MONOMAC1 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description Human acute monocytic leukemia cell line; established from the peripheral blood of a 64-year-old man with relapsed acute monocytic leukemia (AML FAB M5) in 1985 following myeloid metaplasia. Simultaneous sister cell line of MONO-MAC-6. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003928)
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Genes

547 gene knockdowns changing fitness of MONOMAC1 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
ADRA1B adrenoceptor alpha 1B 3.19235
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 3.11179
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.69442
ZNF845 zinc finger protein 845 2.51075
ZNF611 zinc finger protein 611 2.50979
UGP2 UDP-glucose pyrophosphorylase 2 2.43638
SRP9 signal recognition particle 9kDa 2.41608
TRIM60 tripartite motif containing 60 2.36762
IL2RA interleukin 2 receptor, alpha 2.32967
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.32942
RHOB ras homolog family member B 2.32435
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 2.2937
USO1 USO1 vesicle transport factor 2.29173
CD8B CD8b molecule 2.26019
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2.24628
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 2.22155
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2.18877
LPAR1 lysophosphatidic acid receptor 1 2.18057
PPP1R10 protein phosphatase 1, regulatory subunit 10 2.17998
SPINK4 serine peptidase inhibitor, Kazal type 4 2.14835
SLC25A40 solute carrier family 25, member 40 2.12372
CHID1 chitinase domain containing 1 2.11643
HOXA6 homeobox A6 2.10763
SPDEF SAM pointed domain containing ETS transcription factor 2.09009
AP3D1 adaptor-related protein complex 3, delta 1 subunit 2.06955
PDCL3 phosducin-like 3 2.06737
ZFP36L2 ZFP36 ring finger protein-like 2 2.02206
YAP1 Yes-associated protein 1 2.00345
ETFDH electron-transferring-flavoprotein dehydrogenase 1.98791
VRK3 vaccinia related kinase 3 1.98549
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 1.98496
NQO1 NAD(P)H dehydrogenase, quinone 1 1.95475
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M 1.94667
BCL2L1 BCL2-like 1 1.94152
CDC25B cell division cycle 25B 1.91287
SYT4 synaptotagmin IV 1.91186
AOC3 amine oxidase, copper containing 3 1.90832
SP3 Sp3 transcription factor 1.8956
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 1.89219
TXNDC17 thioredoxin domain containing 17 1.88651
CXCR2 chemokine (C-X-C motif) receptor 2 1.88385
SMAD9 SMAD family member 9 1.87075
ZFHX3 zinc finger homeobox 3 1.86584
ARL2-SNX15 ARL2-SNX15 readthrough (NMD candidate) 1.8592
RBM22 RNA binding motif protein 22 1.85906
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.83897
SECISBP2L SECIS binding protein 2-like 1.83463
PRPF38A pre-mRNA processing factor 38A 1.83388
FCRL5 Fc receptor-like 5 1.83187
SNX15 sorting nexin 15 1.82782
TLR6 toll-like receptor 6 1.8121
PAN2 PAN2 poly(A) specific ribonuclease subunit 1.80723
SNW1 SNW domain containing 1 1.79252
OR10J1 olfactory receptor, family 10, subfamily J, member 1 1.77838
ZNF320 zinc finger protein 320 1.77183
AAK1 AP2 associated kinase 1 1.77062
TPR translocated promoter region, nuclear basket protein 1.76712
KCNK10 potassium channel, two pore domain subfamily K, member 10 1.76634
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 1.75111
ZNF236 zinc finger protein 236 1.74532
ARHGAP17 Rho GTPase activating protein 17 1.74134
PTPRC protein tyrosine phosphatase, receptor type, C 1.73678
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 1.73651
USP30 ubiquitin specific peptidase 30 1.73322
SEC24D SEC24 family member D 1.72719
MARK3 MAP/microtubule affinity-regulating kinase 3 1.72208
FERMT1 fermitin family member 1 1.71519
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 1.69712
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 1.68469
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 1.68066
