MSX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description msh homeobox 2|This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4488)
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Genes

299 genes differentially expressed following the MSX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NIM1K NIM1 serine/threonine protein kinase 2.82639
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.82639
TAS2R19 taste receptor, type 2, member 19 2.82639
SPATA22 spermatogenesis associated 22 2.82639
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.82639
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.82639
LTB lymphotoxin beta (TNF superfamily, member 3) 2.82639
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.82639
MUC16 mucin 16, cell surface associated 2.82639
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.82639
FAM177B family with sequence similarity 177, member B 2.82639
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.82639
IRF4 interferon regulatory factor 4 2.82639
LOC124906892 uncharacterized LOC124906892 2.82639
ZC3H12D zinc finger CCCH-type containing 12D 2.82639
ADGRG3 adhesion G protein-coupled receptor G3 2.82639
CD28 CD28 molecule 2.82639
CCDC177 coiled-coil domain containing 177 2.82639
ADAP1 ArfGAP with dual PH domains 1 2.82639
PSD2 pleckstrin and Sec7 domain containing 2 2.82639
TMEM52B transmembrane protein 52B 2.82639
HORMAD2 HORMA domain containing 2 2.8096
RHOXF2 Rhox homeobox family, member 2 2.8096
ABHD16B abhydrolase domain containing 16B 2.8096
NCF1 neutrophil cytosolic factor 1 2.8096
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.8096
ZNF467 zinc finger protein 467 2.8096
PDYN prodynorphin 2.8096
HMGN1 high mobility group nucleosome binding domain 1 2.8096
PON1 paraoxonase 1 2.8096
ADAD2 adenosine deaminase domain containing 2 2.8096
AKR1C4 aldo-keto reductase family 1, member C4 2.8096
PRELP proline/arginine-rich end leucine-rich repeat protein 2.8096
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.8096
CELF3 CUGBP, Elav-like family member 3 2.8096
GJB1 gap junction protein, beta 1, 32kDa 2.8096
HES2 hes family bHLH transcription factor 2 2.8096
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.8096
CPB2 carboxypeptidase B2 (plasma) 2.8096
GLRA3 glycine receptor, alpha 3 2.8096
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.8096
MMP20 matrix metallopeptidase 20 2.8096
THEMIS thymocyte selection associated 2.8096
C3ORF22 chromosome 3 open reading frame 22 2.8096
KCNRG potassium channel regulator 2.8096
MYOM2 myomesin 2 2.8096
IFNK interferon, kappa 2.8096
AVP arginine vasopressin 2.8096
CPLX3 complexin 3 2.8096
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.8096
SIGLEC9 sialic acid binding Ig-like lectin 9 2.8096
C9ORF152 chromosome 9 open reading frame 152 2.8096
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.8096
PARP3 poly (ADP-ribose) polymerase family, member 3 2.8096
CHADL chondroadherin-like 2.8096
WNT16 wingless-type MMTV integration site family, member 16 2.8096
MYEOV myeloma overexpressed 2.8096
BDKRB1 bradykinin receptor B1 2.8096
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.8096
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.8096
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.8096
FMO2 flavin containing monooxygenase 2 (non-functional) 2.8096
CLDN14 claudin 14 2.8096
SELE selectin E 2.8096
H2BC1 H2B clustered histone 1 2.8096
ALPG alkaline phosphatase, germ cell 2.8096
VXN vexin 2.8096
FREY1 Frey regulator of sperm-oocyte fusion 1 2.8096
GSTT4 glutathione S-transferase theta 4 2.8096
ZNF593OS ZNF593 opposite strand 2.8096
CIMAP1D CIMAP1 family member D 2.8096
WASL-DT WASL divergent transcript 2.8096
MLANA melan-A 2.8096
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.8096
CCDC42 coiled-coil domain containing 42 2.8096
SELPLG selectin P ligand 2.8096
FER1L6 fer-1-like family member 6 2.8096
NDRG1 N-myc downstream regulated 1 2.8096
TSSK4 testis-specific serine kinase 4 2.8096
KLHL33 kelch-like family member 33 2.8096
PCDHB10 protocadherin beta 10 2.8096
IRF5 interferon regulatory factor 5 2.8096
CBLN2 cerebellin 2 precursor 2.8096
TLR8 toll-like receptor 8 2.8096
EXOC3L1 exocyst complex component 3-like 1 2.8096
CCR3 chemokine (C-C motif) receptor 3 2.8096
OR10K1 olfactory receptor, family 10, subfamily K, member 1 2.8096
C7ORF57 chromosome 7 open reading frame 57 2.8096
SAMD11 sterile alpha motif domain containing 11 2.8096
TAS1R1 taste receptor, type 1, member 1 2.8096
GDF6 growth differentiation factor 6 2.8096
CNTN6 contactin 6 2.8096
SPATA31G1 SPATA31 subfamily G member 1 2.8096
ACADL acyl-CoA dehydrogenase, long chain 2.8096
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.8096
KLK3 kallikrein-related peptidase 3 2.8096
SAMD9 sterile alpha motif domain containing 9 2.8096
