MORC3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description MORC family CW-type zinc finger 3|This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 23515)
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Genes

352 genes differentially expressed following the MORC3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.34197
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.34197
MFAP5 microfibrillar associated protein 5 3.34197
TAL2 T-cell acute lymphocytic leukemia 2 3.34197
MYOM2 myomesin 2 3.34197
GIMAP4 GTPase, IMAP family member 4 3.34197
NRROS negative regulator of reactive oxygen species 3.34197
POSTN periostin, osteoblast specific factor 3.34197
GADL1 glutamate decarboxylase-like 1 3.34197
SFTPB surfactant protein B 3.34197
TUBB8 tubulin, beta 8 class VIII 3.34197
GJB5 gap junction protein, beta 5, 31.1kDa 3.34197
CABP4 calcium binding protein 4 3.34197
PRELP proline/arginine-rich end leucine-rich repeat protein 3.34197
MAGEA4 melanoma antigen family A4 3.34197
ZFP57 ZFP57 zinc finger protein 3.34197
GLUD2 glutamate dehydrogenase 2 3.34197
TM4SF1 transmembrane 4 L six family member 1 3.34197
OSGIN1 oxidative stress induced growth inhibitor 1 3.34197
TBX15 T-box 15 3.34197
SLC25A45 solute carrier family 25, member 45 3.34197
BSX brain-specific homeobox 3.34197
SHISA7 shisa family member 7 3.34197
MOGAT3 monoacylglycerol O-acyltransferase 3 3.34197
IL2RB interleukin 2 receptor, beta 3.34197
TMC8 transmembrane channel-like 8 3.34197
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.34197
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.34197
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.34197
STEAP4 STEAP family member 4 3.34197
HRG histidine-rich glycoprotein 3.34197
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.34197
ICAM1 intercellular adhesion molecule 1 3.34197
MUC22 mucin 22 3.34197
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.34197
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.34197
GLIS1 GLIS family zinc finger 1 3.34197
OCSTAMP osteoclast stimulatory transmembrane protein 3.34197
F2 coagulation factor II (thrombin) 3.34197
DTNB dystrobrevin, beta 3.34197
MAGED4 melanoma antigen family D4 3.34197
PLK5 polo-like kinase 5 3.34197
YY2 YY2 transcription factor 3.34197
S100A1 S100 calcium binding protein A1 3.34197
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.34197
SACK1A scaffolding CK1 anchoring protein A 3.34197
SPATA31G1 SPATA31 subfamily G member 1 3.34197
TBC1D3L TBC1 domain family, member 3L 3.34197
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.34197
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.34197
TMPRSS3 transmembrane protease, serine 3 3.34197
TSPAN8 tetraspanin 8 3.34197
GATA2 GATA binding protein 2 3.34197
PRDM6 PR domain containing 6 3.34197
CSAG2 CSAG family, member 2 3.34197
GPR83 G protein-coupled receptor 83 3.34197
LDB3 LIM domain binding 3 3.34197
CCER2 coiled-coil glutamate-rich protein 2 3.34197
CIMIP7 ciliary microtubule inner protein 7 3.34197
TEX53 testis expressed 53 3.34197
FAM240C family with sequence similarity 240 member C 3.34197
SAXO4 stabilizer of axonemal microtubules 4 3.34197
C17ORF113 chromosome 17 open reading frame 113 3.34197
LOC124903233 uncharacterized LOC124903233 3.34197
GARIN1A golgi associated RAB2 interactor 1A 3.34197
HJV hemojuvelin BMP co-receptor 3.34197
GBP1 guanylate binding protein 1, interferon-inducible 3.34197
PLEK2 pleckstrin 2 3.34197
PGLYRP1 peptidoglycan recognition protein 1 3.34197
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.34197
KLHL33 kelch-like family member 33 3.34197
RBBP5 retinoblastoma binding protein 5 3.34197
ATP13A5 ATPase type 13A5 3.34197
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.34197
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.34197
MYT1L myelin transcription factor 1-like 3.34197
TMPRSS11F transmembrane protease, serine 11F 3.34197
STKLD1 serine/threonine kinase-like domain containing 1 3.34197
CD5 CD5 molecule 3.34197
PCDHB13 protocadherin beta 13 3.34197
BIK BCL2-interacting killer (apoptosis-inducing) 3.34197
NPFF neuropeptide FF-amide peptide precursor 3.34197
CREB3L3 cAMP responsive element binding protein 3-like 3 3.34197
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.34197
TLR7 toll-like receptor 7 3.34197
TMEM233 transmembrane protein 233 3.34197
C3ORF80 chromosome 3 open reading frame 80 3.34197
