MTA1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description metastasis associated 1|This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 9112)
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Genes

303 genes differentially expressed following the MTA1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CCDC170 coiled-coil domain containing 170 3.81866
SMIM36 small integral membrane protein 36 3.81866
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.81866
C9ORF152 chromosome 9 open reading frame 152 3.81866
KLK11 kallikrein-related peptidase 11 3.81866
ACER1 alkaline ceramidase 1 3.81866
GHRH growth hormone releasing hormone 3.81866
C3ORF22 chromosome 3 open reading frame 22 3.81866
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.81866
GOLGA6L4 golgin A6 family-like 4 3.81866
LOX lysyl oxidase 3.81866
GPR12 G protein-coupled receptor 12 3.81866
FGF7 fibroblast growth factor 7 3.81866
ANKRD62 ankyrin repeat domain 62 3.81866
DNAI7 dynein axonemal intermediate chain 7 3.81866
TMEM272 transmembrane protein 272 3.81866
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.81866
LGALS12 lectin, galactoside-binding, soluble, 12 3.81866
BCL2L15 BCL2-like 15 3.81866
FOLR1 folate receptor 1 (adult) 3.81866
TBX15 T-box 15 3.81502
SLC25A41 solute carrier family 25, member 41 3.81502
EPPIN epididymal peptidase inhibitor 3.81502
GLUD2 glutamate dehydrogenase 2 3.81502
HCRTR1 hypocretin (orexin) receptor 1 3.81502
CCDC116 coiled-coil domain containing 116 3.81502
UCN urocortin 3.81502
SOX1 SRY (sex determining region Y)-box 1 3.81502
PLIN1 perilipin 1 3.81502
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.81502
ZACN zinc activated ligand-gated ion channel 3.81502
CDH5 cadherin 5, type 2 (vascular endothelium) 3.81502
CTRC chymotrypsin C (caldecrin) 3.81502
PAX8 paired box 8 3.81502
LBX2 ladybird homeobox 2 3.81502
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.81502
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.81502
C8ORF74 chromosome 8 open reading frame 74 3.81502
MAGED4 melanoma antigen family D4 3.81502
TMEM121 transmembrane protein 121 3.81502
EDDM3B epididymal protein 3B 3.81502
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.81502
GJB5 gap junction protein, beta 5, 31.1kDa 3.81502
PCDH8 protocadherin 8 3.81502
RGL4 ral guanine nucleotide dissociation stimulator-like 4 3.81502
BIRC3 baculoviral IAP repeat containing 3 3.81502
TRIM77 tripartite motif containing 77 3.81502
ASB10 ankyrin repeat and SOCS box containing 10 3.81502
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.81502
PAX6 paired box 6 3.81502
IL2RG interleukin 2 receptor, gamma 3.81502
WEE2 WEE1 homolog 2 (S. pombe) 3.81502
DPF3 D4, zinc and double PHD fingers, family 3 3.81502
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 3.81502
CLEC6A C-type lectin domain family 6, member A 3.81502
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.81502
MYL10 myosin, light chain 10, regulatory 3.81502
HTRA4 HtrA serine peptidase 4 3.81502
VGLL2 vestigial-like family member 2 3.81502
LTB4R2 leukotriene B4 receptor 2 3.81502
GBP4 guanylate binding protein 4 3.81502
FYB1 FYN binding protein 1 3.81502
TMEM275 transmembrane protein 275 3.81502
MYOCOS myocilin opposite strand 3.81502
H2BW2 H2B.W histone 2 3.81502
MINDY4B MINDY family member 4B 3.81502
H4C12 H4 clustered histone 12 3.81502
EXOC1L exocyst complex component 1 like 3.81502
ZC3H11C zinc finger CCCH-type containing 11C 3.81502
FAM90A12 family with sequence similarity 90 member A12 3.81502
DYNAP dynactin associated protein 3.81502
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.81502
HHEX hematopoietically expressed homeobox 3.81502
ATP13A5 ATPase type 13A5 3.81502