ZNF281 zinc finger protein 281 1.67846
RRAGC Ras-related GTP binding C 1.67768
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 1.67508
MC4R melanocortin 4 receptor 1.63807
ATF7IP2 activating transcription factor 7 interacting protein 2 1.63335
BRIP1 BRCA1 interacting protein C-terminal helicase 1 1.63239
ABHD13 abhydrolase domain containing 13 1.63121
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 1.62469
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 1.62346
CXCL11 chemokine (C-X-C motif) ligand 11 1.62199
PPA1 pyrophosphatase (inorganic) 1 1.61259
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.60664
THBS3 thrombospondin 3 1.60036
CALCR calcitonin receptor 1.59825
BAZ1B bromodomain adjacent to zinc finger domain, 1B 1.59238
GTPBP4 GTP binding protein 4 1.58696
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 1.58107
CYB5A cytochrome b5 type A (microsomal) 1.57855
C5AR1 complement component 5a receptor 1 1.57597
FZD8 frizzled class receptor 8 1.57311
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 1.57294
NRD1 nardilysin (N-arginine dibasic convertase) 1.5686
RNF17 ring finger protein 17 1.55278
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 1.54647
ADI1 acireductone dioxygenase 1 1.53014
PAK1IP1 PAK1 interacting protein 1 1.52972
CWC22 CWC22 spliceosome-associated protein 1.52418
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 1.51346
C6ORF118 chromosome 6 open reading frame 118 1.50994
COL8A1 collagen, type VIII, alpha 1 1.50724
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 1.50417
HSPA1B heat shock 70kDa protein 1B 1.49946
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1.49907
AADAT aminoadipate aminotransferase 1.49209
DCLRE1C DNA cross-link repair 1C 1.48478
ZNF426 zinc finger protein 426 1.4823
RNF217 ring finger protein 217 1.47989
ZNF22 zinc finger protein 22 1.474
NUMBL numb homolog (Drosophila)-like 1.47379
FGFR3 fibroblast growth factor receptor 3 1.47355
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 1.46951
PCDHGB3 protocadherin gamma subfamily B, 3 1.45851
FAM13A family with sequence similarity 13, member A 1.45548
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 1.45362
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 1.45108
RAB33A RAB33A, member RAS oncogene family 1.44622
BCL2L2 BCL2-like 2 1.43872
IL7 interleukin 7 1.43429
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 1.43034
GJB1 gap junction protein, beta 1, 32kDa 1.4302
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 1.4278
PARP12 poly (ADP-ribose) polymerase family, member 12 1.42494
RARA retinoic acid receptor, alpha 1.41983
NTF3 neurotrophin 3 1.41963
VN1R1 vomeronasal 1 receptor 1 1.4173
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.41022
CRLF3 cytokine receptor-like factor 3 1.41014
ZNF146 zinc finger protein 146 1.40876
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 1.40073
EDAR ectodysplasin A receptor 1.3986
SKAP1 src kinase associated phosphoprotein 1 1.39627
BCAS2 breast carcinoma amplified sequence 2 1.39506
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.39459
ZBTB16 zinc finger and BTB domain containing 16 1.38389
GLS2 glutaminase 2 (liver, mitochondrial) 1.37954
KCNK4 potassium channel, two pore domain subfamily K, member 4 1.37802
KRTAP10-5 keratin associated protein 10-5 1.37207
WWOX WW domain containing oxidoreductase 1.36345
HOXC11 homeobox C11 1.36012
BBS4 Bardet-Biedl syndrome 4 1.3578
TONSL tonsoku-like, DNA repair protein 1.35726
BAAT bile acid CoA:amino acid N-acyltransferase 1.3548
SAG S-antigen; retina and pineal gland (arrestin) 1.34844
THRAP3 thyroid hormone receptor associated protein 3 1.3379
PAQR6 progestin and adipoQ receptor family member VI 1.33708
NODAL nodal growth differentiation factor 1.33433
TXNRD1 thioredoxin reductase 1 1.33078
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 1.32705
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 1.32409
