MSC Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description musculin|The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9242)
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Genes

332 genes differentially expressed following the MSC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPDEF SAM pointed domain containing ETS transcription factor 3.28932
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.28932
PNMA6F PNMA family member 6F 3.28932
VIT vitrin 3.28932
CLEC4D C-type lectin domain family 4, member D 3.28932
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.28932
TPTE transmembrane phosphatase with tensin homology 3.28932
FMR1NB fragile X mental retardation 1 neighbor 3.28932
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.28932
CH25H cholesterol 25-hydroxylase 3.28932
TMEM132D transmembrane protein 132D 3.28932
LOXL4 lysyl oxidase-like 4 3.28932
TAS2R19 taste receptor, type 2, member 19 3.28932
HBZ hemoglobin, zeta 3.28932
PCDH8 protocadherin 8 3.28932
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 3.28932
PRSS54 protease, serine, 54 3.28932
OPRL1 opiate receptor-like 1 3.28932
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.28932
ZNF705D zinc finger protein 705D 3.28932
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.28932
OTOF otoferlin 3.28932
UNC93A unc-93 homolog A (C. elegans) 3.28932
PRSS38 protease, serine, 38 3.28932
PHOX2A paired-like homeobox 2a 3.28932
CELF3 CUGBP, Elav-like family member 3 3.18108
CA6 carbonic anhydrase VI 3.18108
H2BW2 H2B.W histone 2 3.18108
BIRC3 baculoviral IAP repeat containing 3 3.18108
GPR101 G protein-coupled receptor 101 3.18108
PTGFR prostaglandin F receptor (FP) 3.18108
GPR21 G protein-coupled receptor 21 3.18108
C19ORF67 chromosome 19 open reading frame 67 3.18108
GYPB glycophorin B (MNS blood group) 3.18108
PLAAT2 phospholipase A and acyltransferase 2 3.18108
NEU4 sialidase 4 3.18108
CCN6 cellular communication network factor 6 3.18108
SIGLEC5 sialic acid binding Ig-like lectin 5 3.18108
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 3.18108
ANGPTL8 angiopoietin like 8 3.18108
ARHGAP36 Rho GTPase activating protein 36 3.18108
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 3.18108
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.18108
H3-7 H3.7 histone (putative) 3.18108
HRG histidine-rich glycoprotein 3.18108
CD180 CD180 molecule 3.18108
LEP leptin 3.18108
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.18108
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.18108
TPPP tubulin polymerization promoting protein 3.18108
KLLN killin, p53-regulated DNA replication inhibitor 3.18108
PRDM13 PR domain containing 13 3.18108
TEX50 testis expressed 50 3.18108
OXT oxytocin/neurophysin I prepropeptide 3.18108
SPAAR small regulatory polypeptide of amino acid response 3.18108
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.18108
PNOC prepronociceptin 3.18108
DLX4 distal-less homeobox 4 3.18108
TSSK2 testis-specific serine kinase 2 3.18108
LRRC10B leucine rich repeat containing 10B 3.18108
ANXA2R annexin A2 receptor 3.18108
LRRC52 leucine rich repeat containing 52 3.18108
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.18108
RHCG Rh family, C glycoprotein 3.18108
SPATA31C1 SPATA31 subfamily C, member 1 3.18108
C1ORF162 chromosome 1 open reading frame 162 3.18108
TLR9 toll-like receptor 9 3.18108
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.18108
MYH13 myosin, heavy chain 13, skeletal muscle 3.18108
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.18108
EXOC3L1 exocyst complex component 3-like 1 3.18108
PTH parathyroid hormone 3.18108
LRRC71 leucine rich repeat containing 71 3.18108
TINAG tubulointerstitial nephritis antigen 3.18108
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.18108
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.18108
IMPG2 interphotoreceptor matrix proteoglycan 2 3.18108
C15ORF62 chromosome 15 open reading frame 62 3.18108
TBX10 T-box 10 3.18108
GAST gastrin 3.18108
HPR haptoglobin-related protein 3.18108
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.18108
H3-5 H3.5 histone 3.18108
MYBPC3 myosin binding protein C, cardiac 3.18108
PCDHGB3 protocadherin gamma subfamily B, 3 3.18108
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 3.18108
MILR1 mast cell immunoglobulin-like receptor 1 3.18108
ZNF662 zinc finger protein 662 3.18108
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 3.18108
SCGB3A1 secretoglobin, family 3A, member 1 3.18108
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 3.18108
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.18108
GPR52 G protein-coupled receptor 52 3.18108
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.18108
PCDHA8 protocadherin alpha 8 3.18108
CFAP99 cilia and flagella associated protein 99 3.18108
MYH7 myosin, heavy chain 7, cardiac muscle, beta 3.18108
CLDN5 claudin 5 3.18108
ZNF705A zinc finger protein 705A 3.18108
TMEM132E transmembrane protein 132E 3.18108
WDFY4 WDFY family member 4 3.18108
GOLGA6D golgin A6 family, member D 3.18108
APOC2 apolipoprotein C-II 3.18108
NUTM2F NUT family member 2F 3.18108
SLC7A4 solute carrier family 7, member 4 3.18108
POU2AF1 POU class 2 associating factor 1 3.18108
TTC9B tetratricopeptide repeat domain 9B 3.18108
DRD5 dopamine receptor D5 3.18108
IFITM5 interferon induced transmembrane protein 5 3.18108
CHRM4 cholinergic receptor, muscarinic 4 3.18108
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 3.18108
PICK1 protein interacting with PRKCA 1 3.18108
CDHR5 cadherin-related family member 5 3.18108
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.18108
CT55 cancer/testis antigen 55 3.18108
IL17REL interleukin 17 receptor E-like 3.18108
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 3.18108
MORC1 MORC family CW-type zinc finger 1 3.18108
CTAGE15 CTAGE family, member 15 3.18108
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 3.18108
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.18108
BTNL2 butyrophilin-like 2 3.18108
ARR3 arrestin 3, retinal (X-arrestin) 3.18108
CTAGE4 CTAGE family, member 4 3.18108
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.18108
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.18108
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.18108
NLRP6 NLR family, pyrin domain containing 6 3.18108
OTP orthopedia homeobox 3.18108
PASD1 PAS domain containing 1 3.18108
CLEC2A C-type lectin domain family 2, member A 3.18108
PLA2G5 phospholipase A2, group V 3.18108
ZPBP zona pellucida binding protein 3.18108
CLEC2B C-type lectin domain family 2, member B 3.18108
MB myoglobin 3.18108
GJC2 gap junction protein, gamma 2, 47kDa 3.18108
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.18108
ANKRD30A ankyrin repeat domain 30A 3.18108
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.18108
ADCY4 adenylate cyclase 4 3.18108
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.18108
TEX12 testis expressed 12 3.18108
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.18108
CLCA4 chloride channel accessory 4 3.18108
ZC3H12D zinc finger CCCH-type containing 12D 3.18108
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 3.18108
TRIM7 tripartite motif containing 7 3.18108
GRAP2 GRB2-related adaptor protein 2 3.18108
DEFB135 defensin, beta 135 3.18108
TGM6 transglutaminase 6 3.18108
GSC2 goosecoid homeobox 2 3.18108
CAPSL calcyphosine-like 3.18108
MZB1 marginal zone B and B1 cell-specific protein 3.18108
PPCS phosphopantothenoylcysteine synthetase 3.15721
C17ORF107 chromosome 17 open reading frame 107 3.12324
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 3.09379
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 3.05873
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 2.90198
BSX brain-specific homeobox 2.87872
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.87834
MXRA7 matrix-remodelling associated 7 2.81862
PAQR8 progestin and adipoQ receptor family member VIII 2.81862
SHMT1 serine hydroxymethyltransferase 1 (soluble) 2.77993
SUOX sulfite oxidase 2.73658
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 2.7286
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 2.70402
CPNE5 copine V 2.70402
