MSH6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mutS homolog 6|This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 2956)
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Genes

359 genes differentially expressed following the MSH6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
C1ORF87 chromosome 1 open reading frame 87 4.20958
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 4.20958
NIPSNAP3B nipsnap homolog 3B (C. elegans) 4.20958
SIGLECL1 SIGLEC family like 1 4.20958
NXPH3 neurexophilin 3 4.20958
TNNI1 troponin I type 1 (skeletal, slow) 4.20958
BTLA B and T lymphocyte associated 4.20958
CNTNAP4 contactin associated protein-like 4 4.20958
PNMA5 paraneoplastic Ma antigen family member 5 4.20958
LRRC14B leucine rich repeat containing 14B 4.20958
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 4.20958
TXLNB taxilin beta 4.20958
VCX2 variable charge, X-linked 2 4.20958
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 4.20958
C5ORF52 chromosome 5 open reading frame 52 4.20958
PTPRH protein tyrosine phosphatase, receptor type, H 4.20958
LIPK lipase, family member K 4.20958
TAS2R31 taste receptor, type 2, member 31 4.20958
FAM3D family with sequence similarity 3, member D 4.20958
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 4.20958
ACR acrosin 4.20958
NDRG1 N-myc downstream regulated 1 4.20958
SBK3 SH3 domain binding kinase family, member 3 4.20958
LY86 lymphocyte antigen 86 4.20958
GJB2 gap junction protein, beta 2, 26kDa 4.20958
LRRC56 leucine rich repeat containing 56 4.20958
MTTP microsomal triglyceride transfer protein 4.20958
MEIKIN meiotic kinetochore factor 4.20958
CCDC38 coiled-coil domain containing 38 4.20958
YY2 YY2 transcription factor 4.20958
LGI1 leucine-rich, glioma inactivated 1 4.20958
LRRIQ4 leucine-rich repeats and IQ motif containing 4 4.20958
TMEM121 transmembrane protein 121 4.20958
BMP3 bone morphogenetic protein 3 4.20958
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 4.20958
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.20958
REM1 RAS (RAD and GEM)-like GTP-binding 1 4.20958
CPB2 carboxypeptidase B2 (plasma) 4.20958
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 4.20958
RGPD4 RANBP2-like and GRIP domain containing 4 4.20958
DSG3 desmoglein 3 4.20958
XCL2 chemokine (C motif) ligand 2 4.20958
SLC30A4 solute carrier family 30 (zinc transporter), member 4 4.20958
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 4.20958
CA6 carbonic anhydrase VI 4.20958
SLC39A5 solute carrier family 39 (zinc transporter), member 5 4.20958
UNC45B unc-45 homolog B (C. elegans) 4.20958
NRROS negative regulator of reactive oxygen species 4.20958
GADL1 glutamate decarboxylase-like 1 4.20958
PCDH8 protocadherin 8 4.20958
LVRN laeverin 4.20958
CLDN9 claudin 9 4.20958
LOC124906892 uncharacterized LOC124906892 4.20958
DERPC DERPC proline and glycine rich nuclear protein 4.20958
PNMA8B PNMA family member 8B 4.20958
GOLGA6L7 golgin A6 family like 7 4.20958
OTOA otoancorin 4.20958
ZNF726 zinc finger protein 726 4.20958
ROPN1L rhophilin associated tail protein 1-like 4.20958
ROPN1B rhophilin associated tail protein 1B 4.20958
LTB4R2 leukotriene B4 receptor 2 4.20958
C2ORF72 chromosome 2 open reading frame 72 4.20958
AANAT aralkylamine N-acetyltransferase 4.20958
LORICRIN loricrin cornified envelope precursor protein 4.20958
RTL5 retrotransposon Gag like 5 4.20958
FLACC1 flagellum associated containing coiled-coil domains 1 4.20958
LOC124904542 uncharacterized LOC124904542 4.20958
