MSI1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description musashi RNA-binding protein 1|This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4440)
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Genes

347 genes differentially expressed following the MSI1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.45587
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.45587
ISL1 ISL LIM homeobox 1 3.45587
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.45587
TEX12 testis expressed 12 3.45587
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 3.45587
THBD thrombomodulin 3.45587
GARIN6 golgi associated RAB2 interactor family member 6 3.45587
TEKT2 tektin 2 (testicular) 3.45587
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.45587
MUSK muscle, skeletal, receptor tyrosine kinase 3.45587
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.45587
EBF2 early B-cell factor 2 3.45587
CLEC4C C-type lectin domain family 4, member C 3.45587
AANAT aralkylamine N-acetyltransferase 3.45587
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.45587
DPPA3 developmental pluripotency associated 3 3.45587
ARL5C ADP-ribosylation factor-like 5C 3.45587
H2BK1 H2B.K variant histone 1 3.45587
PRDM6 PR domain containing 6 3.45587
TMPRSS11A transmembrane protease, serine 11A 3.45587
TSPAN19 tetraspanin 19 3.45587
PITX3 paired-like homeodomain 3 3.45587
TMEM132C transmembrane protein 132C 3.38828
TREML2 triggering receptor expressed on myeloid cells-like 2 3.38828
AVP arginine vasopressin 3.38828
SAA1 serum amyloid A1 3.38828
PGLYRP2 peptidoglycan recognition protein 2 3.38828
TLR1 toll-like receptor 1 3.38828
TMPRSS13 transmembrane protease, serine 13 3.38828
TMEM121 transmembrane protein 121 3.38828
ZAR1L zygote arrest 1-like 3.38828
TCP11 t-complex 11, testis-specific 3.38828
C4BPA complement component 4 binding protein, alpha 3.38828
FCAR Fc fragment of IgA receptor 3.38828
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.38828
RLN3 relaxin 3 3.38828
BHLHA9 basic helix-loop-helix family, member a9 3.38828
GALR2 galanin receptor 2 3.38828
CLEC14A C-type lectin domain family 14, member A 3.38828
CFAP54 cilia and flagella associated 54 3.38828
KIAA1755 KIAA1755 3.38828
NMUR2 neuromedin U receptor 2 3.38828
PRR29 proline rich 29 3.38828
OIT3 oncoprotein induced transcript 3 3.38828
AMY2A amylase, alpha 2A (pancreatic) 3.38828
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.38828
EXOC3L4 exocyst complex component 3-like 4 3.38828
TWIST1 twist family bHLH transcription factor 1 3.38828
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.38828
PSD2 pleckstrin and Sec7 domain containing 2 3.38828
CPLX3 complexin 3 3.38828
CLDN22 claudin 22 3.38828
CREB3L3 cAMP responsive element binding protein 3-like 3 3.38828
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.38828
CPB2 carboxypeptidase B2 (plasma) 3.38828
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.38828
MAGEB3 melanoma antigen family B3 3.38828
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 3.38828
PRSS41 protease, serine, 41 3.38828
PDIA2 protein disulfide isomerase family A, member 2 3.38828
KNG1 kininogen 1 3.38828
FBXL8 F-box and leucine-rich repeat protein 8 3.38828
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.38828
GPR55 G protein-coupled receptor 55 3.38828
DMP1 dentin matrix acidic phosphoprotein 1 3.38828
REG4 regenerating islet-derived family, member 4 3.38828
FOLR1 folate receptor 1 (adult) 3.38828
PCDHA3 protocadherin alpha 3 3.38828
ACTL10 actin-like 10 3.38828
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.38828
RS1 retinoschisin 1 3.38828
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 3.38828
FPR2 formyl peptide receptor 2 3.38828
CLEC19A C-type lectin domain family 19, member A 3.38828
LRRC14B leucine rich repeat containing 14B 3.38828
SGPP2 sphingosine-1-phosphate phosphatase 2 3.38828
GOLGA7B golgin A7 family, member B 3.38828
CXCL16 chemokine (C-X-C motif) ligand 16 3.38828
GMFG glia maturation factor, gamma 3.38828
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.38828
AVPR2 arginine vasopressin receptor 2 3.38828
SLC26A11 solute carrier family 26 (anion exchanger), member 11 3.38828
C16ORF82 chromosome 16 open reading frame 82 3.38828
CATSPER1 cation channel, sperm associated 1 3.38828
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.38828
