MTAP Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description methylthioadenosine phosphorylase|This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4507)
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Genes

333 genes differentially expressed following the MTAP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ADAM21 ADAM metallopeptidase domain 21 2.4573
LY6K lymphocyte antigen 6 complex, locus K 2.4573
PTGDR prostaglandin D2 receptor (DP) 2.4573
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.4573
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.4573
GMNC geminin coiled-coil domain containing 2.4573
ERICH6 glutamate-rich 6 2.4573
CD200R1 CD200 receptor 1 2.4573
LAMP3 lysosomal-associated membrane protein 3 2.4573
FAM186A family with sequence similarity 186, member A 2.4573
FZD1 frizzled class receptor 1 2.4573
FSHR follicle stimulating hormone receptor 2.4573
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.4573
SEZ6L seizure related 6 homolog (mouse)-like 2.4573
CFP complement factor properdin 2.4573
ZNF404 zinc finger protein 404 2.4573
MUC6 mucin 6, oligomeric mucus/gel-forming 2.4573
TPH1 tryptophan hydroxylase 1 2.4573
GREP1 glycine rich extracellular protein 1 2.4573
PLIN4 perilipin 4 2.4573
PRSS22 protease, serine, 22 2.4573
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.4573
BIRC3 baculoviral IAP repeat containing 3 2.39876
TAL2 T-cell acute lymphocytic leukemia 2 2.39876
CXCL2 chemokine (C-X-C motif) ligand 2 2.39876
TCAF2 TRPM8 channel-associated factor 2 2.39876
MRPL53 mitochondrial ribosomal protein L53 2.39876
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.39876
GPR21 G protein-coupled receptor 21 2.39876
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.39876
C6ORF58 chromosome 6 open reading frame 58 2.39876
CSMD3 CUB and Sushi multiple domains 3 2.39876
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.39876
CCNB3 cyclin B3 2.39876
RCSD1 RCSD domain containing 1 2.39876
PTH2 parathyroid hormone 2 2.39876
HAS1 hyaluronan synthase 1 2.39876
LBX2 ladybird homeobox 2 2.39876
SPX spexin hormone 2.39876
CSNK2A2 casein kinase 2, alpha prime polypeptide 2.39876
ASCL1 achaete-scute family bHLH transcription factor 1 2.39876
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 2.39876
ERAP2 endoplasmic reticulum aminopeptidase 2 2.39876
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.39876
NFE2 nuclear factor, erythroid 2 2.39876
TMEM52B transmembrane protein 52B 2.39876
SP6 Sp6 transcription factor 2.39876
ATOH7 atonal homolog 7 (Drosophila) 2.39876
GPI glucose-6-phosphate isomerase 2.39876
PCDH8 protocadherin 8 2.39876
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.39876
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.39876
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.39876
PSCA prostate stem cell antigen 2.39876
CRH corticotropin releasing hormone 2.39876
LMLN leishmanolysin-like (metallopeptidase M8 family) 2.39876
DCST1 DC-STAMP domain containing 1 2.39876
WNT3A wingless-type MMTV integration site family, member 3A 2.39876
DEFB109B defensin beta 109B 2.39876
BCO2 beta-carotene oxygenase 2 2.39876
C15ORF62 chromosome 15 open reading frame 62 2.39876
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.39876
GATA2 GATA binding protein 2 2.39876
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.39876
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 2.39876
CNTN6 contactin 6 2.39876
GDF9 growth differentiation factor 9 2.39876
ZAR1L zygote arrest 1-like 2.39876
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.39876
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.39876
MDFIC2 MyoD family inhibitor domain containing 2 2.39876
AKAIN1 A-kinase anchor inhibitor 1 2.39876
TMEM225B transmembrane protein 225B 2.39876
RTL9 retrotransposon Gag like 9 2.39876
CCDC198 coiled-coil domain containing 198 2.39876
PLAAT4 phospholipase A and acyltransferase 4 2.39876
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2.39876
YIPF7 Yip1 domain family, member 7 2.39876
CAPN9 calpain 9 2.39876
FRK fyn-related Src family tyrosine kinase 2.39876
