MSX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description msh homeobox 1|This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4487)
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Genes

318 genes differentially expressed following the MSX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF843 zinc finger protein 843 3.35381
UPB1 ureidopropionase, beta 3.35381
DOK7 docking protein 7 3.35381
PRB3 proline-rich protein BstNI subfamily 3 3.35381
TMEM176B transmembrane protein 176B 3.35381
ADAM2 ADAM metallopeptidase domain 2 3.35381
ASB12 ankyrin repeat and SOCS box containing 12 3.35381
TACR2 tachykinin receptor 2 3.35381
COL17A1 collagen, type XVII, alpha 1 3.35381
PAX5 paired box 5 3.35381
CXCL13 chemokine (C-X-C motif) ligand 13 3.35381
MEP1B meprin A, beta 3.35381
FER1L6 fer-1-like family member 6 3.35381
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.35381
MCHR1 melanin-concentrating hormone receptor 1 3.35381
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.35381
TMPRSS11A transmembrane protease, serine 11A 3.35381
CD6 CD6 molecule 3.32543
TM4SF4 transmembrane 4 L six family member 4 3.32543
KRT24 keratin 24, type I 3.32543
CD274 CD274 molecule 3.32543
NPPB natriuretic peptide B 3.32543
TNNI1 troponin I type 1 (skeletal, slow) 3.32543
ZNF662 zinc finger protein 662 3.32543
MAP3K7CL MAP3K7 C-terminal like 3.32543
OR5B12 olfactory receptor, family 5, subfamily B, member 12 3.32543
PI16 peptidase inhibitor 16 3.32543
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.32543
CABP4 calcium binding protein 4 3.32543
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.32543
APLN apelin 3.32543
PAX7 paired box 7 3.32543
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.32543
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.32543
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3.32543
TDRD9 tudor domain containing 9 3.32543
LCN15 lipocalin 15 3.32543
PPIAL4G peptidylprolyl isomerase A (cyclophilin A)-like 4G 3.32543
C8ORF74 chromosome 8 open reading frame 74 3.32543
JKAMP JNK1/MAPK8-associated membrane protein 3.32543
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 3.32543
TRAT1 T cell receptor associated transmembrane adaptor 1 3.32543
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.32543
OLIG3 oligodendrocyte transcription factor 3 3.32543
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.32543
MUSK muscle, skeletal, receptor tyrosine kinase 3.32543
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.32543
MFAP5 microfibrillar associated protein 5 3.32543
GPR21 G protein-coupled receptor 21 3.32543
MYOM3 myomesin 3 3.32543
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.32543
SP7 Sp7 transcription factor 3.32543
LBX2 ladybird homeobox 2 3.32543
HLF hepatic leukemia factor 3.32543
ADGRG3 adhesion G protein-coupled receptor G3 3.32543
KRT86 keratin 86, type II 3.32543
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.32543
FCMR Fc fragment of IgM receptor 3.32543
TSPAN8 tetraspanin 8 3.32543
IL16 interleukin 16 3.32543
TMEM119 transmembrane protein 119 3.32543
SPATA31F1 SPATA31 subfamily F member 1 3.32543
PNLIPRP1 pancreatic lipase-related protein 1 3.32543
PNLIPRP3 pancreatic lipase-related protein 3 3.32543
LOC124906010 uncharacterized LOC124906010 3.32543
SPAAR small regulatory polypeptide of amino acid response 3.32543
POU2AF2 POU class 2 homeobox associating factor 2 3.32543
STPG3 sperm-tail PG-rich repeat containing 3 3.32543
CFAP97D1 CFAP97 domain containing 1 3.32543
CLXN calaxin 3.32543
PLAAT2 phospholipase A and acyltransferase 2 3.32543
CD300LF CD300 molecule-like family member f 3.32543
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.32543
XAGE2 X antigen family, member 2 3.32543
REG4 regenerating islet-derived family, member 4 3.32543
SLFN14 schlafen family member 14 3.32543
BPIFA2 BPI fold containing family A, member 2 3.32543
FPR3 formyl peptide receptor 3 3.32543
COL19A1 collagen, type XIX, alpha 1 3.32543