ATF4 activating transcription factor 4 1.31605
NLRP12 NLR family, pyrin domain containing 12 1.3156
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 1.31353
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit 1.30302
RPP40 ribonuclease P/MRP 40kDa subunit 1.29882
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 1.29771
PRDM2 PR domain containing 2, with ZNF domain 1.29311
PRCC papillary renal cell carcinoma (translocation-associated) 1.29275
STX17 syntaxin 17 1.28303
SF3A3 splicing factor 3a, subunit 3, 60kDa 1.28276
MICA MHC class I polypeptide-related sequence A 1.28058
KRT6B keratin 6B, type II 1.28018
ZNF195 zinc finger protein 195 1.27946
TBX4 T-box 4 1.27793
ZNF554 zinc finger protein 554 1.27755
EGFR epidermal growth factor receptor 1.27599
ALG8 ALG8, alpha-1,3-glucosyltransferase 1.27466
CSF1 colony stimulating factor 1 (macrophage) 1.27249
HBG1 hemoglobin, gamma A 1.27197
GEMIN2 gem (nuclear organelle) associated protein 2 1.26295
ZNF101 zinc finger protein 101 1.26194
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.26169
MEN1 multiple endocrine neoplasia I 1.26069
ZNF211 zinc finger protein 211 1.25991
FBXL2 F-box and leucine-rich repeat protein 2 1.25524
HSPA1A heat shock 70kDa protein 1A 1.24628
PCDH15 protocadherin-related 15 1.24487
RPA2 replication protein A2, 32kDa 1.24311
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 1.24127
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 1.23552
TRPV3 transient receptor potential cation channel, subfamily V, member 3 1.23251
CHERP calcium homeostasis endoplasmic reticulum protein 1.22857
RAD23A RAD23 homolog A (S. cerevisiae) 1.2258
SLC35E4 solute carrier family 35, member E4 1.2254
IRX6 iroquois homeobox 6 1.22127
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 1.22088
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 1.22086
MED30 mediator complex subunit 30 1.21968
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 1.21743
PPP6C protein phosphatase 6, catalytic subunit 1.209
DSG4 desmoglein 4 1.20793
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.20304
OR2H1 olfactory receptor, family 2, subfamily H, member 1 1.20294
QARS glutaminyl-tRNA synthetase 1.20036
ZNF587 zinc finger protein 587 1.19744
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 1.19622
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.19495
ATF7 activating transcription factor 7 1.19179
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 1.18932
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 1.18576
PLK3 polo-like kinase 3 1.1847
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.18441
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 1.18374
PAQR8 progestin and adipoQ receptor family member VIII 1.1829
PIGR polymeric immunoglobulin receptor 1.18092
ALDOA aldolase A, fructose-bisphosphate 1.18036
MAN1A1 mannosidase, alpha, class 1A, member 1 1.17907
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.17851
PPP1R12B protein phosphatase 1, regulatory subunit 12B 1.17756
GOPC golgi-associated PDZ and coiled-coil motif containing 1.17682
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 1.17664
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 1.1744
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 1.17149
GSS glutathione synthetase 1.17027
S1PR5 sphingosine-1-phosphate receptor 5 1.16929
DUSP18 dual specificity phosphatase 18 1.16548
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.15851
FPGS folylpolyglutamate synthase 1.15416
ARHGAP39 Rho GTPase activating protein 39 1.15392
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 1.15228
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.15031
TP73 tumor protein p73 1.14699
EHBP1 EH domain binding protein 1 1.14681
VIM vimentin 1.14355
EPB41L1 erythrocyte membrane protein band 4.1-like 1 1.14261
OR8A1 olfactory receptor, family 8, subfamily A, member 1 1.14117
