MRE-269 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9931891
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Genes

200 proteins with high or low expression in MRE-269 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
DNAH6 dynein, axonemal, heavy chain 6 2.62
SGSH N-sulfoglucosamine sulfohydrolase 1.46
KMT2B lysine (K)-specific methyltransferase 2B 1.24
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 1.04
HRH1 histamine receptor H1 0.86
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.82
PAQR7 progestin and adipoQ receptor family member VII 0.82
FKBP1A FK506 binding protein 1A, 12kDa 0.72
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.71
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.63
KIF27 kinesin family member 27 0.59
HIPK2 homeodomain interacting protein kinase 2 0.57
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.56
PNPO pyridoxamine 5'-phosphate oxidase 0.55
TEN1 TEN1 CST complex subunit 0.53
ANKRD13B ankyrin repeat domain 13B 0.53
BFAR bifunctional apoptosis regulator 0.53
CDCA4 cell division cycle associated 4 0.5
B2M beta-2-microglobulin 0.49
ZNF845 zinc finger protein 845 0.49
RPL30 ribosomal protein L30 0.48
INO80D INO80 complex subunit D 0.48
TMPO thymopoietin 0.47
CCDC18 coiled-coil domain containing 18 0.46
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.45
CLN3 ceroid-lipofuscinosis, neuronal 3 0.44
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 0.44
ATL1 atlastin GTPase 1 0.41
LIN7A lin-7 homolog A (C. elegans) 0.41
CCDC91 coiled-coil domain containing 91 0.4
TMEM200A transmembrane protein 200A 0.4
COA5 cytochrome c oxidase assembly factor 5 0.4
DCLRE1B DNA cross-link repair 1B 0.39
ABHD4 abhydrolase domain containing 4 0.39
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 0.39
MED10 mediator complex subunit 10 0.38
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.37
HJURP Holliday junction recognition protein 0.37
KIAA1586 KIAA1586 0.37
HNF4A hepatocyte nuclear factor 4, alpha 0.36
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.36
SLC25A39 solute carrier family 25, member 39 0.35
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.35
MARVELD3 MARVEL domain containing 3 0.35
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.34
CLGN calmegin 0.34
NADK NAD kinase 0.34
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.34
EHF ets homologous factor 0.33
GAS6 growth arrest-specific 6 0.33
NEU3 sialidase 3 (membrane sialidase) 0.33
MT-CO1 cytochrome c oxidase subunit I 0.32
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 0.32
NIP7 NIP7, nucleolar pre-rRNA processing protein 0.32
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.32
TECR trans-2,3-enoyl-CoA reductase 0.32
MIDN midnolin 0.32
RBSN rabenosyn, RAB effector 0.32
CBX5 chromobox homolog 5 0.32
CENPN centromere protein N 0.31
MPND MPN domain containing 0.31
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.31
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.31
WSB1 WD repeat and SOCS box containing 1 0.31
TRMO tRNA methyltransferase O 0.31
TMEM38B transmembrane protein 38B 0.3
CCNQ cyclin Q 0.3
FKBPL FK506 binding protein like 0.3
ELOC elongin C 0.3
RWDD3 RWD domain containing 3 0.3
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.29
MOB2 MOB kinase activator 2 0.29
MYORG myogenesis regulating glycosidase (putative) 0.29
MARCHF7 membrane associated ring-CH-type finger 7 0.29
GATD1 glutamine amidotransferase class 1 domain containing 1 0.29
TOR4A torsin family 4, member A 0.28
DIPK1B divergent protein kinase domain 1B 0.28
SASH1 SAM and SH3 domain containing 1 0.28
PEPD peptidase D 0.28
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.28
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.28
PGAM1 phosphoglycerate mutase 1 (brain) 0.28
NOS3 nitric oxide synthase 3 (endothelial cell) 0.28
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.27
NFYA nuclear transcription factor Y, alpha 0.27
ASPHD2 aspartate beta-hydroxylase domain containing 2 0.27
LMBRD1 LMBR1 domain containing 1 0.27
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 0.27
MAST3 microtubule associated serine/threonine kinase 3 0.26
ETNK2 ethanolamine kinase 2 0.26
SLC39A3 solute carrier family 39 (zinc transporter), member 3 0.26
DBNL drebrin-like 0.26
SNU13 small nuclear ribonucleoprotein 13 0.26
RRAGC Ras-related GTP binding C 0.26
PROSER3 proline and serine rich 3 0.26
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 0.26
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.26
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.26
STARD10 StAR-related lipid transfer (START) domain containing 10 0.26
CD81 CD81 molecule 0.26