CNTFR ciliary neurotrophic factor receptor 2.39876
CCR8 chemokine (C-C motif) receptor 8 2.39876
LBHD1 LBH domain containing 1 2.39876
LRTM3 leucine rich repeat transmembrane protein 3 2.39876
SRL sarcalumenin 2.39876
CFHR4 complement factor H-related 4 2.39876
SIX3 SIX homeobox 3 2.39876
UPK3B uroplakin 3B 2.39876
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.39876
AKAP14 A kinase (PRKA) anchor protein 14 2.39876
SLC35G5 solute carrier family 35, member G5 2.39876
FOXD1 forkhead box D1 2.39876
PCDHA8 protocadherin alpha 8 2.39876
PRR18 proline rich 18 2.39876
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.39876
C1QL3 complement component 1, q subcomponent-like 3 2.39876
SCRT2 scratch family zinc finger 2 2.39876
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.39876
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.39876
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.39876
ITK IL2-inducible T-cell kinase 2.39876
CDX2 caudal type homeobox 2 2.39876
TNNI2 troponin I type 2 (skeletal, fast) 2.39876
KISS1 KiSS-1 metastasis-suppressor 2.39876
GPR68 G protein-coupled receptor 68 2.39876
CTSV cathepsin V 2.39876
FAM50A family with sequence similarity 50, member A 2.39876
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.39876
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.39876
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.39876
UBXN10 UBX domain protein 10 2.39876
TCAP titin-cap 2.39876
TSNAXIP1 translin-associated factor X interacting protein 1 2.39876
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.39876
FLRT3 fibronectin leucine rich transmembrane protein 3 2.39876
PCDHGB4 protocadherin gamma subfamily B, 4 2.39876
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.39876
STAB1 stabilin 1 2.39876
LRRC32 leucine rich repeat containing 32 2.39876
CLEC7A C-type lectin domain family 7, member A 2.39876
LGALS12 lectin, galactoside-binding, soluble, 12 2.39876
VAV1 vav 1 guanine nucleotide exchange factor 2.39876
NDE1 nudE neurodevelopment protein 1 2.39876
VWA3A von Willebrand factor A domain containing 3A 2.39876
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.39876
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.39876
TTC9B tetratricopeptide repeat domain 9B 2.39876
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 2.39876
EMILIN1 elastin microfibril interfacer 1 2.39876
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.39876
FBXL20 F-box and leucine-rich repeat protein 20 2.39876
MAB21L2 mab-21-like 2 (C. elegans) 2.39876
C11ORF16 chromosome 11 open reading frame 16 2.39876
PRPH peripherin 2.39876
SVOP SV2 related protein homolog (rat) 2.39876
LRRC15 leucine rich repeat containing 15 2.39876
WFDC9 WAP four-disulfide core domain 9 2.39876
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.39876
MORN5 MORN repeat containing 5 2.39876
FAM222A family with sequence similarity 222, member A 2.39876
HCAR1 hydroxycarboxylic acid receptor 1 2.39876
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.39876
PRSS55 protease, serine, 55 2.39876
PHACTR2 phosphatase and actin regulator 2 2.39876
LRRC38 leucine rich repeat containing 38 2.39876
TMPRSS13 transmembrane protease, serine 13 2.39876
TEX35 testis expressed 35 2.39876
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.39876
AMDHD1 amidohydrolase domain containing 1 2.39876
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.39876
CFB complement factor B 2.39876
POU5F2 POU domain class 5, transcription factor 2 2.39876
CFH complement factor H 2.39876
PGM5 phosphoglucomutase 5 2.39876
TAS2R46 taste receptor, type 2, member 46 2.39876
MMP12 matrix metallopeptidase 12 2.39876
ART1 ADP-ribosyltransferase 1 2.39876
MEIOB meiosis specific with OB domains 2.39876
ITGA8 integrin, alpha 8 2.39876
POPDC2 popeye domain containing 2 2.39876
CIB4 calcium and integrin binding family member 4 2.39876
DMRTC2 DMRT-like family C2 2.39876
ZNF385B zinc finger protein 385B 2.39876
ABHD1 abhydrolase domain containing 1 2.39876
PPCS phosphopantothenoylcysteine synthetase 2.39876