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.32543
TSSK4 testis-specific serine kinase 4 3.32543
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.32543
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.32543
ULBP1 UL16 binding protein 1 3.32543
EXOC3L4 exocyst complex component 3-like 4 3.32543
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.32543
CFAP45 cilia and flagella associated protein 45 3.32543
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.32543
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.32543
MYH15 myosin, heavy chain 15 3.32543
TFEC transcription factor EC 3.32543
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.32543
RBM33-DT RBM33 divergent transcript 3.32543
HHLA2 HERV-H LTR-associating 2 3.32543
PCDHGB4 protocadherin gamma subfamily B, 4 3.32543
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.32543
VCAM1 vascular cell adhesion molecule 1 3.32543
CLCA2 chloride channel accessory 2 3.32543
SAMD7 sterile alpha motif domain containing 7 3.32543
CLCNKB chloride channel, voltage-sensitive Kb 3.32543
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.32543
LY96 lymphocyte antigen 96 3.32543
TMPRSS15 transmembrane protease, serine 15 3.32543
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.32543
GRAPL GRB2-related adaptor protein-like 3.32543
NKPD1 NTPase, KAP family P-loop domain containing 1 3.32543
RAB7B RAB7B, member RAS oncogene family 3.32543
ACKR2 atypical chemokine receptor 2 3.32543
SLITRK6 SLIT and NTRK-like family, member 6 3.32543
PLSCR5 phospholipid scramblase family, member 5 3.32543
CYSLTR1 cysteinyl leukotriene receptor 1 3.32543
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 3.32543
MYF6 myogenic factor 6 (herculin) 3.32543
TAS2R50 taste receptor, type 2, member 50 3.32543
KRT17 keratin 17, type I 3.32543
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.32543
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.32543
PRSS55 protease, serine, 55 3.32543
DMTN dematin actin binding protein 3.32543
MAB21L2 mab-21-like 2 (C. elegans) 3.32543
PCDHGA3 protocadherin gamma subfamily A, 3 3.32543
CARNS1 carnosine synthase 1 3.32543
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.32543
GSTA2 glutathione S-transferase alpha 2 3.32543
NEUROD1 neuronal differentiation 1 3.32543
RGS4 regulator of G-protein signaling 4 3.32543
NWD2 NACHT and WD repeat domain containing 2 3.32543
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.32543
MB myoglobin 3.32543
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.32543
RTP3 receptor (chemosensory) transporter protein 3 3.32543
C2ORF78 chromosome 2 open reading frame 78 3.32543
IL18RAP interleukin 18 receptor accessory protein 3.32543
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.32543
CPLX1 complexin 1 3.32543
GOLGA8K golgin A8 family, member K 3.32543
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.32543
PRDM16 PR domain containing 16 3.32543
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.32543
MGP matrix Gla protein 3.32543
IRX1 iroquois homeobox 1 3.32543
LGALS14 lectin, galactoside-binding, soluble, 14 3.32543
TECTB tectorin beta 3.32543
NT5C1B 5'-nucleotidase, cytosolic IB 3.32543
ARHGAP40 Rho GTPase activating protein 40 3.32543
RBBP8NL RBBP8 N-terminal like 3.32543
LHX5 LIM homeobox 5 3.32543
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 3.26278
CCDC177 coiled-coil domain containing 177 3.26278
SYTL4 synaptotagmin-like 4 3.26278
POTEJ POTE ankyrin domain family, member J 3.01919
SP3 Sp3 transcription factor 2.84264
SEPTIN6 septin 6 2.70458
ALPK3 alpha-kinase 3 2.68265
RAB5C RAB5C, member RAS oncogene family 2.56925
TSPAN13 tetraspanin 13 2.52328
KCMF1 potassium channel modulatory factor 1 2.51813
SDCBP2 syndecan binding protein (syntenin) 2 2.51124
LHFPL2 lipoma HMGIC fusion partner-like 2 2.48457
CAND1 cullin-associated and neddylation-dissociated 1 2.45086
PINK1 PTEN induced putative kinase 1 2.42707
