH2-containing protein -2.30721
LRP1B low density lipoprotein receptor-related protein 1B -2.27577
NAV3 neuron navigator 3 -2.26815
CASP10 caspase 10, apoptosis-related cysteine peptidase -2.26784
EFHC1 EF-hand domain (C-terminal) containing 1 -2.24209
HLA-DRA major histocompatibility complex, class II, DR alpha -2.23673
SLC61A1 solute carrier family 61 member 1 -2.14337
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -2.13639
DNAH9 dynein, axonemal, heavy chain 9 -2.13639
SUGCT succinyl-CoA:glutarate-CoA transferase -2.12003
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.10009
DCAKD dephospho-CoA kinase domain containing -2.10009
ANGPT4 angiopoietin 4 -2.09198
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.09095
MRPL50 mitochondrial ribosomal protein L50 -2.09083
NR3C2 nuclear receptor subfamily 3, group C, member 2 -2.05434
NSUN6 NOP2/Sun domain family, member 6 -2.04155
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.04155
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.0387
PRR3 proline rich 3 -2.0387
TBC1D31 TBC1 domain family, member 31 -2.0387
MATCAP1 microtubule associated tyrosine carboxypeptidase 1 -2.01914
LIMD1 LIM domains containing 1 -2.01438
TM9SF4 transmembrane 9 superfamily protein member 4 -2.01183
FAM110C family with sequence similarity 110, member C -2.00069