MTF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description metal-regulatory transcription factor 1|This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4520)
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Genes

368 genes differentially expressed following the MTF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ESR1 estrogen receptor 1 2.64004
WFDC8 WAP four-disulfide core domain 8 2.64004
TPH1 tryptophan hydroxylase 1 2.64004
ACSL6 acyl-CoA synthetase long-chain family member 6 2.64004
CCDC83 coiled-coil domain containing 83 2.64004
GSG1L GSG1-like 2.64004
MYBPHL myosin binding protein H-like 2.64004
RAG1 recombination activating gene 1 2.64004
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.64004
NOD2 nucleotide-binding oligomerization domain containing 2 2.64004
TRAF1 TNF receptor-associated factor 1 2.64004
ADRA1A adrenoceptor alpha 1A 2.64004
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.64004
WDR93 WD repeat domain 93 2.64004
ZNF132 zinc finger protein 132 2.64004
ACADL acyl-CoA dehydrogenase, long chain 2.64004
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.64004
RAB36 RAB36, member RAS oncogene family 2.64004
RIMBP2 RIMS binding protein 2 2.64004
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.64004
MAP2K2 mitogen-activated protein kinase kinase 2 2.64004
SYT15B synaptotagmin 15B 2.64004
PLA2G2C phospholipase A2, group IIC 2.64004
TRHR thyrotropin-releasing hormone receptor 2.64004
SNX3 sorting nexin 3 2.64004
DND1 DND microRNA-mediated repression inhibitor 1 2.64004
CCDC78 coiled-coil domain containing 78 2.64004
VAMP5 vesicle-associated membrane protein 5 2.64004
IZUMO3 IZUMO family member 3 2.61078
SLC46A2 solute carrier family 46, member 2 2.61078
TMEM176A transmembrane protein 176A 2.61078
LCN12 lipocalin 12 2.61078
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.61078
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.61078
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.61078
PRB2 proline-rich protein BstNI subfamily 2 2.61078
ZNF98 zinc finger protein 98 2.61078
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.61078
MEP1B meprin A, beta 2.61078
ACR acrosin 2.61078
LCN15 lipocalin 15 2.61078
LCN10 lipocalin 10 2.61078
KLHL34 kelch-like family member 34 2.61078
CFHR3 complement factor H-related 3 2.61078
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.61078
BTK Bruton agammaglobulinemia tyrosine kinase 2.61078
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.61078
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.61078
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.61078
ARHGAP36 Rho GTPase activating protein 36 2.61078
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.61078
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.61078
FAM90A1 family with sequence similarity 90, member A1 2.61078
FETUB fetuin B 2.61078
PLCH2 phospholipase C, eta 2 2.61078
GDNF glial cell derived neurotrophic factor 2.61078
RPL27A ribosomal protein L27a 2.61078
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.61078
HORMAD1 HORMA domain containing 1 2.61078
ADAMTSL2 ADAMTS-like 2 2.61078
TRIM50 tripartite motif containing 50 2.61078
PTGFR prostaglandin F receptor (FP) 2.61078
MYBPC3 myosin binding protein C, cardiac 2.61078
GPR26 G protein-coupled receptor 26 2.61078
OSR2 odd-skipped related transciption factor 2 2.61078
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.61078
H3-7 H3.7 histone (putative) 2.61078
PTPRC protein tyrosine phosphatase, receptor type, C 2.61078
SPMIP11 sperm microtubule inner protein 11 2.61078
MINAR2 membrane integral NOTCH2 associated receptor 2 2.61078
TBXT T-box transcription factor T 2.61078
CCN5 cellular communication network factor 5 2.61078
ATP5MC1 ATP synthase membrane subunit c locus 1 2.61078
PLAAT4 phospholipase A and acyltransferase 4 2.61078
DEPP1 DEPP autophagy regulator 1 2.61078
H3-3A H3.3 histone A 2.61078
SARS1 seryl-tRNA synthetase 1 2.61078
ADGRG3 adhesion G protein-coupled receptor G3 2.61078
ACER1 alkaline ceramidase 1 2.61078
MSANTD5 Myb/SANT DNA binding domain containing 5 2.61078
ITPRID1 ITPR interacting domain containing 1 2.61078
SPMIP10 sperm microtubule inner protein 10 2.61078
DNAAF19 dynein axonemal assembly factor 19 2.61078
WASL-DT WASL divergent transcript 2.61078
DUSP13B dual specificity phosphatase 13B 2.61078
C8ORF90 chromosome 8 open reading frame 90 2.61078
H3C13 H3 clustered histone 13 2.61078
GREP1 glycine rich extracellular protein 1 2.61078
