MUC1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description mucin 1, cell surface associated|This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 4582)
External Link http://www.ncbi.nlm.nih.gov/gene/4582
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Genes

83 interacting proteins for MUC1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
APC adenomatous polyposis coli
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BAX BCL2-associated X protein
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C1GALT1C1 C1GALT1-specific chaperone 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GCNT6 glucosaminyl (N-acetyl) transferase 6
GCNT7 glucosaminyl (N-acetyl) transferase family member 7
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IPO5 importin 5
JUN jun proto-oncogene
JUP junction plakoglobin
LCK LCK proto-oncogene, Src family tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
NUP62 nucleoporin 62kDa
OSGEP O-sialoglycoprotein endopeptidase
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
TBP TATA box binding protein
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBC ubiquitin C
WBSCR17 Williams-Beuren syndrome chromosome region 17
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa