MSH3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mutS homolog 3|The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 4437)
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Genes

326 genes differentially expressed following the MSH3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HKDC1 hexokinase domain containing 1 2.58324
BTC betacellulin 2.58324
SPHKAP SPHK1 interactor, AKAP domain containing 2.58324
NUTM2A NUT family member 2A 2.58324
RGS22 regulator of G-protein signaling 22 2.58324
LRRC55 leucine rich repeat containing 55 2.58324
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.58324
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.58324
EXOC3L1 exocyst complex component 3-like 1 2.58324
BEAN1 brain expressed, associated with NEDD4, 1 2.58324
ANXA1 annexin A1 2.58324
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.58324
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.58324
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.58324
COL5A3 collagen, type V, alpha 3 2.58324
CD5 CD5 molecule 2.58324
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.58324
TNS4 tensin 4 2.58324
GJA9 gap junction protein, alpha 9, 59kDa 2.58324
RORC RAR-related orphan receptor C 2.58324
PCSK7 proprotein convertase subtilisin/kexin type 7 2.58324
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.58324
C11ORF52 chromosome 11 open reading frame 52 2.58324
WEE2 WEE1 homolog 2 (S. pombe) 2.58324
MYO1A myosin IA 2.58324
CD27 CD27 molecule 2.58324
VXN vexin 2.58324
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.49656
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.49656
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.49656
NPPB natriuretic peptide B 2.49656
DUXB double homeobox B 2.49656
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.49656
GPR52 G protein-coupled receptor 52 2.49656
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.49656
MYBPHL myosin binding protein H-like 2.49656
LURAP1L leucine rich adaptor protein 1-like 2.49656
SLFN11 schlafen family member 11 2.49656
HLF hepatic leukemia factor 2.49656
SCGB3A1 secretoglobin, family 3A, member 1 2.49656
MSC musculin 2.49656
ASB12 ankyrin repeat and SOCS box containing 12 2.49656
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.49656
OPRL1 opiate receptor-like 1 2.49656
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.49656
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.49656
TNIP3 TNFAIP3 interacting protein 3 2.49656
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.49656
SFTPB surfactant protein B 2.49656
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.49656
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.49656
EPB42 erythrocyte membrane protein band 4.2 2.49656
CAMP cathelicidin antimicrobial peptide 2.49656
ZFP57 ZFP57 zinc finger protein 2.49656
PCDHB8 protocadherin beta 8 2.49656
ADAD2 adenosine deaminase domain containing 2 2.49656
HES7 hes family bHLH transcription factor 7 2.49656
CSH2 chorionic somatomammotropin hormone 2 2.49656
LMO1 LIM domain only 1 (rhombotin 1) 2.49656
SSMEM1 serine-rich single-pass membrane protein 1 2.49656
BSX brain-specific homeobox 2.49656
ACKR5 atypical chemokine receptor 5 2.49656
CLDN16 claudin 16 2.49656
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 2.49656
HTRA4 HtrA serine peptidase 4 2.49656
ELOVL3 ELOVL fatty acid elongase 3 2.49656
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.49656
PDC phosducin 2.49656
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.49656
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.49656
DOK7 docking protein 7 2.49656
LTB4R2 leukotriene B4 receptor 2 2.49656
MCHR1 melanin-concentrating hormone receptor 1 2.49656
ZAR1 zygote arrest 1 2.49656
EXOC1L exocyst complex component 1 like 2.49656
SMIM45 small integral membrane protein 45 2.49656
C20ORF204 chromosome 20 open reading frame 204 2.49656
TMEM238L transmembrane protein 238 like 2.49656
SMIM35 small integral membrane protein 35 2.49656
