MSH4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mutS homolog 4|This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 4438)
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Genes

364 genes differentially expressed following the MSH4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.73552
GPR55 G protein-coupled receptor 55 2.73552
GPR52 G protein-coupled receptor 52 2.73552
HEATR9 HEAT repeat containing 9 2.73552
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.73552
TMEM176A transmembrane protein 176A 2.73552
MUC1 mucin 1, cell surface associated 2.73552
ZNF662 zinc finger protein 662 2.73552
SLC35G5 solute carrier family 35, member G5 2.73552
GPR151 G protein-coupled receptor 151 2.73552
RIMBP2 RIMS binding protein 2 2.73552
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.73552
PEAR1 platelet endothelial aggregation receptor 1 2.73552
AGTR1 angiotensin II receptor, type 1 2.73552
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 2.73552
KLHL31 kelch-like family member 31 2.73552
PCDHA2 protocadherin alpha 2 2.73552
HDC histidine decarboxylase 2.73552
CPED1 cadherin-like and PC-esterase domain containing 1 2.73552
CD300E CD300e molecule 2.73552
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.73552
MEP1B meprin A, beta 2.73552
WEE2 WEE1 homolog 2 (S. pombe) 2.73552
SBK3 SH3 domain binding kinase family, member 3 2.73552
SIX6 SIX homeobox 6 2.73552
TMPRSS11F transmembrane protease, serine 11F 2.73552
COL20A1 collagen, type XX, alpha 1 2.73552
SLC25A41 solute carrier family 25, member 41 2.73552
DUSP12 dual specificity phosphatase 12 2.73552
GJA10 gap junction protein, alpha 10, 62kDa 2.73552
TRIM42 tripartite motif containing 42 2.73552
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.73552
LGI1 leucine-rich, glioma inactivated 1 2.73552
PNOC prepronociceptin 2.73552
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.73552
CRYGC crystallin, gamma C 2.73552
SLC37A3 solute carrier family 37, member 3 2.73552
ACOT12 acyl-CoA thioesterase 12 2.73552
BMP2 bone morphogenetic protein 2 2.73552
EIF1AD eukaryotic translation initiation factor 1A domain containing 2.73552
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.73552
NMUR1 neuromedin U receptor 1 2.73552
MEIKIN meiotic kinetochore factor 2.73552
DLX4 distal-less homeobox 4 2.73552
PLCH2 phospholipase C, eta 2 2.73552
SIGLEC5 sialic acid binding Ig-like lectin 5 2.73552
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.73552
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.73552
ALPK2 alpha-kinase 2 2.73552
TNIP3 TNFAIP3 interacting protein 3 2.73552
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.73552
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.73552
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.73552
GLRA3 glycine receptor, alpha 3 2.73552
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.73552
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.73552
SERTM1 serine-rich and transmembrane domain containing 1 2.73552
SPMAP2L sperm microtubule associated protein 2 like 2.73552
ODAPH odontogenesis associated phosphoprotein 2.73552
DUSP29 dual specificity phosphatase 29 2.73552
CALHM5 calcium homeostasis modulator family member 5 2.73552
CYBC1 cytochrome b-245 chaperone 1 2.73552
ALPG alkaline phosphatase, germ cell 2.73552
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.73552
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 2.73552
CXCL13 chemokine (C-X-C motif) ligand 13 2.73552
ACER1 alkaline ceramidase 1 2.73552
STX11 syntaxin 11 2.73552
SRGN serglycin 2.73552
PKD2L1 polycystic kidney disease 2-like 1 2.73552
IHO1 interactor of HORMAD1 1 2.73552
IQCN IQ motif containing N 2.73552
ZNF606-AS1 ZNF606 antisense RNA 1 2.73552
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.73552
NHERF4 NHERF family PDZ scaffold protein 4 2.73552
CIMIP3 ciliary microtubule inner protein 3 2.73552
CIMAP1D CIMAP1 family member D 2.73552
C17ORF113 chromosome 17 open reading frame 113 2.73552
TMA7B translation machinery associated 7 homolog B 2.73552
SMIM45 small integral membrane protein 45 2.73552
MCTS2 MCTS family member 2 2.73552
RHEX regulator of hemoglobinization and erythroid cell expansion 2.73552
CIBAR2 CBY1 interacting BAR domain containing 2 2.73552
GLYATL1B glycine-N-acyltransferase like 1B 2.73552
LOC107986837 uncharacterized LOC107986837 2.73552
TRIM31 tripartite motif containing 31 2.73552