OR5H2 olfactory receptor, family 5, subfamily H, member 2 3.81502
SECTM1 secreted and transmembrane 1 3.81502
NKX2-6 NK2 homeobox 6 3.81502
CFAP99 cilia and flagella associated protein 99 3.81502
CLDN2 claudin 2 3.81502
ZSWIM2 zinc finger, SWIM-type containing 2 3.81502
MAG myelin associated glycoprotein 3.81502
MSX2 msh homeobox 2 3.81502
SLAMF1 signaling lymphocytic activation molecule family member 1 3.81502
TBX3 T-box 3 3.81502
VCX3B variable charge, X-linked 3B 3.81502
BLNK B-cell linker 3.81502
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.81502
TAS1R1 taste receptor, type 1, member 1 3.81502
PLEK2 pleckstrin 2 3.81502
SPMAP1 sperm microtubule associated protein 1 3.81502
CNGB1 cyclic nucleotide gated channel beta 1 3.81502
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.81502
ALAS2 5'-aminolevulinate synthase 2 3.81502
DES desmin 3.81502
KRT17 keratin 17, type I 3.81502
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.81502
DMTN dematin actin binding protein 3.81502
CD177 CD177 molecule 3.81502
PIP prolactin-induced protein 3.81502
ZNF534 zinc finger protein 534 3.81502
NPAS4 neuronal PAS domain protein 4 3.81502
GLT6D1 glycosyltransferase 6 domain containing 1 3.81502
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.81502
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.81502
AQP1 aquaporin 1 (Colton blood group) 3.81502
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.81502
CCL24 chemokine (C-C motif) ligand 24 3.81502
RSAD2 radical S-adenosyl methionine domain containing 2 3.81502
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.81502
CASQ2 calsequestrin 2 (cardiac muscle) 3.81502
C1ORF105 chromosome 1 open reading frame 105 3.81502
EFCC1 EF-hand and coiled-coil domain containing 1 3.81502
RGS4 regulator of G-protein signaling 4 3.81502
HAND2 heart and neural crest derivatives expressed 2 3.81502
DLX6 distal-less homeobox 6 3.81502
FBXO40 F-box protein 40 3.81502
CCL15 chemokine (C-C motif) ligand 15 3.81502
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.81502
SPO11 SPO11 meiotic protein covalently bound to DSB 3.81502
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.81502
OR11L1 olfactory receptor, family 11, subfamily L, member 1 3.81502
CLRN2 clarin 2 3.81502
VNN2 vanin 2 3.81502
BTNL2 butyrophilin-like 2 3.81502
ZBED6 zinc finger, BED-type containing 6 3.81502
RTN4RL1 reticulon 4 receptor-like 1 3.81502
FCAR Fc fragment of IgA receptor 3.81502
IL2RA interleukin 2 receptor, alpha 3.81502
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.81502
DSPP dentin sialophosphoprotein 3.81502
MMRN1 multimerin 1 3.81502
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.81502
ZNF648 zinc finger protein 648 3.81502
IRX5 iroquois homeobox 5 3.81502
PASD1 PAS domain containing 1 3.81502
BTBD16 BTB (POZ) domain containing 16 3.81502
SPNS3 spinster homolog 3 (Drosophila) 3.81502
ADRA1B adrenoceptor alpha 1B 3.81502
C5ORF46 chromosome 5 open reading frame 46 3.81502
SP5 Sp5 transcription factor 3.81502
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.81502
C4BPA complement component 4 binding protein, alpha 3.81502
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.81502
LVRN laeverin 3.81502
SPEG SPEG complex locus 3.75028
STXBP5 syntaxin binding protein 5 (tomosyn) 3.53017
SERTM1 serine-rich and transmembrane domain containing 1 3.40403
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 3.26392
FAM110D family with sequence similarity 110, member D 3.26127
CISH cytokine inducible SH2-containing protein 3.26127
YJU2 YJU2 splicing factor homolog 3.16637
CASP9 caspase 9, apoptosis-related cysteine peptidase 3.02473
HCRT hypocretin (orexin) neuropeptide precursor 2.97003