EZHIP EZH inhibitory protein 2.49656
TMEM270 transmembrane protein 270 2.49656
VEGFD vascular endothelial growth factor D 2.49656
SMIM38 small integral membrane protein 38 2.49656
CMKLR1 chemerin chemokine-like receptor 1 2.49656
SELL selectin L 2.49656
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.49656
SIM2 single-minded family bHLH transcription factor 2 2.49656
MSX2 msh homeobox 2 2.49656
ZBTB16 zinc finger and BTB domain containing 16 2.49656
PCDHA1 protocadherin alpha 1 2.49656
PXDNL peroxidasin-like 2.49656
ACTL10 actin-like 10 2.49656
LIPJ lipase, family member J 2.49656
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.49656
MYT1L myelin transcription factor 1-like 2.49656
RNF113B ring finger protein 113B 2.49656
CELA2A chymotrypsin-like elastase family, member 2A 2.49656
C6 complement component 6 2.49656
C15ORF62 chromosome 15 open reading frame 62 2.49656
LAMA4 laminin, alpha 4 2.49656
CLEC6A C-type lectin domain family 6, member A 2.49656
C4ORF50 chromosome 4 open reading frame 50 2.49656
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.49656
LTF lactotransferrin 2.49656
TAS1R1 taste receptor, type 1, member 1 2.49656
OPN4 opsin 4 2.49656
VCX3B variable charge, X-linked 3B 2.49656
GPR75 G protein-coupled receptor 75 2.49656
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.49656
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.49656
OTC ornithine carbamoyltransferase 2.49656
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.49656
BTNL8 butyrophilin-like 8 2.49656
OR10R2 olfactory receptor, family 10, subfamily R, member 2 2.49656
LCN1 lipocalin 1 2.49656
KLF1 Kruppel-like factor 1 (erythroid) 2.49656
CAGE1 cancer antigen 1 2.49656
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.49656
TSNAXIP1 translin-associated factor X interacting protein 1 2.49656
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.49656
TMEM132D transmembrane protein 132D 2.49656
CASS4 Cas scaffolding protein family member 4 2.49656
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.49656
PHOSPHO1 phosphatase, orphan 1 2.49656
LRRC36 leucine rich repeat containing 36 2.49656
STAB1 stabilin 1 2.49656
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 2.49656
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.49656
CCDC154 coiled-coil domain containing 154 2.49656
RAB29 RAB29, member RAS oncogene family 2.49656
AGXT2 alanine--glyoxylate aminotransferase 2 2.49656
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.49656
GSTA2 glutathione S-transferase alpha 2 2.49656
NDE1 nudE neurodevelopment protein 1 2.49656
TMEM31 transmembrane protein 31 2.49656
LHX3 LIM homeobox 3 2.49656
RGS4 regulator of G-protein signaling 4 2.49656
FKBP15 FK506 binding protein 15, 133kDa 2.49656
C1ORF185 chromosome 1 open reading frame 185 2.49656
BHLHA15 basic helix-loop-helix family, member a15 2.49656
C7ORF33 chromosome 7 open reading frame 33 2.49656
AMN amnion associated transmembrane protein 2.49656
RBM24 RNA binding motif protein 24 2.49656
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.49656
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.49656
C20ORF144 chromosome 20 open reading frame 144 2.49656
KLK5 kallikrein-related peptidase 5 2.49656
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.49656
EPHA10 EPH receptor A10 2.49656
VSTM1 V-set and transmembrane domain containing 1 2.49656
OCM oncomodulin 2.49656
GOLGA8J golgin A8 family, member J 2.49656
IL12A interleukin 12A 2.49656
PADI1 peptidyl arginine deiminase, type I 2.49656
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.49656
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.49656
LAMP3 lysosomal-associated membrane protein 3 2.49656
TMEM132C transmembrane protein 132C 2.49656
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.49656
CYSRT1 cysteine-rich tail protein 1 2.49656
FXYD3 FXYD domain containing ion transport regulator 3 2.49656
PITX2 paired-like homeodomain 2 2.49656
NLRP11 NLR family, pyrin domain containing 11 2.49656