LIX1 Lix1 homolog (chicken) 3.38828
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.38828
SIGLEC8 sialic acid binding Ig-like lectin 8 3.38828
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.38828
FFAR4 free fatty acid receptor 4 3.38828
TMEM100 transmembrane protein 100 3.38828
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.38828
MAL mal, T-cell differentiation protein 3.38828
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.38828
KLK15 kallikrein-related peptidase 15 3.38828
ZC3H11D zinc finger CCCH-type containing 11D 3.38828
PRDM9 PR domain containing 9 3.38828
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.38828
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.38828
ISL2 ISL LIM homeobox 2 3.38828
DUSP29 dual specificity phosphatase 29 3.38828
RTL5 retrotransposon Gag like 5 3.38828
VWA3A von Willebrand factor A domain containing 3A 3.38828
AGXT2 alanine--glyoxylate aminotransferase 2 3.38828
PCDHGA3 protocadherin gamma subfamily A, 3 3.38828
CCDC27 coiled-coil domain containing 27 3.38828
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.38828
MAGEE2 melanoma antigen family E2 3.38828
TRADD TNFRSF1A-associated via death domain 3.38828
FAM177B family with sequence similarity 177, member B 3.38828
CALHM3 calcium homeostasis modulator 3 3.38828
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.38828
C8A complement component 8, alpha polypeptide 3.38828
PRR35 proline rich 35 3.38828
CPHXL cytoplasmic polyadenylated homeobox like 3.38828
CATSPERH catsper channel auxiliary subunit eta 3.38828
TEX29 testis expressed 29 3.38828
SFTA2 surfactant associated 2 3.38828
CXORF58 chromosome X open reading frame 58 3.38828
FAM90A12 family with sequence similarity 90 member A12 3.38828
LMX1B LIM homeobox transcription factor 1, beta 3.38828
IL25 interleukin 25 3.38828
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.38828
DRC5 dynein regulatory complex subunit 5 3.38828
TYR tyrosinase 3.38828
CIMIP2A ciliary microtubule inner protein 2A 3.38828
ORM2 orosomucoid 2 3.38828
HMGB4 high mobility group box 4 3.38828
CIMIP2C ciliary microtubule inner protein 2C 3.38828
SIGLEC11 sialic acid binding Ig-like lectin 11 3.38828
TPPP3 tubulin polymerization-promoting protein family member 3 3.38828
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.38828
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.38828
ACE2 angiotensin I converting enzyme 2 3.38828
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.38828
KIF4B kinesin family member 4B 3.38828
CARD6 caspase recruitment domain family, member 6 3.38828
SPATA22 spermatogenesis associated 22 3.38828
VSIG8 V-set and immunoglobulin domain containing 8 3.38828
NR2E1 nuclear receptor subfamily 2, group E, member 1 3.38828
SLITRK2 SLIT and NTRK-like family, member 2 3.38828
POTEF POTE ankyrin domain family, member F 3.38828
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.38828
FGF17 fibroblast growth factor 17 3.38828
FGR FGR proto-oncogene, Src family tyrosine kinase 3.38828
AQP1 aquaporin 1 (Colton blood group) 3.38828
CSAG1 chondrosarcoma associated gene 1 3.38828
ITPKA inositol-trisphosphate 3-kinase A 3.38828
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.38828
LTA lymphotoxin alpha 3.38828
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.38828
ONECUT3 one cut homeobox 3 3.38828
C2ORF66 chromosome 2 open reading frame 66 3.38828
RGS13 regulator of G-protein signaling 13 3.38828
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.38828
RAG1 recombination activating gene 1 3.38828
TREX2 three prime repair exonuclease 2 3.38828
UBQLN3 ubiquilin 3 3.38828
SQOR sulfide quinone oxidoreductase 3.38828
H1-6 H1.6 linker histone, cluster member 3.38828
RFPL1 ret finger protein-like 1 3.38828
CLPS colipase, pancreatic 3.38828
RPA4 replication protein A4, 30kDa 3.38828
VAX2 ventral anterior homeobox 2 3.38828
SMIM22 small integral membrane protein 22 3.38828
GP1BA glycoprotein Ib (platelet), alpha polypeptide 3.38828
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 3.27078
ACADL acyl-CoA dehydrogenase, long chain 3.24009
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 3.24009
CSMD3 CUB and Sushi multiple domains 3 3.24009
CLEC2A C-type lectin domain family 2, member A 3.12571
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.12571
SCRN2 secernin 2 3.09762
