MPI Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mannose phosphate isomerase|Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 4351)
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Genes

359 genes differentially expressed following the MPI gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ATP13A4 ATPase type 13A4 3.32755
ZNF503 zinc finger protein 503 3.32755
VWA5B2 von Willebrand factor A domain containing 5B2 3.32755
NPPB natriuretic peptide B 3.32755
CD209 CD209 molecule 3.32755
DNASE1L2 deoxyribonuclease I-like 2 3.32755
TMEM244 transmembrane protein 244 3.32755
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 3.32755
PCDHGB3 protocadherin gamma subfamily B, 3 3.32755
RRAD Ras-related associated with diabetes 3.32755
AFM afamin 3.32755
SGPP2 sphingosine-1-phosphate phosphatase 2 3.32755
CLEC12A C-type lectin domain family 12, member A 3.32755
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.32755
ISM2 isthmin 2 3.32755
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.32755
TBX22 T-box 22 3.32755
HNF4A hepatocyte nuclear factor 4, alpha 3.32755
GPR4 G protein-coupled receptor 4 3.32755
COL19A1 collagen, type XIX, alpha 1 3.32755
TMPRSS11F transmembrane protease, serine 11F 3.32755
RNF17 ring finger protein 17 3.32755
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.32755
AGTR1 angiotensin II receptor, type 1 3.32755
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 3.32755
CCL5 chemokine (C-C motif) ligand 5 3.32755
CCDC146 coiled-coil domain containing 146 3.32755
GUCY2F guanylate cyclase 2F, retinal 3.32755
RPL3L ribosomal protein L3-like 3.32755
TDRD9 tudor domain containing 9 3.32755
TNS4 tensin 4 3.32755
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.32755
S100A1 S100 calcium binding protein A1 3.32755
LRRC61 leucine rich repeat containing 61 3.32755
MRC1 mannose receptor, C type 1 3.32755
AIRE autoimmune regulator 3.32755
CPLX1 complexin 1 3.32755
GRP gastrin-releasing peptide 3.32755
ADAMTSL5 ADAMTS-like 5 3.32755
RAPSN receptor-associated protein of the synapse 3.32755
DSG3 desmoglein 3 3.32755
PDE7B phosphodiesterase 7B 3.32755
PTH2 parathyroid hormone 2 3.32755
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.32755
ESX1 ESX homeobox 1 3.32755
SIGLEC5 sialic acid binding Ig-like lectin 5 3.32755
ASB12 ankyrin repeat and SOCS box containing 12 3.32755
ASB10 ankyrin repeat and SOCS box containing 10 3.32755
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.32755
TCAF2 TRPM8 channel-associated factor 2 3.32755
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.32755
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 3.32755
ACOT1 acyl-CoA thioesterase 1 3.32755
OR56B2 olfactory receptor family 56 subfamily B member 2 3.32755
SPI1 Spi-1 proto-oncogene 3.32755
PLN phospholamban 3.32755
RD3 retinal degeneration 3 3.32755
KRT80 keratin 80, type II 3.32755
SPRR2E small proline-rich protein 2E 3.32755
TBC1D3B TBC1 domain family, member 3B 3.32755
MUSTN1 musculoskeletal, embryonic nuclear protein 1 3.32755
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.32755
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.32755
SMPX small muscle protein, X-linked 3.32755
BDKRB1 bradykinin receptor B1 3.32755
CD300LF CD300 molecule-like family member f 3.32755
ZNF726 zinc finger protein 726 3.32755
CIMAP1B ciliary microtubule associated protein 1B 3.32755
H4C15 H4 clustered histone 15 3.32755
POU2AF2 POU class 2 homeobox associating factor 2 3.32755
LHFPL7 LHFPL tetraspan subfamily member 7 3.32755
GSTT4 glutathione S-transferase theta 4 3.32755
ELOA2 elongin A2 3.32755
DIPK2B divergent protein kinase domain 2B 3.32755
CFAP119 cilia and flagella associated protein 119 3.32755
ASDURF ASNSD1 upstream open reading frame 3.32755
STING1 stimulator of interferon response cGAMP interactor 1 3.32755
GBP4 guanylate binding protein 4 3.32755
F5 coagulation factor V (proaccelerin, labile factor) 3.32755
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.32755
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 3.32755
MYH13 myosin, heavy chain 13, skeletal muscle 3.32755
TLR6 toll-like receptor 6 3.32755
OR1R1 olfactory receptor family 1 subfamily R member 1 3.32755
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.32755
ANXA10 annexin A10 3.32755
OR7C1 olfactory receptor, family 7, subfamily C, member 1 3.32755
