MTOR Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description mechanistic target of rapamycin (serine/threonine kinase)|The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 2475)
External Link http://www.ncbi.nlm.nih.gov/gene/2475
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Genes

81 substrates of the kinase MTOR from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AFAP1 actin filament associated protein 1
AHNAK AHNAK nucleoprotein
AKAP11 A kinase (PRKA) anchor protein 11
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AMBRA1 autophagy/beclin-1 regulator 1
ANKRD17 ankyrin repeat domain 17
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARHGAP29 Rho GTPase activating protein 29
ATXN2L ataxin 2-like
BAG3 BCL2-associated athanogene 3
BRD9 bromodomain containing 9
C1ORF131 chromosome 1 open reading frame 131
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CUX1 cut-like homeobox 1
DAP death-associated protein
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DEPTOR DEP domain containing MTOR-interacting protein
DLG5 discs, large homolog 5 (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYSL3 dihydropyrimidinase-like 3
DUSP10 dual specificity phosphatase 10
EEF2K eukaryotic elongation factor 2 kinase
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELL elongation factor RNA polymerase II
FAM21A family with sequence similarity 21, member A
FASN fatty acid synthase
FBXW8 F-box and WD repeat domain containing 8
FLNA filamin A, alpha
FOXK1 forkhead box K1
FOXK2 forkhead box K2
GRB10 growth factor receptor-bound protein 10
HSF1 heat shock transcription factor 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISCU iron-sulfur cluster assembly enzyme
JUN jun proto-oncogene
LARP1 La ribonucleoprotein domain family, member 1
MAF1 MAF1 homolog (S. cerevisiae)
MAP1B microtubule-associated protein 1B
MAPKAP1 mitogen-activated protein kinase associated protein 1
MCL1 myeloid cell leukemia 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NES nestin
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFRKB nuclear factor related to kappaB binding protein
NUMA1 nuclear mitotic apparatus protein 1
NUP188 nucleoporin 188kDa
OXSR1 oxidative stress responsive 1
PATL1 protein associated with topoisomerase II homolog 1 (yeast)
PHLDB1 pleckstrin homology-like domain, family B, member 1
PHLDB2 pleckstrin homology-like domain, family B, member 2
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RC3H1 ring finger and CCCH-type domains 1
RPRD1B regulation of nuclear pre-mRNA domain containing 1B
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
SGK1 serum/glucocorticoid regulated kinase 1
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8
SQSTM1 sequestosome 1
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
ST5 suppression of tumorigenicity 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK4 serine/threonine kinase 4
SZT2 seizure threshold 2 homolog (mouse)
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TBC1D10B TBC1 domain family, member 10B
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
UBR4 ubiquitin protein ligase E3 component n-recognin 4
ULK1 unc-51 like autophagy activating kinase 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
WNK1 WNK lysine deficient protein kinase 1
ZNF768 zinc finger protein 768