MX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description MX dynamin-like GTPase 2|The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4600)
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Genes

341 genes differentially expressed following the MX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
WNT5A wingless-type MMTV integration site family, member 5A 2.22098
STYK1 serine/threonine/tyrosine kinase 1 2.14999
TMEM233 transmembrane protein 233 2.14999
CDK20 cyclin-dependent kinase 20 2.14583
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.14583
IAPP islet amyloid polypeptide 2.14583
PLN phospholamban 2.14583
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.14583
BEST2 bestrophin 2 2.14583
GPR78 G protein-coupled receptor 78 2.14583
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.14583
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.14583
C2ORF81 chromosome 2 open reading frame 81 2.14583
RNASEK ribonuclease, RNase K 2.14583
PPP1R42 protein phosphatase 1, regulatory subunit 42 2.14583
NCAN neurocan 2.14583
TLDC2 TBC/LysM-associated domain containing 2 2.14583
GJD2 gap junction protein, delta 2, 36kDa 2.14583
ZNF804B zinc finger protein 804B 2.14583
PODNL1 podocan-like 1 2.14583
THBS4 thrombospondin 4 2.10301
EPPIN epididymal peptidase inhibitor 2.10214
BTC betacellulin 2.10214
TRIM15 tripartite motif containing 15 2.10214
PDYN prodynorphin 2.10214
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.10214
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.10214
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.10214
FPR3 formyl peptide receptor 3 2.10214
TBX20 T-box 20 2.10214
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.10214
MYT1L myelin transcription factor 1-like 2.10214
GJA5 gap junction protein, alpha 5, 40kDa 2.10214
ZNF285 zinc finger protein 285 2.10214
AGTR1 angiotensin II receptor, type 1 2.10214
INHBC inhibin, beta C 2.10214
GRHL3 grainyhead-like 3 (Drosophila) 2.10214
IL15RA interleukin 15 receptor, alpha 2.10214
FOXA2 forkhead box A2 2.10214
POLQ polymerase (DNA directed), theta 2.10214
OXT oxytocin/neurophysin I prepropeptide 2.10214
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.10214
CORO6 coronin 6 2.10214
LGALS2 lectin, galactoside-binding, soluble, 2 2.10214
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.10214
LOC102724877 uncharacterized LOC102724877 2.10214
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.10214
PANO1 proapoptotic nucleolar protein 1 2.10214
ERAP2 endoplasmic reticulum aminopeptidase 2 2.10214
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.10214
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.10214
C9ORF152 chromosome 9 open reading frame 152 2.10214
TMEM151A transmembrane protein 151A 2.10214
C8ORF48 chromosome 8 open reading frame 48 2.10214
SLC9C2 solute carrier family 9, member C2 (putative) 2.10214
AKR1C1 aldo-keto reductase family 1, member C1 2.10214
LYNX1 Ly6/neurotoxin 1 2.10214
C12ORF71 chromosome 12 open reading frame 71 2.10214
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.10214
GFI1 growth factor independent 1 transcription repressor 2.10214
ADGB androglobin 2.10214
BAAT bile acid CoA:amino acid N-acyltransferase 2.10214
RSPO1 R-spondin 1 2.10214
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.10214
LOC124903317 uncharacterized LOC124903317 2.10214
PCDHGA9 protocadherin gamma subfamily A, 9 2.10214
KY kyphoscoliosis peptidase 2.10214
EFNB1 ephrin-B1 2.10214
YIPF5 Yip1 domain family, member 5 2.10214
ROPN1L rhophilin associated tail protein 1-like 2.10214
VN1R2 vomeronasal 1 receptor 2 2.10214
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.10214
SPEM1 spermatid maturation 1 2.10214
SPRR2G small proline-rich protein 2G 2.10214
SMLR1 small leucine-rich protein 1 2.10214
GET3 guided entry of tail-anchored proteins factor 3, ATPase 2.10214
GPAT3 glycerol-3-phosphate acyltransferase 3 2.10214
PLPPR4 phospholipid phosphatase related 4 2.10214
FAM240A family with sequence similarity 240 member A 2.10214
RPS21-DT RPS21 divergent transcript 2.10214
SAXO4 stabilizer of axonemal microtubules 4 2.10214
NOTCH2NLB notch 2 N-terminal like B 2.10214
