MS751 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from Cervical Carcinoma Metastasis (Cell Model Passports, SIDM00638)
External Link https://depmap.org/portal/cell_line/ACH-001360
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Genes

208 gene knockdowns changing fitness of MS751 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
COPS7A COP9 signalosome subunit 7A 7.18848
ZER1 zyg-11 related, cell cycle regulator 6.2749
UBE3A ubiquitin protein ligase E3A 5.21403
KRTDAP keratinocyte differentiation-associated protein 4.70442
PSKH2 protein serine kinase H2 4.66377
SIAH3 siah E3 ubiquitin protein ligase family member 3 4.63443
CRTC3 CREB regulated transcription coactivator 3 4.55037
GJB6 gap junction protein, beta 6, 30kDa 4.48601
ECT2L epithelial cell transforming 2 like 4.20431
SIPA1L3 signal-induced proliferation-associated 1 like 3 4.14219
SSX7 synovial sarcoma, X breakpoint 7 4.04788
CYTIP cytohesin 1 interacting protein 4.02751
DACH2 dachshund family transcription factor 2 3.906
PABPC3 poly(A) binding protein, cytoplasmic 3 3.9041
SLC25A48 solute carrier family 25, member 48 3.84763
FKBP1B FK506 binding protein 1B, 12.6 kDa 3.79558
CAPN5 calpain 5 3.71672
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.63132
KRT18 keratin 18, type I 3.60612
ZNF611 zinc finger protein 611 3.59926
KCTD9 potassium channel tetramerization domain containing 9 3.54495
TSC1 tuberous sclerosis 1 3.49655
CAMTA2 calmodulin binding transcription activator 2 3.46849
MGP matrix Gla protein 3.40217
WNT8A wingless-type MMTV integration site family, member 8A 3.36715
ECM1 extracellular matrix protein 1 3.35263
HDC histidine decarboxylase 3.34546
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.32183
NT5C3B 5'-nucleotidase, cytosolic IIIB 3.31271
HOMER2 homer scaffolding protein 2 3.26573
HOXD12 homeobox D12 3.26346
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.21349
MAPT microtubule-associated protein tau 3.20269
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 3.17003
ATP7B ATPase, Cu++ transporting, beta polypeptide 3.12625
TRHR thyrotropin-releasing hormone receptor 3.12051
IFNB1 interferon, beta 1, fibroblast 3.11647
BEST1 bestrophin 1 3.10891
GCM1 glial cells missing homolog 1 (Drosophila) 3.07201
PPP1R32 protein phosphatase 1, regulatory subunit 32 3.04342
STAP1 signal transducing adaptor family member 1 3.00876
LAMP2 lysosomal-associated membrane protein 2 3.00045
CALM1 calmodulin 1 (phosphorylase kinase, delta) 2.99599
ANKRD29 ankyrin repeat domain 29 2.9937
SMR3A submaxillary gland androgen regulated protein 3A 2.99355
FCAMR Fc receptor, IgA, IgM, high affinity 2.96149
PLAAT3 phospholipase A and acyltransferase 3 2.95911
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.93107
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 2.92349
UBE2R2 ubiquitin-conjugating enzyme E2R 2 2.90554
PRKD1 protein kinase D1 2.89602
CCNB3 cyclin B3 2.86868
NMBR neuromedin B receptor 2.86841
RFTN2 raftlin family member 2 2.85104
AMER3 APC membrane recruitment protein 3 2.82954
UNC45B unc-45 homolog B (C. elegans) 2.82759
DCX doublecortin 2.81286
ZNF630 zinc finger protein 630 2.80882
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 2.8029
TMEM174 transmembrane protein 174 2.78184
WDR86 WD repeat domain 86 2.77393
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.77313
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 2.77291
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.77054
C3ORF18 chromosome 3 open reading frame 18 2.76937
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.76715
KSR2 kinase suppressor of ras 2 2.70954
MYO1H myosin IH 2.69893
LHFPL5 lipoma HMGIC fusion partner-like 5 2.68848
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.6546
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.64232
MMP2 matrix metallopeptidase 2 2.63339
PRF1 perforin 1 (pore forming protein) 2.62401
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.60767
SIM1 single-minded family bHLH transcription factor 1 2.60411
EGR3 early growth response 3 2.60281
IQCF6 IQ motif containing F6 2.60165
CCL16 chemokine (C-C motif) ligand 16 2.59795
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.5905
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.58986
THAP10 THAP domain containing 10 2.5895
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.58397
SSMEM1 serine-rich single-pass membrane protein 1 2.57396
ASTL astacin-like metallo-endopeptidase (M12 family) 2.57373
XAGE5 X antigen family, member 5 2.55815
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.55677
TCP10L t-complex 10-like 2.5547
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 2.54543
DRP2 dystrophin related protein 2 2.53754
ASB12 ankyrin repeat and SOCS box containing 12 2.53674
MCHR2 melanin-concentrating hormone receptor 2 2.53616
GPR158 G protein-coupled receptor 158 2.53156
GAST gastrin 2.52459
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 2.52084
SIRPB1 signal-regulatory protein beta 1 2.51776
TM4SF5 transmembrane 4 L six family member 5 2.51661