ACAT2 acetyl-CoA acetyltransferase 2 1.13952
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.13904
FOXD1 forkhead box D1 1.13901
SYTL2 synaptotagmin-like 2 1.13407
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 1.13287
QSOX1 quiescin Q6 sulfhydryl oxidase 1 1.12954
HK3 hexokinase 3 (white cell) 1.12607
IQGAP2 IQ motif containing GTPase activating protein 2 1.12586
SRRM1 serine/arginine repetitive matrix 1 1.12505
MAT1A methionine adenosyltransferase I, alpha 1.12309
ZNF521 zinc finger protein 521 1.11858
GRB2 growth factor receptor-bound protein 2 1.11651
MC5R melanocortin 5 receptor 1.11388
GRK5 G protein-coupled receptor kinase 5 1.11381
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 1.11142
HOXC5 homeobox C5 1.10856
CPA4 carboxypeptidase A4 1.10548
RARS2 arginyl-tRNA synthetase 2, mitochondrial 1.10521
C1ORF87 chromosome 1 open reading frame 87 1.10393
INHBA inhibin, beta A 1.10372
FHIT fragile histidine triad 1.10241
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 1.0962
HLA-E major histocompatibility complex, class I, E 1.091
DARS aspartyl-tRNA synthetase 1.0902
CD58 CD58 molecule 1.08875
JDP2 Jun dimerization protein 2 1.08641
NCBP1 nuclear cap binding protein subunit 1, 80kDa 1.0848
KISS1 KiSS-1 metastasis-suppressor 1.0823
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 1.08219
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 1.08012
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 1.07957
NONO non-POU domain containing, octamer-binding 1.07842
SLC16A12 solute carrier family 16, member 12 1.07824
MKRN3 makorin ring finger protein 3 1.07768
ZNF8 zinc finger protein 8 1.07421
EBNA1BP2 EBNA1 binding protein 2 1.07309
CLCNKB chloride channel, voltage-sensitive Kb 1.07022
BMP8A bone morphogenetic protein 8a 1.06991
TAS1R1 taste receptor, type 1, member 1 1.0683
PCDHB5 protocadherin beta 5 1.06641
ADAM22 ADAM metallopeptidase domain 22 1.06618
CNGB1 cyclic nucleotide gated channel beta 1 1.06435
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.06294
LRRK2 leucine-rich repeat kinase 2 1.0629
PRDM4 PR domain containing 4 1.05868
DPCR1 diffuse panbronchiolitis critical region 1 1.05756
CXCR1 chemokine (C-X-C motif) receptor 1 1.05687
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 1.05637
TGFBR1 transforming growth factor, beta receptor 1 1.05488
EPHA4 EPH receptor A4 1.05303
RBM5 RNA binding motif protein 5 1.05197
RAD17 RAD17 homolog (S. pombe) 1.05017
FANCD2 Fanconi anemia, complementation group D2 1.04875
IL1RN interleukin 1 receptor antagonist 1.04446
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1.04324
RASA2 RAS p21 protein activator 2 1.03891
TUSC2 tumor suppressor candidate 2 1.03882
NFRKB nuclear factor related to kappaB binding protein 1.0352
PADI3 peptidyl arginine deiminase, type III 1.0343
RPL7 ribosomal protein L7 1.03002
RAB23 RAB23, member RAS oncogene family 1.02969
FAM120A family with sequence similarity 120A 1.02706
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 1.02363
UBE2I ubiquitin-conjugating enzyme E2I 1.0226
CLK2 CDC-like kinase 2 1.01972
AWAT2 acyl-CoA wax alcohol acyltransferase 2 1.01753
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 1.01633
DNAI1 dynein, axonemal, intermediate chain 1 1.01293
XAB2 XPA binding protein 2 1.01157
CKM creatine kinase, muscle 1.00998
CAMK1D calcium/calmodulin-dependent protein kinase ID 1.00853
GJA5 gap junction protein, alpha 5, 40kDa 1.00692
NRIP1 nuclear receptor interacting protein 1 1.00575
LUC7L2 LUC7-like 2 (S. cerevisiae) 1.00324
ANK2 ankyrin 2, neuronal 1.00084
PGF placental growth factor 1.00022

decreased fitness

Symbol Name Standardized Value
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 -3.2155
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 -3.13359
TRAT1 T cell receptor associated transmembrane adaptor 1 -2.9328
GPR22 G protein-coupled receptor 22 -2.8359
POC1B-GALNT4 POC1B-GALNT4 readthrough -2.81364
KCNIP4 Kv channel interacting protein 4 -2.56846
