MTOR_UP.N4.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MTOR_UP.N4.V1_UP
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Genes

385 genes differentially expressed following the MTOR_UP.N4.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ACACA acetyl-CoA carboxylase alpha
ADAM9 ADAM metallopeptidase domain 9
ADARB1 adenosine deaminase, RNA-specific, B1
ADM adrenomedullin
ANXA3 annexin A3
APOL6 apolipoprotein L, 6
ARG2 arginase 2
ARL3 ADP-ribosylation factor-like 3
ARL4A ADP-ribosylation factor-like 4A
ASCC1 activating signal cointegrator 1 complex subunit 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BATF basic leucine zipper transcription factor, ATF-like
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCHE butyrylcholinesterase
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BSPRY B-box and SPRY domain containing
C8B complement component 8, beta polypeptide
CALML4 calmodulin-like 4
CAMKV CaM kinase-like vesicle-associated
CARS cysteinyl-tRNA synthetase
CASR calcium-sensing receptor
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC86 coiled-coil domain containing 86
CD79B CD79b molecule, immunoglobulin-associated beta
CDK16 cyclin-dependent kinase 16
CDRT1 CMT1A duplicated region transcript 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHUK conserved helix-loop-helix ubiquitous kinase
CLIC4 chloride intracellular channel 4
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNIH4 cornichon family AMPA receptor auxiliary protein 4
COASY CoA synthase
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
CTSG cathepsin G
CUTC cutC copper transporter
CYTL1 cytokine-like 1
DBN1 drebrin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDN dendrin
DHCR7 7-dehydrocholesterol reductase
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOK2 docking protein 2, 56kDa
DSCR4 Down syndrome critical region 4
E2F5 E2F transcription factor 5, p130-binding
E2F6 E2F transcription factor 6
EAF2 ELL associated factor 2
EBNA1BP2 EBNA1 binding protein 2
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EMC2 ER membrane protein complex subunit 2
ETNK1 ethanolamine kinase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FGF1 fibroblast growth factor 1 (acidic)
FKBP11 FK506 binding protein 11, 19 kDa
GALE UDP-galactose-4-epimerase
GALK2 galactokinase 2
GAS2L1 growth arrest-specific 2 like 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCH1 GTP cyclohydrolase 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GH1 growth hormone 1
GK glycerol kinase
GK3P glycerol kinase 3 pseudogene
GLRX2 glutaredoxin 2
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPR65 G protein-coupled receptor 65
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRM2 glutamate receptor, metabotropic 2
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HYAL3 hyaluronoglucosaminidase 3
ICT1 immature colon carcinoma transcript 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IFI30 interferon, gamma-inducible protein 30
IFRD1 interferon-related developmental regulator 1
IL21R interleukin 21 receptor
IL7R interleukin 7 receptor
ISOC2 isochorismatase domain containing 2
ITK IL2-inducible T-cell kinase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0020 KIAA0020
KIF21B kinesin family member 21B
KLHL7 kelch-like family member 7
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LDLR low density lipoprotein receptor
LGMN legumain
LHX2 LIM homeobox 2
LIMA1 LIM domain and actin binding 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
MAP1A microtubule-associated protein 1A
MARS methionyl-tRNA synthetase
MAST2 microtubule associated serine/threonine kinase 2
MCPH1 microcephalin 1
MFAP4 microfibrillar-associated protein 4
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIPEP mitochondrial intermediate peptidase
MRPL22 mitochondrial ribosomal protein L22
MRPL39 mitochondrial ribosomal protein L39
MSMO1 methylsterol monooxygenase 1
NANS N-acetylneuraminic acid synthase
NFIL3 nuclear factor, interleukin 3 regulated
NME7 NME/NM23 family member 7
NQO2 NAD(P)H dehydrogenase, quinone 2
NUP155 nucleoporin 155kDa
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OGN osteoglycin
OPCML opioid binding protein/cell adhesion molecule-like
