MRCKA Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description CDC42 binding protein kinase alpha (DMPK-like)|The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8476)
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Genes

100 substrates of the kinase MRCKA from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
SAP30L SAP30-like
ZBTB44 zinc finger and BTB domain containing 44
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
KIAA1211L KIAA1211-like
IER2 immediate early response 2
LYST lysosomal trafficking regulator
KIAA1671 KIAA1671
C11ORF30 chromosome 11 open reading frame 30
HEATR3 HEAT repeat containing 3
CTR9 CTR9, Paf1/RNA polymerase II complex component
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
KSR2 kinase suppressor of ras 2
BRCA1 breast cancer 1, early onset
PNKP polynucleotide kinase 3'-phosphatase
MKI67 marker of proliferation Ki-67
TRA2A transformer 2 alpha homolog (Drosophila)
PDE3A phosphodiesterase 3A, cGMP-inhibited
SCAF1 SR-related CTD-associated factor 1
PLXNB1 plexin B1
ARHGAP11A Rho GTPase activating protein 11A
WNK1 WNK lysine deficient protein kinase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
TOR4A torsin family 4, member A
WDR81 WD repeat domain 81
ESR2 estrogen receptor 2 (ER beta)
ESR1 estrogen receptor 1
THOC5 THO complex 5
PBRM1 polybromo 1
ZNF687 zinc finger protein 687
RPS6 ribosomal protein S6
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
TBC1D30 TBC1 domain family, member 30
SF3B1 splicing factor 3b, subunit 1, 155kDa
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
CREBZF CREB/ATF bZIP transcription factor
S1PR1 sphingosine-1-phosphate receptor 1
DEPDC5 DEP domain containing 5
MYO3A myosin IIIA
RACGAP1 Rac GTPase activating protein 1
BAHD1 bromo adjacent homology domain containing 1
TRPS1 trichorhinophalangeal syndrome I
MVD mevalonate (diphospho) decarboxylase
SRSF2 serine/arginine-rich splicing factor 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
ATR ATR serine/threonine kinase
MLPH melanophilin
STAR steroidogenic acute regulatory protein
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
PYGO2 pygopus family PHD finger 2
PRKD2 protein kinase D2
PRKD3 protein kinase D3
RARA retinoic acid receptor, alpha
TP53BP1 tumor protein p53 binding protein 1
GRK7 G protein-coupled receptor kinase 7
MAP3K11 mitogen-activated protein kinase kinase kinase 11
RARG retinoic acid receptor, gamma
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
ZC3H13 zinc finger CCCH-type containing 13
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
PRKD1 protein kinase D1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
GON4L gon-4-like (C. elegans)
STIM1 stromal interaction molecule 1
CDCA2 cell division cycle associated 2
CDCA7 cell division cycle associated 7
CHKB choline kinase beta
DSP desmoplakin
IL1A interleukin 1, alpha
AEBP2 AE binding protein 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
ATRX alpha thalassemia/mental retardation syndrome X-linked
CDR2L cerebellar degeneration-related protein 2-like
FAM214B family with sequence similarity 214, member B
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
POU5F1 POU class 5 homeobox 1
SETD1A SET domain containing 1A
RBM15B RNA binding motif protein 15B
NELFA negative elongation factor complex member A
MAP3K2 mitogen-activated protein kinase kinase kinase 2
SETD2 SET domain containing 2
NUMA1 nuclear mitotic apparatus protein 1
CDK13 cyclin-dependent kinase 13
CDC25A cell division cycle 25A
UBR5 ubiquitin protein ligase E3 component n-recognin 5
DGAT1 diacylglycerol O-acyltransferase 1
ALPK3 alpha-kinase 3
PIANP PILR alpha associated neural protein
AURKB aurora kinase B
AURKC aurora kinase C
BAG6 BCL2-associated athanogene 6
KANK1 KN motif and ankyrin repeat domains 1
SUN2 Sad1 and UNC84 domain containing 2
SUN1 Sad1 and UNC84 domain containing 1
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
CEP170 centrosomal protein 170kDa
UBE2O ubiquitin-conjugating enzyme E2O