PANO1 proapoptotic nucleolar protein 1 2.49656
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.49656
CDCP2 CUB domain containing protein 2 2.49656
LRRC31 leucine rich repeat containing 31 2.49656
FLG2 filaggrin family member 2 2.49656
PISD phosphatidylserine decarboxylase 2.49656
ALOX15B arachidonate 15-lipoxygenase, type B 2.49656
HCST hematopoietic cell signal transducer 2.49656
POTEF POTE ankyrin domain family, member F 2.49656
MAGED4 melanoma antigen family D4 2.49656
MT1H metallothionein 1H 2.49656
TAS2R19 taste receptor, type 2, member 19 2.49656
POU5F2 POU domain class 5, transcription factor 2 2.49656
PRDM16 PR domain containing 16 2.49656
CHRM1 cholinergic receptor, muscarinic 1 2.49656
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.49656
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.49656
TEX36 testis expressed 36 2.49656
NT5DC2 5'-nucleotidase domain containing 2 2.48139
ASL argininosuccinate lyase 2.47629
RXFP1 relaxin/insulin-like family peptide receptor 1 2.45342
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.4369
PDCL2 phosducin-like 2 2.41589
HMOX2 heme oxygenase 2 2.40843
ZNF783 zinc finger family member 783 2.38963
CTSF cathepsin F 2.36368
RAPSN receptor-associated protein of the synapse 2.36368
SAMM50 SAMM50 sorting and assembly machinery component 2.29592
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.28006
CTSK cathepsin K 2.27976
STX1A syntaxin 1A (brain) 2.24102
LPIN1 lipin 1 2.22672
TEKT5 tektin 5 2.22672
ABI1 abl-interactor 1 2.20463
FABP3 fatty acid binding protein 3, muscle and heart 2.19758
JAGN1 jagunal homolog 1 (Drosophila) 2.19352
RNF4 ring finger protein 4 2.16507
RNF152 ring finger protein 152 2.16138
TRIP4 thyroid hormone receptor interactor 4 2.14951
SMIM20 small integral membrane protein 20 2.14666
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 2.11354
TRPT1 tRNA phosphotransferase 1 2.11087
SLAIN1 SLAIN motif family, member 1 2.09515
LIMK2 LIM domain kinase 2 2.09441
USP39 ubiquitin specific peptidase 39 2.0846
LPAR4 lysophosphatidic acid receptor 4 2.07575
ATP9B ATPase, class II, type 9B 2.05337
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 2.05316
SNTG1 syntrophin, gamma 1 2.03409
KRIT1 KRIT1, ankyrin repeat containing 2.02474
CDADC1 cytidine and dCMP deaminase domain containing 1 2.01553
GPR158 G protein-coupled receptor 158 2.01553
NRARP NOTCH-regulated ankyrin repeat protein 2.01553
ZNF226 zinc finger protein 226 2.01553

decreased expression

Symbol Name Standardized Value
CDAN1 codanin 1 -2.58324
ADHFE1 alcohol dehydrogenase, iron containing, 1 -2.58324
SFSWAP splicing factor, suppressor of white-apricot family -2.53925
CREG2 cellular repressor of E1A-stimulated genes 2 -2.53925
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -2.53925
SYT15B synaptotagmin 15B -2.53925
RIPK4 receptor-interacting serine-threonine kinase 4 -2.49656
ADAMTSL4 ADAMTS-like 4 -2.49656
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -2.49656
YY2 YY2 transcription factor -2.49656
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -2.49656
RRP1B ribosomal RNA processing 1B -2.49656
CHD5 chromodomain helicase DNA binding protein 5 -2.49656
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.49656
KISS1R KISS1 receptor -2.49656
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.49656
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.49656
PRSS22 protease, serine, 22 -2.49656
SET SET nuclear proto-oncogene -2.49656
DHRS3 dehydrogenase/reductase (SDR family) member 3 -2.49656
TWIST1 twist family bHLH transcription factor 1 -2.49656
GRM6 glutamate receptor, metabotropic 6 -2.49656
ASMT acetylserotonin O-methyltransferase -2.49656
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.49656
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.49656
BLNK B-cell linker -2.49656
GMPS guanine monphosphate synthase -2.49656
HBQ1 hemoglobin, theta 1 -2.49656
ADGRG1 adhesion G protein-coupled receptor G1 -2.49656