RSAD2 radical S-adenosyl methionine domain containing 2 2.8096
TMEM132E transmembrane protein 132E 2.8096
CCDC154 coiled-coil domain containing 154 2.8096
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.8096
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.8096
DES desmin 2.8096
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 2.8096
IL12A interleukin 12A 2.8096
CALML6 calmodulin-like 6 2.8096
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.8096
TBC1D28 TBC1 domain family, member 28 2.8096
SUN3 Sad1 and UNC84 domain containing 3 2.8096
EDN3 endothelin 3 2.8096
KLK5 kallikrein-related peptidase 5 2.8096
TTC16 tetratricopeptide repeat domain 16 2.8096
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.8096
MKRN3 makorin ring finger protein 3 2.8096
CPA3 carboxypeptidase A3 (mast cell) 2.8096
CGB7 chorionic gonadotropin, beta polypeptide 7 2.8096
PCP2 Purkinje cell protein 2 2.8096
PRR23A proline rich 23A 2.8096
IL1B interleukin 1, beta 2.8096
C11ORF96 chromosome 11 open reading frame 96 2.8096
THTPA thiamine triphosphatase 2.8096
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.8096
CHI3L2 chitinase 3-like 2 2.8096
CST1 cystatin SN 2.8096
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.8096
KLK14 kallikrein-related peptidase 14 2.8096
PXT1 peroxisomal, testis specific 1 2.8096
NPAS4 neuronal PAS domain protein 4 2.8096
TMEM255A transmembrane protein 255A 2.8096
LHB luteinizing hormone beta polypeptide 2.8096
TGM6 transglutaminase 6 2.8096
ZPLD1 zona pellucida-like domain containing 1 2.8096
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.8096
RAB6C RAB6C, member RAS oncogene family 2.8096
IFITM10 interferon induced transmembrane protein 10 2.8096
ANKRD65 ankyrin repeat domain 65 2.8096
MB myoglobin 2.8096
GCSAML germinal center-associated, signaling and motility-like 2.8096
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.8096
CHRDL2 chordin-like 2 2.8096
IRX1 iroquois homeobox 1 2.8096
CFB complement factor B 2.8096
AMPD1 adenosine monophosphate deaminase 1 2.8096
TMPRSS15 transmembrane protease, serine 15 2.8096
REEP1 receptor accessory protein 1 2.8096
RTN4RL1 reticulon 4 receptor-like 1 2.8096
CD8B CD8b molecule 2.8096
LYZ lysozyme 2.8096
ARGFX arginine-fifty homeobox 2.8096
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.8096
CCNO cyclin O 2.8096
TTC24 tetratricopeptide repeat domain 24 2.8096
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.80939
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.78609
GLRB glycine receptor, beta 2.78609
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 2.74239
LBP lipopolysaccharide binding protein 2.73374
FGFR3 fibroblast growth factor receptor 3 2.73374
CHIC1 cysteine-rich hydrophobic domain 1 2.72435
ZNF717 zinc finger protein 717 2.71287
BVES blood vessel epicardial substance 2.67597
NFX1 nuclear transcription factor, X-box binding 1 2.59799
ANGPTL1 angiopoietin-like 1 2.57461
AGMAT agmatine ureohydrolase (agmatinase) 2.56826
ZNF835 zinc finger protein 835 2.52553
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.52553
HUNK hormonally up-regulated Neu-associated kinase 2.52553
LOX lysyl oxidase 2.40079
CCN3 cellular communication network factor 3 2.4004
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 2.4004
CHIT1 chitinase 1 (chitotriosidase) 2.4004
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.4004
DEFB134 defensin, beta 134 2.35201
TAS2R13 taste receptor, type 2, member 13 2.35201
ZNF630 zinc finger protein 630 2.31895
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 2.25897
NISCH nischarin 2.25897
ERBIN erbb2 interacting protein 2.24422
TIAM2 T-cell lymphoma invasion and metastasis 2 2.22295
MAGOHB mago-nashi homolog B (Drosophila) 2.21359
FAM186B family with sequence similarity 186, member B 2.20792
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.18733
MACIR macrophage immunometabolism regulator 2.18122
PTPRJ protein tyrosine phosphatase, receptor type, J 2.17333
UBE2D3 ubiquitin-conjugating enzyme E2D 3 2.14678
UCKL1 uridine-cytidine kinase 1-like 1 2.13395
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.12382
WSCD1 WSC domain containing 1 2.12008
GIPC1 GIPC PDZ domain containing family, member 1 2.12008
NRP2 neuropilin 2 2.1147
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.11456
HELB helicase (DNA) B 2.10321
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.10321
NEGR1 neuronal growth regulator 1 2.09697
STMP1 short transmembrane mitochondrial protein 1 2.09697
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 2.09697
MTSS2 MTSS I-BAR domain containing 2 2.06987
DPY30 dpy-30 homolog (C. elegans) 2.06982
ZNF182 zinc finger protein 182 2.0638
IGFBP4 insulin-like growth factor binding protein 4 2.04661
TDRD3 tudor domain containing 3 2.01798
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.01223
GLA galactosidase, alpha 2.00564