IL31RA interleukin 31 receptor A 3.34197
HPR haptoglobin-related protein 3.34197
PYDC1 PYD (pyrin domain) containing 1 3.34197
TXLNB taxilin beta 3.34197
ZNF648 zinc finger protein 648 3.34197
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.34197
TMEM132D transmembrane protein 132D 3.34197
FNDC9 fibronectin type III domain containing 9 3.34197
SEMG1 semenogelin I 3.34197
CCDC159 coiled-coil domain containing 159 3.34197
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.34197
COL9A2 collagen, type IX, alpha 2 3.34197
ANKRD55 ankyrin repeat domain 55 3.34197
CIDEA cell death-inducing DFFA-like effector a 3.34197
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.34197
IL12A interleukin 12A 3.34197
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.34197
IER5L immediate early response 5-like 3.34197
NTSR1 neurotensin receptor 1 (high affinity) 3.34197
DAW1 dynein assembly factor with WDR repeat domains 1 3.34197
C20ORF144 chromosome 20 open reading frame 144 3.34197
GAGE10 G antigen 10 3.34197
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.34197
C11ORF16 chromosome 11 open reading frame 16 3.34197
TDRD12 tudor domain containing 12 3.34197
TDRD10 tudor domain containing 10 3.34197
PEBP1 phosphatidylethanolamine binding protein 1 3.34197
MAB21L1 mab-21-like 1 (C. elegans) 3.34197
RANBP3L RAN binding protein 3-like 3.34197
KLF9 Kruppel-like factor 9 3.34197
DRD2 dopamine receptor D2 3.34197
OR10R2 olfactory receptor, family 10, subfamily R, member 2 3.34197
CXCR4 chemokine (C-X-C motif) receptor 4 3.34197
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.34197
DHH desert hedgehog 3.34197
ZBP1 Z-DNA binding protein 1 3.34197
PSG6 pregnancy specific beta-1-glycoprotein 6 3.34197
QRFP pyroglutamylated RFamide peptide 3.34197
BATF2 basic leucine zipper transcription factor, ATF-like 2 3.34197
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.34197
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.34197
ADRA1D adrenoceptor alpha 1D 3.34197
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.34197
BPIFC BPI fold containing family C 3.34197
IL26 interleukin 26 3.34197
POU5F2 POU domain class 5, transcription factor 2 3.34197
MEPE matrix extracellular phosphoglycoprotein 3.34197
CCDC78 coiled-coil domain containing 78 3.34197
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 3.34197
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.34197
MMP10 matrix metallopeptidase 10 3.34197
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.34197
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.34197
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.34197
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 3.34197
TULP2 tubby like protein 2 3.34197
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 3.34197
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.34197
C1ORF105 chromosome 1 open reading frame 105 3.34197
POTEF POTE ankyrin domain family, member F 3.34197
INSL6 insulin-like 6 3.34197
NEGR1 neuronal growth regulator 1 3.26834
CKS1B CDC28 protein kinase regulatory subunit 1B 3.19454
PLPPR4 phospholipid phosphatase related 4 3.18298
SLA Src-like-adaptor 3.18298
COBLL1 cordon-bleu WH2 repeat protein-like 1 3.1221
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.90351
TUSC3 tumor suppressor candidate 3 2.89758
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.73938
RBM18 RNA binding motif protein 18 2.71709
RDH10 retinol dehydrogenase 10 (all-trans) 2.6332
ARHGAP17 Rho GTPase activating protein 17 2.54237
KIF19 kinesin family member 19 2.52594
NTN5 netrin 5 2.52594
RPS11 ribosomal protein S11 2.50657
ING1 inhibitor of growth family, member 1 2.49548
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.47593
ABHD2 abhydrolase domain containing 2 2.46218
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.45943
YIPF6 Yip1 domain family, member 6 2.43008
STAG1 stromal antigen 1 2.41276
CLRN1 clarin 1 2.40195
CCR10 chemokine (C-C motif) receptor 10 2.38856
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.38836
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.379
SHBG sex hormone-binding globulin 2.37838
PRELID1 PRELI domain containing 1 2.35619
NPIPB7 nuclear pore complex interacting protein family, member B7 2.3524
SYF2 SYF2 pre-mRNA-splicing factor 2.3524
MAEA macrophage erythroblast attacher 2.3467
CELF2 CUGBP, Elav-like family member 2 2.3467