VIT vitrin -2.49656
ARL5C ADP-ribosylation factor-like 5C -2.49656
CPNE8-AS1 CPNE8 antisense RNA 1 -2.49656
KLHL35 kelch-like family member 35 -2.49656
PLAAT4 phospholipase A and acyltransferase 4 -2.49656
SSTR1 somatostatin receptor 1 -2.49656
PDRG1 p53 and DNA-damage regulated 1 -2.49656
NME8 NME/NM23 family member 8 -2.49656
TGFB3 transforming growth factor, beta 3 -2.49656
TAFA3 TAFA chemokine like family member 3 -2.49656
CTXND1 cortexin domain containing 1 -2.49656
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.49656
LKAAEAR1 LKAAEAR motif containing 1 -2.49656
ANKRD55 ankyrin repeat domain 55 -2.49656
TICAM1 toll-like receptor adaptor molecule 1 -2.49656
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.49656
CLEC4A C-type lectin domain family 4, member A -2.49656
DRC1 dynein regulatory complex subunit 1 -2.49656
LGALS14 lectin, galactoside-binding, soluble, 14 -2.49656
CDH17 cadherin 17, LI cadherin (liver-intestine) -2.49656
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.49656
AURKC aurora kinase C -2.49656
ALLC allantoicase -2.49656
TMEM185B transmembrane protein 185B -2.49656
IRX5 iroquois homeobox 5 -2.49656
KIF19 kinesin family member 19 -2.49656
SIGLEC10 sialic acid binding Ig-like lectin 10 -2.49656
PROX2 prospero homeobox 2 -2.49656
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -2.49656
MMP12 matrix metallopeptidase 12 -2.49656
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 -2.49656
MBOAT4 membrane bound O-acyltransferase domain containing 4 -2.49656
DHFR dihydrofolate reductase -2.47031
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.46761
TMTC3 transmembrane and tetratricopeptide repeat containing 3 -2.45342
CHMP7 charged multivesicular body protein 7 -2.45342
KDM3A lysine (K)-specific demethylase 3A -2.4255
FABP7 fatty acid binding protein 7, brain -2.4254
IRX2 iroquois homeobox 2 -2.40981
TMEM114 transmembrane protein 114 -2.38963
TCEAL4 transcription elongation factor A (SII)-like 4 -2.38963
MYL5 myosin, light chain 5, regulatory -2.36461
AUP1 ancient ubiquitous protein 1 -2.36407
PYY peptide YY -2.35623
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -2.35623
MSH3 mutS homolog 3 -2.35521
ZNF718 zinc finger protein 718 -2.35333
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 -2.32241
PROCA1 protein interacting with cyclin A1 -2.3131
INTS6L integrator complex subunit 6 like -2.30975
ZNG1C Zn regulated GTPase metalloprotein activator 1C -2.29592
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.29592
TMPO thymopoietin -2.2824
FAM171B family with sequence similarity 171, member B -2.26472
ASXL1 additional sex combs like transcriptional regulator 1 -2.24385
FANCE Fanconi anemia, complementation group E -2.23159
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -2.23159
MARCHF6 membrane associated ring-CH-type finger 6 -2.23159
C1QTNF7 C1q and tumor necrosis factor related protein 7 -2.23159
DNAH6 dynein, axonemal, heavy chain 6 -2.15257
FCRL5 Fc receptor-like 5 -2.15257
TMEM17 transmembrane protein 17 -2.11503
SLC7A14 solute carrier family 7, member 14 -2.11186
TTC9C tetratricopeptide repeat domain 9C -2.11186
MAEA macrophage erythroblast attacher -2.10524
TIGAR TP53 induced glycolysis regulatory phosphatase -2.10446
MACIR macrophage immunometabolism regulator -2.09515
PLAG1 pleiomorphic adenoma gene 1 -2.09515
NPIPA1 nuclear pore complex interacting protein family, member A1 -2.08966
SHCBP1 SHC SH2-domain binding protein 1 -2.07312
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) -2.06622
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.05337
DUSP28 dual specificity phosphatase 28 -2.05337
PTAFR platelet-activating factor receptor -2.05337
GLIPR2 GLI pathogenesis-related 2 -2.03445
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -2.03445
USH1C Usher syndrome 1C (autosomal recessive, severe) -2.03445
MED15 mediator complex subunit 15 -2.01553
FAM120B family with sequence similarity 120B -2.01553
AEBP1 AE binding protein 1 -2.01553