MRAS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description muscle RAS oncogene homolog|This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (NCBI Entrez Gene Database, 22808)
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Genes

346 genes differentially expressed following the MRAS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 3.37619
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 3.37619
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.37619
TM4SF20 transmembrane 4 L six family member 20 3.37619
SMIM35 small integral membrane protein 35 3.37619
NTSR2 neurotensin receptor 2 3.37619
ITPRID1 ITPR interacting domain containing 1 3.37619
PRDM16 PR domain containing 16 3.37619
DAO D-amino-acid oxidase 3.37619
TMEM204 transmembrane protein 204 3.37619
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 3.37619
PCDHGB2 protocadherin gamma subfamily B, 2 3.37619
IFI6 interferon, alpha-inducible protein 6 3.37619
CDHR5 cadherin-related family member 5 3.37619
RHAG Rh-associated glycoprotein 3.37619
AHSG alpha-2-HS-glycoprotein 3.37619
HNF4A hepatocyte nuclear factor 4, alpha 3.37619
RBP4 retinol binding protein 4, plasma 3.37619
TSPAN1 tetraspanin 1 3.37619
CARD18 caspase recruitment domain family, member 18 3.37619
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.37619
STRIT1 small transmembrane regulator of ion transport 1 3.37619
LAMP3 lysosomal-associated membrane protein 3 3.37619
GREM1 gremlin 1, DAN family BMP antagonist 3.34314
ANGPTL7 angiopoietin-like 7 3.34314
AVP arginine vasopressin 3.34314
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 3.34314
ATOH1 atonal homolog 1 (Drosophila) 3.34314
C8ORF74 chromosome 8 open reading frame 74 3.34314
EMCN endomucin 3.34314
NPIPA3 nuclear pore complex interacting protein family, member A3 3.34314
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.34314
IL2RB interleukin 2 receptor, beta 3.34314
ZG16 zymogen granule protein 16 3.34314
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.34314
ROPN1B rhophilin associated tail protein 1B 3.34314
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 3.34314
SCRT2 scratch family zinc finger 2 3.34314
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.34314
OIT3 oncoprotein induced transcript 3 3.34314
OR4E2 olfactory receptor, family 4, subfamily E, member 2 3.34314
GYS2 glycogen synthase 2 (liver) 3.34314
REM2 RAS (RAD and GEM)-like GTP binding 2 3.34314
AVPR1B arginine vasopressin receptor 1B 3.34314
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.34314
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.34314
LEP leptin 3.34314
PTK6 protein tyrosine kinase 6 3.34314
SPEM1 spermatid maturation 1 3.34314
CCR6 chemokine (C-C motif) receptor 6 3.34314
PARVG parvin, gamma 3.34314
CD163 CD163 molecule 3.34314
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.34314
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.34314
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.34314
IGFL3 IGF-like family member 3 3.34314
PRB4 proline-rich protein BstNI subfamily 4 3.34314
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 3.34314
NAPSA napsin A aspartic peptidase 3.34314
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 3.34314
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.34314
TMPRSS11F transmembrane protease, serine 11F 3.34314
OR5H2 olfactory receptor, family 5, subfamily H, member 2 3.34314
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.34314
CD300E CD300e molecule 3.34314
PEAR1 platelet endothelial aggregation receptor 1 3.34314
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.34314
RGPD3 RANBP2-like and GRIP domain containing 3 3.34314
SPRR2F small proline-rich protein 2F 3.34314
C2ORF80 chromosome 2 open reading frame 80 3.34314
TDRD9 tudor domain containing 9 3.34314
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.34314
OXTR oxytocin receptor 3.34314
FIMP1 fertilization-influencing membrane protein 1 3.34314
POSTN periostin, osteoblast specific factor 3.34314
ADAD2 adenosine deaminase domain containing 2 3.34314
GPR26 G protein-coupled receptor 26 3.34314
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 3.34314
TMPRSS5 transmembrane protease, serine 5 3.34314
SKOR2 SKI family transcriptional corepressor 2 3.34314
VSTM2L V-set and transmembrane domain containing 2 like 3.34314