C1ORF202 chromosome 1 open reading frame 202 2.10214
ACP7 acid phosphatase 7, tartrate resistant (putative) 2.10214
ACP4 acid phosphatase 4 2.10214
GARIN6 golgi associated RAB2 interactor family member 6 2.10214
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.10214
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.10214
ACSL6 acyl-CoA synthetase long-chain family member 6 2.10214
TBX10 T-box 10 2.10214
F5 coagulation factor V (proaccelerin, labile factor) 2.10214
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.10214
MYH13 myosin, heavy chain 13, skeletal muscle 2.10214
CGREF1 cell growth regulator with EF-hand domain 1 2.10214
ACP5 acid phosphatase 5, tartrate resistant 2.10214
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.10214
TVP23A trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) 2.10214
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.10214
CBLN2 cerebellin 2 precursor 2.10214
CD79B CD79b molecule, immunoglobulin-associated beta 2.10214
GOLGA6L4 golgin A6 family-like 4 2.10214
ZAN zonadhesin (gene/pseudogene) 2.10214
PLCB2 phospholipase C, beta 2 2.10214
MOB3A MOB kinase activator 3A 2.10214
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 2.10214
ASIC3 acid sensing (proton gated) ion channel 3 2.10214
DDTL D-dopachrome tautomerase-like 2.10214
ABHD15 abhydrolase domain containing 15 2.10214
VCX3B variable charge, X-linked 3B 2.10214
CELA2A chymotrypsin-like elastase family, member 2A 2.10214
CCR9 chemokine (C-C motif) receptor 9 2.10214
CCDC121 coiled-coil domain containing 121 2.10214
CFAP43 cilia and flagella associated protein 43 2.10214
CFAP45 cilia and flagella associated protein 45 2.10214
RPS19 ribosomal protein S19 2.10214
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.10214
C11ORF16 chromosome 11 open reading frame 16 2.10214
LRRK2 leucine-rich repeat kinase 2 2.10214
ZNF841 zinc finger protein 841 2.10214
PTH2R parathyroid hormone 2 receptor 2.10214
UTS2B urotensin 2B 2.10214
CALR3 calreticulin 3 2.10214
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.10214
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.10214
ZGLP1 zinc finger, GATA-like protein 1 2.10214
ANKRD55 ankyrin repeat domain 55 2.10214
FCRL4 Fc receptor-like 4 2.10214
DMRT2 doublesex and mab-3 related transcription factor 2 2.10214
EMILIN1 elastin microfibril interfacer 1 2.10214
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.10214
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.10214
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.10214
TMED5 transmembrane emp24 protein transport domain containing 5 2.10214
CPA2 carboxypeptidase A2 (pancreatic) 2.10214
MRAP melanocortin 2 receptor accessory protein 2.10214
MAB21L2 mab-21-like 2 (C. elegans) 2.10214
CYS1 cystin 1 2.10214
CGB7 chorionic gonadotropin, beta polypeptide 7 2.10214
DENND2A DENN/MADD domain containing 2A 2.10214
PCDHGA8 protocadherin gamma subfamily A, 8 2.10214
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.10214
C17ORF99 chromosome 17 open reading frame 99 2.10214
SIGLEC15 sialic acid binding Ig-like lectin 15 2.10214
VWF von Willebrand factor 2.10214
HLA-DMB major histocompatibility complex, class II, DM beta 2.10214
FAM151A family with sequence similarity 151, member A 2.10214
SP140L SP140 nuclear body protein-like 2.10214
GBX2 gastrulation brain homeobox 2 2.10214
PPT1 palmitoyl-protein thioesterase 1 2.10214
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.10214
MB myoglobin 2.10214
GOLGA8K golgin A8 family, member K 2.10214
GOLGA8H golgin A8 family, member H 2.10214
CCDC170 coiled-coil domain containing 170 2.10214
CCDC178 coiled-coil domain containing 178 2.10214
REG1A regenerating islet-derived 1 alpha 2.10214
ABLIM1 actin binding LIM protein 1 2.10214
ADAP2 ArfGAP with dual PH domains 2 2.10214
IP6K3 inositol hexakisphosphate kinase 3 2.10214
OTOP3 otopetrin 3 2.10214
CPXM1 carboxypeptidase X (M14 family), member 1 2.10214
NOBOX NOBOX oogenesis homeobox 2.10214
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.10214
LHX2 LIM homeobox 2 2.10214
TRIM7 tripartite motif containing 7 2.10214
CLEC1A C-type lectin domain family 1, member A 2.10214