EML4 echinoderm microtubule associated protein like 4 2.67285
FAM199X family with sequence similarity 199, X-linked 2.60951
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 2.59198
DSCAML1 Down syndrome cell adhesion molecule like 1 2.59198
ZNF718 zinc finger protein 718 2.56222
CCDC68 coiled-coil domain containing 68 2.54746
CYTL1 cytokine-like 1 2.54648
TTC7A tetratricopeptide repeat domain 7A 2.53481
ZNF429 zinc finger protein 429 2.52443
ANK2 ankyrin 2, neuronal 2.50572
ANKRD17 ankyrin repeat domain 17 2.49945
TSG101 tumor susceptibility 101 2.47048
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 2.45452
IL23A interleukin 23, alpha subunit p19 2.4519
DEMA1 DPM1 ER membrane anchor 1 2.45111
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.43272
C12ORF56 chromosome 12 open reading frame 56 2.41344
B3GAT3 beta-1,3-glucuronyltransferase 3 2.38365
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.35603
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 2.34602
WNT8B wingless-type MMTV integration site family, member 8B 2.3225
ITGB7 integrin, beta 7 2.3225
C19ORF84 chromosome 19 open reading frame 84 2.31394
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.30365
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.29311
ZPLD1 zona pellucida-like domain containing 1 2.29311
XKRX XK, Kell blood group complex subunit-related, X-linked 2.29311
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.2676
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.24818
ASF1A anti-silencing function 1A histone chaperone 2.21896
CAMKMT calmodulin-lysine N-methyltransferase 2.21896
REEP3 receptor accessory protein 3 2.21815
NKAIN1 Na+/K+ transporting ATPase interacting 1 2.21815
IPO8 importin 8 2.2114
RPL7L1 ribosomal protein L7-like 1 2.20816
TCF25 transcription factor 25 (basic helix-loop-helix) 2.20215
EFHC2 EF-hand domain (C-terminal) containing 2 2.18517
VCL vinculin 2.18372
DYM dymeclin 2.17923
PEX13 peroxisomal biogenesis factor 13 2.1746
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.17456
IRGQ immunity-related GTPase family, Q 2.17296
PKP2 plakophilin 2 2.17296
CACTIN cactin, spliceosome C complex subunit 2.17296
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.17296
COX7B cytochrome c oxidase subunit VIIb 2.17168
SPMIP3 sperm microtubule inner protein 3 2.17065
PRR22 proline rich 22 2.17065
C10ORF67 chromosome 10 open reading frame 67 2.17065
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.17065
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.17065
E2F4 E2F transcription factor 4, p107/p130-binding 2.12678
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.11808
TCEA2 transcription elongation factor A (SII), 2 2.0965
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.08518
NSUN4 NOP2/Sun domain family, member 4 2.07855
GRK5 G protein-coupled receptor kinase 5 2.06426
MED8 mediator complex subunit 8 2.05238
IL3RA interleukin 3 receptor, alpha (low affinity) 2.05043
RMI2 RecQ mediated genome instability 2 2.02282
PLEKHA7 pleckstrin homology domain containing, family A member 7 2.01972
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.01891
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 2.00272

decreased expression

Symbol Name Standardized Value
RPA4 replication protein A4, 30kDa -3.28932
ZBTB16 zinc finger and BTB domain containing 16 -3.28932
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.28932
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -3.28932
HLA-DMB major histocompatibility complex, class II, DM beta -3.28932
ATN1 atrophin 1 -3.2328
GABRP gamma-aminobutyric acid (GABA) A receptor, pi -3.18108
PCDHA7 protocadherin alpha 7 -3.18108
SLAIN1 SLAIN motif family, member 1 -3.18108
TEX35 testis expressed 35 -3.18108
ADRA1B adrenoceptor alpha 1B -3.18108
TMEM176B transmembrane protein 176B -3.18108
RAX retina and anterior neural fold homeobox -3.18108
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -3.18108
GPR179 G protein-coupled receptor 179 -3.18108
WNT5A wingless-type MMTV integration site family, member 5A -3.18108
RRAD Ras-related associated with diabetes -3.18108
TNS4 tensin 4 -3.18108