OPN3 opsin 3
OPRL1 opiate receptor-like 1
PAK1IP1 PAK1 interacting protein 1
PANK3 pantothenate kinase 3
PCCA propionyl CoA carboxylase, alpha polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDHX pyruvate dehydrogenase complex, component X
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PECAM1 platelet/endothelial cell adhesion molecule 1
PFKM phosphofructokinase, muscle
PHACTR2 phosphatase and actin regulator 2
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLS1 plastin 1
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PSPH phosphoserine phosphatase
PTPRK protein tyrosine phosphatase, receptor type, K
PTS 6-pyruvoyltetrahydropterin synthase
PYCR1 pyrroline-5-carboxylate reductase 1
RABEPK Rab9 effector protein with kelch motifs
RBM28 RNA binding motif protein 28
RIMS3 regulating synaptic membrane exocytosis 3
RIT1 Ras-like without CAAX 1
RPAP1 RNA polymerase II associated protein 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SAR1B secretion associated, Ras related GTPase 1B
SARS seryl-tRNA synthetase
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRED2 sprouty-related, EVH1 domain containing 2
SQRDL sulfide quinone reductase-like (yeast)
SREBF1 sterol regulatory element binding transcription factor 1
SSTR2 somatostatin receptor 2
STX4 syntaxin 4
SYNPO synaptopodin
TBRG4 transforming growth factor beta regulator 4
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)
TM6SF1 transmembrane 6 superfamily member 1
TMEM135 transmembrane protein 135
TRAF3IP2 TRAF3 interacting protein 2
TRIB3 tribbles pseudokinase 3
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TSC22D3 TSC22 domain family, member 3
TSNAXIP1 translin-associated factor X interacting protein 1
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase
ULBP1 UL16 binding protein 1
USH1C Usher syndrome 1C (autosomal recessive, severe)
VARS valyl-tRNA synthetase
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZPR1 ZPR1 zinc finger

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADORA2A adenosine A2a receptor
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
ANGEL2 angel homolog 2 (Drosophila)
ANKRD36B ankyrin repeat domain 36B
ANP32A-IT1 ANP32A intronic transcript 1
ANXA5 annexin A5
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF1 activating transcription factor 1
ATF7IP activating transcription factor 7 interacting protein
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BAALC brain and acute leukemia, cytoplasmic
BBS1 Bardet-Biedl syndrome 1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCOR BCL6 corepressor
BIN2 bridging integrator 2
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRWD1 bromodomain and WD repeat domain containing 1
BTG2 BTG family, member 2
C11ORF95 chromosome 11 open reading frame 95
C1ORF56 chromosome 1 open reading frame 56
C9ORF69 chromosome 9 open reading frame 69
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARF calcium responsive transcription factor
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBX7 chromobox homolog 7
CCDC28A coiled-coil domain containing 28A
CCNE1 cyclin E1
CCNG2 cyclin G2
CD1A CD1a molecule
CD1B CD1b molecule
CD1C CD1c molecule
CD1E CD1e molecule
CD52 CD52 molecule
CEP135 centrosomal protein 135kDa
CEP295 centrosomal protein 295kDa
CEP68 centrosomal protein 68kDa
CHIC2 cysteine-rich hydrophobic domain 2
CIR1 corepressor interacting with RBPJ, 1
CLK1 CDC-like kinase 1
CLK4 CDC-like kinase 4
CLN5 ceroid-lipofuscinosis, neuronal 5
CRBN cereblon
CUX1 cut-like homeobox 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DACH1 dachshund family transcription factor 1
DCAF16 DDB1 and CUL4 associated factor 16
DMXL1 Dmx-like 1
DNTT DNA nucleotidylexotransferase
DPY19L2P2 DPY19L2 pseudogene 2
ECHDC2 enoyl CoA hydratase domain containing 2
EFHC1 EF-hand domain (C-terminal) containing 1
ELAC1 elaC ribonuclease Z 1
ELF2 E74-like factor 2 (ets domain transcription factor)
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERAP1 endoplasmic reticulum aminopeptidase 1
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
FAIM Fas apoptotic inhibitory molecule
FAM13B family with sequence similarity 13, member B
FBLN5 fibulin 5
FBXL4 F-box and leucine-rich repeat protein 4
FLJ42627 uncharacterized LOC645644
FOLR1 folate receptor 1 (adult)
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCC2 GRIP and coiled-coil domain containing 2
GIMAP6 GTPase, IMAP family member 6
GPA33 glycoprotein A33 (transmembrane)
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HHAT hedgehog acyltransferase
HHLA3 HERV-H LTR-associating 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2AM histone cluster 1, H2am
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HOXA7 homeobox A7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IFT140 intraflagellar transport 140
IGBP1 immunoglobulin (CD79A) binding protein 1
IKZF2 IKAROS family zinc finger 2 (Helios)
ING4 inhibitor of growth family, member 4
KAT2B K(lysine) acetyltransferase 2B
KIAA0355 KIAA0355
KIAA0430 KIAA0430
KIAA0754 KIAA0754
KIAA1661 KIAA1661 protein
KRBOX4 KRAB box domain containing 4
LINC00342 long intergenic non-protein coding RNA 342
LINC00597 long intergenic non-protein coding RNA 597
LONP2 lon peptidase 2, peroxisomal
LRRC37A leucine rich repeat containing 37A
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LTB lymphotoxin beta (TNF superfamily, member 3)
LZTFL1 leucine zipper transcription factor-like 1
MAML1 mastermind-like 1 (Drosophila)
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MEPCE methylphosphate capping enzyme
MIS18BP1 MIS18 binding protein 1
MME membrane metallo-endopeptidase
MNT MAX network transcriptional repressor
MPHOSPH8 M-phase phosphoprotein 8
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MXD4 MAX dimerization protein 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2 nuclear factor, erythroid 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCNXL2 pecanex-like 2 (Drosophila)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLCL1 phospholipase C-like 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLH polymerase (DNA directed), eta
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAD51B RAD51 paralog B
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RCOR3 REST corepressor 3
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RNF44 ring finger protein 44
RPS28 ribosomal protein S28
RYR2 ryanodine receptor 2 (cardiac)
S1PR1 sphingosine-1-phosphate receptor 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SENP6 SUMO1/sentrin specific peptidase 6
SENP7 SUMO1/sentrin specific peptidase 7
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC41A3 solute carrier family 41, member 3
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SOGA1 suppressor of glucose, autophagy associated 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPATS2 spermatogenesis associated, serine-rich 2
SPHAR S-phase response (cyclin related)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
ST18 suppression of tumorigenicity 18, zinc finger
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STMN3 stathmin-like 3
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYF2 SYF2 pre-mRNA-splicing factor
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM7SF3 transmembrane 7 superfamily member 3
TMEM260 transmembrane protein 260
TMEM80 transmembrane protein 80
TNRC6B trinucleotide repeat containing 6B
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TRAT1 T cell receptor associated transmembrane adaptor 1
TRIM23 tripartite motif containing 23
TRIOBP TRIO and F-actin binding protein
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TXNIP thioredoxin interacting protein
VEZF1 vascular endothelial zinc finger 1
VNN2 vanin 2
WDR45 WD repeat domain 45
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)
ZBED8 zinc finger, BED-type containing 8
ZBTB16 zinc finger and BTB domain containing 16
ZBTB20 zinc finger and BTB domain containing 20
ZNF117 zinc finger protein 117
ZNF124 zinc finger protein 124
ZNF14 zinc finger protein 14
ZNF180 zinc finger protein 180
ZNF268 zinc finger protein 268
ZNF271P zinc finger protein 271, pseudogene
ZNF277 zinc finger protein 277
ZNF34 zinc finger protein 34
ZNF394 zinc finger protein 394
ZNF443 zinc finger protein 443
ZNF544 zinc finger protein 544
ZNF682 zinc finger protein 682
ZNF711 zinc finger protein 711
ZSCAN26 zinc finger and SCAN domain containing 26
ZXDC ZXD family zinc finger C
Funding