NXPE4 neurexophilin and PC-esterase domain family, member 4 3.32755
TEX101 testis expressed 101 3.32755
CLDN9 claudin 9 3.32755
C5ORF58 chromosome 5 open reading frame 58 3.32755
TBX3 T-box 3 3.32755
INSRR insulin receptor-related receptor 3.32755
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.32755
GATA3 GATA binding protein 3 3.32755
CSAG2 CSAG family, member 2 3.32755
CCDC42 coiled-coil domain containing 42 3.32755
BEST3 bestrophin 3 3.32755
RGS21 regulator of G-protein signaling 21 3.32755
NR0B2 nuclear receptor subfamily 0, group B, member 2 3.32755
CLDN22 claudin 22 3.32755
CDKN2A cyclin-dependent kinase inhibitor 2A 3.32755
GJD2 gap junction protein, delta 2, 36kDa 3.32755
GJD4 gap junction protein, delta 4, 40.1kDa 3.32755
OASL 2'-5'-oligoadenylate synthetase-like 3.32755
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.32755
CSTA cystatin A (stefin A) 3.32755
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.32755
AQP7 aquaporin 7 3.32755
S100Z S100 calcium binding protein Z 3.32755
NOX1 NADPH oxidase 1 3.32755
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 3.32755
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.32755
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.32755
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.32755
DRD2 dopamine receptor D2 3.32755
C2CD4A C2 calcium-dependent domain containing 4A 3.32755
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.32755
PALMD palmdelphin 3.32755
PRSS57 protease, serine, 57 3.32755
TCF21 transcription factor 21 3.32755
HSF4 heat shock transcription factor 4 3.32755
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 3.32755
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 3.32755
SLC25A52 solute carrier family 25, member 52 3.32755
APOH apolipoprotein H (beta-2-glycoprotein I) 3.32755
PRF1 perforin 1 (pore forming protein) 3.32755
PCDHGB5 protocadherin gamma subfamily B, 5 3.32755
A3GALT2 alpha 1,3-galactosyltransferase 2 3.32755
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.32755
C17ORF99 chromosome 17 open reading frame 99 3.32755
VWA7 von Willebrand factor A domain containing 7 3.32755
TRIM7 tripartite motif containing 7 3.32755
LRRC25 leucine rich repeat containing 25 3.32755
GSC2 goosecoid homeobox 2 3.32755
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.32755
IGIP IgA-inducing protein 3.32755
PLA2G2C phospholipase A2, group IIC 3.32755
ESPNL espin-like 3.32755
CNR2 cannabinoid receptor 2 (macrophage) 3.32755
DRC1 dynein regulatory complex subunit 1 3.32755
GSDMA gasdermin A 3.32755
CFB complement factor B 3.32755
IDI2 isopentenyl-diphosphate delta isomerase 2 3.32755
HSPD1 heat shock 60kDa protein 1 (chaperonin) 3.32755
THBD thrombomodulin 3.32755
C8ORF89 chromosome 8 open reading frame 89 3.32755
EGR4 early growth response 4 3.32755
TEX12 testis expressed 12 3.32755
ASTL astacin-like metallo-endopeptidase (M12 family) 3.32755
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.32755
FGR FGR proto-oncogene, Src family tyrosine kinase 3.32755
SYNGR4 synaptogyrin 4 3.32755
NT5C1B 5'-nucleotidase, cytosolic IB 3.32755
ZIM2 zinc finger, imprinted 2 3.32755
CTSF cathepsin F 3.32755
ITGA8 integrin, alpha 8 3.32755
MC5R melanocortin 5 receptor 3.32755
LAMP3 lysosomal-associated membrane protein 3 3.32755
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.32755
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.32755
FXYD4 FXYD domain containing ion transport regulator 4 3.32755
MSLN mesothelin 3.32755
R3HDML R3H domain containing-like 3.32755
PITX1 paired-like homeodomain 1 3.32755
TMPRSS13 transmembrane protease, serine 13 3.32755
ANKRD30A ankyrin repeat domain 30A 3.32755
NPC1L1 NPC1-like 1 3.32755
IRX1 iroquois homeobox 1 3.32755
TAS2R43 taste receptor, type 2, member 43 3.32755
NEUROD4 neuronal differentiation 4 3.32755
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.32755
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.32755
DUOXA1 dual oxidase maturation factor 1 3.32755
HRG histidine-rich glycoprotein 3.32755
GREM1 gremlin 1, DAN family BMP antagonist 3.32755
AMER3 APC membrane recruitment protein 3 3.32755
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 3.32755
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.32755
LRRC74A leucine rich repeat containing 74A 3.32755
APOL6 apolipoprotein L, 6 3.32755
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.32755