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -2.56695
ADAMTSL4 ADAMTS-like 4 -2.47798
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.47371
WHSC1 Wolf-Hirschhorn syndrome candidate 1 -2.41228
ERVW-1 endogenous retrovirus group W, member 1 -2.38665
PER2 period circadian clock 2 -2.32951
MAN2A1 mannosidase, alpha, class 2A, member 1 -2.30651
HMGN1 high mobility group nucleosome binding domain 1 -2.19268
ANXA3 annexin A3 -2.17054
NAAA N-acylethanolamine acid amidase -2.1465
PGK2 phosphoglycerate kinase 2 -2.12645
S100A6 S100 calcium binding protein A6 -2.10378
PPAP2C phosphatidic acid phosphatase type 2C -2.05474
FGF22 fibroblast growth factor 22 -2.02309
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.01495
FLCN folliculin -2.0037
EOMES eomesodermin -1.99926
OR7A5 olfactory receptor, family 7, subfamily A, member 5 -1.99514
TMPRSS5 transmembrane protease, serine 5 -1.99075
CHD9 chromodomain helicase DNA binding protein 9 -1.97894
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -1.94726
CELA1 chymotrypsin-like elastase family, member 1 -1.94038
PLSCR3 phospholipid scramblase 3 -1.93338
OR4D11 olfactory receptor, family 4, subfamily D, member 11 -1.92473
PROKR2 prokineticin receptor 2 -1.92078
DPP8 dipeptidyl-peptidase 8 -1.90425
CARM1 coactivator-associated arginine methyltransferase 1 -1.90272
ZNF227 zinc finger protein 227 -1.89448
FABP1 fatty acid binding protein 1, liver -1.88884
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 -1.8826
MYEF2 myelin expression factor 2 -1.87089
DMAP1 DNA methyltransferase 1 associated protein 1 -1.86937
BMP5 bone morphogenetic protein 5 -1.86287
CLCN1 chloride channel, voltage-sensitive 1 -1.84793
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -1.8435
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -1.8403
BCL7A B-cell CLL/lymphoma 7A -1.83912
RB1 retinoblastoma 1 -1.82748
FLT3 fms-related tyrosine kinase 3 -1.80351
ZMYND11 zinc finger, MYND-type containing 11 -1.79792
SP7 Sp7 transcription factor -1.79571
C10ORF2 chromosome 10 open reading frame 2 -1.79536
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -1.76915
GPR107 G protein-coupled receptor 107 -1.75108
KRTAP5-2 keratin associated protein 5-2 -1.75014
PCDHA4 protocadherin alpha 4 -1.73669
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -1.7336
MDK midkine (neurite growth-promoting factor 2) -1.73126
OR51V1 olfactory receptor, family 51, subfamily V, member 1 -1.72335
ART5 ADP-ribosyltransferase 5 -1.7053
BCAT1 branched chain amino-acid transaminase 1, cytosolic -1.6863
PSEN1 presenilin 1 -1.66675
NRTN neurturin -1.65773
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -1.6464
RHBDD2 rhomboid domain containing 2 -1.646
FGD4 FYVE, RhoGEF and PH domain containing 4 -1.62138
LAMP1 lysosomal-associated membrane protein 1 -1.6017
SPI1 Spi-1 proto-oncogene -1.59661
FBLN1 fibulin 1 -1.59356
KRT23 keratin 23, type I -1.5909
ZNF619 zinc finger protein 619 -1.58948
CDK19 cyclin-dependent kinase 19 -1.58621
TECTA tectorin alpha -1.58535
ANKRD29 ankyrin repeat domain 29 -1.56484
TDRD9 tudor domain containing 9 -1.54854
JMJD1C jumonji domain containing 1C -1.5422
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -1.53937
DHFR dihydrofolate reductase -1.53344
PRKCE protein kinase C, epsilon -1.53199
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene -1.52643
GADD45G growth arrest and DNA-damage-inducible, gamma -1.52618
RAPSN receptor-associated protein of the synapse -1.52511
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -1.52327
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) -1.51269
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -1.49573
MAST2 microtubule associated serine/threonine kinase 2 -1.49025
AOC2 amine oxidase, copper containing 2 (retina-specific) -1.48973
ZNF473 zinc finger protein 473 -1.48735
MADD MAP-kinase activating death domain -1.474
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -1.47089
