MRS 2578 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/16078986
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Genes

199 proteins with high or low expression in MRS 2578 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PIP prolactin-induced protein 3.06
HMOX1 heme oxygenase 1 1.93
ADAM22 ADAM metallopeptidase domain 22 1.56
TAZ tafazzin 1.5
NF1 neurofibromin 1 1.3
JUN jun proto-oncogene 1.27
HBA1 hemoglobin, alpha 1 1.25
SBSN suprabasin 1.21
DOP1A DOP1 leucine zipper like protein A 1.18
COL1A1 collagen, type I, alpha 1 1.12
CLU clusterin 1.06
KMT2B lysine (K)-specific methyltransferase 2B 0.98
TMUB1 transmembrane and ubiquitin-like domain containing 1 0.95
F5 coagulation factor V (proaccelerin, labile factor) 0.94
SESN2 sestrin 2 0.91
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.91
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 0.89
BAG3 BCL2-associated athanogene 3 0.89
CCDC158 coiled-coil domain containing 158 0.87
UPP1 uridine phosphorylase 1 0.85
CPN1 carboxypeptidase N, polypeptide 1 0.85
PRG4 proteoglycan 4 0.83
TP73 tumor protein p73 0.82
TMOD2 tropomodulin 2 (neuronal) 0.81
HIPK1 homeodomain interacting protein kinase 1 0.81
LAMB3 laminin, beta 3 0.81
ALPK3 alpha-kinase 3 0.79
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.76
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.76
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.75
COL14A1 collagen, type XIV, alpha 1 0.75
GSTA1 glutathione S-transferase alpha 1 0.73
DCHS2 dachsous cadherin-related 2 0.72
HSPA1A heat shock 70kDa protein 1A 0.71
CTSL cathepsin L 0.71
FOSL1 FOS-like antigen 1 0.7
FHIT fragile histidine triad 0.69
IFRD1 interferon-related developmental regulator 1 0.68
LAMC2 laminin, gamma 2 0.68
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.68
PEX2 peroxisomal biogenesis factor 2 0.67
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.67
RAP1B RAP1B, member of RAS oncogene family 0.66
VTN vitronectin 0.66
F2 coagulation factor II (thrombin) 0.66
INHBA inhibin, beta A 0.65
TRIML2 tripartite motif family-like 2 0.65
ADCY10 adenylate cyclase 10 (soluble) 0.65
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.64
THBS1 thrombospondin 1 0.63
HAL histidine ammonia-lyase 0.62
XBP1 X-box binding protein 1 0.62
IGFBP3 insulin-like growth factor binding protein 3 0.62
ALAS1 5'-aminolevulinate synthase 1 0.61
RND3 Rho family GTPase 3 0.61
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.61
TACC3 transforming, acidic coiled-coil containing protein 3 0.6
SPATA13 spermatogenesis associated 13 0.6
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 0.6
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 0.59
FLNC filamin C, gamma 0.59
HSPA8 heat shock 70kDa protein 8 0.59
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.59
C18ORF32 chromosome 18 open reading frame 32 0.58
DENND3 DENN/MADD domain containing 3 0.58
TSPYL2 TSPY-like 2 0.58
IGFBP5 insulin-like growth factor binding protein 5 0.58
TIMP3 TIMP metallopeptidase inhibitor 3 0.57
SLC35F3 solute carrier family 35, member F3 0.56
TROAP trophinin associated protein 0.56
NCKAP1L NCK-associated protein 1-like 0.56
KIAA0513 KIAA0513 0.55
DNLZ DNL-type zinc finger 0.55
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.55
OTC ornithine carbamoyltransferase 0.55
TTC14 tetratricopeptide repeat domain 14 0.54
DENND2D DENN/MADD domain containing 2D 0.53
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.53
RNF6 ring finger protein (C3H2C3 type) 6 0.53
SRXN1 sulfiredoxin 1 0.52
KIAA0825 KIAA0825 0.52
IRS2 insulin receptor substrate 2 0.52
ZFP36L1 ZFP36 ring finger protein-like 1 0.52
FJX1 four jointed box 1 (Drosophila) 0.52
CCN2 cellular communication network factor 2 0.51
NIBAN1 niban apoptosis regulator 1 0.51
TRIB3 tribbles pseudokinase 3 0.49
TMC4 transmembrane channel-like 4 0.49
FITM2 fat storage-inducing transmembrane protein 2 0.49
C2CD3 C2 calcium-dependent domain containing 3 0.49
SMTN smoothelin 0.49
MCL1 myeloid cell leukemia 1 0.48
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.48
MFSD5 major facilitator superfamily domain containing 5 0.48
TTC17 tetratricopeptide repeat domain 17 0.48
DUOX1 dual oxidase 1 0.48
ZDHHC21 zinc finger, DHHC-type containing 21 0.48
ARMCX5 armadillo repeat containing, X-linked 5 0.48
LAMA3 laminin, alpha 3 0.47
MREG melanoregulin 0.47

