MONO-MAC-6 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human acute monocytic leukemia cell line; established from the peripheral blood of a 64-year-old man with relapsed acute monocytic leukemia (AML FAB M5) in 1985 following myeloid metaplasia. Sister cell line of MONO-MAC-1. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002333)
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Genes

267 genes mutated in the MONO-MAC-6 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACAT1 acetyl-CoA acetyltransferase 1
ACTG1 actin gamma 1
ACTR6 ARP6 actin-related protein 6 homolog (yeast)
ADAM2 ADAM metallopeptidase domain 2
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADD2 adducin 2 (beta)
ADGRF1 adhesion G protein-coupled receptor F1
ADGRV1 adhesion G protein-coupled receptor V1
AFTPH aftiphilin
AK1 adenylate kinase 1
AKT1S1 AKT1 substrate 1 (proline-rich)
ALLC allantoicase
ALPI alkaline phosphatase, intestinal
AMZ1 archaelysin family metallopeptidase 1
ANKIB1 ankyrin repeat and IBR domain containing 1
ANKRD28 ankyrin repeat domain 28
ANKRD36 ankyrin repeat domain 36
ANO7 anoctamin 7
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGAP23 Rho GTPase activating protein 23
ARHGAP29 Rho GTPase activating protein 29
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ASB4 ankyrin repeat and SOCS box containing 4
ASB8 ankyrin repeat and SOCS box containing 8
ASXL1 additional sex combs like transcriptional regulator 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAIAP2 BAI1-associated protein 2
BIRC6 baculoviral IAP repeat containing 6
BPI bactericidal/permeability-increasing protein
CABIN1 calcineurin binding protein 1
CCDC109B coiled-coil domain containing 109B
CD207 CD207 molecule, langerin
CDK14 cyclin-dependent kinase 14
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEL carboxyl ester lipase
CENPE centromere protein E, 312kDa
CEP170B centrosomal protein 170B
CER1 cerberus 1, DAN family BMP antagonist
CFI complement factor I
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLIC4 chloride intracellular channel 4
COL11A2 collagen, type XI, alpha 2
COL9A3 collagen, type IX, alpha 3
CRMP1 collapsin response mediator protein 1
CTBS chitobiase, di-N-acetyl-
DCDC1 doublecortin domain containing 1
DCLRE1C DNA cross-link repair 1C
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DGKI diacylglycerol kinase, iota
DNAH5 dynein, axonemal, heavy chain 5
DOCK5 dedicator of cytokinesis 5
DPP6 dipeptidyl-peptidase 6
DSG1 desmoglein 1
DUOX1 dual oxidase 1
EGFL8 EGF-like-domain, multiple 8
ELN elastin
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
FAM184A family with sequence similarity 184, member A
FAM8A1 family with sequence similarity 8, member A1
FAT2 FAT atypical cadherin 2
FAT4 FAT atypical cadherin 4
FBN2 fibrillin 2
FCRL2 Fc receptor-like 2
FGF2 fibroblast growth factor 2 (basic)
FLT3 fms-related tyrosine kinase 3
FMN2 formin 2
FOXK2 forkhead box K2
FPR3 formyl peptide receptor 3
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1
GGT1 gamma-glutamyltransferase 1
GGT7 gamma-glutamyltransferase 7
GLYAT glycine-N-acyltransferase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GP2 glycoprotein 2 (zymogen granule membrane)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPR155 G protein-coupled receptor 155
GRK5 G protein-coupled receptor kinase 5
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HMBS hydroxymethylbilane synthase
HNF4G hepatocyte nuclear factor 4, gamma
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1
HPX hemopexin
HRNR hornerin
HTT huntingtin
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
INTS1 integrator complex subunit 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JAKMIP3 Janus kinase and microtubule interacting protein 3
JPH2 junctophilin 2
KANK1 KN motif and ankyrin repeat domains 1
KAT6B K(lysine) acetyltransferase 6B
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0907 KIAA0907
KIAA1958 KIAA1958
KIF1B kinesin family member 1B
KIF26B kinesin family member 26B
KRTAP10-9 keratin associated protein 10-9
KRTAP29-1 keratin associated protein 29-1
KRTAP5-10 keratin associated protein 5-10
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LECT2 leukocyte cell-derived chemotaxin 2
LGSN lengsin, lens protein with glutamine synthetase domain
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LIPJ lipase, family member J
LMO7 LIM domain 7
LOC390956 peptidyl-prolyl cis-trans isomerase A pseudogene
LRP1B low density lipoprotein receptor-related protein 1B
LRRTM3 leucine rich repeat transmembrane neuronal 3
LSR lipolysis stimulated lipoprotein receptor
MACF1 microtubule-actin crosslinking factor 1
MAP1B microtubule-associated protein 1B
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MAST4 microtubule associated serine/threonine kinase family member 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MCM3AP minichromosome maintenance complex component 3 associated protein
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1
MED28 mediator complex subunit 28
MROH2A maestro heat-like repeat family member 2A
MRPL40 mitochondrial ribosomal protein L40
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC4 mucin 4, cell surface associated