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 2.40324
PSPH phosphoserine phosphatase 2.39838
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.36712
WNT16 wingless-type MMTV integration site family, member 16 2.36213
COTL1 coactosin-like F-actin binding protein 1 2.34408
SWI5 SWI5 recombination repair homolog (yeast) 2.34128
ROGDI rogdi homolog (Drosophila) 2.33468
COQ6 coenzyme Q6 monooxygenase 2.28808
PRPF31 pre-mRNA processing factor 31 2.28808
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.27957
DERA deoxyribose-phosphate aldolase (putative) 2.27957
TMEM223 transmembrane protein 223 2.27452
GREB1L growth regulation by estrogen in breast cancer-like 2.26961
CCNC cyclin C 2.26961
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.26689
TM4SF20 transmembrane 4 L six family member 20 2.26689
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.26689
IGSF23 immunoglobulin superfamily, member 23 2.26689
MMRN1 multimerin 1 2.26689
TENT5D terminal nucleotidyltransferase 5D 2.26689
MMP28 matrix metallopeptidase 28 2.26689
DDTL D-dopachrome tautomerase-like 2.26689
DHH desert hedgehog 2.26689
RPS15A ribosomal protein S15a 2.26689
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.26689
LMOD2 leiomodin 2 (cardiac) 2.26689
SYPL1 synaptophysin-like 1 2.24817
KPNA3 karyopherin alpha 3 (importin alpha 4) 2.21001
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 2.19122
CENPA centromere protein A 2.18011
SPARCL1 SPARC-like 1 (hevin) 2.17733
HIST1H2BF histone cluster 1, H2bf 2.16842
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.16042
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.15369
G6PC3 glucose 6 phosphatase, catalytic, 3 2.1258
RIC8B RIC8 guanine nucleotide exchange factor B 2.12232
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 2.11401
ZNF431 zinc finger protein 431 2.10737
EMC6 ER membrane protein complex subunit 6 2.10719
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 2.09131
ASRGL1 asparaginase like 1 2.08965
RPLP1 ribosomal protein, large, P1 2.08965
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.08457
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.08457
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 2.08064
DCTPP1 dCTP pyrophosphatase 1 2.07176
NBPF15 neuroblastoma breakpoint family, member 15 2.07176
NOP10 NOP10 ribonucleoprotein 2.06942
NLRP7 NLR family, pyrin domain containing 7 2.05975
CNGA4 cyclic nucleotide gated channel alpha 4 2.05424
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.05259
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.0316
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 2.03053
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 2.02318
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.02248
HMGA1 high mobility group AT-hook 1 2.01689

decreased expression

Symbol Name Standardized Value
TMIGD3 transmembrane and immunoglobulin domain containing 3 -3.35381
CFAP47 cilia and flagella associated protein 47 -3.35381
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -3.35381
LMOD1 leiomodin 1 (smooth muscle) -3.35381
ARHGAP30 Rho GTPase activating protein 30 -3.35381
TEX46 testis expressed 46 -3.35381
SEPTIN12 septin 12 -3.32543
SYT15 synaptotagmin XV -3.32543
AMIGO1 adhesion molecule with Ig-like domain 1 -3.32543
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -3.32543
VILL villin-like -3.32543
TMEM132D transmembrane protein 132D -3.32543
PLVAP plasmalemma vesicle associated protein -3.32543
C10ORF67 chromosome 10 open reading frame 67 -3.32543
GP1BB glycoprotein Ib (platelet), beta polypeptide -3.32543
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -3.32543
PCDHGB5 protocadherin gamma subfamily B, 5 -3.32543
GRAP GRB2-related adaptor protein -3.32543
MISP3 MISP family member 3 -3.32543
OSGIN1 oxidative stress induced growth inhibitor 1 -3.32543
NGFR nerve growth factor receptor -3.32543
PRDM1 PR domain containing 1, with ZNF domain -3.32543
