MTHFR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description methylenetetrahydrofolate reductase (NAD(P)H)|The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 4524)
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Genes

310 genes differentially expressed following the MTHFR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHB14 protocadherin beta 14 3.16544
GPR62 G protein-coupled receptor 62 3.16544
TCAF2 TRPM8 channel-associated factor 2 3.16544
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 3.16544
GJB3 gap junction protein, beta 3, 31kDa 3.16544
GRAPL GRB2-related adaptor protein-like 3.16544
WDR93 WD repeat domain 93 3.16544
TNNI1 troponin I type 1 (skeletal, slow) 3.16544
CCR4 chemokine (C-C motif) receptor 4 3.16544
SHOX2 short stature homeobox 2 3.16544
PRSS57 protease, serine, 57 3.16544
DMBX1 diencephalon/mesencephalon homeobox 1 3.16544
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.16544
SMLR1 small leucine-rich protein 1 3.16544
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.16544
CHCT1 CHD1 helical C-terminal domain containing 1 3.16544
C1ORF105 chromosome 1 open reading frame 105 3.16544
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.16544
CRYGA crystallin, gamma A 3.16544
NRROS negative regulator of reactive oxygen species 3.11315
FAM167A family with sequence similarity 167, member A 3.11315
ASB15 ankyrin repeat and SOCS box containing 15 3.11315
LRRC61 leucine rich repeat containing 61 3.11315
SYCP2 synaptonemal complex protein 2 3.11315
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.11315
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.11315
CD300E CD300e molecule 3.11315
RAB41 RAB41, member RAS oncogene family 3.11315
CDX1 caudal type homeobox 1 3.11315
ALOX15 arachidonate 15-lipoxygenase 3.11315
SPINK4 serine peptidase inhibitor, Kazal type 4 3.11315
SLC35G6 solute carrier family 35, member G6 3.11315
ADGB androglobin 3.11315
TREX2 three prime repair exonuclease 2 3.11315
EDDM3A epididymal protein 3A 3.11315
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 3.11315
SSMEM1 serine-rich single-pass membrane protein 1 3.11315
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 3.11315
ACY3 aminoacylase 3 3.11315
TTLL8 tubulin tyrosine ligase-like family member 8 3.11315
DLX4 distal-less homeobox 4 3.11315
NCF1 neutrophil cytosolic factor 1 3.11315
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.11315
NPIPA8 nuclear pore complex interacting protein family, member A8 3.11315
WNT8B wingless-type MMTV integration site family, member 8B 3.11315
HLX H2.0-like homeobox 3.11315
RHOXF2 Rhox homeobox family, member 2 3.11315
WDR38 WD repeat domain 38 3.11315
ASB4 ankyrin repeat and SOCS box containing 4 3.11315
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 3.11315
IQCF1 IQ motif containing F1 3.11315
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.11315
RAX2 retina and anterior neural fold homeobox 2 3.11315
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.11315
AVPR1B arginine vasopressin receptor 1B 3.11315
PCDHGA9 protocadherin gamma subfamily A, 9 3.11315
CES4A carboxylesterase 4A 3.11315
ASDURF ASNSD1 upstream open reading frame 3.11315
CCN6 cellular communication network factor 6 3.11315
PLAAT2 phospholipase A and acyltransferase 2 3.11315
CFAP97D1 CFAP97 domain containing 1 3.11315
NFILZ NFIL3 like basic leucine zipper 3.11315
NPIPA6 nuclear pore complex interacting protein family, member A6 3.11315
LOC114841035 uncharacterized LOC114841035 3.11315
DRC5 dynein regulatory complex subunit 5 3.11315
DOK7 docking protein 7 3.11315
TSPAN1 tetraspanin 1 3.11315
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 3.11315
CLEC3A C-type lectin domain family 3, member A 3.11315
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.11315
ANXA13 annexin A13 3.11315
TLR4 toll-like receptor 4 3.11315
PGC progastricsin (pepsinogen C) 3.11315
