| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6603931 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in MRS 1754 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOE | apolipoprotein E | 2.04 |
| ZNF518B | zinc finger protein 518B | 1.31 |
| HBA1 | hemoglobin, alpha 1 | 0.74 |
| CFAP54 | cilia and flagella associated 54 | 0.7 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.62 |
| TRIM23 | tripartite motif containing 23 | 0.52 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.49 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 0.48 |
| ATG10 | autophagy related 10 | 0.45 |
| LRRC58 | leucine rich repeat containing 58 | 0.43 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.43 |
| KALRN | kalirin, RhoGEF kinase | 0.42 |
| C4ORF33 | chromosome 4 open reading frame 33 | 0.41 |
| ZBED6 | zinc finger, BED-type containing 6 | 0.41 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.41 |
| NRXN3 | neurexin 3 | 0.39 |
| MOSPD1 | motile sperm domain containing 1 | 0.39 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.38 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.38 |
| FSIP2 | fibrous sheath interacting protein 2 | 0.37 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.37 |
| CNTNAP1 | contactin associated protein 1 | 0.36 |
| JOSD1 | Josephin domain containing 1 | 0.35 |
| CCDC9B | coiled-coil domain containing 9B | 0.35 |
| GPANK1 | G patch domain and ankyrin repeats 1 | 0.35 |
| F2 | coagulation factor II (thrombin) | 0.35 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.34 |
| ATG12 | autophagy related 12 | 0.34 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.34 |
| FAM171A1 | family with sequence similarity 171, member A1 | 0.33 |
| SUCO | SUN domain containing ossification factor | 0.33 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.32 |
| ZNF584 | zinc finger protein 584 | 0.32 |
| COL1A1 | collagen, type I, alpha 1 | 0.32 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.31 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 0.31 |
| MED31 | mediator complex subunit 31 | 0.31 |
| FOXD2 | forkhead box D2 | 0.3 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.3 |
| RPS27A | ribosomal protein S27a | 0.3 |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.3 |
| FAM161A | family with sequence similarity 161, member A | 0.3 |
| ODC1 | ornithine decarboxylase 1 | 0.3 |
| SF1 | splicing factor 1 | 0.29 |
| TMEM64 | transmembrane protein 64 | 0.29 |
| SMAD1 | SMAD family member 1 | 0.29 |
| ZMYND19 | zinc finger, MYND-type containing 19 | 0.29 |
| USP46 | ubiquitin specific peptidase 46 | 0.29 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | 0.28 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.28 |
| RMND5A | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.28 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.28 |
| RANBP17 | RAN binding protein 17 | 0.28 |
| C5ORF34 | chromosome 5 open reading frame 34 | 0.28 |
| PIF1 | PIF1 5'-to-3' DNA helicase | 0.28 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.26 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | 0.26 |
| EEF1AKMT1 | EEF1A lysine methyltransferase 1 | 0.26 |
| ANKRD24 | ankyrin repeat domain 24 | 0.26 |
| ALDOB | aldolase B, fructose-bisphosphate | 0.26 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.26 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.26 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.26 |
| GPATCH2L | G patch domain containing 2-like | 0.25 |
| ZNF799 | zinc finger protein 799 | 0.25 |
| MADD | MAP-kinase activating death domain | 0.25 |
| SLC2A4RG | SLC2A4 regulator | 0.25 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.25 |
| TMEM120B | transmembrane protein 120B | 0.25 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | 0.25 |
| BTBD1 | BTB (POZ) domain containing 1 | 0.25 |
| SLC25A44 | solute carrier family 25, member 44 | 0.25 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 0.25 |
| FBXO17 | F-box protein 17 | 0.25 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | 0.24 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.24 |
| RNF115 | ring finger protein 115 | 0.24 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.24 |
| ADM | adrenomedullin | 0.24 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 0.24 |
| PROS1 | protein S (alpha) | 0.23 |
| KCTD2 | potassium channel tetramerization domain containing 2 | 0.23 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.23 |
| RMI2 | RecQ mediated genome instability 2 | 0.23 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 0.23 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | 0.23 |
| CYTH3 | cytohesin 3 | 0.23 |
| MRPL33 | mitochondrial ribosomal protein L33 | 0.23 |
| BANF1 | barrier to autointegration factor 1 | 0.22 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.22 |
| C19ORF54 | chromosome 19 open reading frame 54 | 0.22 |
| EIF4E2 | eukaryotic translation initiation factor 4E family member 2 | 0.22 |
| CCDC170 | coiled-coil domain containing 170 | 0.22 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 0.22 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.22 |
| GCFC2 | GC-rich sequence DNA-binding factor 2 | 0.22 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | 0.22 |
