MSH5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mutS homolog 5|This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 4439)
Similar Terms
Downloads & Tools

Genes

281 genes differentially expressed following the MSH5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GCSAML germinal center-associated, signaling and motility-like 3.19412
NFAM1 NFAT activating protein with ITAM motif 1 3.19412
XCL2 chemokine (C motif) ligand 2 3.19412
FOLR3 folate receptor 3 (gamma) 3.19412
MEI1 meiosis inhibitor 1 3.19412
ESX1 ESX homeobox 1 3.19412
FETUB fetuin B 3.19412
DSG3 desmoglein 3 3.19412
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.19412
LMO1 LIM domain only 1 (rhombotin 1) 3.19412
APLN apelin 3.19412
SLC25A41 solute carrier family 25, member 41 3.19412
OR10A3 olfactory receptor, family 10, subfamily A, member 3 3.19412
TM4SF1 transmembrane 4 L six family member 1 3.19412
ZNF662 zinc finger protein 662 3.19412
GFRA4 GDNF family receptor alpha 4 3.19412
TSGA13 testis specific, 13 3.19412
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.19412
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.19412
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.19412
MYOZ2 myozenin 2 3.19412
TMEM88 transmembrane protein 88 3.19412
LPO lactoperoxidase 3.19412
ICAM5 intercellular adhesion molecule 5, telencephalin 3.19412
ACADL acyl-CoA dehydrogenase, long chain 3.19412
GALP galanin-like peptide 3.19412
ERAP2 endoplasmic reticulum aminopeptidase 2 3.19412
KIAA1755 KIAA1755 3.19412
TMEM132C transmembrane protein 132C 3.19412
HES2 hes family bHLH transcription factor 2 3.19412
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.19412
ASGR2 asialoglycoprotein receptor 2 3.19412
TAS2R10 taste receptor, type 2, member 10 3.19412
FABP12 fatty acid binding protein 12 3.19412
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.19412
TDRD9 tudor domain containing 9 3.19412
PECAM1 platelet/endothelial cell adhesion molecule 1 3.19412
IZUMO3 IZUMO family member 3 3.19412
COLEC10 collectin sub-family member 10 (C-type lectin) 3.19412
COL20A1 collagen, type XX, alpha 1 3.19412
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.19412
KRT83 keratin 83, type II 3.19412
OTOS otospiralin 3.19412
PNMA8B PNMA family member 8B 3.19412
H1-6 H1.6 linker histone, cluster member 3.19412
DERPC DERPC proline and glycine rich nuclear protein 3.19412
CCN3 cellular communication network factor 3 3.19412
TEX55 testis expressed 55 3.19412
CBLL2 Cbl proto-oncogene like 2 3.19412
CFAP276 cilia and flagella associated protein 276 3.19412
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.19412
TNS1-AS1 TNS1 antisense RNA 1 3.19412
LINC02268 long intergenic non-protein coding RNA 2268 3.19412
WASH8P WAS protein family homolog 8, pseudogene 3.19412
CIMIP2C ciliary microtubule inner protein 2C 3.19412
SPMIP10 sperm microtubule inner protein 10 3.19412
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.19412
SPATA22 spermatogenesis associated 22 3.19412
DYNLRB2 dynein, light chain, roadblock-type 2 3.19412
OR5P2 olfactory receptor, family 5, subfamily P, member 2 3.19412
SIX2 SIX homeobox 2 3.19412
GJA3 gap junction protein, alpha 3, 46kDa 3.19412
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.19412
FABP9 fatty acid binding protein 9, testis 3.19412
IZUMO4 IZUMO family member 4 3.19412
PCDHA3 protocadherin alpha 3 3.19412
TUBA3D tubulin, alpha 3d 3.19412
C4ORF17 chromosome 4 open reading frame 17 3.19412
MAGEB2 melanoma antigen family B2 3.19412
ZIC4 Zic family member 4 3.19412
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.19412
BHLHA9 basic helix-loop-helix family, member a9 3.19412
PRR18 proline rich 18 3.19412
ASIC4 acid sensing (proton gated) ion channel family member 4 3.19412
PRDM7 PR domain containing 7 3.19412
C15ORF62 chromosome 15 open reading frame 62 3.19412
LOC107986837 uncharacterized LOC107986837 3.19412
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.19412
CLC Charcot-Leyden crystal galectin 3.19412
ZSCAN4 zinc finger and SCAN domain containing 4 3.19412
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.19412
TCAP titin-cap 3.19412
LRRC46 leucine rich repeat containing 46 3.19412
LRCOL1 leucine rich colipase-like 1 3.19412
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.19412
CABP7 calcium binding protein 7 3.19412
MORC1 MORC family CW-type zinc finger 1 3.19412
ESAM endothelial cell adhesion molecule 3.19412
CSF1R colony stimulating factor 1 receptor 3.19412
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.19412
LHX2 LIM homeobox 2 3.19412
PGR progesterone receptor 3.19412
LY96 lymphocyte antigen 96 3.19412
