| Dataset | InterPro Predicted Protein Domain Annotations |
| Category | structural or functional annotations |
| Type | protein domain |
| Description | murine retrovirus integration site 1 homolog|This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011] (NCBI Entrez Gene Database, 10335) |
| External Link | https://www.ebi.ac.uk/interpro/entry/IPR008677 |
| Similar Terms | |
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2 proteins predicted to have the MRVI1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.