UMOD uromodulin 3.34314
CLEC19A C-type lectin domain family 19, member A 3.34314
ZNF436 zinc finger protein 436 3.34314
MPL MPL proto-oncogene, thrombopoietin receptor 3.34314
TEKTL1 tektin like 1 3.34314
LRRC72 leucine rich repeat containing 72 3.34314
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.34314
PDZRN4 PDZ domain containing ring finger 4 3.34314
SLC22A24 solute carrier family 22, member 24 3.34314
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.34314
TUBA4B tubulin, alpha 4b 3.34314
S100G S100 calcium binding protein G 3.34314
GJD2 gap junction protein, delta 2, 36kDa 3.34314
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.34314
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.34314
ADAM2 ADAM metallopeptidase domain 2 3.34314
WFDC9 WAP four-disulfide core domain 9 3.34314
WFDC6 WAP four-disulfide core domain 6 3.34314
PRM2 protamine 2 3.34314
BPIFB1 BPI fold containing family B, member 1 3.34314
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.34314
SPATA9 spermatogenesis associated 9 3.34314
C17ORF113 chromosome 17 open reading frame 113 3.34314
MZB1 marginal zone B and B1 cell-specific protein 3.34314
BHLHA15 basic helix-loop-helix family, member a15 3.34314
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.34314
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 3.34314
TEX29 testis expressed 29 3.34314
DLK2 delta-like 2 homolog (Drosophila) 3.34314
GBX1 gastrulation brain homeobox 1 3.34314
TM4SF19 transmembrane 4 L six family member 19 3.34314
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.34314
GPR149 G protein-coupled receptor 149 3.34314
FAIM2 Fas apoptotic inhibitory molecule 2 3.34314
TEX53 testis expressed 53 3.34314
CA5A carbonic anhydrase VA, mitochondrial 3.34314
DEFA5 defensin, alpha 5, Paneth cell-specific 3.34314
PROK1 prokineticin 1 3.34314
FGF7 fibroblast growth factor 7 3.34314
BARHL1 BarH-like homeobox 1 3.34314
TGM6 transglutaminase 6 3.34314
HSPB6 heat shock protein, alpha-crystallin-related, B6 3.34314
PLGLB2 plasminogen-like B2 3.34314
NUTM2F NUT family member 2F 3.34314
NUTM2D NUT family member 2D 3.34314
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.34314
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.34314
RERGL RERG/RAS-like 3.34314
ERVW-1 endogenous retrovirus group W, member 1 3.34314
PRAP1 proline-rich acidic protein 1 3.34314
CLCNKA chloride channel, voltage-sensitive Ka 3.34314
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.34314
TEX38 testis expressed 38 3.34314
TEX36 testis expressed 36 3.34314
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 3.34314
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.34314
TFAP2D transcription factor AP-2 delta (activating enhancer binding protein 2 delta) 3.34314
DES desmin 3.34314
ZNF132 zinc finger protein 132 3.34314
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 3.34314
LCNL1 lipocalin-like 1 3.34314
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.34314
CFAP206 cilia and flagella associated protein 206 3.34314
GARIN1A golgi associated RAB2 interactor 1A 3.34314
GSG1L2 GSG1 like 2 3.34314
TEX46 testis expressed 46 3.34314
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 3.25695
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 3.25552
GOLGA8H golgin A8 family, member H 3.20163
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.20163
COL10A1 collagen, type X, alpha 1 3.14919
DARS1 aspartyl-tRNA synthetase 1 3.08896
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 3.02786
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.98778
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 2.96134
INO80B INO80 complex subunit B 2.96059
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.81917
PRKD2 protein kinase D2 2.7265
ZNF260 zinc finger protein 260 2.7174
GANAB glucosidase, alpha; neutral AB 2.65473
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 2.65306
ATP10B ATPase, class V, type 10B 2.60947
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 2.58904
DPH5 diphthamide biosynthesis 5 2.55324
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 2.54509
PPL periplakin 2.52485
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.51394
PRPF39 pre-mRNA processing factor 39 2.49805
YIPF1 Yip1 domain family, member 1 2.49805
SERHL2 serine hydrolase-like 2 2.46046