BRPF3 bromodomain and PHD finger containing, 3 2.34629
CLASP2 cytoplasmic linker associated protein 2 2.34629
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 2.31648
ARHGAP1 Rho GTPase activating protein 1 2.31638
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2.2992
MYOCD myocardin 2.27327
CA1 carbonic anhydrase I 2.27168
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.27168
LIMK1 LIM domain kinase 1 2.25762
ABRAXAS2 abraxas 2, BRISC complex subunit 2.24432
FAM111B family with sequence similarity 111, member B 2.20168
HSPA8 heat shock 70kDa protein 8 2.20081
DNASE1L1 deoxyribonuclease I-like 1 2.19529
ZNF699 zinc finger protein 699 2.18425
NRBP1 nuclear receptor binding protein 1 2.17871
SNPH syntaphilin 2.17572
ADSS1 adenylosuccinate synthase 1 2.17572
RTP1 receptor (chemosensory) transporter protein 1 2.17572
FRMPD1 FERM and PDZ domain containing 1 2.17572
MSR1 macrophage scavenger receptor 1 2.17572
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.17572
PEX6 peroxisomal biogenesis factor 6 2.17076
CDCA7L cell division cycle associated 7-like 2.16229
ZNF713 zinc finger protein 713 2.16118
ZC3HAV1 zinc finger CCCH-type, antiviral 1 2.16118
HIRA histone cell cycle regulator 2.12997
XPO6 exportin 6 2.11494
WDR72 WD repeat domain 72 2.10962
CNIH1 cornichon family AMPA receptor auxiliary protein 1 2.10319
HHLA1 HERV-H LTR-associating 1 2.09896
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.09756
NAP1L2 nucleosome assembly protein 1-like 2 2.09078
ARL6 ADP-ribosylation factor-like 6 2.08719
LETMD1 LETM1 domain containing 1 2.08701
FADS1 fatty acid desaturase 1 2.07067
C5ORF24 chromosome 5 open reading frame 24 2.06826
PNPLA3 patatin-like phospholipase domain containing 3 2.06072
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.03747
LIAS lipoic acid synthetase 2.03719
STRAP serine/threonine kinase receptor associated protein 2.03719
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.013
RPL35A ribosomal protein L35a 2.00429

decreased expression

Symbol Name Standardized Value
MYL7 myosin, light chain 7, regulatory -3.34197
ARHGAP30 Rho GTPase activating protein 30 -3.34197
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -3.34197
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -3.34197
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -3.34197
SSUH2 ssu-2 homolog (C. elegans) -3.34197
FER1L5 fer-1-like family member 5 -3.34197
ZNF583 zinc finger protein 583 -3.34197
TBX22 T-box 22 -3.34197
CPNE5 copine V -3.34197
SOX21 SRY (sex determining region Y)-box 21 -3.34197
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -3.34197
ACSF2 acyl-CoA synthetase family member 2 -3.34197
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -3.34197
NPSR1 neuropeptide S receptor 1 -3.34197
NPIPA5 nuclear pore complex interacting protein family, member A5 -3.34197
DCST1 DC-STAMP domain containing 1 -3.34197
KIAA0319 KIAA0319 -3.34197
DNAH6 dynein, axonemal, heavy chain 6 -3.34197
NKPD1 NTPase, KAP family P-loop domain containing 1 -3.34197
TRAF3IP3 TRAF3 interacting protein 3 -3.34197
AKR1C1 aldo-keto reductase family 1, member C1 -3.34197
LRRC39 leucine rich repeat containing 39 -3.34197
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -3.34197
NOS2 nitric oxide synthase 2, inducible -3.34197
PAQR6 progestin and adipoQ receptor family member VI -3.34197
EPHX4 epoxide hydrolase 4 -3.34197
FOSL1 FOS-like antigen 1 -3.34197
RHOBTB2 Rho-related BTB domain containing 2 -3.34197
ZCCHC18 zinc finger, CCHC domain containing 18 -3.34197
PCDHA11 protocadherin alpha 11 -3.34197
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -3.34197
TMEM190 transmembrane protein 190 -3.34197
PROC protein C (inactivator of coagulation factors Va and VIIIa) -3.34197
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -3.34197
BGN biglycan -3.34197
CES4A carboxylesterase 4A -3.34197
SPATA18 spermatogenesis associated 18 -3.34197
TEKTIP1 tektin bundle interacting protein 1 -3.34197
GLYATL1B glycine-N-acyltransferase like 1B -3.34197
ABI3 ABI family, member 3 -3.34197
PKD1L1 polycystic kidney disease 1 like 1 -3.34197
SEC14L4 SEC14-like 4 (S. cerevisiae) -3.34197
C1ORF167 chromosome 1 open reading frame 167 -3.34197
SIM2 single-minded family bHLH transcription factor 2 -3.34197
FAM222A family with sequence similarity 222, member A -3.34197
CXCR6 chemokine (C-X-C motif) receptor 6 -3.34197