CFAP45 cilia and flagella associated protein 45 3.11315
BARHL1 BarH-like homeobox 1 3.11315
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.11315
PLD4 phospholipase D family, member 4 3.11315
C9 complement component 9 3.11315
PTH parathyroid hormone 3.11315
LRRC71 leucine rich repeat containing 71 3.11315
ACE2 angiotensin I converting enzyme 2 3.11315
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.11315
FAM228A family with sequence similarity 228, member A 3.11315
VSIG8 V-set and immunoglobulin domain containing 8 3.11315
LRTM3 leucine rich repeat transmembrane protein 3 3.11315
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.11315
BCL2A1 BCL2-related protein A1 3.11315
PKDREJ polycystin (PKD) family receptor for egg jelly 3.11315
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 3.11315
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.11315
ADAM8 ADAM metallopeptidase domain 8 3.11315
SPO11 SPO11 meiotic protein covalently bound to DSB 3.11315
WFDC6 WAP four-disulfide core domain 6 3.11315
RETNLB resistin like beta 3.11315
HHLA2 HERV-H LTR-associating 2 3.11315
UBQLNL ubiquilin-like 3.11315
EFCAB3 EF-hand calcium binding domain 3 3.11315
ERICH3 glutamate-rich 3 3.11315
GLYATL3 glycine-N-acyltransferase-like 3 3.11315
MYF6 myogenic factor 6 (herculin) 3.11315
CABP5 calcium binding protein 5 3.11315
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.11315
C16ORF78 chromosome 16 open reading frame 78 3.11315
SMR3B submaxillary gland androgen regulated protein 3B 3.11315
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.11315
OR52N5 olfactory receptor, family 52, subfamily N, member 5 3.11315
LRRC24 leucine rich repeat containing 24 3.11315
IL18RAP interleukin 18 receptor accessory protein 3.11315
CLEC18B C-type lectin domain family 18, member B 3.11315
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.11315
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.11315
NYX nyctalopin 3.11315
MOBP myelin-associated oligodendrocyte basic protein 3.11315
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.11315
CTSF cathepsin F 3.11315
DLX3 distal-less homeobox 3 3.11315
PLA2G12B phospholipase A2, group XIIB 3.11315
C20ORF144 chromosome 20 open reading frame 144 3.11315
PCDHGA2 protocadherin gamma subfamily A, 2 3.11315
C9ORF50 chromosome 9 open reading frame 50 3.11315
MC5R melanocortin 5 receptor 3.11315
TGM2 transglutaminase 2 3.11315
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.11315
PASD1 PAS domain containing 1 3.11315
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.11315
NLRP9 NLR family, pyrin domain containing 9 3.11315
MAGEC3 melanoma antigen family C3 3.11315
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.11315
C5ORF46 chromosome 5 open reading frame 46 3.11315
MYOZ2 myozenin 2 3.11315
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.11315
KIF19 kinesin family member 19 3.11315
SLFN11 schlafen family member 11 3.11315
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 3.11315
WFDC11 WAP four-disulfide core domain 11 3.11315
SLC7A4 solute carrier family 7, member 4 3.11315
KRTAP5-5 keratin associated protein 5-5 3.11315
SLC10A5 solute carrier family 10, member 5 3.11315
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.11315
TWIST1 twist family bHLH transcription factor 1 3.11315
ANXA2R annexin A2 receptor 3.11315
OR4E2 olfactory receptor, family 4, subfamily E, member 2 3.11315
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 3.00316
SPATA6 spermatogenesis associated 6 2.86401
PDE4DIP phosphodiesterase 4D interacting protein 2.60165
PMF1 polyamine-modulated factor 1 2.53005
DNAL4 dynein, axonemal, light chain 4 2.52139
RB1 retinoblastoma 1 2.51873
SNPH syntaphilin 2.51365
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.48171
PTCD3 pentatricopeptide repeat domain 3 2.46103
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.41591
