MTHFD2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase|This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 10797)
External Link http://www.ncbi.nlm.nih.gov/gene/10797
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Genes

381 interacting proteins for MTHFD2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACLY ATP citrate lyase
ACOT8 acyl-CoA thioesterase 8
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTA1 actin, alpha 1, skeletal muscle
ACTG1 actin gamma 1
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ADCK3 aarF domain containing kinase 3
ADRM1 adhesion regulating molecule 1
AFG3L2 AFG3-like AAA ATPase 2
AGK acylglycerol kinase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP3B1 adaptor-related protein complex 3, beta 1 subunit
ASPH aspartate beta-hydroxylase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
ATXN10 ataxin 10
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BSG basigin (Ok blood group)
C19ORF70 chromosome 19 open reading frame 70
C2ORF47 chromosome 2 open reading frame 47
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALML5 calmodulin-like 5
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CANX calnexin
CCDC85C coiled-coil domain containing 85C
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CEPT1 choline/ethanolamine phosphotransferase 1
CFL1 cofilin 1 (non-muscle)
CHD4 chromodomain helicase DNA binding protein 4
CKAP5 cytoskeleton associated protein 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COPA coatomer protein complex, subunit alpha
COPB1 coatomer protein complex, subunit beta 1
COPE coatomer protein complex, subunit epsilon
COPG2 coatomer protein complex, subunit gamma 2
COX6C cytochrome c oxidase subunit VIc
CUL3 cullin 3
CYB5R3 cytochrome b5 reductase 3
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DARS aspartyl-tRNA synthetase
DDB1 damage-specific DNA binding protein 1, 127kDa
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DIAPH1 diaphanous-related formin 1
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF3L eukaryotic translation initiation factor 3, subunit L
ELAVL1 ELAV like RNA binding protein 1
EMD emerin
EPRS glutamyl-prolyl-tRNA synthetase
ERP44 endoplasmic reticulum protein 44
ESYT2 extended synaptotagmin-like protein 2
FAF2 Fas associated factor family member 2
FANCI Fanconi anemia, complementation group I
FAR1 fatty acyl CoA reductase 1
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FKBP8 FK506 binding protein 8, 38kDa
FOXK1 forkhead box K1
FOXK2 forkhead box K2
GANAB glucosidase, alpha; neutral AB
GATAD2A GATA zinc finger domain containing 2A
GCC1 GRIP and coiled-coil domain containing 1
GCDH glutaryl-CoA dehydrogenase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GLUD1 glutamate dehydrogenase 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GTF2I general transcription factor IIi
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa
HACD3 3-hydroxyacyl-CoA dehydratase 3
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HAX1 HCLS1 associated protein X-1
HEATR1 HEAT repeat containing 1
HELLS helicase, lymphoid-specific
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H2BB histone cluster 1, H2bb
HIST2H2AA4 histone cluster 2, H2aa4
HK1 hexokinase 1
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPR heterogeneous nuclear ribonucleoprotein R
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IFIH1 interferon induced with helicase C domain 1
IGHA1 immunoglobulin heavy constant alpha 1
IGKC immunoglobulin kappa constant
IMMT inner membrane protein, mitochondrial
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO5 importin 5
IPO7 importin 7
IQGAP3 IQ motif containing GTPase activating protein 3
IRS4 insulin receptor substrate 4
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KHSRP KH-type splicing regulatory protein
KIAA0368 KIAA0368
KIF2A kinesin heavy chain member 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
LAGE3 L antigen family, member 3
LARS leucyl-tRNA synthetase
LAS1L LAS1-like (S. cerevisiae)
LBR lamin B receptor
LDHA lactate dehydrogenase A
LDHAL6A lactate dehydrogenase A-like 6A
LDHB lactate dehydrogenase B
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LRRC47 leucine rich repeat containing 47
LRRK2 leucine-rich repeat kinase 2
LYPLAL1 lysophospholipase-like 1
LZTR1 leucine-zipper-like transcription regulator 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MARS methionyl-tRNA synthetase
MAT2A methionine adenosyltransferase II, alpha
MBD3 methyl-CpG binding domain protein 3
MCC mutated in colorectal cancers
MCM3 minichromosome maintenance complex component 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGME1 mitochondrial genome maintenance exonuclease 1
MINOS1 mitochondrial inner membrane organizing system 1