H4C15 H4 clustered histone 15 4.20958
H4C12 H4 clustered histone 12 4.20958
SERTM2 serine rich and transmembrane domain containing 2 4.20958
PEAK3 PEAK family member 3 4.20958
DEFB131B defensin beta 131B 4.20958
SPDYE9 speedy/RINGO cell cycle regulator family member E9 4.20958
DIPK1C divergent protein kinase domain 1C 4.20958
VXN vexin 4.20958
TEKTIP1 tektin bundle interacting protein 1 4.20958
VN1R1 vomeronasal 1 receptor 1 4.20958
PLN phospholamban 4.20958
ACTA2 actin, alpha 2, smooth muscle, aorta 4.20958
C7 complement component 7 4.20958
OVOL1 ovo-like zinc finger 1 4.20958
S100G S100 calcium binding protein G 4.20958
RASAL3 RAS protein activator like 3 4.20958
INSRR insulin receptor-related receptor 4.20958
GLP2R glucagon-like peptide 2 receptor 4.20958
ZNF575 zinc finger protein 575 4.20958
GGACT gamma-glutamylamine cyclotransferase 4.20958
IL31RA interleukin 31 receptor A 4.20958
EDAR ectodysplasin A receptor 4.20958
DDTL D-dopachrome tautomerase-like 4.20958
DLK1 delta-like 1 homolog (Drosophila) 4.20958
DYNAP dynactin associated protein 4.20958
DNAAF1 dynein, axonemal, assembly factor 1 4.20958
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 4.20958
PROX2 prospero homeobox 2 4.20958
DOK7 docking protein 7 4.20958
GRAP GRB2-related adaptor protein 4.20958
OR52E5 olfactory receptor, family 52, subfamily E, member 5 4.20958
LY6K lymphocyte antigen 6 complex, locus K 4.20958
GCSAM germinal center-associated, signaling and motility 4.20958
SMTNL1 smoothelin-like 1 4.20958
TUBA4B tubulin, alpha 4b 4.20958
CLDN5 claudin 5 4.20958
LEP leptin 4.20958
PRSS33 protease, serine, 33 4.20958
GP1BB glycoprotein Ib (platelet), beta polypeptide 4.20958
NACA2 nascent polypeptide-associated complex alpha subunit 2 4.20958
PRPH peripherin 4.20958
CCL27 chemokine (C-C motif) ligand 27 4.20958
CCL25 chemokine (C-C motif) ligand 25 4.20958
HHAT hedgehog acyltransferase 4.20958
ASTL astacin-like metallo-endopeptidase (M12 family) 4.20958
BRDT bromodomain, testis-specific 4.20958
BMX BMX non-receptor tyrosine kinase 4.20958
C17ORF107 chromosome 17 open reading frame 107 4.20958
PLA2G4D phospholipase A2, group IVD (cytosolic) 4.20958
DLX1 distal-less homeobox 1 4.20958
PRAM1 PML-RARA regulated adaptor molecule 1 4.20958
ACSM4 acyl-CoA synthetase medium-chain family member 4 4.20958
FCRLB Fc receptor-like B 4.20958
ANKRD62 ankyrin repeat domain 62 4.20958
ENDOU endonuclease, polyU-specific 4.20958
TSPAN32 tetraspanin 32 4.20958
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 4.20958
FBXO40 F-box protein 40 4.20958
CDC20B cell division cycle 20B 4.20958
CST7 cystatin F (leukocystatin) 4.20958
NIPAL4 NIPA-like domain containing 4 4.20958
HKDC1 hexokinase domain containing 1 4.20958
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 4.20958
MAB21L2 mab-21-like 2 (C. elegans) 4.20958
CGB7 chorionic gonadotropin, beta polypeptide 7 4.20958
PCDHGA4 protocadherin gamma subfamily A, 4 4.20958
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 4.20958
PCDHGA2 protocadherin gamma subfamily A, 2 4.20958
HAVCR1 hepatitis A virus cellular receptor 1 4.20958
FAM163A family with sequence similarity 163, member A 4.20958
BCL2A1 BCL2-related protein A1 4.20958
UBQLNL ubiquilin-like 4.20958
AQP7 aquaporin 7 4.20958
FBXO48 F-box protein 48 4.20958
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 4.20958
CTAGE9 CTAGE family, member 9 4.20958
CPSF4L cleavage and polyadenylation specific factor 4-like 4.20958
CYSLTR1 cysteinyl leukotriene receptor 1 4.20958