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 2.38772
RNF43 ring finger protein 43 2.37293
CCT4 chaperonin containing TCP1, subunit 4 (delta) 2.34626
MT2A metallothionein 2A 2.33873
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.32062
UTS2B urotensin 2B 2.32062
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.32062
TCERG1 transcription elongation regulator 1 2.30303
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 2.30303
FAM120B family with sequence similarity 120B 2.27056
GPM6B glycoprotein M6B 2.27056
ZFHX3 zinc finger homeobox 3 2.24058
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.22099
WDR13 WD repeat domain 13 2.21979
EPHA7 EPH receptor A7 2.21605
CRTAP cartilage associated protein 2.19107
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.19107
LHFPL3 lipoma HMGIC fusion partner-like 3 2.18088
RPTOR regulatory associated protein of MTOR, complex 1 2.18088
PDCD6 programmed cell death 6 2.17765
GJA5 gap junction protein, alpha 5, 40kDa 2.1776
TET3 tet methylcytosine dioxygenase 3 2.17333
H2AC25 H2A clustered histone 25 2.16937
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 2.15276
SRP72 signal recognition particle 72kDa 2.13767
RINL Ras and Rab interactor-like 2.13767
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.137
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2.12061
IQGAP2 IQ motif containing GTPase activating protein 2 2.11159
MARCHF4 membrane associated ring-CH-type finger 4 2.1056
SPHK2 sphingosine kinase 2 2.09698
NUP35 nucleoporin 35kDa 2.09536
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.09536
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 2.0804
PNPO pyridoxamine 5'-phosphate oxidase 2.0804
SGSM2 small G protein signaling modulator 2 2.05619
THAP11 THAP domain containing 11 2.04467
SIDT1 SID1 transmembrane family, member 1 2.0392
ZC3H11C zinc finger CCCH-type containing 11C 2.0392
FAM107A family with sequence similarity 107, member A 2.0392
TUBA4B tubulin, alpha 4b 2.0392
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.0392
BGN biglycan 2.0392
DUSP8 dual specificity phosphatase 8 2.0392
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.03794
IL20RB interleukin 20 receptor beta 2.01289
L1CAM L1 cell adhesion molecule 2.0075
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 2.0002

decreased expression

Symbol Name Standardized Value
OVGP1 oviductal glycoprotein 1, 120kDa -3.16544
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -3.16544
PYGO1 pygopus family PHD finger 1 -3.16544
HIPK4 homeodomain interacting protein kinase 4 -3.16544
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -3.16544
KRT222 keratin 222, type II -3.11315
CST1 cystatin SN -3.11315
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -3.11315
GPR20 G protein-coupled receptor 20 -3.11315
NEU4 sialidase 4 -3.11315
CCDC154 coiled-coil domain containing 154 -3.11315
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -3.11315
USP50 ubiquitin specific peptidase 50 -3.11315
C8ORF74 chromosome 8 open reading frame 74 -3.11315
FOXJ1 forkhead box J1 -3.11315
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -3.11315
MT1M metallothionein 1M -3.11315
MYO16 myosin XVI -3.11315
SPINT4 serine peptidase inhibitor, Kunitz type 4 -3.11315
FAM209A family with sequence similarity 209, member A -3.11315
BCO1 beta-carotene oxygenase 1 -3.11315
C20ORF204 chromosome 20 open reading frame 204 -3.11315
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 -3.11315
NPM2 nucleophosmin/nucleoplasmin 2 -3.11315
TTC24 tetratricopeptide repeat domain 24 -3.11315
SERTM2 serine rich and transmembrane domain containing 2 -3.11315
CCN3 cellular communication network factor 3 -3.11315
LTB lymphotoxin beta (TNF superfamily, member 3) -3.11315
ITK IL2-inducible T-cell kinase -3.11315
MDFIC2 MyoD family inhibitor domain containing 2 -3.11315
TBX10 T-box 10 -3.11315
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -3.11315