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2.51399
VWA3B von Willebrand factor A domain containing 3B 2.50226
CFAP45 cilia and flagella associated protein 45 2.50204
ZNF385B zinc finger protein 385B 2.49073
API5 apoptosis inhibitor 5 2.48875
GIMAP2 GTPase, IMAP family member 2 2.4883
GPX6 glutathione peroxidase 6 2.48808
ARHGAP15 Rho GTPase activating protein 15 2.47544
ZNF233 zinc finger protein 233 2.47181
NLK nemo-like kinase 2.45294
TRO trophinin 2.43881
HEBP1 heme binding protein 1 2.42729
CLIC6 chloride intracellular channel 6 2.41813
ZPBP zona pellucida binding protein 2.4137
HOXB2 homeobox B2 2.40365
FMNL2 formin-like 2 2.40237
C19ORF67 chromosome 19 open reading frame 67 2.39874
TSC2 tuberous sclerosis 2 2.39067
IQCJ IQ motif containing J 2.38958
TRPV1 transient receptor potential cation channel, subfamily V, member 1 2.37586
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.36279
CABP2 calcium binding protein 2 2.35343
SNX30 sorting nexin family member 30 2.34464
CKM creatine kinase, muscle 2.33713
CCL2 chemokine (C-C motif) ligand 2 2.33461
PHOSPHO1 phosphatase, orphan 1 2.33096
RGPD4 RANBP2-like and GRIP domain containing 4 2.32674
ZNF18 zinc finger protein 18 2.32469
CCL20 chemokine (C-C motif) ligand 20 2.32264
IZUMO3 IZUMO family member 3 2.30879
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 2.30844
STOML3 stomatin (EPB72)-like 3 2.3075
RIPPLY1 ripply transcriptional repressor 1 2.29726
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.2896
AOX1 aldehyde oxidase 1 2.28356
PDE11A phosphodiesterase 11A 2.26493
KRTAP6-2 keratin associated protein 6-2 2.26379
JAZF1 JAZF zinc finger 1 2.25777
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.25554
ALOX15B arachidonate 15-lipoxygenase, type B 2.24068
MSS51 MSS51 mitochondrial translational activator 2.23914
DMRT2 doublesex and mab-3 related transcription factor 2 2.23872
SNX20 sorting nexin 20 2.23736
LHX8 LIM homeobox 8 2.2364
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.23452
LPL lipoprotein lipase 2.22597
ARMCX4 armadillo repeat containing, X-linked 4 2.22567
GJA3 gap junction protein, alpha 3, 46kDa 2.22322
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 2.22066
TSLIG2 tRNA splicing ligase complex subunit 2 2.22013
HYPM huntingtin interacting protein M 2.21628
ABRACL ABRA C-terminal like 2.21497
DPP3 dipeptidyl-peptidase 3 2.21482
FAM69C family with sequence similarity 69, member C 2.20943
CPQ carboxypeptidase Q 2.20932
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.20404
KRTAP26-1 keratin associated protein 26-1 2.20402
SMIM14 small integral membrane protein 14 2.20376
GXYLT2 glucoside xylosyltransferase 2 2.20245
NRG1 neuregulin 1 2.20196
CCNE2 cyclin E2 2.20172
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.20094
GPX5 glutathione peroxidase 5 2.19102
UBASH3A ubiquitin associated and SH3 domain containing A 2.18647
STEAP1B STEAP family member 1B 2.18295
IER3IP1 immediate early response 3 interacting protein 1 2.17743
RNF14 ring finger protein 14 2.17442
PAGE4 P antigen family, member 4 (prostate associated) 2.17344
SCN2A sodium channel, voltage gated, type II alpha subunit 2.17291
MCC mutated in colorectal cancers 2.17281
OLFM4 olfactomedin 4 2.17118
CCDC170 coiled-coil domain containing 170 2.17101
SYNDIG1 synapse differentiation inducing 1 2.17025
TSPYL5 TSPY-like 5 2.16175
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.15959
LPXN leupaxin 2.15077
ARMCX6 armadillo repeat containing, X-linked 6 2.1473
CLEC1B C-type lectin domain family 1, member B 2.13786
KRT27 keratin 27, type I 2.13513
BLVRA biliverdin reductase A 2.13136
ZNF775 zinc finger protein 775 2.1265
C2ORF42 chromosome 2 open reading frame 42 2.12359
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.12209
CST9 cystatin 9 (testatin) 2.11674
CENPJ centromere protein J 2.11046
SETD1B SET domain containing 1B 2.11037
SMIM17 small integral membrane protein 17 2.10919
ZNF720 zinc finger protein 720 2.1019
LY75 lymphocyte antigen 75 2.09628
SLC35G6 solute carrier family 35, member G6 2.09264
ANG angiogenin, ribonuclease, RNase A family, 5 2.09172
TMOD2 tropomodulin 2 (neuronal) 2.08691
GBP2 guanylate binding protein 2, interferon-inducible 2.08552
ZCCHC16 zinc finger, CCHC domain containing 16 2.08396
LECT2 leukocyte cell-derived chemotaxin 2 2.07908
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.07499
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.06648
MARK4 MAP/microtubule affinity-regulating kinase 4 2.06474
NPY2R neuropeptide Y receptor Y2 2.05391
VPREB3 pre-B lymphocyte 3 2.05129
SELENBP1 selenium binding protein 1 2.04179
FAM163A family with sequence similarity 163, member A 2.03947
FAM122C family with sequence similarity 122C 2.03781
ARG1 arginase 1 2.0293
RD3L retinal degeneration 3-like 2.02841
PEX5 peroxisomal biogenesis factor 5 2.0262
PNMA2 paraneoplastic Ma antigen 2 2.02216
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.0089
SPANXN3 SPANX family, member N3 2.0054
OTUD5 OTU deubiquitinase 5 2.00519
DTX1 deltex 1, E3 ubiquitin ligase 2.00432
NXPH3 neurexophilin 3 2.00105