RHOQ ras homolog family member Q 2.95814
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.9457
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.9457
AP1M1 adaptor-related protein complex 1, mu 1 subunit 2.82263
LMAN2L lectin, mannose-binding 2-like 2.73364
TMOD2 tropomodulin 2 (neuronal) 2.73364
ANKRD53 ankyrin repeat domain 53 2.72194
EGFL6 EGF-like-domain, multiple 6 2.72194
MT1G metallothionein 1G 2.72194
RGS11 regulator of G-protein signaling 11 2.72194
CFAP54 cilia and flagella associated 54 2.72194
PLB1 phospholipase B1 2.72194
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.63448
PSEN1 presenilin 1 2.59477
ARHGAP28 Rho GTPase activating protein 28 2.57326
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 2.47665
ENSA endosulfine alpha 2.46631
TMEM209 transmembrane protein 209 2.44675
HEG1 heart development protein with EGF-like domains 1 2.40261
MYCT1 myc target 1 2.32873
COPG1 coatomer protein complex, subunit gamma 1 2.32462
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.29503
FHL1 four and a half LIM domains 1 2.29347
KCTD12 potassium channel tetramerization domain containing 12 2.29347
MT1H metallothionein 1H 2.2749
NPIPB8 nuclear pore complex interacting protein family, member B8 2.24099
CCSAP centriole, cilia and spindle-associated protein 2.20987
BMP8A bone morphogenetic protein 8a 2.19097
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 2.15297
CLPTM1L CLPTM1-like 2.14214
ZNF66 zinc finger protein 66 2.1294
IFT46 intraflagellar transport 46 2.10883
C1QTNF6 C1q and tumor necrosis factor related protein 6 2.10192
ZNF563 zinc finger protein 563 2.10096
SERP1 stress-associated endoplasmic reticulum protein 1 2.09667
ASNSD1 asparagine synthetase domain containing 1 2.09382
PDE4D phosphodiesterase 4D, cAMP-specific 2.07244
KCTD6 potassium channel tetramerization domain containing 6 2.063
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 2.03126
THADA thyroid adenoma associated 2.0204
CPNE4 copine IV 2.01402
CD276 CD276 molecule 2.01402
SOX4 SRY (sex determining region Y)-box 4 2.01381
LUC7L LUC7-like (S. cerevisiae) 2.01272
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.01272
NID2 nidogen 2 (osteonidogen) 2.01028

decreased expression

Symbol Name Standardized Value
RHCE Rh blood group, CcEe antigens -3.81866
TNMD tenomodulin -3.81866
ADH6 alcohol dehydrogenase 6 (class V) -3.81866
VWC2 von Willebrand factor C domain containing 2 -3.81866
TBC1D26 TBC1 domain family, member 26 -3.81502
CFAP53 cilia and flagella associated protein 53 -3.81502
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -3.81502
OC90 otoconin 90 -3.81502
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -3.81502
RAD9B RAD9 homolog B (S. pombe) -3.81502
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.81502
PITX2 paired-like homeodomain 2 -3.81502
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -3.81502
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -3.81502
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 -3.81502
IL17B interleukin 17B -3.81502
RNF112 ring finger protein 112 -3.81502
AMIGO1 adhesion molecule with Ig-like domain 1 -3.81502
CD19 CD19 molecule -3.81502
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -3.81502
ACTN3 actinin, alpha 3 (gene/pseudogene) -3.81502
DEFB131B defensin beta 131B -3.81502
TCAP titin-cap -3.81502
IP6K3 inositol hexakisphosphate kinase 3 -3.81502
PRSS38 protease, serine, 38 -3.81502
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.81502
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -3.81502
LY6K lymphocyte antigen 6 complex, locus K -3.81502
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -3.81502
IMPG1 interphotoreceptor matrix proteoglycan 1 -3.81502
