MTOR_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MTOR_UP.V1_UP
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Genes

353 genes differentially expressed following the MTOR_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ADORA2B adenosine A2b receptor
ADRA1B adrenoceptor alpha 1B
ADRA2B adrenoceptor alpha 2B
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ALPK2 alpha-kinase 2
ANKRD33 ankyrin repeat domain 33
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOOL apolipoprotein O-like
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
ATF3 activating transcription factor 3
ATXN7L1 ataxin 7-like 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BID BH3 interacting domain death agonist
BLK BLK proto-oncogene, Src family tyrosine kinase
BST2 bone marrow stromal cell antigen 2
C9 complement component 9
CAPN12 calpain 12
CCAR2 cell cycle and apoptosis regulator 2
CCDC86 coiled-coil domain containing 86
CCL5 chemokine (C-C motif) ligand 5
CD300LD CD300 molecule-like family member d
CDC20 cell division cycle 20
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK1 cyclin-dependent kinase 1
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CMA1 chymase 1, mast cell
CMBL carboxymethylenebutenolidase homolog (Pseudomonas)
COA7 cytochrome c oxidase assembly factor 7 (putative)
COMTD1 catechol-O-methyltransferase domain containing 1
COQ4 coenzyme Q4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CTRB1 chymotrypsinogen B1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBF4 DBF4 zinc finger
DFNA5 deafness, autosomal dominant 5
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLG4 discs, large homolog 4 (Drosophila)
DUOXA1 dual oxidase maturation factor 1
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ERN1 endoplasmic reticulum to nucleus signaling 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM131A family with sequence similarity 131, member A
FAM134C family with sequence similarity 134, member C
FAM3B family with sequence similarity 3, member B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFBP1 fibroblast growth factor binding protein 1
FNDC7 fibronectin type III domain containing 7
FOXI1 forkhead box I1
FTMT ferritin mitochondrial
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GCH1 GTP cyclohydrolase 1
GGACT gamma-glutamylamine cyclotransferase
GPX2 glutathione peroxidase 2
GSDMA gasdermin A
GSDMC gasdermin C
GSS glutathione synthetase
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HELLS helicase, lymphoid-specific
HIST1H2BD histone cluster 1, H2bd
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13
HSPE1 heat shock 10kDa protein 1
HTT huntingtin
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI30 interferon, gamma-inducible protein 30
IFI35 interferon-induced protein 35
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGLL1 immunoglobulin lambda-like polypeptide 1
IL18RAP interleukin 18 receptor accessory protein
IL27RA interleukin 27 receptor, alpha
INTS3 integrator complex subunit 3
ISYNA1 inositol-3-phosphate synthase 1
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNK4 potassium channel, two pore domain subfamily K, member 4
KIF9 kinesin family member 9
KRBA1 KRAB-A domain containing 1
LDHC lactate dehydrogenase C
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIPG lipase, endothelial
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTV1 LTV1 ribosome biogenesis factor
MAK male germ cell-associated kinase
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MGARP mitochondria-localized glutamic acid-rich protein
MINA MYC induced nuclear antigen
MKL2 MKL/myocardin-like 2
MS4A7 membrane-spanning 4-domains, subfamily A, member 7
MSMO1 methylsterol monooxygenase 1
MSX2 msh homeobox 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYO7B myosin VIIB
NABP1 nucleic acid binding protein 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NIPSNAP3A nipsnap homolog 3A (C. elegans)
NKAIN1 Na+/K+ transporting ATPase interacting 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTSR1 neurotensin receptor 1 (high affinity)
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCDHB5 protocadherin beta 5
PCNA proliferating cell nuclear antigen
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKP phosphofructokinase, platelet
PLAT plasminogen activator, tissue
PPAN peter pan homolog (Drosophila)
PRAF2 PRA1 domain family, member 2
PREP prolyl endopeptidase
PRKCA protein kinase C, alpha
PSAT1 phosphoserine aminotransferase 1
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PYGL phosphorylase, glycogen, liver
RANBP9 RAN binding protein 9
RCOR2 REST corepressor 2
RD3 retinal degeneration 3
RGS11 regulator of G-protein signaling 11
RRM2 ribonucleotide reductase M2
S100A14 S100 calcium binding protein A14
SC5D sterol-C5-desaturase
SCGB3A2 secretoglobin, family 3A, member 2
SEPT9 septin 9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC41A3 solute carrier family 41, member 3
SMTNL1 smoothelin-like 1
SP100 SP100 nuclear antigen
SPRR1A small proline-rich protein 1A
SQLE squalene epoxidase
STARD4 StAR-related lipid transfer (START) domain containing 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TCF19 transcription factor 19
TESC tescalcin
TFRC transferrin receptor
TG thyroglobulin
TIPIN TIMELESS interacting protein
TMEM106A transmembrane protein 106A
TMEM40 transmembrane protein 40
TMEM53 transmembrane protein 53
TMEM97 transmembrane protein 97
TMPRSS4 transmembrane protease, serine 4
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPH1 tryptophan hydroxylase 1
TRMT5 tRNA methyltransferase 5
UBE2C ubiquitin-conjugating enzyme E2C
UHRF1 ubiquitin-like with PHD and ring finger domains 1
USP18 ubiquitin specific peptidase 18
VIP vasoactive intestinal peptide
ZNF518B zinc finger protein 518B

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADCK3 aarF domain containing kinase 3
AOC3 amine oxidase, copper containing 3
AQP5 aquaporin 5
ARL4D ADP-ribosylation factor-like 4D
ARTN artemin
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2
BACE1 beta-site APP-cleaving enzyme 1