CCDC83 coiled-coil domain containing 83 3.32755
TLDC2 TBC/LysM-associated domain containing 2 3.32755
H4C6 H4 clustered histone 6 3.29716
ACTA1 actin, alpha 1, skeletal muscle 3.1859
ZMYM4 zinc finger, MYM-type 4 3.15204
PDLIM7 PDZ and LIM domain 7 (enigma) 3.00258
ZNF609 zinc finger protein 609 2.93915
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.90271
STAB2 stabilin 2 2.79528
BBS5 Bardet-Biedl syndrome 5 2.79528
MUC4 mucin 4, cell surface associated 2.71554
TMEM63B transmembrane protein 63B 2.6988
TCEAL4 transcription elongation factor A (SII)-like 4 2.66442
MCM3AP minichromosome maintenance complex component 3 associated protein 2.63151
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 2.6244
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.59769
MROH6 maestro heat-like repeat family member 6 2.59769
MRPL36 mitochondrial ribosomal protein L36 2.59076
SEPTIN11 septin 11 2.57664
CDK2 cyclin-dependent kinase 2 2.55541
LGALSL lectin, galactoside-binding-like 2.53893
BTLA B and T lymphocyte associated 2.47338
IZUMO4 IZUMO family member 4 2.47338
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.46113
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.44264
IRX2 iroquois homeobox 2 2.43392
C17ORF113 chromosome 17 open reading frame 113 2.3896
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 2.33176
SCN10A sodium channel, voltage gated, type X alpha subunit 2.33005
SHROOM3 shroom family member 3 2.31762
KLHL29 kelch-like family member 29 2.31116
LHFPL4 lipoma HMGIC fusion partner-like 4 2.29058
LOX lysyl oxidase 2.27077
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.27077
UFM1 ubiquitin-fold modifier 1 2.27077
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.27077
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 2.25661
PLA2G15 phospholipase A2, group XV 2.23115
RIPOR2 RHO family interacting cell polarization regulator 2 2.21938
JADE1 jade family PHD finger 1 2.20768
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 2.20343
CIAPIN1 cytokine induced apoptosis inhibitor 1 2.20062
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 2.20062
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 2.18448
PRPF38B pre-mRNA processing factor 38B 2.17526
PSAP prosaposin 2.16073
TPMT thiopurine S-methyltransferase 2.15621
RSAD1 radical S-adenosyl methionine domain containing 1 2.15587
ZFAND2A zinc finger, AN1-type domain 2A 2.15245
ZNF30 zinc finger protein 30 2.13836
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 2.13581
TNS2 tensin 2 2.11808
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.11233
STRADB STE20-related kinase adaptor beta 2.11072
LRRC8C leucine rich repeat containing 8 family, member C 2.11069
MYO9B myosin IXB 2.08008
GPS1 G protein pathway suppressor 1 2.0794
PPP1R16A protein phosphatase 1, regulatory subunit 16A 2.0755
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 2.06058
RTL6 retrotransposon Gag like 6 2.0578
PLAAT3 phospholipase A and acyltransferase 3 2.05361
PDPK1 3-phosphoinositide dependent protein kinase 1 2.04685
PDE4D phosphodiesterase 4D, cAMP-specific 2.04567
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.0214
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 2.01772
ATF6B activating transcription factor 6 beta 2.01211
ARF3 ADP-ribosylation factor 3 2.01202
KIFBP kinesin family binding protein 2.0093
TRIM65 tripartite motif containing 65 2.00119
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.00119
ZNF35 zinc finger protein 35 2.00119

decreased expression

Symbol Name Standardized Value
HBA2 hemoglobin, alpha 2 -3.32755
FAM81B family with sequence similarity 81, member B -3.32755
GRM2 glutamate receptor, metabotropic 2 -3.32755
TMEM88 transmembrane protein 88 -3.32755
YPEL4 yippee-like 4 (Drosophila) -3.32755
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -3.32755
HLA-C major histocompatibility complex, class I, C -3.32755
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -3.32755
CARD6 caspase recruitment domain family, member 6 -3.32755
CPZ carboxypeptidase Z -3.32755
SHOX2 short stature homeobox 2 -3.32755
ERICH6 glutamate-rich 6 -3.32755
DUSP8 dual specificity phosphatase 8 -3.32755
STMN4 stathmin-like 4 -3.32755
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -3.32755
LRRD1 leucine-rich repeats and death domain containing 1 -3.32755
CHADL chondroadherin-like -3.32755