DYNLT5 dynein light chain Tctex-type family member 5 2.61078
GLYATL1B glycine-N-acyltransferase like 1B 2.61078
TMEM225B transmembrane protein 225B 2.61078
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.61078
KLB klotho beta 2.61078
RPL28 ribosomal protein L28 2.61078
FGFBP2 fibroblast growth factor binding protein 2 2.61078
SAMD15 sterile alpha motif domain containing 15 2.61078
ABHD15 abhydrolase domain containing 15 2.61078
CNTFR ciliary neurotrophic factor receptor 2.61078
GNPDA1 glucosamine-6-phosphate deaminase 1 2.61078
RAG2 recombination activating gene 2 2.61078
TBX6 T-box 6 2.61078
MYH13 myosin, heavy chain 13, skeletal muscle 2.61078
ANXA10 annexin A10 2.61078
BID BH3 interacting domain death agonist 2.61078
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.61078
LRRC73 leucine rich repeat containing 73 2.61078
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.61078
RDH8 retinol dehydrogenase 8 (all-trans) 2.61078
WNT16 wingless-type MMTV integration site family, member 16 2.61078
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 2.61078
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 2.61078
PRDM7 PR domain containing 7 2.61078
TUBA4B tubulin, alpha 4b 2.61078
LTK leukocyte receptor tyrosine kinase 2.61078
GDF6 growth differentiation factor 6 2.61078
GPR83 G protein-coupled receptor 83 2.61078
CFAP99 cilia and flagella associated protein 99 2.61078
GLRA3 glycine receptor, alpha 3 2.61078
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.61078
LRRC74B leucine rich repeat containing 74B 2.61078
EMP1 epithelial membrane protein 1 2.61078
GRAPL GRB2-related adaptor protein-like 2.61078
SYTL4 synaptotagmin-like 4 2.61078
DRD3 dopamine receptor D3 2.61078
CLCNKB chloride channel, voltage-sensitive Kb 2.61078
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.61078
CCDC166 coiled-coil domain containing 166 2.61078
NNMT nicotinamide N-methyltransferase 2.61078
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.61078
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.61078
SFR1 SWI5-dependent recombination repair 1 2.61078
ANXA8 annexin A8 2.61078
TAT tyrosine aminotransferase 2.61078
PGM2 phosphoglucomutase 2 2.61078
CNGB3 cyclic nucleotide gated channel beta 3 2.61078
TBX1 T-box 1 2.61078
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.61078
FGF16 fibroblast growth factor 16 2.61078
SMAD7 SMAD family member 7 2.61078
CLIC5 chloride intracellular channel 5 2.61078
CLIC2 chloride intracellular channel 2 2.61078
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.61078
GAL3ST2 galactose-3-O-sulfotransferase 2 2.61078
OLFML1 olfactomedin-like 1 2.61078
ANKRD62 ankyrin repeat domain 62 2.61078
FBP1 fructose-1,6-bisphosphatase 1 2.61078
HAVCR1 hepatitis A virus cellular receptor 1 2.61078
NIPAL4 NIPA-like domain containing 4 2.61078
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.61078
LPAR5 lysophosphatidic acid receptor 5 2.61078
CARNS1 carnosine synthase 1 2.61078
POTEF POTE ankyrin domain family, member F 2.61078
HKDC1 hexokinase domain containing 1 2.61078
CLEC4C C-type lectin domain family 4, member C 2.61078
ANGPTL7 angiopoietin-like 7 2.61078
LRRC24 leucine rich repeat containing 24 2.61078
SMIM9 small integral membrane protein 9 2.61078
PRSS33 protease, serine, 33 2.61078
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.61078
MMP3 matrix metallopeptidase 3 2.61078
CDH22 cadherin 22, type 2 2.61078
TSHZ1 teashirt zinc finger homeobox 1 2.61078
BMP3 bone morphogenetic protein 3 2.61078
AVP arginine vasopressin 2.61078
NMUR1 neuromedin U receptor 1 2.61078
TRPC5OS TRPC5 opposite strand 2.61078
IL2RA interleukin 2 receptor, alpha 2.61078
ADCY4 adenylate cyclase 4 2.61078
CLEC18B C-type lectin domain family 18, member B 2.61078
GPRIN3 GPRIN family member 3 2.61078
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.61078
TMEM132C transmembrane protein 132C 2.61078
SPAG6 sperm associated antigen 6 2.61078
AMIGO3 adhesion molecule with Ig-like domain 3 2.61078
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.61078
ANXA2R annexin A2 receptor 2.61078
ASCL5 achaete-scute family bHLH transcription factor 5 2.61078
RBM24 RNA binding motif protein 24 2.61078
CTAG2 cancer/testis antigen 2 2.61078
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.61078
MNX1 motor neuron and pancreas homeobox 1 2.61078
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.61078
KLK3 kallikrein-related peptidase 3 2.61078