JSRP1 junctional sarcoplasmic reticulum protein 1 -3.34197
CCDC92 coiled-coil domain containing 92 -3.34197
LEF1 lymphoid enhancer-binding factor 1 -3.34197
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -3.34197
REC114 REC114 meiotic recombination protein -3.34197
PRKG2 protein kinase, cGMP-dependent, type II -3.20681
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -3.20681
SLF1 SMC5-SMC6 complex localization factor 1 -3.01861
SPDYA speedy/RINGO cell cycle regulator family member A -3.01861
KLC3 kinesin light chain 3 -3.01861
RNASEH2A ribonuclease H2, subunit A -2.97053
ARL17A ADP-ribosylation factor-like 17A -2.96175
SERTAD2 SERTA domain containing 2 -2.79951
CUX1 cut-like homeobox 1 -2.75261
CTPS2 CTP synthase 2 -2.72188
INPP5J inositol polyphosphate-5-phosphatase J -2.70106
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.67747
REEP2 receptor accessory protein 2 -2.6332
ARFGEF3 ARFGEF family member 3 -2.6332
IL6ST-DT IL6ST divergent transcript -2.57029
ADGRG5 adhesion G protein-coupled receptor G5 -2.56951
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 -2.56143
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -2.54936
HSH2D hematopoietic SH2 domain containing -2.38811
H3C8 H3 clustered histone 8 -2.379
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.379
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -2.36434
GAREM2 GRB2 associated regulator of MAPK1 subtype 2 -2.3524
BBS9 Bardet-Biedl syndrome 9 -2.3326
CHRAC1 chromatin accessibility complex 1 -2.32328
RND1 Rho family GTPase 1 -2.29781
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -2.2977
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -2.28878
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.27597
IQSEC3 IQ motif and Sec7 domain 3 -2.27597
NUTM2E NUT family member 2E -2.27597
TOGARAM2 TOG array regulator of axonemal microtubules 2 -2.25762
FXYD1 FXYD domain containing ion transport regulator 1 -2.25762
AGK acylglycerol kinase -2.25711
CDV3 CDV3 homolog (mouse) -2.25034
C3ORF18 chromosome 3 open reading frame 18 -2.25034
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 -2.25034
CFAP70 cilia and flagella associated protein 70 -2.25034
TMC1 transmembrane channel-like 1 -2.2483
GTF2A1 general transcription factor IIA, 1, 19/37kDa -2.23282
TMEM123 transmembrane protein 123 -2.23282
HLA-DOA major histocompatibility complex, class II, DO alpha -2.23282
FDX2 ferredoxin 2 -2.22457
ITGB4 integrin, beta 4 -2.22457
NUTM1 NUT midline carcinoma, family member 1 -2.22457
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.22457
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.21902
GOSR1 golgi SNAP receptor complex member 1 -2.19503
DAP death-associated protein -2.17572
RIGI RNA sensor RIG-I -2.17572
TEDC2 tubulin epsilon and delta complex 2 -2.17572
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.17572
ERVH48-1 endogenous retrovirus group 48, member 1 -2.16776
HAGHL hydroxyacylglutathione hydrolase-like -2.16526
RGS10 regulator of G-protein signaling 10 -2.14946
CDH8 cadherin 8, type 2 -2.11494
TRIP6 thyroid hormone receptor interactor 6 -2.11494
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.11494
TEC tec protein tyrosine kinase -2.11494
MYB v-myb avian myeloblastosis viral oncogene homolog -2.11494
TMEM170B transmembrane protein 170B -2.09694
ZNF317 zinc finger protein 317 -2.07791
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.07446
MMP25 matrix metallopeptidase 25 -2.07446
IGFBP5 insulin-like growth factor binding protein 5 -2.06826
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 -2.06826
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -2.06826
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.05226
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit -2.04124
GLS2 glutaminase 2 (liver, mitochondrial) -2.03747
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.03747
MYBPC2 myosin binding protein C, fast type -2.03719
ARHGAP24 Rho GTPase activating protein 24 -2.03719
RASA3 RAS p21 protein activator 3 -2.03192
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -2.02453
MORC3 MORC family CW-type zinc finger 3 -2.02311
C1ORF94 chromosome 1 open reading frame 94 -2.01735
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -2.01176
CNKSR1 connector enhancer of kinase suppressor of Ras 1 -2.00429
CDK11B cyclin-dependent kinase 11B -2.00217