HOPX HOP homeobox 4.20958
ALOXE3 arachidonate lipoxygenase 3 4.20958
WNT10B wingless-type MMTV integration site family, member 10B 4.20958
BPIFC BPI fold containing family C 4.20958
VMO1 vitelline membrane outer layer 1 homolog (chicken) 4.20958
SPDEF SAM pointed domain containing ETS transcription factor 4.20958
ALOX12B arachidonate 12-lipoxygenase, 12R type 4.20958
PTPN7 protein tyrosine phosphatase, non-receptor type 7 4.20958
CCNA1 cyclin A1 4.20958
GRAP2 GRB2-related adaptor protein 2 4.20958
GCM2 glial cells missing homolog 2 (Drosophila) 4.20958
RAD9B RAD9 homolog B (S. pombe) 4.20958
CTRB1 chymotrypsinogen B1 4.20958
SHISA3 shisa family member 3 4.20958
FGF4 fibroblast growth factor 4 4.20958
FAM81B family with sequence similarity 81, member B 4.20958
EBI3 Epstein-Barr virus induced 3 4.20958
PASD1 PAS domain containing 1 4.20958
ICAM5 intercellular adhesion molecule 5, telencephalin 4.20958
OXER1 oxoeicosanoid (OXE) receptor 1 4.20958
NKPD1 NTPase, KAP family P-loop domain containing 1 4.20958
IL37 interleukin 37 4.20958
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 4.20958
OR14A16 olfactory receptor, family 14, subfamily A, member 16 4.20958
GSC2 goosecoid homeobox 2 4.20958
ACKR3 atypical chemokine receptor 3 4.20958
PSG3 pregnancy specific beta-1-glycoprotein 3 4.20958
POTEJ POTE ankyrin domain family, member J 4.20958
EFCAB12 EF-hand calcium binding domain 12 4.20958
NMBR neuromedin B receptor 4.20958
PCDHAC2 protocadherin alpha subfamily C, 2 4.20958
IL25 interleukin 25 4.20958
POU3F2 POU class 3 homeobox 2 4.20958
WFDC10A WAP four-disulfide core domain 10A 4.20958
SCN3A sodium channel, voltage gated, type III alpha subunit 4.20958
NPAS4 neuronal PAS domain protein 4 4.20958
NOX3 NADPH oxidase 3 4.10209
SERF1A small EDRK-rich factor 1A (telomeric) 4.10209
COL11A2 collagen, type XI, alpha 2 4.10209
TGDS TDP-glucose 4,6-dehydratase 3.97497
AK8 adenylate kinase 8 3.8571
ZNF354C zinc finger protein 354C 3.82477
IL11 interleukin 11 3.03341
CXCL14 chemokine (C-X-C motif) ligand 14 3.03341
PEX12 peroxisomal biogenesis factor 12 3.03341
LHFPL2 lipoma HMGIC fusion partner-like 2 2.93398
PLEKHA5 pleckstrin homology domain containing, family A member 5 2.92743
LACC1 laccase (multicopper oxidoreductase) domain containing 1 2.85133
GSK3B glycogen synthase kinase 3 beta 2.81916
ASPNAT aspartate N-acetyltransferase 2.7161
MYO5A myosin VA (heavy chain 12, myoxin) 2.69635
TECR trans-2,3-enoyl-CoA reductase 2.61841
MCMDC2 minichromosome maintenance domain containing 2 2.61429
SCAPER S-phase cyclin A-associated protein in the ER 2.59998
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2.59212
FKBP6 FK506 binding protein 6, 36kDa 2.56252
TTK TTK protein kinase 2.55519
RHOC ras homolog family member C 2.54085
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.54065
FUCA1 fucosidase, alpha-L- 1, tissue 2.50553
PSD pleckstrin and Sec7 domain containing 2.4945
CCDC74B coiled-coil domain containing 74B 2.49357
OCA2 oculocutaneous albinism II 2.46384
TTC22 tetratricopeptide repeat domain 22 2.45403
TMEM179 transmembrane protein 179 2.45403
ZNF444 zinc finger protein 444 2.40574
PLAGL1 pleiomorphic adenoma gene-like 1 2.40574
COTL1 coactosin-like F-actin binding protein 1 2.39898
SNTG1 syntrophin, gamma 1 2.3986
RPL38 ribosomal protein L38 2.39287
PTGES2 prostaglandin E synthase 2 2.36743
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.35428
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.32427