PAPOLB poly(A) polymerase beta (testis specific) 2.73552
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.73552
TMEM183A transmembrane protein 183A 2.73552
MYH13 myosin, heavy chain 13, skeletal muscle 2.73552
BHLHA9 basic helix-loop-helix family, member a9 2.73552
TFEC transcription factor EC 2.73552
IDO2 indoleamine 2,3-dioxygenase 2 2.73552
GOLGA6L4 golgin A6 family-like 4 2.73552
AXDND1 axonemal dynein light chain domain containing 1 2.73552
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.73552
BBS5 Bardet-Biedl syndrome 5 2.73552
CHRD chordin 2.73552
TRIM60 tripartite motif containing 60 2.73552
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.73552
EXOC3L4 exocyst complex component 3-like 4 2.73552
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.73552
TREX2 three prime repair exonuclease 2 2.73552
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.73552
KHDC1L KH homology domain containing 1-like 2.73552
GATA2 GATA binding protein 2 2.73552
GATA5 GATA binding protein 5 2.73552
LTB lymphotoxin beta (TNF superfamily, member 3) 2.73552
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.73552
TAS1R1 taste receptor, type 1, member 1 2.73552
VCX3B variable charge, X-linked 3B 2.73552
C7 complement component 7 2.73552
C9 complement component 9 2.73552
SNX20 sorting nexin 20 2.73552
FNIP1 folliculin interacting protein 1 2.73552
AQP7 aquaporin 7 2.73552
CXCR5 chemokine (C-X-C motif) receptor 5 2.73552
CXCR6 chemokine (C-X-C motif) receptor 6 2.73552
S100Z S100 calcium binding protein Z 2.73552
HSPA1L heat shock 70kDa protein 1-like 2.73552
TPSG1 tryptase gamma 1 2.73552
RTBDN retbindin 2.73552
GOLGA6C golgin A6 family, member C 2.73552
WFDC8 WAP four-disulfide core domain 8 2.73552
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.73552
PLET1 placenta expressed transcript 1 2.73552
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.73552
AQP4 aquaporin 4 2.73552
KLHL6 kelch-like family member 6 2.73552
NGFR nerve growth factor receptor 2.73552
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.73552
PCDHGB4 protocadherin gamma subfamily B, 4 2.73552
NPPA natriuretic peptide A 2.73552
CCDC154 coiled-coil domain containing 154 2.73552
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.73552
AKR1B15 aldo-keto reductase family 1, member B15 2.73552
SHOX2 short stature homeobox 2 2.73552
C18ORF63 chromosome 18 open reading frame 63 2.73552
LRTM2 leucine-rich repeats and transmembrane domains 2 2.73552
EFCAB9 EF-hand calcium binding domain 9 2.73552
DQX1 DEAQ box RNA-dependent ATPase 1 2.73552
MAB21L2 mab-21-like 2 (C. elegans) 2.73552
MUC13 mucin 13, cell surface associated 2.73552
SH2D1B SH2 domain containing 1B 2.73552
QRFP pyroglutamylated RFamide peptide 2.73552
GPR146 G protein-coupled receptor 146 2.73552
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.73552
OPTC opticin 2.73552
MEIS1 Meis homeobox 1 2.73552
CCNA1 cyclin A1 2.73552
C22ORF31 chromosome 22 open reading frame 31 2.73552
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.73552
TRIML1 tripartite motif family-like 1 2.73552
CFP complement factor properdin 2.73552
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.73552
SYNGR4 synaptogyrin 4 2.73552
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.73552
DHH desert hedgehog 2.73552
CNGB3 cyclic nucleotide gated channel beta 3 2.73552
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.73552
C20ORF144 chromosome 20 open reading frame 144 2.73552
ZC3H11D zinc finger CCCH-type containing 11D 2.73552
UTS2B urotensin 2B 2.73552
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.73552
CHIT1 chitinase 1 (chitotriosidase) 2.73552
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.73552
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.73552
RASL11A RAS-like, family 11, member A 2.73552
AMN amnion associated transmembrane protein 2.73552
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.73552
RASL12 RAS-like, family 12 2.73552
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.73552
RP2 retinitis pigmentosa 2 (X-linked recessive) 2.73552
MMP10 matrix metallopeptidase 10 2.73552
ADAM20 ADAM metallopeptidase domain 20 2.73552
WFDC10A WAP four-disulfide core domain 10A 2.73552
AQP1 aquaporin 1 (Colton blood group) 2.73552
CHIA chitinase, acidic 2.73552
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.73552
PF4V1 platelet factor 4 variant 1 2.73552