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -1.46741
CADM3 cell adhesion molecule 3 -1.46267
APOA2 apolipoprotein A-II -1.46006
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 -1.44296
TARBP1 TAR (HIV-1) RNA binding protein 1 -1.44296
CTSE cathepsin E -1.44069
OR1S2 olfactory receptor, family 1, subfamily S, member 2 -1.44059
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -1.44028
NRIP3 nuclear receptor interacting protein 3 -1.43384
MXD4 MAX dimerization protein 4 -1.42426
RYK receptor-like tyrosine kinase -1.42016
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -1.41955
RUFY1 RUN and FYVE domain containing 1 -1.41764
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -1.41591
ADCY2 adenylate cyclase 2 (brain) -1.41278
OSGEP O-sialoglycoprotein endopeptidase -1.4061
ORM2 orosomucoid 2 -1.39155
IL2RB interleukin 2 receptor, beta -1.38868
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -1.3871
CTTN cortactin -1.38689
RBP5 retinol binding protein 5, cellular -1.37623
DRD4 dopamine receptor D4 -1.37569
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -1.36282
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -1.3624
NEK2 NIMA-related kinase 2 -1.35718
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -1.35679
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -1.35601
ISL1 ISL LIM homeobox 1 -1.3549
MEX3D mex-3 RNA binding family member D -1.35164
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 -1.34918
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -1.3467
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -1.3452
OR2L13 olfactory receptor, family 2, subfamily L, member 13 -1.34098
IFT20 intraflagellar transport 20 -1.34093
AFF4 AF4/FMR2 family, member 4 -1.33268
RAB7A RAB7A, member RAS oncogene family -1.32934
TMPRSS13 transmembrane protease, serine 13 -1.32664
PSKH2 protein serine kinase H2 -1.3237
LTK leukocyte receptor tyrosine kinase -1.32264
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -1.32247
SLC26A1 solute carrier family 26 (anion exchanger), member 1 -1.32097
SARDH sarcosine dehydrogenase -1.31684
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 -1.3168
PRDM10 PR domain containing 10 -1.31641
RHAG Rh-associated glycoprotein -1.30083
OR1N2 olfactory receptor, family 1, subfamily N, member 2 -1.29904
ZNF254 zinc finger protein 254 -1.29564
SREBF2 sterol regulatory element binding transcription factor 2 -1.29246
MPG N-methylpurine-DNA glycosylase -1.29241
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -1.28998
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -1.2819
ZNF248 zinc finger protein 248 -1.27893
ITGA6 integrin, alpha 6 -1.27882
PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A -1.27784
CCNT2 cyclin T2 -1.27535
FRK fyn-related Src family tyrosine kinase -1.27334
GPR132 G protein-coupled receptor 132 -1.27253
MYLIP myosin regulatory light chain interacting protein -1.27065
SLC12A8 solute carrier family 12, member 8 -1.26683
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 -1.2664
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -1.26383
BCOR BCL6 corepressor -1.26246
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -1.25963
ADIPOR2 adiponectin receptor 2 -1.25564
CCNB1 cyclin B1 -1.2548
SOAT2 sterol O-acyltransferase 2 -1.25186
BAZ1A bromodomain adjacent to zinc finger domain, 1A -1.24358
PCDHA10 protocadherin alpha 10 -1.24335
DGKB diacylglycerol kinase, beta 90kDa -1.24259
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) -1.24174
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 -1.23951
ZNF497 zinc finger protein 497 -1.23739
PPP4R1 protein phosphatase 4, regulatory subunit 1 -1.23637
ACR acrosin -1.23525
UNC5C unc-5 homolog C (C. elegans) -1.23497
ABR active BCR-related -1.22255
FN3K fructosamine 3 kinase -1.21705
LPPR3 lipid phosphate phosphatase-related protein type 3 -1.21396
SOX4 SRY (sex determining region Y)-box 4 -1.21287
