MSH6 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description mutS homolog 6|This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 2956)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_MSH6
Similar Terms
Downloads & Tools

Genes

31 co-expressed genes for MSH6 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADSL adenylosuccinate lyase
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CSE1L CSE1 chromosome segregation 1-like (yeast)
GMPS guanine monphosphate synthase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
H2AFZ H2A histone family, member Z
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
IARS isoleucyl-tRNA synthetase
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
LIG1 ligase I, DNA, ATP-dependent
LRPPRC leucine-rich pentatricopeptide repeat containing
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM3 minichromosome maintenance complex component 3
MLH1 mutL homolog 1
MRPL42 mitochondrial ribosomal protein L42
MRPS27 mitochondrial ribosomal protein S27
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPF small nuclear ribonucleoprotein polypeptide F
TCP1 t-complex 1