FCRLB Fc receptor-like B -3.11315
AMH anti-Mullerian hormone -3.11315
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -3.11315
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -3.11315
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -3.11315
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 -3.03227
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) -3.00387
CCNB1 cyclin B1 -2.97469
CC2D1A coiled-coil and C2 domain containing 1A -2.80018
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -2.78888
ECEL1 endothelin converting enzyme-like 1 -2.75687
MARCHF6 membrane associated ring-CH-type finger 6 -2.68642
WDR20 WD repeat domain 20 -2.68614
USHBP1 Usher syndrome 1C binding protein 1 -2.66652
KIF27 kinesin family member 27 -2.65058
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -2.64024
NPAS1 neuronal PAS domain protein 1 -2.59863
TLCD4 TLC domain containing 4 -2.52801
CAB39L calcium binding protein 39-like -2.51365
TIGD2 tigger transposable element derived 2 -2.51115
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 -2.48171
ZNF615 zinc finger protein 615 -2.47419
UBE2K ubiquitin-conjugating enzyme E2K -2.46933
CEP83 centrosomal protein 83kDa -2.46933
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) -2.45697
ARRDC2 arrestin domain containing 2 -2.43755
CDX4 caudal type homeobox 4 -2.43755
ZGLP1 zinc finger, GATA-like protein 1 -2.43755
PLXNB2 plexin B2 -2.43322
ESR1 estrogen receptor 1 -2.41591
STAB2 stabilin 2 -2.39844
ICAM5 intercellular adhesion molecule 5, telencephalin -2.39844
MYT1L myelin transcription factor 1-like -2.39844
ALYREF Aly/REF export factor -2.38772
CXXC5 CXXC finger protein 5 -2.37482
GEMIN6 gem (nuclear organelle) associated protein 6 -2.36892
POU2F3 POU class 2 homeobox 3 -2.36892
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.30303
RBL2 retinoblastoma-like 2 -2.30303
ARID5A AT rich interactive domain 5A (MRF1-like) -2.27056
VSTM2A V-set and transmembrane domain containing 2A -2.27056
OPTC opticin -2.27056
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.22679
MANSC4 MANSC domain containing 4 -2.22679
KPNA4 karyopherin alpha 4 (importin alpha 3) -2.21979
NAGLU N-acetylglucosaminidase, alpha -2.21979
TMED6 transmembrane emp24 protein transport domain containing 6 -2.21979
PROKR1 prokineticin receptor 1 -2.21979
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.20243
FOXN4 forkhead box N4 -2.20243
TMEM175 transmembrane protein 175 -2.19525
FBXL3 F-box and leucine-rich repeat protein 3 -2.19107
IGLON5 IgLON family member 5 -2.18221
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.1776
TAS2R4 taste receptor, type 2, member 4 -2.17483
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 -2.16677
SLC10A3 solute carrier family 10, member 3 -2.15699
DCDC1 doublecortin domain containing 1 -2.15276
COL13A1 collagen, type XIII, alpha 1 -2.13882
MAP10 microtubule-associated protein 10 -2.13767
FBRS fibrosin -2.13767
SMOC1 SPARC related modular calcium binding 1 -2.13767
XPR1 xenotropic and polytropic retrovirus receptor 1 -2.12231
RBBP5 retinoblastoma binding protein 5 -2.09924
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 -2.09717
ABRACL ABRA C-terminal like -2.09717
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.09536
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -2.09536
EXD1 exonuclease 3'-5' domain containing 1 -2.09536
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.0744
KCTD17 potassium channel tetramerization domain containing 17 -2.0744
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.06297
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.06045
FXYD7 FXYD domain containing ion transport regulator 7 -2.05955
GRIA1 glutamate receptor, ionotropic, AMPA 1 -2.02982
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.00608
LRR1 leucine rich repeat protein 1 -2.00272
ZBTB7B zinc finger and BTB domain containing 7B -2.0002