BSND barttin CLCNK-type chloride channel accessory beta subunit -3.32755
PLIN1 perilipin 1 -3.32755
ZC3H11C zinc finger CCCH-type containing 11C -3.32755
TSGA13 testis specific, 13 -3.32755
S100G S100 calcium binding protein G -3.32755
IMPG1 interphotoreceptor matrix proteoglycan 1 -3.32755
TMPRSS6 transmembrane protease, serine 6 -3.32755
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -3.32755
TTLL10 tubulin tyrosine ligase-like family member 10 -3.32755
SYT5 synaptotagmin V -3.32755
SLC31A2 solute carrier family 31 (copper transporter), member 2 -3.32755
AMH anti-Mullerian hormone -3.32755
RBM24 RNA binding motif protein 24 -3.32755
ADGRD1 adhesion G protein-coupled receptor D1 -3.32755
CLEC4A C-type lectin domain family 4, member A -3.32755
C1ORF105 chromosome 1 open reading frame 105 -3.32755
HLA-G major histocompatibility complex, class I, G -3.32755
ADAM12 ADAM metallopeptidase domain 12 -3.32755
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -3.32755
MLIP muscular LMNA-interacting protein -3.32755
ALOX12B arachidonate 12-lipoxygenase, 12R type -3.32755
BTNL8 butyrophilin-like 8 -3.32755
CXCR2 chemokine (C-X-C motif) receptor 2 -3.32755
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -3.32755
BTNL2 butyrophilin-like 2 -3.32755
RAB40A RAB40A, member RAS oncogene family -3.22148
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.99815
SARAF store-operated calcium entry-associated regulatory factor -2.99434
WDR73 WD repeat domain 73 -2.85215
RNF122 ring finger protein 122 -2.72336
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -2.7157
PIGS phosphatidylinositol glycan anchor biosynthesis, class S -2.62995
CFAP90 cilia and flagella associated protein 90 -2.59322
MYO1D myosin ID -2.47338
KIF2A kinesin heavy chain member 2A -2.42411
CERS3 ceramide synthase 3 -2.41467
UBA6 ubiquitin-like modifier activating enzyme 6 -2.41116
MTUS1 microtubule associated tumor suppressor 1 -2.39835
DEUP1 deuterosome assembly protein 1 -2.36014
FAM186A family with sequence similarity 186, member A -2.35713
PCDHB16 protocadherin beta 16 -2.33726
L3MBTL2 l(3)mbt-like 2 (Drosophila) -2.31762
C1ORF210 chromosome 1 open reading frame 210 -2.27671
NUP62CL nucleoporin 62kDa C-terminal like -2.27077
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.2278
FHL3 four and a half LIM domains 3 -2.216
SLC16A6 solute carrier family 16, member 6 -2.20768
CRHR1 corticotropin releasing hormone receptor 1 -2.20768
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -2.20768
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.20768
FXYD3 FXYD domain containing ion transport regulator 3 -2.20768
MYO16 myosin XVI -2.20768
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.20768
AGA-DT AGA divergent transcript -2.20768
GPR82 G protein-coupled receptor 82 -2.20768
SHLD1 shieldin complex subunit 1 -2.20713
H2BC4 H2B clustered histone 4 -2.1898
GK5 glycerol kinase 5 (putative) -2.18904
ELMO2 engulfment and cell motility 2 -2.18904
GLIS3 GLIS family zinc finger 3 -2.18585
PZP pregnancy-zone protein -2.18039
ZNF404 zinc finger protein 404 -2.16073
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -2.16073
REN renin -2.16073
NTNG2 netrin G2 -2.15621
BCL6B B-cell CLL/lymphoma 6, member B -2.1559
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.15587
TMEM123 transmembrane protein 123 -2.1535
TMEM74 transmembrane protein 74 -2.1514
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -2.13607
CIAO2A cytosolic iron-sulfur assembly component 2A -2.13402
RTL8C retrotransposon Gag like 8C -2.13273
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.12597
SANBR SANT and BTB domain regulator of CSR -2.1131
MMP26 matrix metallopeptidase 26 -2.11185
STRIP2 striatin interacting protein 2 -2.10866
DPP8 dipeptidyl-peptidase 8 -2.07514
PRMT5 protein arginine methyltransferase 5 -2.06058
CAPN5 calpain 5 -2.04716
NR4A1 nuclear receptor subfamily 4, group A, member 1 -2.04716
CDC16 cell division cycle 16 -2.04716
FOXL2NB FOXL2 neighbor -2.04716
TRAK2 trafficking protein, kinesin binding 2 -2.04063
ELL elongation factor RNA polymerase II -2.04063
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.04063
LRRC59 leucine rich repeat containing 59 -2.03304
NTF4 neurotrophin 4 -2.03115
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 -2.00589
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.00521