MRVI1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description murine retrovirus integration site 1 homolog|This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011] (NCBI Entrez Gene Database, 10335)
External Link http://www.ncbi.nlm.nih.gov/gene/10335
Similar Terms
Downloads & Tools

Genes

72 interacting proteins for MRVI1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARL1 ADP-ribosylation factor-like 1
ARMC10 armadillo repeat containing 10
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CLEC4M C-type lectin domain family 4, member M
CNN1 calponin 1, basic, smooth muscle
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
FAAH fatty acid amide hydrolase
FAHD1 fumarylacetoacetate hydrolase domain containing 1
FECH ferrochelatase
FLOT2 flotillin 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
HIST1H2AI histone cluster 1, H2ai
HSPA1B heat shock 70kDa protein 1B
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK2 interleukin-1 receptor-associated kinase 2
ITFG3 integrin alpha FG-GAP repeat containing 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KBTBD3 kelch repeat and BTB (POZ) domain containing 3
KRT10 keratin 10, type I
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LMNA lamin A/C
LONP1 lon peptidase 1, mitochondrial
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MRPL44 mitochondrial ribosomal protein L44
MRPS25 mitochondrial ribosomal protein S25
MTDH metadherin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYH9 myosin, heavy chain 9, non-muscle
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
NNT nicotinamide nucleotide transhydrogenase
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OPA1 optic atrophy 1 (autosomal dominant)
PCNA proliferating cell nuclear antigen
PDIA5 protein disulfide isomerase family A, member 5
PLN phospholamban
POTEH POTE ankyrin domain family, member H
PRKG1 protein kinase, cGMP-dependent, type I
PRKG2 protein kinase, cGMP-dependent, type II
RAP2B RAP2B, member of RAS oncogene family
RBM39 RNA binding motif protein 39
RPL30 ribosomal protein L30
RPS10 ribosomal protein S10
RPS23 ribosomal protein S23
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SACK1F scaffolding CK1 anchoring protein F
SDF4 stromal cell derived factor 4
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRSF11 serine/arginine-rich splicing factor 11
SSR4 signal sequence receptor, delta
TM9SF1 transmembrane 9 superfamily member 1
TNPO1 transportin 1
TUBB8 tubulin, beta 8 class VIII
UBAC2 UBA domain containing 2
UTRN utrophin
VDAC2 voltage-dependent anion channel 2
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZMPSTE24 zinc metallopeptidase STE24