low expression

Symbol Name Standardized Value
ZFHX2 zinc finger homeobox 2 -1.04
SNRPF small nuclear ribonucleoprotein polypeptide F -0.76
MCFD2 multiple coagulation factor deficiency 2 -0.74
LRRC49 leucine rich repeat containing 49 -0.69
PITX1 paired-like homeodomain 1 -0.67
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.67
FGFR2 fibroblast growth factor receptor 2 -0.66
CCDC85B coiled-coil domain containing 85B -0.63
MID2 midline 2 -0.62
JPT1 Jupiter microtubule associated homolog 1 -0.58
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -0.57
GLRX glutaredoxin (thioltransferase) -0.54
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.53
TTC3 tetratricopeptide repeat domain 3 -0.53
HEXD hexosaminidase D -0.52
TRIM39 tripartite motif containing 39 -0.52
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.52
CIB1 calcium and integrin binding 1 (calmyrin) -0.5
COL14A1 collagen, type XIV, alpha 1 -0.5
LCORL ligand dependent nuclear receptor corepressor-like -0.48
BPTF bromodomain PHD finger transcription factor -0.48
BBS2 Bardet-Biedl syndrome 2 -0.46
NEIL3 nei endonuclease VIII-like 3 (E. coli) -0.45
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -0.44
NOMO1 NODAL modulator 1 -0.43
PXN paxillin -0.43
ALYREF Aly/REF export factor -0.43
COL6A6 collagen, type VI, alpha 6 -0.42
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -0.42
SERF2 small EDRK-rich factor 2 -0.42
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -0.41
TBPL2 TATA box binding protein like 2 -0.41
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -0.39
LAPTM4A lysosomal protein transmembrane 4 alpha -0.38
NKAPD1 NKAP domain containing 1 -0.38
FAM221A family with sequence similarity 221, member A -0.38
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like -0.38
TOX2 TOX high mobility group box family member 2 -0.38
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.37
SPATA2 spermatogenesis associated 2 -0.37
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -0.36
SOAT1 sterol O-acyltransferase 1 -0.35
STX4 syntaxin 4 -0.35
MARK4 MAP/microtubule affinity-regulating kinase 4 -0.35
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -0.35
ELF4 E74-like factor 4 (ets domain transcription factor) -0.35
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.35
MYH11 myosin, heavy chain 11, smooth muscle -0.35
MYNN myoneurin -0.35
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -0.35
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -0.35
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.35
ALPK1 alpha-kinase 1 -0.34
POMP proteasome maturation protein -0.34
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -0.34
SNAP91 synaptosomal-associated protein, 91kDa -0.33
GLMP glycosylated lysosomal membrane protein -0.33
NFYB nuclear transcription factor Y, beta -0.33
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -0.33
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 -0.33
MRPL12 mitochondrial ribosomal protein L12 -0.33
ZNF616 zinc finger protein 616 -0.33
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -0.33
ZMYM6 zinc finger, MYM-type 6 -0.33
PTMA prothymosin, alpha -0.32
UBXN2A UBX domain protein 2A -0.32
CDX2 caudal type homeobox 2 -0.32
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -0.32
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) -0.32
CDC26 cell division cycle 26 -0.32
ZC3H10 zinc finger CCCH-type containing 10 -0.32
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -0.32
HGH1 HGH1 homolog (S. cerevisiae) -0.32
TUSC2 tumor suppressor candidate 2 -0.32
ATP5PF ATP synthase peripheral stalk subunit F6 -0.31
MPDU1 mannose-P-dolichol utilization defect 1 -0.31
TESK1 testis-specific kinase 1 -0.31
CARD8 caspase recruitment domain family, member 8 -0.31
ADARB1 adenosine deaminase, RNA-specific, B1 -0.31
YAF2 YY1 associated factor 2 -0.31
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -0.31
SC5D sterol-C5-desaturase -0.3
NEK3 NIMA-related kinase 3 -0.3
ARHGAP45 Rho GTPase activating protein 45 -0.3
CCDC66 coiled-coil domain containing 66 -0.3
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.3
C1ORF43 chromosome 1 open reading frame 43 -0.3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.3
CA8 carbonic anhydrase VIII -0.3
OPHN1 oligophrenin 1 -0.3
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -0.3
UBXN8 UBX domain protein 8 -0.3
TMEM41B transmembrane protein 41B -0.3
SMOX spermine oxidase -0.3
ERH enhancer of rudimentary homolog (Drosophila) -0.3
PRF1 perforin 1 (pore forming protein) -0.29
ENOX2 ecto-NOX disulfide-thiol exchanger 2 -0.29
GALT galactose-1-phosphate uridylyltransferase -0.29
HSBP1 heat shock factor binding protein 1 -0.29
C1ORF50 chromosome 1 open reading frame 50 -0.29