MAEL maelstrom spermatogenic transposon silencer 2.39876
KLHDC1 kelch domain containing 1 2.39876
MST1 macrophage stimulating 1 2.39876
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.39876
GBX2 gastrulation brain homeobox 2 2.39876
ZNF534 zinc finger protein 534 2.39876
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.39876
GRAPL GRB2-related adaptor protein-like 2.39876
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.39876
NLRP3 NLR family, pyrin domain containing 3 2.39876
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.39876
GOLGA8N golgin A8 family, member N 2.39876
ACSS1 acyl-CoA synthetase short-chain family member 1 2.39876
ACKR3 atypical chemokine receptor 3 2.37853
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.37421
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 2.37415
COQ6 coenzyme Q6 monooxygenase 2.37415
TNNC2 troponin C type 2 (fast) 2.37415
IL15RA interleukin 15 receptor, alpha 2.37415
C1ORF216 chromosome 1 open reading frame 216 2.37415
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 2.37415
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.34825
H2BC12 H2B clustered histone 12 2.34825
SERTAD4 SERTA domain containing 4 2.34825
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.34825
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.32149
LACTB2 lactamase, beta 2 2.31865
SGMS2 sphingomyelin synthase 2 2.3162
ACD adrenocortical dysplasia homolog (mouse) 2.29437
DENND4A DENN/MADD domain containing 4A 2.2792
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 2.2792
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.26807
YJU2B YJU2 splicing factor homolog B 2.24261
NCAPD3 non-SMC condensin II complex, subunit D3 2.24241
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 2.23314
PRPF19 pre-mRNA processing factor 19 2.21847
TNK1 tyrosine kinase, non-receptor, 1 2.19734
PDHX pyruvate dehydrogenase complex, component X 2.19734
FSCN1 fascin actin-bundling protein 1 2.17583
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.17085
ADORA2B adenosine A2b receptor 2.1703
EBP emopamil binding protein (sterol isomerase) 2.13492
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 2.13222
PCDH7 protocadherin 7 2.12058
N4BP1 NEDD4 binding protein 1 2.11941
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.11829
PDGFD platelet derived growth factor D 2.10899
YY1AP1 YY1 associated protein 1 2.10361
PCOLCE procollagen C-endopeptidase enhancer 2.07609
BCAR3 breast cancer anti-estrogen resistance 3 2.06628
FAM222B family with sequence similarity 222, member B 2.06203
KLHL14 kelch-like family member 14 2.06203
MATN2 matrilin 2 2.04572
CLOCK clock circadian regulator 2.04128
PZP pregnancy-zone protein 2.04128
SYTL2 synaptotagmin-like 2 2.03752
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2.03189
DVL2 dishevelled segment polarity protein 2 2.02614
CCDC86 coiled-coil domain containing 86 2.01647
ZMAT1 zinc finger, matrin-type 1 2.0162
ANOS1 anosmin 1 2.0162
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.0162
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 2.01362

decreased expression

Symbol Name Standardized Value
MTAP methylthioadenosine phosphorylase -2.4573
SPMIP4 sperm microtubule inner protein 4 -2.4573
RAD51D RAD51 paralog D -2.4573
GLB1 galactosidase, beta 1 -2.4573
USP21 ubiquitin specific peptidase 21 -2.40298
CNTN2 contactin 2 (axonal) -2.39876
ZNF74 zinc finger protein 74 -2.39876
ZNF223 zinc finger protein 223 -2.39876
TENT5C terminal nucleotidyltransferase 5C -2.39876
PFDN1 prefoldin subunit 1 -2.39876
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.39876
RAB31 RAB31, member RAS oncogene family -2.39876
GPATCH8 G patch domain containing 8 -2.39876
LZTS1 leucine zipper, putative tumor suppressor 1 -2.39876
PTPRS protein tyrosine phosphatase, receptor type, S -2.39876
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.39876
SGSH N-sulfoglucosamine sulfohydrolase -2.39876
ADAM33 ADAM metallopeptidase domain 33 -2.39876
ZBTB47 zinc finger and BTB domain containing 47 -2.39876
COL16A1 collagen, type XVI, alpha 1 -2.39876