CHRDL2 chordin-like 2 2.61078
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.61078
KLK6 kallikrein-related peptidase 6 2.61078
MRTFB myocardin related transcription factor B 2.51629
RPS19 ribosomal protein S19 2.49763
LRR1 leucine rich repeat protein 1 2.47068
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.47068
C16ORF86 chromosome 16 open reading frame 86 2.46497
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 2.46497
KLK1 kallikrein 1 2.46497
ADGRF3 adhesion G protein-coupled receptor F3 2.46497
LDLRAD2 low density lipoprotein receptor class A domain containing 2 2.46497
CLVS2 clavesin 2 2.46497
VSTM2L V-set and transmembrane domain containing 2 like 2.46497
KY kyphoscoliosis peptidase 2.46497
GCK glucokinase (hexokinase 4) 2.45999
BBS9 Bardet-Biedl syndrome 9 2.44837
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.44837
CCDC27 coiled-coil domain containing 27 2.41407
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.40741
SPATA5L1 spermatogenesis associated 5-like 1 2.39311
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 2.39207
LMAN2 lectin, mannose-binding 2 2.38379
RPLP2 ribosomal protein, large, P2 2.35967
ZIC4 Zic family member 4 2.34274
NMBR neuromedin B receptor 2.34274
PRNP prion protein 2.33067
ASGR1 asialoglycoprotein receptor 1 2.32115
RPS18 ribosomal protein S18 2.31689
MRPL1 mitochondrial ribosomal protein L1 2.31689
MLH1 mutL homolog 1 2.30702
MOB2 MOB kinase activator 2 2.28976
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2.28339
CDK12 cyclin-dependent kinase 12 2.26485
CFAP410 cilia and flagella associated protein 410 2.24601
MPLKIP M-phase specific PLK1 interacting protein 2.24069
CHMP4B charged multivesicular body protein 4B 2.20843
NR6A1 nuclear receptor subfamily 6, group A, member 1 2.20784
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 2.20784
ISCA2 iron-sulfur cluster assembly 2 2.20278
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 2.20278
SV2C synaptic vesicle glycoprotein 2C 2.15509
KIFC1 kinesin family member C1 2.15282
GIGYF1 GRB10 interacting GYF protein 1 2.14443
NOTCH2NLA notch 2 N-terminal like A 2.12293
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 2.11274
FAM13C family with sequence similarity 13, member C 2.10084
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.09921
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 2.09693
ZDHHC3 zinc finger, DHHC-type containing 3 2.05393
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2.04766
MZF1 myeloid zinc finger 1 2.04066
RAP1GAP2 RAP1 GTPase activating protein 2 2.04066
SAXO6 stabilizer of axonemal microtubules 6 2.04066
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.04066
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.03252
EIF3G eukaryotic translation initiation factor 3, subunit G 2.03252
ANXA4 annexin A4 2.03025
FJX1 four jointed box 1 (Drosophila) 2.03025
ASTN1 astrotactin 1 2.03025
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 2.03025
DRG1 developmentally regulated GTP binding protein 1 2.02594
CDK16 cyclin-dependent kinase 16 2.02436
FAM110A family with sequence similarity 110, member A 2.01977
RPS4X ribosomal protein S4, X-linked 2.00197

decreased expression

Symbol Name Standardized Value
CFAP58 cilia and flagella associated protein 58 -2.64004
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.64004
GFRA1 GDNF family receptor alpha 1 -2.64004
PRDM16 PR domain containing 16 -2.61078
BRICD5 BRICHOS domain containing 5 -2.61078
KIF25 kinesin family member 25 -2.61078
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.61078
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.61078
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -2.61078
CPLX1 complexin 1 -2.61078
TENT5C terminal nucleotidyltransferase 5C -2.61078
FGF2 fibroblast growth factor 2 (basic) -2.61078
FAM161B family with sequence similarity 161, member B -2.61078
DZIP3 DAZ interacting zinc finger protein 3 -2.61078
ELL3 elongation factor RNA polymerase II-like 3 -2.61078
LKAAEAR1 LKAAEAR motif containing 1 -2.61078
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -2.61078
DNAH6 dynein, axonemal, heavy chain 6 -2.61078
MMP19 matrix metallopeptidase 19 -2.61078
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.61078
BMP8B bone morphogenetic protein 8b -2.61078
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.61078
H3C1 H3 clustered histone 1 -2.61078
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.61078