MYBBP1A MYB binding protein (P160) 1a
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO7B myosin VIIB
NBAS neuroblastoma amplified sequence
NCKAP5 NCK-associated protein 5
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDRG2 NDRG family member 2
NFE2L3 nuclear factor, erythroid 2-like 3
NKX6-2 NK6 homeobox 2
NLK nemo-like kinase
NOTO notochord homeobox
NPC1L1 NPC1-like 1
NPDC1 neural proliferation, differentiation and control, 1
NRTN neurturin
NUBPL nucleotide binding protein-like
OLFML2A olfactomedin-like 2A
OR10G3 olfactory receptor, family 10, subfamily G, member 3
OR1C1 olfactory receptor, family 1, subfamily C, member 1
OR2A5 olfactory receptor, family 2, subfamily A, member 5
OR5D14 olfactory receptor, family 5, subfamily D, member 14
OR5T1 olfactory receptor, family 5, subfamily T, member 1
PAQR6 progestin and adipoQ receptor family member VI
PASK PAS domain containing serine/threonine kinase
PCLO piccolo presynaptic cytomatrix protein
PCSK5 proprotein convertase subtilisin/kexin type 5
PDCD11 programmed cell death 11
PDE4DIP phosphodiesterase 4D interacting protein
PDPN podoplanin
PIEZO1 piezo-type mechanosensitive ion channel component 1
PKD1L1 polycystic kidney disease 1 like 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCH2 phospholipase C, eta 2
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4
PNPLA5 patatin-like phospholipase domain containing 5
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRAMEF14 PRAME family member 14
PRKG1 protein kinase, cGMP-dependent, type I
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
PRRC2A proline-rich coiled-coil 2A
PSD3 pleckstrin and Sec7 domain containing 3
PTPRG protein tyrosine phosphatase, receptor type, G
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic)
RARB retinoic acid receptor, beta
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RERG RAS-like, estrogen-regulated, growth inhibitor
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNF14 ring finger protein 14
RNF213 ring finger protein 213
RNLS renalase, FAD-dependent amine oxidase
RPRD1B regulation of nuclear pre-mRNA domain containing 1B
RTN2 reticulon 2
RUNX1 runt-related transcription factor 1
SALL2 spalt-like transcription factor 2
SAR1B secretion associated, Ras related GTPase 1B
SARS2 seryl-tRNA synthetase 2, mitochondrial
SBF1 SET binding factor 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SEC31A SEC31 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT9 septin 9
SEZ6L seizure related 6 homolog (mouse)-like
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3RF1 SH3 domain containing ring finger 1
SHANK1 SH3 and multiple ankyrin repeat domains 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SI sucrase-isomaltase (alpha-glucosidase)
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene)
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
SLC25A44 solute carrier family 25, member 44
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNX5 sorting nexin 5
SPI1 Spi-1 proto-oncogene
SPTBN2 spectrin, beta, non-erythrocytic 2
SRCAP Snf2-related CREBBP activator protein
ST7 suppression of tumorigenicity 7
STAU1 staufen double-stranded RNA binding protein 1
STK31 serine/threonine kinase 31
STK32A serine/threonine kinase 32A
SYNPO2 synaptopodin 2
TBC1D3P2 TBC1 domain family, member 3 pseudogene 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCEA1 transcription elongation factor A (SII), 1
TCF21 transcription factor 21
TGM7 transglutaminase 7
TGS1 trimethylguanosine synthase 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TLR10 toll-like receptor 10
TM4SF1 transmembrane 4 L six family member 1
TMCO4 transmembrane and coiled-coil domains 4
TMEM8C transmembrane protein 8C
TP53 tumor protein p53
TRIM16 tripartite motif containing 16
TRMT61B tRNA methyltransferase 61B
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TTC14 tetratricopeptide repeat domain 14
TTC16 tetratricopeptide repeat domain 16
TTLL9 tubulin tyrosine ligase-like family member 9
TTN titin
TUBGCP5 tubulin, gamma complex associated protein 5
TUBGCP6 tubulin, gamma complex associated protein 6
U2AF1 U2 small nuclear RNA auxiliary factor 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2C ubiquitin-conjugating enzyme E2C
UFL1 UFM1-specific ligase 1
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
UMOD uromodulin
UROD uroporphyrinogen decarboxylase
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP36 ubiquitin specific peptidase 36
USP40 ubiquitin specific peptidase 40
VAV1 vav 1 guanine nucleotide exchange factor
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
WDFY2 WD repeat and FYVE domain containing 2
WDR63 WD repeat domain 63
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
XAB2 XPA binding protein 2
XYLT1 xylosyltransferase I
XYLT2 xylosyltransferase II
ZC3H7B zinc finger CCCH-type containing 7B
ZFP64 ZFP64 zinc finger protein
ZNF212 zinc finger protein 212
ZNF445 zinc finger protein 445
ZNF558 zinc finger protein 558
ZNF646 zinc finger protein 646
ZNF675 zinc finger protein 675
ZNF695 zinc finger protein 695
ZNF714 zinc finger protein 714
ZNF747 zinc finger protein 747
ZNF749 zinc finger protein 749
ZSWIM6 zinc finger, SWIM-type containing 6
ZW10 zw10 kinetochore protein