BBS2 Bardet-Biedl syndrome 2
C1QTNF4 C1q and tumor necrosis factor related protein 4
C1R complement component 1, r subcomponent
C2 complement component 2
C7ORF73 chromosome 7 open reading frame 73
CCDC134 coiled-coil domain containing 134
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CES3 carboxylesterase 3
CHRD chordin
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIRBP cold inducible RNA binding protein
CLCA3P chloride channel accessory 3, pseudogene
CLEC4M C-type lectin domain family 4, member M
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL11A2 collagen, type XI, alpha 2
COL20A1 collagen, type XX, alpha 1
CPE carboxypeptidase E
CRY2 cryptochrome circadian clock 2
CSAD cysteine sulfinic acid decarboxylase
CSDC2 cold shock domain containing C2, RNA binding
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSRP2 cysteine and glycine-rich protein 2
CTNS cystinosin, lysosomal cystine transporter
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDIT3 DNA-damage-inducible transcript 3
DENND1A DENN/MADD domain containing 1A
DNASE2 deoxyribonuclease II, lysosomal
DNMBP dynamin binding protein
DPEP1 dipeptidase 1 (renal)
DTX2 deltex 2, E3 ubiquitin ligase
DUSP1 dual specificity phosphatase 1
EDRF1 erythroid differentiation regulatory factor 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EXOSC1 exosome component 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FANK1 fibronectin type III and ankyrin repeat domains 1
FBXO32 F-box protein 32
FN3K fructosamine 3 kinase
FXYD1 FXYD domain containing ion transport regulator 1
FZD9 frizzled class receptor 9
GCOM1 GRINL1A complex locus 1
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GEMIN2 gem (nuclear organelle) associated protein 2
GRAMD1A GRAM domain containing 1A
H1FX H1 histone family, member X
HIGD1C HIG1 hypoxia inducible domain family, member 1C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB5 homeobox B5
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
HTRA1 HtrA serine peptidase 1
HYAL3 hyaluronoglucosaminidase 3
ICOSLG inducible T-cell co-stimulator ligand
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFT172 intraflagellar transport 172
IGF1 insulin-like growth factor 1 (somatomedin C)
IRS2 insulin receptor substrate 2
ISL1 ISL LIM homeobox 1
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KAT6B K(lysine) acetyltransferase 6B
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLF2 Kruppel-like factor 2
KRT15 keratin 15, type I
KRT5 keratin 5, type II
L2HGDH L-2-hydroxyglutarate dehydrogenase
LIFR leukemia inhibitory factor receptor alpha
LTBP1 latent transforming growth factor beta binding protein 1
MAX MYC associated factor X
MED12L mediator complex subunit 12-like
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
MFAP2 microfibrillar-associated protein 2
MIF4GD MIF4G domain containing
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type
MOXD1 monooxygenase, DBH-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCAM1 neural cell adhesion molecule 1
NCF4 neutrophil cytosolic factor 4, 40kDa
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NFXL1 nuclear transcription factor, X-box binding-like 1
NGFR nerve growth factor receptor
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTHL1 nth endonuclease III-like 1 (E. coli)
OLFML3 olfactomedin-like 3
OSGIN1 oxidative stress induced growth inhibitor 1
OSMR oncostatin M receptor
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PALD1 phosphatase domain containing, paladin 1
PDE10A phosphodiesterase 10A
PDE4B phosphodiesterase 4B, cAMP-specific
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PDE9A phosphodiesterase 9A
PDGFA platelet-derived growth factor alpha polypeptide
PDIA5 protein disulfide isomerase family A, member 5
PDLIM3 PDZ and LIM domain 3
PHAX phosphorylated adaptor for RNA export
PHC1 polyhomeotic homolog 1 (Drosophila)
PHF1 PHD finger protein 1
PHIP pleckstrin homology domain interacting protein
PI16 peptidase inhibitor 16
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLTP phospholipid transfer protein
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDM4 PR domain containing 4
PRSS23 protease, serine, 23
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRS protein tyrosine phosphatase, receptor type, S
QPRT quinolinate phosphoribosyltransferase
RASD1 RAS, dexamethasone-induced 1
RBP1 retinol binding protein 1, cellular
RCE1 Ras converting CAAX endopeptidase 1
RFTN2 raftlin family member 2
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
S1PR3 sphingosine-1-phosphate receptor 3
SASH1 SAM and SH3 domain containing 1
SCARA3 scavenger receptor class A, member 3
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SH2D1B SH2 domain containing 1B
SH3BGR SH3 domain binding glutamate-rich protein
SIX5 SIX homeobox 5
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC39A13 solute carrier family 39 (zinc transporter), member 13
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLIT3 slit homolog 3 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNHG11 small nucleolar RNA host gene 11
STX1A syntaxin 1A (brain)
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYF2 SYF2 pre-mRNA-splicing factor
SYN2 synapsin II
TBC1D17 TBC1 domain family, member 17
TCF3 transcription factor 3
TGIF2 TGFB-induced factor homeobox 2
TH tyrosine hydroxylase
THBS3 thrombospondin 3
TMEM186 transmembrane protein 186
TNIP2 TNFAIP3 interacting protein 2
TNNC2 troponin C type 2 (fast)
TNS2 tensin 2
TREM2 triggering receptor expressed on myeloid cells 2
TSPAN4 tetraspanin 4
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UBXN2A UBX domain protein 2A
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
UNC119 unc-119 homolog (C. elegans)
UPB1 ureidopropionase, beta
VSIG2 V-set and immunoglobulin domain containing 2
WBSCR27 Williams Beuren syndrome chromosome region 27
WDTC1 WD and tetratricopeptide repeats 1
WFDC1 WAP four-disulfide core domain 1
WIF1 WNT inhibitory factor 1
XDH xanthine dehydrogenase
ZMYM5 zinc finger, MYM-type 5
ZNF213 zinc finger protein 213
ZNF746 zinc finger protein 746
Funding