| Dataset | NURSA Protein-Protein Interactions |
| Category | proteomics |
| Type | interacting protein |
| Description | MRE11 meiotic recombination 11 homolog A (S. cerevisiae)|This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4361) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/4361 |
| Similar Terms | |
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2 interacting proteins for MRE11A from the NURSA Protein-Protein Interactions dataset.