| RCE1 | Ras converting CAAX endopeptidase 1 | 0.22 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -2.95 |
| ZNF264 | zinc finger protein 264 | -0.99 |
| UBXN8 | UBX domain protein 8 | -0.84 |
| ZNF513 | zinc finger protein 513 | -0.75 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | -0.71 |
| USP12 | ubiquitin specific peptidase 12 | -0.57 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.56 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | -0.55 |
| ZNF276 | zinc finger protein 276 | -0.52 |
| RGL3 | ral guanine nucleotide dissociation stimulator-like 3 | -0.52 |
| IRF5 | interferon regulatory factor 5 | -0.51 |
| SNX33 | sorting nexin 33 | -0.44 |
| MPZL2 | myelin protein zero-like 2 | -0.43 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.43 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | -0.42 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.42 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.42 |
| LPIN1 | lipin 1 | -0.42 |
| CENPT | centromere protein T | -0.41 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -0.4 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | -0.4 |
| SNX25 | sorting nexin 25 | -0.39 |
| CUL9 | cullin 9 | -0.39 |
| DSCAM | Down syndrome cell adhesion molecule | -0.39 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.39 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.37 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | -0.37 |
| MYORG | myogenesis regulating glycosidase (putative) | -0.37 |
| SARDH | sarcosine dehydrogenase | -0.37 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.37 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.36 |
| CEP85L | centrosomal protein 85kDa-like | -0.36 |
| TMEM222 | transmembrane protein 222 | -0.36 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.36 |
| GDF15 | growth differentiation factor 15 | -0.36 |
| CSNK1G2 | casein kinase 1, gamma 2 | -0.35 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.35 |
| DCHS1 | dachsous cadherin-related 1 | -0.35 |
| TTC31 | tetratricopeptide repeat domain 31 | -0.34 |
| RAD52 | RAD52 homolog (S. cerevisiae) | -0.34 |
| RAB6D | RAB6D, member RAS oncogene family | -0.33 |
| FGGY | FGGY carbohydrate kinase domain containing | -0.33 |
| TMEM184A | transmembrane protein 184A | -0.33 |
| KLHL5 | kelch-like family member 5 | -0.33 |
| DSE | dermatan sulfate epimerase | -0.33 |
| HOMEZ | homeobox and leucine zipper encoding | -0.32 |
| MRNIP | MRN complex interacting protein | -0.32 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | -0.31 |
| TECPR2 | tectonin beta-propeller repeat containing 2 | -0.31 |
| C6ORF47 | chromosome 6 open reading frame 47 | -0.31 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | -0.31 |
| MIIP | migration and invasion inhibitory protein | -0.3 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | -0.3 |
| BRD3 | bromodomain containing 3 | -0.3 |
| CENPH | centromere protein H | -0.3 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | -0.3 |
| ADIRF | adipogenesis regulatory factor | -0.3 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.3 |
| TMEM135 | transmembrane protein 135 | -0.3 |
| MSMO1 | methylsterol monooxygenase 1 | -0.29 |
| SMOX | spermine oxidase | -0.29 |
| STX1A | syntaxin 1A (brain) | -0.29 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.29 |
| GON7 | GON7 subunit of KEOPS complex | -0.29 |
| ZNF532 | zinc finger protein 532 | -0.29 |
| HINFP | histone H4 transcription factor | -0.29 |
| VAMP4 | vesicle-associated membrane protein 4 | -0.29 |
| NCKAP5L | NCK-associated protein 5-like | -0.28 |
| CCDC28A | coiled-coil domain containing 28A | -0.28 |
| TRAM2 | translocation associated membrane protein 2 | -0.28 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.28 |
| ATXN3 | ataxin 3 | -0.28 |
| ISL2 | ISL LIM homeobox 2 | -0.28 |
| ZNF594 | zinc finger protein 594 | -0.28 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.27 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | -0.27 |
| OSCP1 | organic solute carrier partner 1 | -0.27 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.27 |
| TRIM9 | tripartite motif containing 9 | -0.27 |
| CASZ1 | castor zinc finger 1 | -0.27 |
| COPRS | coordinator of PRMT5, differentiation stimulator | -0.27 |
| SIRT2 | sirtuin 2 | -0.27 |
| CRAT | carnitine O-acetyltransferase | -0.27 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.27 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.27 |
| GNPAT | glyceronephosphate O-acyltransferase | -0.27 |
| CAB39L | calcium binding protein 39-like | -0.26 |
| FTL | ferritin, light polypeptide | -0.26 |
| INPP5J | inositol polyphosphate-5-phosphatase J | -0.26 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.26 |
| AASS | aminoadipate-semialdehyde synthase | -0.26 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.26 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -0.26 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | -0.26 |
| DVL3 | dishevelled segment polarity protein 3 | -0.26 |
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | -0.26 |
| DOCK11 | dedicator of cytokinesis 11 | -0.26 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | -0.26 |
| FABP6 | fatty acid binding protein 6, ileal | -0.26 |