ASCL2 achaete-scute family bHLH transcription factor 2 -3.32543
SPEF1 sperm flagellar 1 -3.32543
PCDHA11 protocadherin alpha 11 -3.32543
TEX12 testis expressed 12 -3.32543
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -3.32543
CBX4 chromobox homolog 4 -3.32133
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -3.27633
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -3.12642
RAB3A RAB3A, member RAS oncogene family -2.93045
NFYA nuclear transcription factor Y, alpha -2.86156
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.84264
SYMPK symplekin -2.82479
FES FES proto-oncogene, tyrosine kinase -2.81572
ASIC1 acid sensing (proton gated) ion channel 1 -2.81572
GALT galactose-1-phosphate uridylyltransferase -2.7795
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.73716
ATP7A ATPase, Cu++ transporting, alpha polypeptide -2.73239
CCKBR cholecystokinin B receptor -2.69114
PCBP1 poly(rC) binding protein 1 -2.63223
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -2.56121
ATG9A autophagy related 9A -2.51871
SMCO2 single-pass membrane protein with coiled-coil domains 2 -2.51639
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 -2.51124
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.50984
LRRC1 leucine rich repeat containing 1 -2.48457
LRRC7 leucine rich repeat containing 7 -2.44676
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) -2.44676
ZNF112 zinc finger protein 112 -2.43884
PYY peptide YY -2.43095
PRR13 proline rich 13 -2.41659
TOX thymocyte selection-associated high mobility group box -2.39838
HSF2 heat shock transcription factor 2 -2.39494
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.38953
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.36889
LPL lipoprotein lipase -2.36435
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -2.35832
DNAAF4 dynein axonemal assembly factor 4 -2.34484
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.33106
TSC22D2 TSC22 domain family, member 2 -2.32642
FAM194C family with sequence similarity 149 member C -2.32586
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -2.31969
LYRM7 LYR motif containing 7 -2.31554
BICDL1 BICD family like cargo adaptor 1 -2.31554
PRDM14 PR domain containing 14 -2.31256
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.28808
LDLR low density lipoprotein receptor -2.28808
MIER2 mesoderm induction early response 1, family member 2 -2.28345
MTBP MDM2 binding protein -2.26961
IQGAP3 IQ motif containing GTPase activating protein 3 -2.26961
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -2.26689
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.26689
ZBTB24 zinc finger and BTB domain containing 24 -2.26562
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.25394
OSMR oncostatin M receptor -2.25394
CD300A CD300a molecule -2.25394
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.22104
STXBP2 syntaxin binding protein 2 -2.20812
CHN2 chimerin 2 -2.18132
VANGL2 VANGL planar cell polarity protein 2 -2.17423
CORO1C coronin, actin binding protein, 1C -2.17263
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.16415
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -2.13942
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -2.13888
NTSR1 neurotensin receptor 1 (high affinity) -2.13705
GYPC glycophorin C (Gerbich blood group) -2.13705
FAT2 FAT atypical cadherin 2 -2.11732
SUFU suppressor of fused homolog (Drosophila) -2.10032
SLITRK3 SLIT and NTRK-like family, member 3 -2.08064
M6PR mannose-6-phosphate receptor (cation dependent) -2.07335
TMEM80 transmembrane protein 80 -2.06917
STIP1 stress-induced phosphoprotein 1 -2.04833
UST uronyl-2-sulfotransferase -2.04766
KAT6B K(lysine) acetyltransferase 6B -2.04763
TMEM158 transmembrane protein 158 (gene/pseudogene) -2.04763
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -2.03748
TMEM255B transmembrane protein 255B -2.03748
CD302 CD302 molecule -2.03005
GPR162 G protein-coupled receptor 162 -2.02318
PRKCB protein kinase C, beta -2.02149