RGPD1 RANBP2-like and GRIP domain containing 1 2.32427
CA7 carbonic anhydrase VII 2.32427
SLC30A5 solute carrier family 30 (zinc transporter), member 5 2.32427
SYN3 synapsin III 2.32427
MT1X metallothionein 1X 2.31756
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 2.31315
WDR55 WD repeat domain 55 2.29726
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 2.26979
UNC119B unc-119 homolog B (C. elegans) 2.2696
CRYBG3 beta-gamma crystallin domain containing 3 2.1932
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 2.18463
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.16188
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 2.15002
GAL3ST3 galactose-3-O-sulfotransferase 3 2.14405
ZNF233 zinc finger protein 233 2.07859
C18ORF54 chromosome 18 open reading frame 54 2.06903
MPDU1 mannose-P-dolichol utilization defect 1 2.06696
TRPV1 transient receptor potential cation channel, subfamily V, member 1 2.05409
RAB39A RAB39A, member RAS oncogene family 2.05409
BOLA2B bolA family member 2B 2.028
PHF3 PHD finger protein 3 2.028

decreased expression

Symbol Name Standardized Value
SOST sclerostin -4.20958
COLEC10 collectin sub-family member 10 (C-type lectin) -4.20958
CX3CL1 chemokine (C-X3-C motif) ligand 1 -4.20958
HES3 hes family bHLH transcription factor 3 -4.20958
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -4.20958
SLA2 Src-like-adaptor 2 -4.20958
IQCJ IQ motif containing J -4.20958
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -4.20958
ABHD1 abhydrolase domain containing 1 -4.20958
FBLL1 fibrillarin-like 1 -4.20958
FLI1 Fli-1 proto-oncogene, ETS transcription factor -4.20958
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -4.20958
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -4.20958
CLCA1 chloride channel accessory 1 -4.20958
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -4.20958
CCDC83 coiled-coil domain containing 83 -4.20958
ADAM21 ADAM metallopeptidase domain 21 -4.20958
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -4.20958
ZNF492 zinc finger protein 492 -4.20958
CRYBB3 crystallin, beta B3 -4.20958
PROKR1 prokineticin receptor 1 -4.20958
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -4.20958
XKR7 XK, Kell blood group complex subunit-related family, member 7 -4.20958
EEF1AKMT3 EEF1A lysine methyltransferase 3 -4.20958
OTP orthopedia homeobox -4.20958
MINAR2 membrane integral NOTCH2 associated receptor 2 -4.20958
TENT5D terminal nucleotidyltransferase 5D -4.20958
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -4.20958
KLF4 Kruppel-like factor 4 (gut) -4.20958
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -4.20958
ZXDB zinc finger, X-linked, duplicated B -4.13673
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -3.99307
FXR2 fragile X mental retardation, autosomal homolog 2 -3.45836
BPHL biphenyl hydrolase-like (serine hydrolase) -3.42799
PAPPA2 pappalysin 2 -3.32937
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -3.32937
ZNF169 zinc finger protein 169 -3.29216
LCTL lactase-like -3.14537
NPB neuropeptide B -3.10009
CD82 CD82 molecule -3.10009
CFAP221 cilia and flagella associated protein 221 -3.10009
ZNF284 zinc finger protein 284 -3.10009
SMIM18 small integral membrane protein 18 -3.10009
SHD Src homology 2 domain containing transforming protein D -3.10009
RAB40A RAB40A, member RAS oncogene family -3.10009
HRH4 histamine receptor H4 -3.10009
FAM133A family with sequence similarity 133, member A -3.07446
KMT2A lysine (K)-specific methyltransferase 2A -2.99957