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.02259
ALDOC aldolase C, fructose-bisphosphate 2.98485
VAC14 Vac14 homolog (S. cerevisiae) 2.87488
KDM7A lysine (K)-specific demethylase 7A 2.8496
DACH1 dachshund family transcription factor 1 2.76196
ZNF586 zinc finger protein 586 2.71991
TIMP2 TIMP metallopeptidase inhibitor 2 2.67804
ZNF83 zinc finger protein 83 2.66185
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.60348
OTX2 orthodenticle homeobox 2 2.5411
THADA thyroid adenoma associated 2.5064
GLS2 glutaminase 2 (liver, mitochondrial) 2.49599
CCL2 chemokine (C-C motif) ligand 2 2.47585
SCFD1 sec1 family domain containing 1 2.47585
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.43188
MACIR macrophage immunometabolism regulator 2.37825
CETN2 centrin, EF-hand protein, 2 2.34561
SCD5 stearoyl-CoA desaturase 5 2.33872
TMEM260 transmembrane protein 260 2.31681
OSBPL10 oxysterol binding protein-like 10 2.3063
ATP5F1A ATP synthase F1 subunit alpha 2.3063
C12ORF76 chromosome 12 open reading frame 76 2.30529
ADAP2 ArfGAP with dual PH domains 2 2.29607
ERVV-2 endogenous retrovirus group V, member 2 2.28338
MUCL3 mucin like 3 2.28338
DAND5 DAN domain family member 5, BMP antagonist 2.28338
LDHC lactate dehydrogenase C 2.28338
C17ORF75 chromosome 17 open reading frame 75 2.27892
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 2.27658
ULK2 unc-51 like autophagy activating kinase 2 2.27658
ADGRB3 adhesion G protein-coupled receptor B3 2.26434
TPM4 tropomyosin 4 2.2549
MRPS30 mitochondrial ribosomal protein S30 2.2341
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.22868
PPP1R21 protein phosphatase 1, regulatory subunit 21 2.21518
ZSCAN9 zinc finger and SCAN domain containing 9 2.21518
MICALL2 MICAL-like 2 2.20414
TEFM transcription elongation factor, mitochondrial 2.19679
XYLT1 xylosyltransferase I 2.18426
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.18426
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.18019
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 2.178
ADIRF adipogenesis regulatory factor 2.178
TMEM255A transmembrane protein 255A 2.178
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.178
OPRL1 opiate receptor-like 1 2.178
FGF23 fibroblast growth factor 23 2.178
DUSP8 dual specificity phosphatase 8 2.178
STRIT1 small transmembrane regulator of ion transport 1 2.178
GLOD4 glyoxalase domain containing 4 2.17396
CREB3L1 cAMP responsive element binding protein 3-like 1 2.15515
HRH1 histamine receptor H1 2.14953
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 2.14877
SORCS3 sortilin-related VPS10 domain containing receptor 3 2.12613
MMP16 matrix metallopeptidase 16 (membrane-inserted) 2.1213
ZFAND2B zinc finger, AN1-type domain 2B 2.11065
SORCS2 sortilin-related VPS10 domain containing receptor 2 2.10916
CEP57 centrosomal protein 57kDa 2.10916
TBC1D30 TBC1 domain family, member 30 2.10563
CARF calcium responsive transcription factor 2.09505
SNRPG small nuclear ribonucleoprotein polypeptide G 2.08843
AHCYL2 adenosylhomocysteinase-like 2 2.07426
NUCB1 nucleobindin 1 2.06649
COX14 COX14 cytochrome c oxidase assembly factor 2.05135
GPAA1 glycosylphosphatidylinositol anchor attachment 1 2.04358
RIPK4 receptor-interacting serine-threonine kinase 4 2.04358
MLF2 myeloid leukemia factor 2 2.04351
MRPS5 mitochondrial ribosomal protein S5 2.02175
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.01813
MSH4 mutS homolog 4 2.01287
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 2.00498
CIZ1 CDKN1A interacting zinc finger protein 1 2.00359

decreased expression

Symbol Name Standardized Value
NRIP2 nuclear receptor interacting protein 2 -3.45587
SPHK1 sphingosine kinase 1 -3.45587
ANKRD53 ankyrin repeat domain 53 -3.45587
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -3.45587
TEX53 testis expressed 53 -3.38828
SHISA8 shisa family member 8 -3.38828
CD164 CD164 molecule, sialomucin -3.38828
CCDC13 coiled-coil domain containing 13 -3.38828
KLHL6 kelch-like family member 6 -3.38828
TMIE transmembrane inner ear -3.38828
ZMYND15 zinc finger, MYND-type containing 15 -3.38828
IZUMO3 IZUMO family member 3 -3.38828
SOGA3 SOGA family member 3 -3.38828
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 -3.38828
MST1 macrophage stimulating 1 -3.38828
CLCNKA chloride channel, voltage-sensitive Ka -3.38828
ZNF843 zinc finger protein 843 -3.38828