MLF2 myeloid leukemia factor 2
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MOGS mannosyl-oligosaccharide glucosidase
MSH2 mutS homolog 2
MSH5 mutS homolog 5
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTCH1 mitochondrial carrier 1
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO1B myosin IB
MYO1C myosin IC
MYO1D myosin ID
NAGK N-acetylglucosamine kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCLN nicalin
NDUFA4 NDUFA4, mitochondrial complex associated
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
NMT1 N-myristoyltransferase 1
NOMO2 NODAL modulator 2
NTPCR nucleoside-triphosphatase, cancer-related
NUCLEOLIN nucleolin multifunctional protein
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP160 nucleoporin 160kDa
NUP205 nucleoporin 205kDa
NUP93 nucleoporin 93kDa
OSBPL8 oxysterol binding protein-like 8
OSGEP O-sialoglycoprotein endopeptidase
PARP3 poly (ADP-ribose) polymerase family, member 3
PCBP2 poly(rC) binding protein 2
PCNA proliferating cell nuclear antigen
PELO pelota homolog (Drosophila)
PFKP phosphofructokinase, platelet
PGM3 phosphoglucomutase 3
PGRMC1 progesterone receptor membrane component 1
PHB prohibitin
PHB2 prohibitin 2
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PKM pyruvate kinase, muscle
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPP6C protein phosphatase 6, catalytic subunit
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF6 pre-mRNA processing factor 6
PRPF8 pre-mRNA processing factor 8
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PTCD3 pentatricopeptide repeat domain 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
PYGB phosphorylase, glycogen; brain
RAB1B RAB1B, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RARS arginyl-tRNA synthetase
RBBP7 retinoblastoma binding protein 7
RBM39 RNA binding motif protein 39
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
RHBDD2 rhomboid domain containing 2
RPL10A ribosomal protein L10a
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL13 ribosomal protein L13
RPL14 ribosomal protein L14
RPL18 ribosomal protein L18
RPL19 ribosomal protein L19
RPL21 ribosomal protein L21
RPL23 ribosomal protein L23
RPL23A ribosomal protein L23a
RPL24 ribosomal protein L24
RPL29 ribosomal protein L29
RPL3 ribosomal protein L3
RPL31 ribosomal protein L31
RPL5 ribosomal protein L5
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPLP0 ribosomal protein, large, P0
RPLP1 ribosomal protein, large, P1
RPN1 ribophorin I
RPN2 ribophorin II
RPS11 ribosomal protein S11
RPS14 ribosomal protein S14
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS19 ribosomal protein S19
RPS2 ribosomal protein S2
RPS20 ribosomal protein S20
RPS23 ribosomal protein S23
RPS27 ribosomal protein S27
RPS3 ribosomal protein S3
RPS3A ribosomal protein S3A
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
S100A11 S100 calcium binding protein A11
SAMHD1 SAM domain and HD domain 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SDF2L1 stromal cell-derived factor 2-like 1
SDF4 stromal cell derived factor 4
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC61B Sec61 beta subunit
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SF3B2 splicing factor 3b, subunit 2, 145kDa
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFXN1 sideroflexin 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLFN5 schlafen family member 5
SMAP1 small ArfGAP 1
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SNRPF small nuclear ribonucleoprotein polypeptide F
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SSR4 signal sequence receptor, delta
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCP1 t-complex 1
TECR trans-2,3-enoyl-CoA reductase
THOC1 THO complex 1
THOC2 THO complex 2
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM33 transmembrane protein 33
TMPO thymopoietin
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOR1AIP1 torsin A interacting protein 1
TP53 tumor protein p53
TRAFD1 TRAF-type zinc finger domain containing 1
TRAP1 TNF receptor-associated protein 1
TRIM28 tripartite motif containing 28
TROVE2 TROVE domain family, member 2
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TUFM Tu translation elongation factor, mitochondrial
UBC ubiquitin C
UBE2S ubiquitin-conjugating enzyme E2S
UBE3C ubiquitin protein ligase E3C
USMG5 up-regulated during skeletal muscle growth 5 homolog (mouse)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VIM vimentin
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WDR5 WD repeat domain 5
WDR6 WD repeat domain 6
XPO1 exportin 1
XPO5 exportin 5
XPOT exportin, tRNA
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YME1L1 YME1-like 1 ATPase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon