| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/46909588 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in MPI-0479605-HCL relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | 3.63 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 2.46 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.85 |
| TP53 | tumor protein p53 | 1.75 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 1.56 |
| PIP | prolactin-induced protein | 1.49 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 1.03 |
| ABHD4 | abhydrolase domain containing 4 | 1.02 |
| S100A2 | S100 calcium binding protein A2 | 0.89 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.88 |
| GDF15 | growth differentiation factor 15 | 0.86 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.81 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.8 |
| FAS | Fas cell surface death receptor | 0.79 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | 0.76 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.74 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.7 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 0.64 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.63 |
| SH2B2 | SH2B adaptor protein 2 | 0.63 |
| DAP | death-associated protein | 0.62 |
| ACY1 | aminoacylase 1 | 0.62 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.6 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.6 |
| ABHD2 | abhydrolase domain containing 2 | 0.59 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | 0.58 |
| GID8 | GID complex subunit 8 | 0.58 |
| CLGN | calmegin | 0.57 |
| CCND1 | cyclin D1 | 0.56 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.56 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.53 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.53 |
| ICOSLG | inducible T-cell co-stimulator ligand | 0.53 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.52 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | 0.51 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.51 |
| NUCB1 | nucleobindin 1 | 0.5 |
| ADIRF | adipogenesis regulatory factor | 0.5 |
| DENND5A | DENN/MADD domain containing 5A | 0.49 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.47 |
| FAM135A | family with sequence similarity 135, member A | 0.46 |
| MXRA7 | matrix-remodelling associated 7 | 0.46 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.46 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 0.46 |
| IRF2 | interferon regulatory factor 2 | 0.46 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 0.45 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.45 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.44 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.44 |
| HINT3 | histidine triad nucleotide binding protein 3 | 0.44 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.43 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | 0.43 |
| CDK10 | cyclin-dependent kinase 10 | 0.43 |
| CDK18 | cyclin-dependent kinase 18 | 0.43 |
| MYCBP | MYC binding protein | 0.43 |
| NUCB2 | nucleobindin 2 | 0.43 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | 0.42 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.41 |
| WASHC3 | WASH complex subunit 3 | 0.41 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.41 |
| FDXR | ferredoxin reductase | 0.41 |
| BANF1 | barrier to autointegration factor 1 | 0.41 |
| SYTL1 | synaptotagmin-like 1 | 0.41 |
| AREG | amphiregulin | 0.41 |
| PCDH1 | protocadherin 1 | 0.41 |
| DESI2 | desumoylating isopeptidase 2 | 0.4 |
| FSTL1 | follistatin-like 1 | 0.4 |
| ARG2 | arginase 2 | 0.4 |
| PSAP | prosaposin | 0.4 |
| RNASET2 | ribonuclease T2 | 0.4 |
| ZNF776 | zinc finger protein 776 | 0.4 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.4 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.4 |
| PUS10 | pseudouridylate synthase 10 | 0.39 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.39 |
| COQ8A | coenzyme Q8A | 0.39 |
| PFDN1 | prefoldin subunit 1 | 0.39 |
| PFDN5 | prefoldin subunit 5 | 0.39 |
| SCAP | SREBF chaperone | 0.39 |
| EVPL | envoplakin | 0.39 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.39 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.38 |
| GLDC | glycine dehydrogenase (decarboxylating) | 0.38 |
| ZNF888 | zinc finger protein 888 | 0.37 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.37 |
| GM2A | GM2 ganglioside activator | 0.37 |
| TMOD2 | tropomodulin 2 (neuronal) | 0.37 |
| TANK | TRAF family member-associated NFKB activator | 0.37 |
| MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) | 0.37 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.37 |
| PLAU | plasminogen activator, urokinase | 0.37 |
| CCN2 | cellular communication network factor 2 | 0.36 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.36 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | 0.36 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.36 |
| RBMXL2 | RNA binding motif protein, X-linked-like 2 | 0.36 |
| C12ORF73 | chromosome 12 open reading frame 73 | 0.36 |
| MED31 | mediator complex subunit 31 | 0.36 |