FNDC7 fibronectin type III domain containing 7 -3.38828
TMEM275 transmembrane protein 275 -3.38828
LRRC8C-DT LRRC8C divergent transcript -3.38828
TMT1B thiol methyltransferase 1B -3.38828
CNR2 cannabinoid receptor 2 (macrophage) -3.38828
GPR20 G protein-coupled receptor 20 -3.38828
IDO2 indoleamine 2,3-dioxygenase 2 -3.38828
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.38828
RAMACL RNA guanine-7 methyltransferase activating subunit like -3.38828
GLYATL1B glycine-N-acyltransferase like 1B -3.38828
VAV1 vav 1 guanine nucleotide exchange factor -3.38828
EXPH5 exophilin 5 -3.24009
AOAH acyloxyacyl hydrolase (neutrophil) -3.14533
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -3.14533
MARK4 MAP/microtubule affinity-regulating kinase 4 -2.97056
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.9625
ELAC2 elaC ribonuclease Z 2 -2.82144
KCTD5 potassium channel tetramerization domain containing 5 -2.73848
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -2.65727
PNMA6A paraneoplastic Ma antigen family member 6A -2.64525
PROKR1 prokineticin receptor 1 -2.64525
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.64525
MLH3 mutL homolog 3 -2.64525
TMEM229A transmembrane protein 229A -2.64525
FAM149B1 family with sequence similarity 149, member B1 -2.64525
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.64525
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.60348
NBPF1 neuroblastoma breakpoint family, member 1 -2.60068
GNS glucosamine (N-acetyl)-6-sulfatase -2.57885
FOXK1 forkhead box K1 -2.54609
POGZ pogo transposable element with ZNF domain -2.51235
LINC02798 long intergenic non-protein coding RNA 2798 -2.46156
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.46156
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.45005
DUSP6 dual specificity phosphatase 6 -2.4472
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -2.44628
RPL36AL ribosomal protein L36a-like -2.39403
HHLA1 HERV-H LTR-associating 1 -2.36498
RAB30 RAB30, member RAS oncogene family -2.34326
NCK2 NCK adaptor protein 2 -2.32987
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.3203
NELL1 NEL-like 1 (chicken) -2.31681
HLA-DMB major histocompatibility complex, class II, DM beta -2.31665
CFAP410 cilia and flagella associated protein 410 -2.31523
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) -2.29981
GOLGA7 golgin A7 -2.2712
ZFR zinc finger RNA binding protein -2.26434
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.2341
POGLUT2 protein O-glucosyltransferase 2 -2.2341
NAP1L4 nucleosome assembly protein 1-like 4 -2.22864
SLFN13 schlafen family member 13 -2.22006
DPY30 dpy-30 homolog (C. elegans) -2.21518
TSC22D4 TSC22 domain family, member 4 -2.20333
DCAF11 DDB1 and CUL4 associated factor 11 -2.19791
VSIG10 V-set and immunoglobulin domain containing 10 -2.19162
BTBD6 BTB (POZ) domain containing 6 -2.178
RAB29 RAB29, member RAS oncogene family -2.17709
ARHGAP33 Rho GTPase activating protein 33 -2.15515
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 -2.14768
SLC39A9 solute carrier family 39, member 9 -2.14546
ZFYVE21 zinc finger, FYVE domain containing 21 -2.14546
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.13559
GRIK1 glutamate receptor, ionotropic, kainate 1 -2.12518
SH2D4A SH2 domain containing 4A -2.1213
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -2.11985
PTPRR protein tyrosine phosphatase, receptor type, R -2.11065
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) -2.10917
CNOT1 CCR4-NOT transcription complex, subunit 1 -2.10486
ESYT1 extended synaptotagmin-like protein 1 -2.08968
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.08213
UNC5A unc-5 homolog A (C. elegans) -2.06649
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -2.06649
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial -2.05766
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -2.05766
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.05585
KDM2A lysine (K)-specific demethylase 2A -2.05114
CLASRP CLK4-associating serine/arginine rich protein -2.04107
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -2.03424
SLC16A13 solute carrier family 16, member 13 -2.02175
CLVS2 clavesin 2 -2.02175
POM121C POM121 transmembrane nucleoporin C -2.02175
YARS1 tyrosyl-tRNA synthetase 1 -2.01668
HAUS4 HAUS augmin-like complex, subunit 4 -2.01668
ZC3H8 zinc finger CCCH-type containing 8 -2.00385