ADTRP androgen-dependent TFPI-regulating protein -3.81502
OVOL3 ovo-like zinc finger 3 -3.81502
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -3.81502
PADI4 peptidyl arginine deiminase, type IV -3.81502
ACKR4 atypical chemokine receptor 4 -3.7511
SCML2 sex comb on midleg-like 2 (Drosophila) -3.61258
LRRC51 leucine rich repeat containing 51 -3.58079
IFT70B intraflagellar transport 70B -3.44583
FRZB frizzled-related protein -3.26127
NHLH2 nescient helix loop helix 2 -3.19189
SYT13 synaptotagmin XIII -3.17355
ZNF75A zinc finger protein 75a -3.09652
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -3.04613
ANO9 anoctamin 9 -3.02272
FRAS1 Fraser extracellular matrix complex subunit 1 -3.0012
SLC35F5 solute carrier family 35, member F5 -2.88857
FAM156A family with sequence similarity 156, member A -2.74485
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.74246
G0S2 G0/G1 switch 2 -2.72895
PSD4 pleckstrin and Sec7 domain containing 4 -2.72895
TP53TG5 TP53 target 5 -2.72895
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 -2.72895
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -2.70723
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -2.67752
ANGEL2 angel homolog 2 (Drosophila) -2.6087
XKR6 XK, Kell blood group complex subunit-related family, member 6 -2.57798
ZNF500 zinc finger protein 500 -2.56746
PDIA6 protein disulfide isomerase family A, member 6 -2.54682
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -2.53014
SMCO2 single-pass membrane protein with coiled-coil domains 2 -2.50757
PRIM1 primase, DNA, polypeptide 1 (49kDa) -2.46631
NXN nucleoredoxin -2.46631
MMUT methylmalonyl-CoA mutase -2.46631
ZNF20 zinc finger protein 20 -2.45378
KIAA1328 KIAA1328 -2.42608
ZNF77 zinc finger protein 77 -2.42608
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.39825
GAGE10 G antigen 10 -2.39825
PCNX1 pecanex 1 -2.34561
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 -2.32873
WLS wntless Wnt ligand secretion mediator -2.31581
TRAPPC2B trafficking protein particle complex 2B -2.29503
SSC5D scavenger receptor cysteine rich family, 5 domains -2.27735
U2AF1 U2 small nuclear RNA auxiliary factor 1 -2.27181
MMD2 monocyte to macrophage differentiation-associated 2 -2.24099
HCST hematopoietic cell signal transducer -2.24099
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.24099
RAPSN receptor-associated protein of the synapse -2.24099
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.24099
CEP295 centrosomal protein 295kDa -2.20987
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -2.20423
MTA1 metastasis associated 1 -2.15297
HES4 hes family bHLH transcription factor 4 -2.13535
LHFPL3 lipoma HMGIC fusion partner-like 3 -2.13518
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.10212
RAB9A RAB9A, member RAS oncogene family -2.09392
COX14 COX14 cytochrome c oxidase assembly factor -2.07244
C5ORF22 chromosome 5 open reading frame 22 -2.07212
LRRC4C leucine rich repeat containing 4C -2.07146
CARD14 caspase recruitment domain family, member 14 -2.07146
TRIB3 tribbles pseudokinase 3 -2.06871
ZNF570 zinc finger protein 570 -2.063
FAM133B family with sequence similarity 133, member B -2.05642
DCTN2 dynactin 2 (p50) -2.03625
IFRD2 interferon-related developmental regulator 2 -2.03126
ZNF485 zinc finger protein 485 -2.03126
AFG1L AFG1 like ATPase -2.03126
GAS2 growth arrest-specific 2 -2.02085
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.0204
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.01402
RPRD1B regulation of nuclear pre-mRNA domain containing 1B -2.01381
LPIN2 lipin 2 -2.01381
LDB1 LIM domain binding 1 -2.01272
CLIP1 CAP-GLY domain containing linker protein 1 -2.0029