low expression

Symbol Name Standardized Value
DPY30 dpy-30 homolog (C. elegans) -1.03
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.98
MRPS18C mitochondrial ribosomal protein S18C -0.95
DCAF16 DDB1 and CUL4 associated factor 16 -0.81
PAK5 p21 (RAC1) activated kinase 5 -0.8
ICK intestinal cell (MAK-like) kinase -0.8
ENO1 enolase 1, (alpha) -0.78
FAM120C family with sequence similarity 120C -0.76
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) -0.76
VWA1 von Willebrand factor A domain containing 1 -0.75
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.73
S100A2 S100 calcium binding protein A2 -0.72
RTL8C retrotransposon Gag like 8C -0.71
PMF1 polyamine-modulated factor 1 -0.7
PTMS parathymosin -0.69
B2M beta-2-microglobulin -0.68
AMACR alpha-methylacyl-CoA racemase -0.68
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -0.68
COL6A3 collagen, type VI, alpha 3 -0.67
ATRN attractin -0.67
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -0.66
PTMA prothymosin, alpha -0.65
PLXNB1 plexin B1 -0.65
SP140L SP140 nuclear body protein-like -0.63
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.63
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -0.62
ZNF428 zinc finger protein 428 -0.61
COA5 cytochrome c oxidase assembly factor 5 -0.61
SOX4 SRY (sex determining region Y)-box 4 -0.6
CENPH centromere protein H -0.59
CEMIP cell migration inducing protein, hyaluronan binding -0.59
THSD4 thrombospondin, type I, domain containing 4 -0.57
DDT D-dopachrome tautomerase -0.57
MED29 mediator complex subunit 29 -0.57
KDM5B lysine (K)-specific demethylase 5B -0.57
GAB1 GRB2-associated binding protein 1 -0.57
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.56
MOB2 MOB kinase activator 2 -0.56
MFAP3 microfibrillar-associated protein 3 -0.56
H3C1 H3 clustered histone 1 -0.56
ADGRF1 adhesion G protein-coupled receptor F1 -0.56
FCHSD2 FCH and double SH3 domains 2 -0.55
GLDC glycine dehydrogenase (decarboxylating) -0.55
RBM41 RNA binding motif protein 41 -0.55
ZDHHC23 zinc finger, DHHC-type containing 23 -0.55
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -0.55
SP100 SP100 nuclear antigen -0.55
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -0.54
ABAT 4-aminobutyrate aminotransferase -0.54
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.54
RWDD1 RWD domain containing 1 -0.54
SIRT3 sirtuin 3 -0.53
OMA1 OMA1 zinc metallopeptidase -0.53
DXO decapping exoribonuclease -0.53
AOC1 amine oxidase, copper containing 1 -0.53
PRKCQ protein kinase C, theta -0.52
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -0.52
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.51
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.51
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) -0.51
BCAM basal cell adhesion molecule (Lutheran blood group) -0.51
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 -0.51
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.51
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -0.5
ENDOV endonuclease V -0.5
YAF2 YY1 associated factor 2 -0.5
PBX3 pre-B-cell leukemia homeobox 3 -0.5
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -0.49
SLC22A23 solute carrier family 22, member 23 -0.49
ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog -0.49
JDP2 Jun dimerization protein 2 -0.48
PAIP2 poly(A) binding protein interacting protein 2 -0.48
NUTF2 nuclear transport factor 2 -0.47
NKAP NFKB activating protein -0.47
FAM171A2 family with sequence similarity 171, member A2 -0.47
SLC25A30 solute carrier family 25, member 30 -0.47
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) -0.47
PGGT1B protein geranylgeranyltransferase type I, beta subunit -0.47
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.47
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 -0.47
NCOR1 nuclear receptor corepressor 1 -0.46
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -0.46
SLC35A4 solute carrier family 35, member A4 -0.45
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 -0.45
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.45
LIMCH1 LIM and calponin homology domains 1 -0.45
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.45
EPN3 epsin 3 -0.44
CYB5A cytochrome b5 type A (microsomal) -0.44
GAS2L1 growth arrest-specific 2 like 1 -0.43
PLCL2 phospholipase C-like 2 -0.43
NECTIN1 nectin cell adhesion molecule 1 -0.43
SASH1 SAM and SH3 domain containing 1 -0.43
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -0.42
MPC2 mitochondrial pyruvate carrier 2 -0.42
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.42
SH3BGRL SH3 domain binding glutamate-rich protein like -0.42
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -0.42
KRAS Kirsten rat sarcoma viral oncogene homolog -0.41