COL4A1 collagen, type IV, alpha 1 2.45857
ZNF582 zinc finger protein 582 2.42032
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.42032
HCK HCK proto-oncogene, Src family tyrosine kinase 2.42032
CD52 CD52 molecule 2.42032
ZC3H12A zinc finger CCCH-type containing 12A 2.42032
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.41084
CDK11A cyclin-dependent kinase 11A 2.39655
AGO2 argonaute RISC catalytic component 2 2.39467
IQGAP2 IQ motif containing GTPase activating protein 2 2.39467
DAPK3 death-associated protein kinase 3 2.38653
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.37196
TGFB3 transforming growth factor, beta 3 2.37196
GFRA3 GDNF family receptor alpha 3 2.37196
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.37196
PATL2 protein associated with topoisomerase II homolog 2 (yeast) 2.37196
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 2.3601
EIF3E eukaryotic translation initiation factor 3, subunit E 2.35579
MYO5A myosin VA (heavy chain 12, myoxin) 2.35018
RASGEF1B RasGEF domain family, member 1B 2.34127
ACKR4 atypical chemokine receptor 4 2.34028
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.28788
ZNF525 zinc finger protein 525 2.27595
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.27225
CPEB3 cytoplasmic polyadenylation element binding protein 3 2.27225
MAN1A1 mannosidase, alpha, class 1A, member 1 2.27225
CEP57 centrosomal protein 57kDa 2.26641
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.26145
GAL3ST3 galactose-3-O-sulfotransferase 3 2.22464
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.19445
PDCD11 programmed cell death 11 2.125
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.1078
CA14 carbonic anhydrase XIV 2.09815
SYNDIG1 synapse differentiation inducing 1 2.09815
YTHDC1 YTH domain containing 1 2.08202
IGSF1 immunoglobulin superfamily, member 1 2.05927
DACH2 dachshund family transcription factor 2 2.05497
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.04603
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2.03198
CAPZB capping protein (actin filament) muscle Z-line, beta 2.03048
FANCB Fanconi anemia, complementation group B 2.02136
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.02136
ANGEL2 angel homolog 2 (Drosophila) 2.01965
ZNF112 zinc finger protein 112 2.01965
REPS1 RALBP1 associated Eps domain containing 1 2.01965
WIPF3 WAS/WASL interacting protein family, member 3 2.01965
FBXO38 F-box protein 38 2.0141
ELOVL7 ELOVL fatty acid elongase 7 2.0141
CCDC43 coiled-coil domain containing 43 2.0141
MED23 mediator complex subunit 23 2.00606
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 2.00606

decreased expression

Symbol Name Standardized Value
NCAPD2 non-SMC condensin I complex, subunit D2 -3.34314
FAS Fas cell surface death receptor -3.34314
DKKL1 dickkopf-like 1 -3.34314
ZXDB zinc finger, X-linked, duplicated B -3.34314
SMIM29 small integral membrane protein 29 -3.28431
CHAF1B chromatin assembly factor 1, subunit B (p60) -3.25695
LIPT2-AS1 LIPT2 antisense RNA 1 -3.20163
ADRA1D adrenoceptor alpha 1D -3.20163
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.20163
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -3.20163
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -3.20163
TMEM236 transmembrane protein 236 -3.20163
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -3.20163
NHLRC4 NHL repeat containing 4 -3.20163
NKPD1 NTPase, KAP family P-loop domain containing 1 -3.20163
COL19A1 collagen, type XIX, alpha 1 -3.20163
WNK4 WNK lysine deficient protein kinase 4 -3.20163
TRIM73 tripartite motif containing 73 -3.20163
GLRA3 glycine receptor, alpha 3 -3.20163
NME5 NME/NM23 family member 5 -3.20163
PTAFR platelet-activating factor receptor -3.20163
SHD Src homology 2 domain containing transforming protein D -3.20163
TBX15 T-box 15 -3.20163
PCDHB4 protocadherin beta 4 -3.20163
CLCN1 chloride channel, voltage-sensitive 1 -3.20163
PTX3 pentraxin 3, long -3.20163
PI15 peptidase inhibitor 15 -3.20163
BTBD16 BTB (POZ) domain containing 16 -3.20163
ARSI arylsulfatase family, member I -3.20163
CCS copper chaperone for superoxide dismutase -3.20163
ZNF688 zinc finger protein 688 -3.20163
CREG2 cellular repressor of E1A-stimulated genes 2 -3.20163
NDNF neuron-derived neurotrophic factor -3.20163
PAX5 paired box 5 -3.20163
INSL6 insulin-like 6 -3.20163