ZBTB22 zinc finger and BTB domain containing 22 -2.61078
DPY19L3 dpy-19-like 3 (C. elegans) -2.61078
LECT2 leukocyte cell-derived chemotaxin 2 -2.61078
CREB3L4 cAMP responsive element binding protein 3-like 4 -2.61078
NPNT nephronectin -2.61078
IDO1 indoleamine 2,3-dioxygenase 1 -2.61078
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -2.61078
FAM43B family with sequence similarity 43, member B -2.61078
LOC124906010 uncharacterized LOC124906010 -2.61078
IL15RA interleukin 15 receptor, alpha -2.61078
PCDHA6 protocadherin alpha 6 -2.61078
SLFN13 schlafen family member 13 -2.61078
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -2.61078
SOX15 SRY (sex determining region Y)-box 15 -2.61078
RGPD5 RANBP2-like and GRIP domain containing 5 -2.61078
ECM1 extracellular matrix protein 1 -2.61078
DIAPH2 diaphanous-related formin 2 -2.61078
GPHA2 glycoprotein hormone alpha 2 -2.61078
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.61078
GAGE10 G antigen 10 -2.61078
TAPBPL TAP binding protein-like -2.61078
TECR trans-2,3-enoyl-CoA reductase -2.61078
DNAH12 dynein, axonemal, heavy chain 12 -2.61078
PCDHGA1 protocadherin gamma subfamily A, 1 -2.61078
NLRC4 NLR family, CARD domain containing 4 -2.61078
GPR18 G protein-coupled receptor 18 -2.61078
ZNF787 zinc finger protein 787 -2.61078
PCDHGA4 protocadherin gamma subfamily A, 4 -2.61078
ALAS2 5'-aminolevulinate synthase 2 -2.61078
DOC2B double C2-like domains, beta -2.61078
CD59 CD59 molecule, complement regulatory protein -2.61078
MCF2 MCF.2 cell line derived transforming sequence -2.61078
MT1X metallothionein 1X -2.61078
PCDHA11 protocadherin alpha 11 -2.61078
MAP1A microtubule-associated protein 1A -2.61078
FAM13B family with sequence similarity 13, member B -2.55738
SEPTIN5 septin 5 -2.54115
MT1F metallothionein 1F -2.53285
ANKDD1B ankyrin repeat and death domain containing 1B -2.51027
WNT3 wingless-type MMTV integration site family, member 3 -2.50024
CRTC2 CREB regulated transcription coactivator 2 -2.49356
ABHD17B abhydrolase domain containing 17B -2.48014
LMNA lamin A/C -2.46634
LRP2 low density lipoprotein receptor-related protein 2 -2.4636
FERMT2 fermitin family member 2 -2.45098
FOXO4 forkhead box O4 -2.43347
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.43347
CCDC120 coiled-coil domain containing 120 -2.40833
ZNF69 zinc finger protein 69 -2.4003
HLTF helicase-like transcription factor -2.38251
KIAA2026 KIAA2026 -2.38129
SYTL3 synaptotagmin-like 3 -2.37357
MPI mannose phosphate isomerase -2.34296
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) -2.33796
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 -2.32815
SELENOO selenoprotein O -2.32722
ANO10 anoctamin 10 -2.32478
TFG TRK-fused gene -2.30702
NCAM1 neural cell adhesion molecule 1 -2.26955
MAGT1 magnesium transporter 1 -2.26485
ITGA9 integrin, alpha 9 -2.26485
MT1G metallothionein 1G -2.26327
RELT RELT tumor necrosis factor receptor -2.23627
CASKIN1 CASK interacting protein 1 -2.2343
WDR1 WD repeat domain 1 -2.20843
ERLIN2 ER lipid raft associated 2 -2.19941
ODAD4 outer dynein arm docking complex subunit 4 -2.17913
LRRC75B leucine rich repeat containing 75B -2.17913
MLKL mixed lineage kinase domain-like -2.16332
NRDC nardilysin convertase -2.15755
ZNF597 zinc finger protein 597 -2.15167
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -2.15167
ZNF816 zinc finger protein 816 -2.14502
H2AC21 H2A clustered histone 21 -2.12293
NEB nebulin -2.11412
SUMF1 sulfatase modifying factor 1 -2.11099
BLM Bloom syndrome, RecQ helicase-like -2.10587
VASN vasorin -2.10339
C5ORF22 chromosome 5 open reading frame 22 -2.10014
ECRG4 ECRG4 augurin precursor -2.09219
ZFYVE16 zinc finger, FYVE domain containing 16 -2.08357
PPHLN1 periphilin 1 -2.07783
LGI4 leucine-rich repeat LGI family, member 4 -2.07783
VIRMA vir like m6A methyltransferase associated -2.07783
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 -2.07122
TMEM209 transmembrane protein 209 -2.0623
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 -2.06168
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -2.05595
PABPN1 poly(A) binding protein, nuclear 1 -2.05393
LCLAT1 lysocardiolipin acyltransferase 1 -2.04046
LMLN leishmanolysin-like (metallopeptidase M8 family) -2.03327
ZNF223 zinc finger protein 223 -2.03327
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 -2.03327
NEU1 sialidase 1 (lysosomal sialidase) -2.03252
TUBB6 tubulin, beta 6 class V -2.03252
OLFML2B olfactomedin-like 2B -2.0015