GLRX2 glutaredoxin 2 -1.20922
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -1.20521
SLC17A4 solute carrier family 17, member 4 -1.20145
ZNF599 zinc finger protein 599 -1.19998
HOXA13 homeobox A13 -1.19995
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -1.19857
SCN1B sodium channel, voltage gated, type I beta subunit -1.1972
RHO rhodopsin -1.19486
TNK2 tyrosine kinase, non-receptor, 2 -1.1933
STK17B serine/threonine kinase 17b -1.19126
MMP25 matrix metallopeptidase 25 -1.1902
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -1.1902
SPINK6 serine peptidase inhibitor, Kazal type 6 -1.18774
PM20D1 peptidase M20 domain containing 1 -1.173
BCAR3 breast cancer anti-estrogen resistance 3 -1.16978
ONECUT1 one cut homeobox 1 -1.16511
NQO2 NAD(P)H dehydrogenase, quinone 2 -1.16464
HILS1 histone linker H1 domain, spermatid-specific 1, pseudogene -1.16265
GRAP2 GRB2-related adaptor protein 2 -1.16212
LMO4 LIM domain only 4 -1.16034
OCRL oculocerebrorenal syndrome of Lowe -1.15249
HIC1 hypermethylated in cancer 1 -1.1516
CIB4 calcium and integrin binding family member 4 -1.14796
UBL3 ubiquitin-like 3 -1.14684
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -1.14445
DHRS13 dehydrogenase/reductase (SDR family) member 13 -1.13867
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -1.13089
VAMP7 vesicle-associated membrane protein 7 -1.12967
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -1.12796
CWC15 CWC15 spliceosome-associated protein -1.12547
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) -1.12329
POLB polymerase (DNA directed), beta -1.12106
LEP leptin -1.11887
TPTE transmembrane phosphatase with tensin homology -1.11854
A2ML1 alpha-2-macroglobulin-like 1 -1.11845
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -1.11819
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 -1.11177
RAB15 RAB15, member RAS oncogene family -1.10446
SETBP1 SET binding protein 1 -1.10377
ZSCAN4 zinc finger and SCAN domain containing 4 -1.09696
KLF13 Kruppel-like factor 13 -1.09449
NXF3 nuclear RNA export factor 3 -1.09263
CX3CR1 chemokine (C-X3-C motif) receptor 1 -1.09162
HABP2 hyaluronan binding protein 2 -1.09151
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -1.08751
TRIM7 tripartite motif containing 7 -1.08598
CCKBR cholecystokinin B receptor -1.0832
TMEM189 transmembrane protein 189 -1.07877
F9 coagulation factor IX -1.07708
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 -1.07697
KRT7 keratin 7, type II -1.07665
PTS 6-pyruvoyltetrahydropterin synthase -1.07525
FOXL2 forkhead box L2 -1.07478
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -1.07459
DLG2 discs, large homolog 2 (Drosophila) -1.07336
H1FOO H1 histone family, member O, oocyte-specific -1.07333
GJA9-MYCBP GJA9-MYCBP readthrough -1.06129
MYB v-myb avian myeloblastosis viral oncogene homolog -1.06064
ZEB2 zinc finger E-box binding homeobox 2 -1.0606
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 -1.05632
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -1.05119
KDM4A lysine (K)-specific demethylase 4A -1.04918
MTM1 myotubularin 1 -1.04496
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -1.04325
ZFP28 ZFP28 zinc finger protein -1.04068
DCP1A decapping mRNA 1A -1.03978
ZNF257 zinc finger protein 257 -1.03476
ZNF12 zinc finger protein 12 -1.03456
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 -1.03291
IL7R interleukin 7 receptor -1.03227
E2F1 E2F transcription factor 1 -1.02359
CD1C CD1c molecule -1.0222
SEC24C SEC24 family member C -1.0182
HYAL1 hyaluronoglucosaminidase 1 -1.01627
CPA6 carboxypeptidase A6 -1.01075
WFDC10B WAP four-disulfide core domain 10B -1.0103
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -1.01019
KAT2B K(lysine) acetyltransferase 2B -1.00987
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -1.00741
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -1.00611
BIRC2 baculoviral IAP repeat containing 2 -1.00382