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 3.19412
PSKH2 protein serine kinase H2 3.19412
CLEC4C C-type lectin domain family 4, member C 3.19412
NPBWR1 neuropeptides B/W receptor 1 3.19412
TRADD TNFRSF1A-associated via death domain 3.19412
CALHM1 calcium homeostasis modulator 1 3.19412
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 3.19412
TAS2R50 taste receptor, type 2, member 50 3.19412
CDHR5 cadherin-related family member 5 3.19412
DLX3 distal-less homeobox 3 3.19412
DGCR6 DiGeorge syndrome critical region gene 6 3.19412
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.19412
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.19412
CIDEA cell death-inducing DFFA-like effector a 3.19412
MYLK2 myosin light chain kinase 2 3.19412
PLGLB2 plasminogen-like B2 3.19412
PXT1 peroxisomal, testis specific 1 3.19412
FGF10 fibroblast growth factor 10 3.19412
WFDC10A WAP four-disulfide core domain 10A 3.19412
AQP1 aquaporin 1 (Colton blood group) 3.19412
CSTL1 cystatin-like 1 3.19412
CGA glycoprotein hormones, alpha polypeptide 3.19412
MSLN mesothelin 3.19412
CIB4 calcium and integrin binding family member 4 3.19412
ZPLD1 zona pellucida-like domain containing 1 3.19412
ITGA8 integrin, alpha 8 3.19412
TNS2 tensin 2 3.19412
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.19412
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.19412
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.19412
CAPSL calcyphosine-like 3.19412
TRIM29 tripartite motif containing 29 3.19412
IL26 interleukin 26 3.19412
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.19412
IL25 interleukin 25 3.19412
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 3.19412
ORM2 orosomucoid 2 3.19412
IL21R interleukin 21 receptor 3.19412
CALML5 calmodulin-like 5 3.19412
NIBAN3 niban apoptosis regulator 3 3.1376
PF4 platelet factor 4 3.1376
GPR18 G protein-coupled receptor 18 3.1376
SHISA9 shisa family member 9 3.07498
H1-0 H1.0 linker histone 2.91402
TINAGL1 tubulointerstitial nephritis antigen-like 1 2.86513
SLC16A6 solute carrier family 16, member 6 2.81933
UBAP2 ubiquitin associated protein 2 2.70975
CPXM2 carboxypeptidase X (M14 family), member 2 2.69836
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 2.66143
NBN nibrin 2.64522
GOLIM4 golgi integral membrane protein 4 2.60439
SLC25A48 solute carrier family 25, member 48 2.51199
ENOSF1 enolase superfamily member 1 2.49494
SKI SKI proto-oncogene 2.42448
PRELID2 PRELI domain containing 2 2.39698
XKR9 XK, Kell blood group complex subunit-related family, member 9 2.38277
MET MET proto-oncogene, receptor tyrosine kinase 2.37853
SPDYE17 speedy/RINGO cell cycle regulator family member E17 2.35085
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.35085
DNAI2 dynein, axonemal, intermediate chain 2 2.32947
FRMD4B FERM domain containing 4B 2.25609
POMT1 protein-O-mannosyltransferase 1 2.23291
MKRN2OS MKRN2 opposite strand 2.17046
TICAM1 toll-like receptor adaptor molecule 1 2.1611
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.1611
PSPN persephin 2.1611
TNMD tenomodulin 2.1611
MRLN myoregulin 2.1611
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.1611
BTNL9 butyrophilin-like 9 2.1611
FIBIN fin bud initiation factor homolog (zebrafish) 2.1611
PTPRA protein tyrosine phosphatase, receptor type, A 2.1611
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.1611
RUNX3 runt-related transcription factor 3 2.1611
RBBP4 retinoblastoma binding protein 4 2.1611
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.1611
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.1611
MIS12 MIS12 kinetochore complex component 2.15507
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.15507
LRRC41 leucine rich repeat containing 41 2.15096
SNX32 sorting nexin 32 2.13466
SERTAD1 SERTA domain containing 1 2.13461
NPTXR neuronal pentraxin receptor 2.1133
RADX RPA1 related single stranded DNA binding protein, X-linked 2.09942
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 2.0875
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.07808
RABL3 RAB, member of RAS oncogene family-like 3 2.06487
VPS13B vacuolar protein sorting 13 homolog B (yeast) 2.04992
ZFYVE21 zinc finger, FYVE domain containing 21 2.0456
NECAP1 NECAP endocytosis associated 1 2.02199
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.02133
TSPYL2 TSPY-like 2 2.02133
TPRG1L tumor protein p63 regulated 1-like 2.01544
PDCD11 programmed cell death 11 2.01309

decreased expression

Symbol Name Standardized Value
KLLN killin, p53-regulated DNA replication inhibitor -3.19412
C21ORF58 chromosome 21 open reading frame 58 -3.19412