TONSL tonsoku-like, DNA repair protein -2.93498
FBXO31 F-box protein 31 -2.93337
MAMDC2 MAM domain containing 2 -2.91579
ZNF785 zinc finger protein 785 -2.8454
RAB32 RAB32, member RAS oncogene family -2.84066
YLPM1 YLP motif containing 1 -2.83418
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.81633
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.78097
ACTC1 actin, alpha, cardiac muscle 1 -2.7405
NUP88 nucleoporin 88kDa -2.7032
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.69224
ZNF92 zinc finger protein 92 -2.67262
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.6683
RAMP2 receptor (G protein-coupled) activity modifying protein 2 -2.66006
LIMK2 LIM domain kinase 2 -2.64771
ZNF597 zinc finger protein 597 -2.6297
PCDH1 protocadherin 1 -2.5792
TRABD2A TraB domain containing 2A -2.55519
COPS8 COP9 signalosome subunit 8 -2.54065
RELL1 RELT-like 1 -2.54065
DPYSL2 dihydropyrimidinase-like 2 -2.50553
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.4945
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.4945
RPL26 ribosomal protein L26 -2.49086
NXNL2 nucleoredoxin-like 2 -2.48964
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.4874
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.45584
SDHAF4 succinate dehydrogenase complex assembly factor 4 -2.42003
MSH6 mutS homolog 6 -2.40269
NRG4 neuregulin 4 -2.39898
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.39898
SPPL2B signal peptide peptidase like 2B -2.36733
LNP1 leukemia NUP98 fusion partner 1 -2.36184
NIT2 nitrilase family, member 2 -2.36
H4C9 H4 clustered histone 9 -2.3565
INKA1 inka box actin regulator 1 -2.35428
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.35428
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.35428
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.2723
SLC35D4 solute carrier family 35 member D4 -2.2699
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.26938
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.26938
MXRA8 matrix-remodelling associated 8 -2.24722
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.24722
LGI4 leucine-rich repeat LGI family, member 4 -2.24475
EXTL2 exostosin-like glycosyltransferase 2 -2.24329
MITF microphthalmia-associated transcription factor -2.2409
AKAP7 A kinase (PRKA) anchor protein 7 -2.21681
SPIRE1 spire-type actin nucleation factor 1 -2.21681
ANOS1 anosmin 1 -2.20875
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.20604
NXT1 nuclear transport factor 2-like export factor 1 -2.19488
WDR48 WD repeat domain 48 -2.18305
GRIPAP1 GRIP1 associated protein 1 -2.15713
ERP29 endoplasmic reticulum protein 29 -2.15002
KRCC1 lysine-rich coiled-coil 1 -2.15002
THAP10 THAP domain containing 10 -2.13592
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -2.11957
TSSK3 testis-specific serine kinase 3 -2.09546
ZMAT4 zinc finger, matrin-type 4 -2.09476
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.09451
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.08048
CIAO3 cytosolic iron-sulfur assembly component 3 -2.0788
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -2.07859
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) -2.06081
EDNRB endothelin receptor type B -2.04261
TUBB2A tubulin, beta 2A class IIa -2.028
RABL3 RAB, member of RAS oncogene family-like 3 -2.02092
SFMBT2 Scm-like with four mbt domains 2 -2.01991
OLFML2B olfactomedin-like 2B -2.01749
USP16 ubiquitin specific peptidase 16 -2.00414
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.00414