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.73552
SDSL serine dehydratase-like 2.73552
TGM6 transglutaminase 6 2.73552
A1CF APOBEC1 complementation factor 2.73552
GRAPL GRB2-related adaptor protein-like 2.73552
UBR1 ubiquitin protein ligase E3 component n-recognin 1 2.73552
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.73552
LPO lactoperoxidase 2.73552
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.73552
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.73552
TLDC2 TBC/LysM-associated domain containing 2 2.73552
MAPK11 mitogen-activated protein kinase 11 2.73552
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.73552
BTBD16 BTB (POZ) domain containing 16 2.73552
C9ORF50 chromosome 9 open reading frame 50 2.73552
C9ORF57 chromosome 9 open reading frame 57 2.73552
MC5R melanocortin 5 receptor 2.73552
ALLC allantoicase 2.73552
WFDC13 WAP four-disulfide core domain 13 2.73552
POTEJ POTE ankyrin domain family, member J 2.73552
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.73552
AMER2 APC membrane recruitment protein 2 2.73552
LPA lipoprotein, Lp(a) 2.73552
TRAF3 TNF receptor-associated factor 3 2.72959
LAMA3 laminin, alpha 3 2.6899
ZSCAN18 zinc finger and SCAN domain containing 18 2.63765
KLHDC7A kelch domain containing 7A 2.61326
YY1AP1 YY1 associated protein 1 2.6125
JAG1 jagged 1 2.59501
KLF9 Kruppel-like factor 9 2.59357
TTC29 tetratricopeptide repeat domain 29 2.59357
BCL7B B-cell CLL/lymphoma 7B 2.53971
CTRL chymotrypsin-like 2.52856
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.52856
GEMIN2 gem (nuclear organelle) associated protein 2 2.52856
CLDND2 claudin domain containing 2 2.4847
CRX cone-rod homeobox 2.45643
CPLX1 complexin 1 2.45643
SAMD14 sterile alpha motif domain containing 14 2.4507
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.44819
GM2A GM2 ganglioside activator 2.43789
MCF2 MCF.2 cell line derived transforming sequence 2.43183
SCYL2 SCY1-like 2 (S. cerevisiae) 2.38889
PCGF6 polycomb group ring finger 6 2.36222
CINP cyclin-dependent kinase 2 interacting protein 2.35929
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 2.34022
LIMS2 LIM and senescent cell antigen-like domains 2 2.32811
SDCCAG8 serologically defined colon cancer antigen 8 2.32787
VGF VGF nerve growth factor inducible 2.32357
ZBTB1 zinc finger and BTB domain containing 1 2.28097
GDNF glial cell derived neurotrophic factor 2.27484
TEKT2 tektin 2 (testicular) 2.27484
POMT2 protein-O-mannosyltransferase 2 2.24232
ZFP36L1 ZFP36 ring finger protein-like 1 2.23262
TECR trans-2,3-enoyl-CoA reductase 2.2272
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 2.21843
ZNF93 zinc finger protein 93 2.21473
ZNF90 zinc finger protein 90 2.18117
ZNF155 zinc finger protein 155 2.16916
SPATA6L spermatogenesis associated 6-like 2.16783
ZDHHC17 zinc finger, DHHC-type containing 17 2.16052
ECSIT ECSIT signalling integrator 2.15922
PAWR PRKC, apoptosis, WT1, regulator 2.15922
MCU mitochondrial calcium uniporter 2.13834
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2.12591
BLTP3A bridge-like lipid transfer protein family member 3A 2.11947
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) 2.10513
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.10142
GTF2B general transcription factor IIB 2.07817
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 2.06399
KIAA1217 KIAA1217 2.06023
CSRNP3 cysteine-serine-rich nuclear protein 3 2.05135
LHX4 LIM homeobox 4 2.04228
TEF thyrotrophic embryonic factor 2.03307
TLE4 transducin-like enhancer of split 4 2.03125
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.03037
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 2.02338
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.00057

decreased expression

Symbol Name Standardized Value
KNSTRN kinetochore-localized astrin/SPAG5 binding protein -2.73552
POMC proopiomelanocortin -2.73552
TMIGD3 transmembrane and immunoglobulin domain containing 3 -2.73552
OR13A1 olfactory receptor, family 13, subfamily A, member 1 -2.73552
ARL5C ADP-ribosylation factor-like 5C -2.73552
LCAT lecithin-cholesterol acyltransferase -2.73552
PYDC1 PYD (pyrin domain) containing 1 -2.73552
CCL27 chemokine (C-C motif) ligand 27 -2.73552
TGFB3 transforming growth factor, beta 3 -2.73552
TTLL10 tubulin tyrosine ligase-like family member 10 -2.73552
CERKL ceramide kinase-like -2.73552
COL6A6 collagen, type VI, alpha 6 -2.73552
DGAT2 diacylglycerol O-acyltransferase 2 -2.73552