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -2.39876
RUSC2 RUN and SH3 domain containing 2 -2.37853
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.37415
PRICKLE4 prickle homolog 4 (Drosophila) -2.37415
FGF9 fibroblast growth factor 9 -2.37415
IRF4 interferon regulatory factor 4 -2.37415
ZC3H11A zinc finger CCCH-type containing 11A -2.37415
LRRC66 leucine rich repeat containing 66 -2.37415
CRLF2 cytokine receptor-like factor 2 -2.37415
HCRTR1 hypocretin (orexin) receptor 1 -2.37415
PANO1 proapoptotic nucleolar protein 1 -2.37415
CLVS2 clavesin 2 -2.37415
NDRG3 NDRG family member 3 -2.37415
ATP13A4 ATPase type 13A4 -2.37415
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 -2.37415
C19ORF12 chromosome 19 open reading frame 12 -2.37415
ZNF597 zinc finger protein 597 -2.37415
CPED1 cadherin-like and PC-esterase domain containing 1 -2.37415
SPDYE5 speedy/RINGO cell cycle regulator family member E5 -2.37415
AGBL1 ATP/GTP binding protein-like 1 -2.37415
FMO1 flavin containing monooxygenase 1 -2.37415
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.37415
H4C14 H4 clustered histone 14 -2.37415
REELD1 reeler domain containing 1 -2.37415
FERMT3 fermitin family member 3 -2.37415
ADGRD2 adhesion G protein-coupled receptor D2 -2.37415
EFCAB12 EF-hand calcium binding domain 12 -2.37415
NOTCH4 notch 4 -2.37415
AGA-DT AGA divergent transcript -2.37415
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -2.37415
BHMT betaine--homocysteine S-methyltransferase -2.37415
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.37415
IL21R interleukin 21 receptor -2.37415
CLRN1 clarin 1 -2.37415
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like -2.37415
NUTM2G NUT family member 2G -2.37415
NPIPB9 nuclear pore complex interacting protein family, member B9 -2.37415
BOLL boule-like RNA-binding protein -2.37415
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.37415
FOXK2 forkhead box K2 -2.37415
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 -2.37415
RAD21L1 RAD21-like 1 (S. pombe) -2.37415
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) -2.37415
COCH cochlin -2.34877
FRYL FRY-like -2.34825
HCFC2 host cell factor C2 -2.34179
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.34145
TIMCC TIM double twin CX3C motif chaperone -2.27814
BAIAP2 BAI1-associated protein 2 -2.25614
CA12 carbonic anhydrase XII -2.23314
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.2271
AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 -2.20293
CXADR coxsackie virus and adenovirus receptor -2.19734
MPZL3 myelin protein zero-like 3 -2.19734
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.19734
ZHX1 zinc fingers and homeoboxes 1 -2.19734
TMEM130 transmembrane protein 130 -2.19734
RNF32 ring finger protein 32 -2.19734
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -2.17648
STK40 serine/threonine kinase 40 -2.1703
NAGA N-acetylgalactosaminidase, alpha- -2.16715
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.15874
PSPC1 paraspeckle component 1 -2.15691
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -2.1499
F8 coagulation factor VIII, procoagulant component -2.135
PTGR2 prostaglandin reductase 2 -2.10768
DENND4B DENN/MADD domain containing 4B -2.07755
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.07448
PTGR3 prostaglandin reductase 3 -2.07448
PLAGL1 pleiomorphic adenoma gene-like 1 -2.07448
ARMC5 armadillo repeat containing 5 -2.07448
C4ORF33 chromosome 4 open reading frame 33 -2.07448
SSPN sarcospan -2.07448
CELF5 CUGBP, Elav-like family member 5 -2.06203
CYB5D2 cytochrome b5 domain containing 2 -2.05262
TSLIG3C tRNA splicing ligase complex subunit 3C -2.04128
CABLES1 Cdk5 and Abl enzyme substrate 1 -2.03348
TRMO tRNA methyltransferase O -2.02614
CNN3 calponin 3, acidic -2.02614
LIF leukemia inhibitory factor -2.02614
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -2.0162
ZBTB25 zinc finger and BTB domain containing 25 -2.00618
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase -2.00618
CHD2 chromodomain helicase DNA binding protein 2 -2.00618
TMEM8B transmembrane protein 8B -2.00097