decreased expression

Symbol Name Standardized Value
RAI1 retinoic acid induced 1 -2.82639
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.8096
MMD monocyte to macrophage differentiation-associated -2.8096
FADS6 fatty acid desaturase 6 -2.8096
MMP21 matrix metallopeptidase 21 -2.8096
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -2.8096
GRHL3 grainyhead-like 3 (Drosophila) -2.8096
CPNE9 copine family member IX -2.8096
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.8096
CASKIN1 CASK interacting protein 1 -2.8096
RUMY3 RUMY family member 3 -2.8096
RIN1 Ras and Rab interactor 1 -2.8096
KIAA0753 KIAA0753 -2.8096
MPDU1 mannose-P-dolichol utilization defect 1 -2.72686
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.70042
ASPA aspartoacylase -2.70042
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.70042
C17ORF113 chromosome 17 open reading frame 113 -2.70042
GNRHR gonadotropin-releasing hormone receptor -2.70042
HEPHL1 hephaestin-like 1 -2.70042
FAM216B family with sequence similarity 216, member B -2.70042
VCX variable charge, X-linked -2.70042
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.70042
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.70042
ZC2HC1B zinc finger, C2HC-type containing 1B -2.70042
SMIM45 small integral membrane protein 45 -2.70042
KLRK1 killer cell lectin-like receptor subfamily K, member 1 -2.70042
PNLIPRP2 pancreatic lipase-related protein 2 -2.70042
FOXN4 forkhead box N4 -2.70042
XKRX XK, Kell blood group complex subunit-related, X-linked -2.70042
PGLYRP1 peptidoglycan recognition protein 1 -2.70042
CXCL14 chemokine (C-X-C motif) ligand 14 -2.70042
CALCA calcitonin-related polypeptide alpha -2.70042
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -2.70042
CFP complement factor properdin -2.70042
HRH1 histamine receptor H1 -2.70042
SCN2A sodium channel, voltage gated, type II alpha subunit -2.70042
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 -2.70042
CYS1 cystin 1 -2.70042
IER5L immediate early response 5-like -2.70042
FIBIN fin bud initiation factor homolog (zebrafish) -2.70042
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.70042
ANKRD55 ankyrin repeat domain 55 -2.70042
LPAR5 lysophosphatidic acid receptor 5 -2.70042
ZMYND15 zinc finger, MYND-type containing 15 -2.70042
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.70042
DYNLT5 dynein light chain Tctex-type family member 5 -2.68576
HVCN1 hydrogen voltage gated channel 1 -2.6595
RIPOR3 RIPOR family member 3 -2.61669
PABPC4L poly(A) binding protein, cytoplasmic 4-like -2.59904
DDHD1 DDHD domain containing 1 -2.57914
ZNF484 zinc finger protein 484 -2.56826
KPNA1 karyopherin alpha 1 (importin alpha 5) -2.56407
KREMEN2 kringle containing transmembrane protein 2 -2.56407
CFD complement factor D (adipsin) -2.56407
VASH1 vasohibin 1 -2.54457
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.53721
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -2.52746
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.51322
MKX mohawk homeobox -2.42104
CERS3 ceramide synthase 3 -2.42104
MGA MGA, MAX dimerization protein -2.40538
ZMIZ1 zinc finger, MIZ-type containing 1 -2.36743
CSNK1G3 casein kinase 1, gamma 3 -2.33284
ERMARD ER membrane-associated RNA degradation -2.3326
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -2.31531
SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C -2.31412
MVD mevalonate (diphospho) decarboxylase -2.30669
EFCAB5 EF-hand calcium binding domain 5 -2.25542
PRTG protogenin -2.25346
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -2.24913
ING5 inhibitor of growth family, member 5 -2.22062
SEC63 SEC63 homolog (S. cerevisiae) -2.19519
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.18653
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.16483
TIPE3 TNF alpha induced protein 8 like 3 -2.16172
CENPO centromere protein O -2.15196
MRPL58 mitochondrial ribosomal protein L58 -2.13395
OTUD4 OTU deubiquitinase 4 -2.12571
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) -2.12008
ZNF26 zinc finger protein 26 -2.11736
KMT2B lysine (K)-specific methyltransferase 2B -2.11456
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -2.09697
CXXC5 CXXC finger protein 5 -2.08644
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.08538
RPS28 ribosomal protein S28 -2.08472
MRPS31 mitochondrial ribosomal protein S31 -2.07441
CPQ carboxypeptidase Q -2.06982
KPNA4 karyopherin alpha 4 (importin alpha 3) -2.06982
DTX3L deltex 3 like, E3 ubiquitin ligase -2.0638
GPR135 G protein-coupled receptor 135 -2.05927
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -2.03963
GLOD4 glyoxalase domain containing 4 -2.03248
DIAPH1 diaphanous-related formin 1 -2.01935
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 -2.01798
FXR2 fragile X mental retardation, autosomal homolog 2 -2.00876