| BMERB1 | bMERB domain containing 1 | 0.36 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OSBPL7 | oxysterol binding protein-like 7 | -4.64 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.64 |
| COL17A1 | collagen, type XVII, alpha 1 | -1.14 |
| SPRTN | SprT-like N-terminal domain | -1.02 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.95 |
| VIM | vimentin | -0.88 |
| KLHL18 | kelch-like family member 18 | -0.64 |
| METTL22 | methyltransferase like 22 | -0.63 |
| TSNARE1 | t-SNARE domain containing 1 | -0.63 |
| UBE3D | ubiquitin protein ligase E3D | -0.62 |
| E2F2 | E2F transcription factor 2 | -0.61 |
| CCDC14 | coiled-coil domain containing 14 | -0.6 |
| EFCAB14 | EF-hand calcium binding domain 14 | -0.59 |
| IQCB1 | IQ motif containing B1 | -0.54 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.53 |
| WSB2 | WD repeat and SOCS box containing 2 | -0.52 |
| CPD | carboxypeptidase D | -0.52 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | -0.51 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -0.51 |
| TMPO | thymopoietin | -0.5 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.5 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.49 |
| KIAA1324L | KIAA1324-like | -0.48 |
| MRPL35 | mitochondrial ribosomal protein L35 | -0.46 |
| ZBTB39 | zinc finger and BTB domain containing 39 | -0.45 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.45 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -0.45 |
| GAS6 | growth arrest-specific 6 | -0.44 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.44 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.43 |
| SEPTIN5 | septin 5 | -0.43 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -0.43 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.42 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | -0.41 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.41 |
| ZNF827 | zinc finger protein 827 | -0.41 |
| GINM1 | glycoprotein integral membrane 1 | -0.4 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | -0.4 |
| PRDM4 | PR domain containing 4 | -0.4 |
| PML | promyelocytic leukemia | -0.4 |
| PRG4 | proteoglycan 4 | -0.4 |
| DMD | dystrophin | -0.4 |
| CCNB2 | cyclin B2 | -0.39 |
| NAGS | N-acetylglutamate synthase | -0.39 |
| ZNF749 | zinc finger protein 749 | -0.39 |
| ZNF746 | zinc finger protein 746 | -0.39 |
| PTTG1 | pituitary tumor-transforming 1 | -0.39 |
| CDC6 | cell division cycle 6 | -0.38 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.38 |
| MZT2A | mitotic spindle organizing protein 2A | -0.38 |
| DIRAS1 | DIRAS family, GTP-binding RAS-like 1 | -0.38 |
| SAPCD2 | suppressor APC domain containing 2 | -0.38 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.38 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | -0.37 |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | -0.37 |
| GABPB2 | GA binding protein transcription factor, beta subunit 2 | -0.37 |
| CERK | ceramide kinase | -0.37 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | -0.36 |
| FBXO42 | F-box protein 42 | -0.36 |
| ZNF28 | zinc finger protein 28 | -0.36 |
| CDCA7 | cell division cycle associated 7 | -0.36 |
| ATAD5 | ATPase family, AAA domain containing 5 | -0.36 |
| PLK1 | polo-like kinase 1 | -0.36 |
| SKA2 | spindle and kinetochore associated complex subunit 2 | -0.36 |
| ANKRD44 | ankyrin repeat domain 44 | -0.36 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | -0.35 |
| PCLAF | PCNA clamp associated factor | -0.35 |
| CDC37 | cell division cycle 37 | -0.35 |
| TSPAN31 | tetraspanin 31 | -0.35 |
| AURKB | aurora kinase B | -0.35 |
| CDC25C | cell division cycle 25C | -0.34 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.34 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.34 |
| C1ORF112 | chromosome 1 open reading frame 112 | -0.34 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.34 |
| ATMIN | ATM interactor | -0.34 |
| SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | -0.33 |
| DOP1A | DOP1 leucine zipper like protein A | -0.33 |
| TRIM38 | tripartite motif containing 38 | -0.33 |
| LRRC45 | leucine rich repeat containing 45 | -0.33 |
| TYRO3 | TYRO3 protein tyrosine kinase | -0.33 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | -0.33 |
| CIC | capicua transcriptional repressor | -0.32 |
| TMEM161B | transmembrane protein 161B | -0.32 |
| CDC25B | cell division cycle 25B | -0.32 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.32 |
| RADX | RPA1 related single stranded DNA binding protein, X-linked | -0.32 |
| RPL37 | ribosomal protein L37 | -0.32 |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit | -0.32 |
| AXL | AXL receptor tyrosine kinase | -0.32 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.32 |
| SLC38A5 | solute carrier family 38, member 5 | -0.32 |
| DEPDC1 | DEP domain containing 1 | -0.31 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -0.31 |
| KIF20B | kinesin family member 20B | -0.31 |
| HMBOX1 | homeobox containing 1 | -0.31 |
| TTK | TTK protein kinase | -0.31 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.31 |
| BRCA1 | breast cancer 1, early onset | -0.3 |