FER1L6 fer-1-like family member 6 -3.19412
GFI1B growth factor independent 1B transcription repressor -3.19412
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -3.19412
EDN1 endothelin 1 -3.19412
EXTL1 exostosin-like glycosyltransferase 1 -3.19412
TCTN3 tectonic family member 3 -3.19412
KLHL1 kelch-like family member 1 -3.19412
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -3.19412
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -3.19412
ZNF492 zinc finger protein 492 -3.19412
VTCN1 V-set domain containing T cell activation inhibitor 1 -3.19412
C1R complement component 1, r subcomponent -3.19412
GLRA3 glycine receptor, alpha 3 -3.19412
SLC10A4 solute carrier family 10, member 4 -3.19412
KRTAP13-4 keratin associated protein 13-4 -3.19412
PRDM12 PR domain containing 12 -3.19412
OXER1 oxoeicosanoid (OXE) receptor 1 -3.19412
ZSCAN26 zinc finger and SCAN domain containing 26 -3.19412
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -3.19412
PF4V1 platelet factor 4 variant 1 -3.19412
KLF1 Kruppel-like factor 1 (erythroid) -3.19412
FPR1 formyl peptide receptor 1 -3.19412
FMO1 flavin containing monooxygenase 1 -3.19412
LGALS14 lectin, galactoside-binding, soluble, 14 -3.19412
ALX3 ALX homeobox 3 -3.19412
AANAT aralkylamine N-acetyltransferase -3.19412
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -3.19412
C11ORF42 chromosome 11 open reading frame 42 -3.19412
GIPC3 GIPC PDZ domain containing family, member 3 -3.19412
CFAP65 cilia and flagella associated protein 65 -3.19412
SMIM41 small integral membrane protein 41 -3.19412
NT5C1B 5'-nucleotidase, cytosolic IB -3.19412
FMO3 flavin containing monooxygenase 3 -3.19412
MYO16 myosin XVI -3.19412
SPINK9 serine peptidase inhibitor, Kazal type 9 -3.19412
GPR83 G protein-coupled receptor 83 -3.19412
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -3.19412
UTS2R urotensin 2 receptor -3.19412
HAL histidine ammonia-lyase -3.19412
LOC124900192 uncharacterized LOC124900192 -3.19412
TSGA10IP testis specific, 10 interacting protein -3.19412
MUC16 mucin 16, cell surface associated -3.19412
PSD4 pleckstrin and Sec7 domain containing 4 -3.09415
EMILIN3 elastin microfibril interfacer 3 -3.09148
NUTF2 nuclear transport factor 2 -3.05572
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 -2.89229
SZRD1 SUZ RNA binding domain containing 1 -2.84663
APOM apolipoprotein M -2.8427
SNPH syntaphilin -2.78808
C5ORF58 chromosome 5 open reading frame 58 -2.7569
GSDMB gasdermin B -2.69022
PHETA2 PH domain containing endocytic trafficking adaptor 2 -2.6786
LIME1 Lck interacting transmembrane adaptor 1 -2.64522
IFRD2 interferon-related developmental regulator 2 -2.64203
PNKD paroxysmal nonkinesigenic dyskinesia -2.57362
RER1 retention in endoplasmic reticulum sorting receptor 1 -2.56958
ZNF749 zinc finger protein 749 -2.45893
MRPL53 mitochondrial ribosomal protein L53 -2.4213
ZNF404 zinc finger protein 404 -2.4213
GRHL3 grainyhead-like 3 (Drosophila) -2.4213
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.4213
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -2.3924
PACS2 phosphofurin acidic cluster sorting protein 2 -2.32324
PHYH phytanoyl-CoA 2-hydroxylase -2.28446
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.28213
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 -2.26957
ZNF688 zinc finger protein 688 -2.25973
TSLIG3C tRNA splicing ligase complex subunit 3C -2.24412
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) -2.24228
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.24228
FAM110A family with sequence similarity 110, member A -2.23961
UBA3 ubiquitin-like modifier activating enzyme 3 -2.16456
TSPAN11 tetraspanin 11 -2.1611
ACTA2 actin, alpha 2, smooth muscle, aorta -2.1611
MYL12B myosin, light chain 12B, regulatory -2.1611
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -2.1611
TMEM127 transmembrane protein 127 -2.1611
BBS1 Bardet-Biedl syndrome 1 -2.1611
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.1611
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.1611
RTTN rotatin -2.15178
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.13507
C5ORF63 chromosome 5 open reading frame 63 -2.13466
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.13466
C1QTNF4 C1q and tumor necrosis factor related protein 4 -2.10129
KATNBL1 katanin p80 subunit B-like 1 -2.09133
RNF123 ring finger protein 123 -2.06484
MYLK4 myosin light chain kinase family, member 4 -2.04992
KLKB1 kallikrein B, plasma (Fletcher factor) 1 -2.04992
RGMB repulsive guidance molecule family member b -2.04992
IL6R interleukin 6 receptor -2.0456
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.02382