ACTRT3 actin-related protein T3 -2.73552
SIX1 SIX homeobox 1 -2.73552
CA1 carbonic anhydrase I -2.73552
CD164L2 CD164 sialomucin-like 2 -2.73552
C6ORF58 chromosome 6 open reading frame 58 -2.73552
MCOLN3 mucolipin 3 -2.73552
ADAT3 adenosine deaminase, tRNA-specific 3 -2.73552
BMP8B bone morphogenetic protein 8b -2.73552
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.73552
OIT3 oncoprotein induced transcript 3 -2.73552
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.73552
CD37 CD37 molecule -2.73552
IRX1 iroquois homeobox 1 -2.73552
CATSPER4 cation channel, sperm associated 4 -2.73552
PIWIL2 piwi-like RNA-mediated gene silencing 2 -2.73552
ZNF527 zinc finger protein 527 -2.73552
VWF von Willebrand factor -2.73552
GPR68 G protein-coupled receptor 68 -2.73552
SEPTIN4 septin 4 -2.73552
NSG2 neuronal vesicle trafficking associated 2 -2.73552
ZNF658 zinc finger protein 658 -2.73552
TEX46 testis expressed 46 -2.73552
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa -2.73552
CEND1 cell cycle exit and neuronal differentiation 1 -2.73552
SIDT2 SID1 transmembrane family, member 2 -2.73552
KLF1 Kruppel-like factor 1 (erythroid) -2.73552
ALX1 ALX homeobox 1 -2.73552
SPATA1 spermatogenesis associated 1 -2.73552
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.73552
BAHCC1 BAH domain and coiled-coil containing 1 -2.73552
SPATA4 spermatogenesis associated 4 -2.73552
TBXA2R thromboxane A2 receptor -2.73552
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.73552
CLDN23 claudin 23 -2.73552
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -2.73552
ZNG1F Zn regulated GTPase metalloprotein activator 1F -2.72918
BEX5 brain expressed, X-linked 5 -2.72204
ZHX3 zinc fingers and homeoboxes 3 -2.69767
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.69504
GRIK5 glutamate receptor, ionotropic, kainate 5 -2.65604
EXOSC5 exosome component 5 -2.64834
ANGEL1 angel homolog 1 (Drosophila) -2.63765
CLVS2 clavesin 2 -2.59501
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.58754
ZNF586 zinc finger protein 586 -2.51167
GDE1 glycerophosphodiester phosphodiesterase 1 -2.49089
EFCAB7 EF-hand calcium binding domain 7 -2.46866
STAT1 signal transducer and activator of transcription 1, 91kDa -2.44464
EMP3 epithelial membrane protein 3 -2.44291
ZMYM4 zinc finger, MYM-type 4 -2.43887
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -2.40121
TMEM179B transmembrane protein 179B -2.3952
TMSB15C thymosin beta 15C -2.38685
ADORA1 adenosine A1 receptor -2.38685
STAB2 stabilin 2 -2.38685
SMIM30 small integral membrane protein 30 -2.38528
RNF207 ring finger protein 207 -2.35005
CCNC cyclin C -2.34501
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 -2.30617
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit -2.28097
LZTR1 leucine-zipper-like transcription regulator 1 -2.28097
PARP4 poly (ADP-ribose) polymerase family, member 4 -2.26104
C5ORF22 chromosome 5 open reading frame 22 -2.25869
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.25114
RASGEF1B RasGEF domain family, member 1B -2.23719
FAT2 FAT atypical cadherin 2 -2.23478
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.22635
AURKB aurora kinase B -2.21575
CAPS2 calcyphosine 2 -2.21473
NOTCH4 notch 4 -2.21198
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.17085
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 -2.16783
SGK1 serum/glucocorticoid regulated kinase 1 -2.16052
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.13834
ARID4B AT rich interactive domain 4B (RBP1-like) -2.13149
OPRD1 opioid receptor, delta 1 -2.12334
HSBP1 heat shock factor binding protein 1 -2.11894
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 -2.11444
IFT122 intraflagellar transport 122 -2.09794
SPEF2 sperm flagellar 2 -2.09303
TBC1D5 TBC1 domain family, member 5 -2.08988
PLP1 proteolipid protein 1 -2.0892
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -2.03507
FRAS1 Fraser extracellular matrix complex subunit 1 -2.03079
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.03079
RYK receptor-like tyrosine kinase -2.03037
DONSON downstream neighbor of SON -2.02338
TNPO2 transportin 2 -2.02338
NAV1 neuron navigator 1 -2.01805
ASCC2 activating signal cointegrator 1 complex subunit 2 -2.01596
RAB11FIP4 RAB11 family interacting protein 4 (class II) -2.01357
IQCH IQ motif containing H -2.00735
LARP1B La ribonucleoprotein domain family, member 1B -2.00057