SCARF1 scavenger receptor class F, member 1 -3.20163
TMEM190 transmembrane protein 190 -3.20163
CD247 CD247 molecule -3.20163
WNT16 wingless-type MMTV integration site family, member 16 -3.20163
MAGEL2 melanoma antigen family L2 -3.20163
TBC1D3L TBC1 domain family, member 3L -3.20163
GPR150 G protein-coupled receptor 150 -3.20163
SMKR1 small lysine-rich protein 1 -3.20163
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -3.20163
ZNF441 zinc finger protein 441 -3.20163
KLK4 kallikrein-related peptidase 4 -3.20163
LCN2 lipocalin 2 -3.20163
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -3.17565
CCL2 chemokine (C-C motif) ligand 2 -3.08586
ZFYVE19 zinc finger, FYVE domain containing 19 -3.03465
DPP7 dipeptidyl-peptidase 7 -3.03465
CLPSL2 colipase-like 2 -3.03293
RGS5 regulator of G-protein signaling 5 -3.02786
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.96622
IRX2 iroquois homeobox 2 -2.88779
ZSCAN31 zinc finger and SCAN domain containing 31 -2.80408
PVR poliovirus receptor -2.75209
SULF1 sulfatase 1 -2.73761
GATD1 glutamine amidotransferase class 1 domain containing 1 -2.71684
RIMS1 regulating synaptic membrane exocytosis 1 -2.61814
ELL elongation factor RNA polymerase II -2.59573
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) -2.58904
ASPHD2 aspartate beta-hydroxylase domain containing 2 -2.57456
LAG3 lymphocyte-activation gene 3 -2.55324
GTF2IRD2 GTF2I repeat domain containing 2 -2.55324
ZNF385D zinc finger protein 385D -2.54159
RAB3B RAB3B, member RAS oncogene family -2.43524
KIF2C kinesin family member 2C -2.43111
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -2.43111
HRH2 histamine receptor H2 -2.43111
MCTP1 multiple C2 domains, transmembrane 1 -2.40878
FXYD7 FXYD domain containing ion transport regulator 7 -2.37177
MPZL2 myelin protein zero-like 2 -2.371
DPEP3 dipeptidase 3 -2.371
ADIRF adipogenesis regulatory factor -2.36658
PC pyruvate carboxylase -2.36658
DYNLRB1 dynein, light chain, roadblock-type 1 -2.35018
PLA2G12A phospholipase A2, group XIIA -2.30088
ISCA2 iron-sulfur cluster assembly 2 -2.28489
H4C13 H4 clustered histone 13 -2.27225
CTSK cathepsin K -2.27225
FERMT3 fermitin family member 3 -2.27225
RFX2 regulatory factor X, 2 (influences HLA class II expression) -2.27225
REEP2 receptor accessory protein 2 -2.27225
AURKC aurora kinase C -2.27225
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -2.27225
MRAP melanocortin 2 receptor accessory protein -2.27225
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 -2.25546
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -2.25155
CACNG7 calcium channel, voltage-dependent, gamma subunit 7 -2.24819
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -2.22289
NRXN3 neurexin 3 -2.18232
ZNF624 zinc finger protein 624 -2.14504
KDM4D lysine (K)-specific demethylase 4D -2.13133
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.10941
PCDHB2 protocadherin beta 2 -2.09946
TTC31 tetratricopeptide repeat domain 31 -2.09028
GIPR gastric inhibitory polypeptide receptor -2.09028
PCGF1 polycomb group ring finger 1 -2.09028
FITM2 fat storage-inducing transmembrane protein 2 -2.09028
USP6NL USP6 N-terminal like -2.0796
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -2.06535
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.0611
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.05475
IRAK1 interleukin-1 receptor-associated kinase 1 -2.05128
TMEM232 transmembrane protein 232 -2.04603
RSL24D1 ribosomal L24 domain containing 1 -2.04603
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 -2.03198
CLCN2 chloride channel, voltage-sensitive 2 -2.02136
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.01965
SLC35E2B solute carrier family 35, member E2B -2.01965
NAGS N-acetylglutamate synthase -2.01965
RGPD6 RANBP2-like and GRIP domain containing 6 -2.01965
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.01965
TRIM69 tripartite motif containing 69 -2.01965
C4ORF33 chromosome 4 open reading frame 33 -2.01965
CYGB cytoglobin -2.01965
GLOD4 glyoxalase domain containing 4 -2.01965
SPATC1 spermatogenesis and centriole associated 1 -2.01965
ARRDC4 arrestin domain containing 4 -2.0141
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.0141
CRYGD crystallin, gamma D -2.01405
FOXA3 forkhead box A3 -2.01279
ST7L suppression of tumorigenicity 7 like -2.00188