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 -3.18108
ITK IL2-inducible T-cell kinase -3.18108
WNT11 wingless-type MMTV integration site family, member 11 -3.18108
RASA4 RAS p21 protein activator 4 -3.18108
C11ORF42 chromosome 11 open reading frame 42 -3.18108
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -3.18108
OVOL3 ovo-like zinc finger 3 -3.18108
ADCY1 adenylate cyclase 1 (brain) -3.18108
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -3.18108
PRAM1 PML-RARA regulated adaptor molecule 1 -3.18108
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -3.18108
IL31RA interleukin 31 receptor A -3.18108
CFAP90 cilia and flagella associated protein 90 -3.18108
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -3.15721
LINC02798 long intergenic non-protein coding RNA 2798 -3.15721
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -3.12988
NIPSNAP2 nipsnap homolog 2 -3.00043
MED30 mediator complex subunit 30 -2.94041
IGSF6 immunoglobulin superfamily, member 6 -2.83747
IFT140 intraflagellar transport 140 -2.82187
C6ORF136 chromosome 6 open reading frame 136 -2.81862
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.81265
ZNF600 zinc finger protein 600 -2.78628
NME5 NME/NM23 family member 5 -2.7286
PEX6 peroxisomal biogenesis factor 6 -2.72222
ZDHHC18 zinc finger, DHHC-type containing 18 -2.65202
PCDHGA1 protocadherin gamma subfamily A, 1 -2.59944
CD101 CD101 molecule -2.56749
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -2.53473
MCMBP minichromosome maintenance complex binding protein -2.51424
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.48905
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.48781
CIB2 calcium and integrin binding family member 2 -2.48322
TAC3 tachykinin 3 -2.45204
MYL10 myosin, light chain 10, regulatory -2.45111
EPHA5 EPH receptor A5 -2.45111
DRICH1 aspartate-rich 1 -2.37488
SRRM5 serine/arginine repetitive matrix 5 -2.37488
KIF5C kinesin family member 5C -2.36135
EFHD1 EF-hand domain family, member D1 -2.30944
ZNF19 zinc finger protein 19 -2.30557
WSCD2 WSC domain containing 2 -2.29535
PTGR3 prostaglandin reductase 3 -2.29223
DOC2A double C2-like domains, alpha -2.29122
ADPRH ADP-ribosylarginine hydrolase -2.24213
MRPL58 mitochondrial ribosomal protein L58 -2.23851
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.2309
HSPA8 heat shock 70kDa protein 8 -2.22632
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -2.22206
EIF3L eukaryotic translation initiation factor 3, subunit L -2.2114
CNTN3 contactin 3 (plasmacytoma associated) -2.19971
MOG myelin oligodendrocyte glycoprotein -2.19971
CTSF cathepsin F -2.19971
HES3 hes family bHLH transcription factor 3 -2.19971
PLK5 polo-like kinase 5 -2.19971
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.19971
ADAM12 ADAM metallopeptidase domain 12 -2.19971
GK5 glycerol kinase 5 (putative) -2.18218
BANP BTG3 associated nuclear protein -2.18218
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -2.1746
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.1746
FOSL2 FOS-like antigen 2 -2.17296
TMEM238L transmembrane protein 238 like -2.17296
SOX7 SRY (sex determining region Y)-box 7 -2.16322
KIF18A kinesin family member 18A -2.12763
RBBP6 retinoblastoma binding protein 6 -2.12678
SH3BP5L SH3-binding domain protein 5-like -2.12678
CBR1 carbonyl reductase 1 -2.11377
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -2.11289
H2BC17 H2B clustered histone 17 -2.11289
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.11193
THEM4 thioesterase superfamily member 4 -2.09673
NPTX1 neuronal pentraxin I -2.07456
TMEM126A transmembrane protein 126A -2.06424
KIFBP kinesin family binding protein -2.06325
MELTF melanotransferrin -2.058
BBS2 Bardet-Biedl syndrome 2 -2.05588
STX7 syntaxin 7 -2.05585
ZC3H7B zinc finger CCCH-type containing 7B -2.04972
TMX4 thioredoxin-related transmembrane protein 4 -2.04152
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.04031
LSR lipolysis stimulated lipoprotein receptor -2.02027
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -2.00464
MRPS12 mitochondrial ribosomal protein S12 -2.00272