RIBC1 RIB43A domain with coiled-coils 1 2.10214
LGALS14 lectin, galactoside-binding, soluble, 14 2.10214
C1ORF105 chromosome 1 open reading frame 105 2.10214
FOXS1 forkhead box S1 2.10214
TDRD10 tudor domain containing 10 2.10214
NFE2 nuclear factor, erythroid 2 2.10214
SMIM1 small integral membrane protein 1 (Vel blood group) 2.10214
TMEM86B transmembrane protein 86B 2.10214
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.10214
AMER2 APC membrane recruitment protein 2 2.10214
RGR retinal G protein coupled receptor 2.10214
C9ORF57 chromosome 9 open reading frame 57 2.10214
FZD1 frizzled class receptor 1 2.10214
PRSS55 protease, serine, 55 2.10214
TMEM150B transmembrane protein 150B 2.10214
ONECUT3 one cut homeobox 3 2.10214
ZNF66 zinc finger protein 66 2.10214
RTN4RL1 reticulon 4 receptor-like 1 2.10214
ACADL acyl-CoA dehydrogenase, long chain 2.10214
PGM5 phosphoglucomutase 5 2.10214
ADAM21 ADAM metallopeptidase domain 21 2.10214
AMDHD1 amidohydrolase domain containing 1 2.10214
IFNE interferon, epsilon 2.10214
DLG4 discs, large homolog 4 (Drosophila) 2.10214
AGBL1 ATP/GTP binding protein-like 1 2.10214
TPH1 tryptophan hydroxylase 1 2.10214
GPR157 G protein-coupled receptor 157 2.10214
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 2.10214
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.10214
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.10214
ENDOG endonuclease G 2.10214
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.10214
CERS3 ceramide synthase 3 2.10214
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.10214
PRSS3 protease, serine, 3 2.10214
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.10214
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.10214
HHATL hedgehog acyltransferase-like 2.10214
F10 coagulation factor X 2.10214
MR1 major histocompatibility complex, class I-related 2.10214
LCNL1 lipocalin-like 1 2.10214
PCP4 Purkinje cell protein 4 2.10214
RBFA ribosome binding factor A (putative) 2.10214
LRRC43 leucine rich repeat containing 43 2.10214
RSAD2 radical S-adenosyl methionine domain containing 2 2.10214
CXCR4 chemokine (C-X-C motif) receptor 4 2.10214
SPATA31E1 SPATA31 subfamily E, member 1 2.10214
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.10214
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 2.10186
FAM110A family with sequence similarity 110, member A 2.10186
MCM3AP minichromosome maintenance complex component 3 associated protein 2.09976
LPAR3 lysophosphatidic acid receptor 3 2.09865
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 2.07375
SMIM10L1 small integral membrane protein 10 like 1 2.07043
TMEM116 transmembrane protein 116 2.0581
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 2.03668
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 2.02954
LMNB2 lamin B2 2.01004
PWWP2A PWWP domain containing 2A 2.00025
ZFR zinc finger RNA binding protein 2.00025
MIF4GD MIF4G domain containing 2.00025
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.00025
C1ORF216 chromosome 1 open reading frame 216 2.00025
CCNL2 cyclin L2 2.00025
CNOT4 CCR4-NOT transcription complex, subunit 4 2.00025
XG Xg blood group 2.00025
LMBRD2 LMBR1 domain containing 2 2.00025
FAM171A2 family with sequence similarity 171, member A2 2.00025

decreased expression

Symbol Name Standardized Value
ZNF615 zinc finger protein 615 -2.22098
DPY19L3 dpy-19-like 3 (C. elegans) -2.22098
BAG3 BCL2-associated athanogene 3 -2.22098
TMUB2 transmembrane and ubiquitin-like domain containing 2 -2.22098
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like -2.22098
CHD9NB CHD9 neighbor -2.14999
FLOT1 flotillin 1 -2.14583
AUP1 ancient ubiquitous protein 1 -2.14583
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.14583
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.14583
TMEM54 transmembrane protein 54 -2.14583
SYT1 synaptotagmin I -2.14583
INVS inversin -2.10214
PNKP polynucleotide kinase 3'-phosphatase -2.10214
LARP1 La ribonucleoprotein domain family, member 1 -2.10214
INTS1 integrator complex subunit 1 -2.10214
BLVRB biliverdin reductase B -2.10214
RPP21 ribonuclease P/MRP 21kDa subunit -2.10214
CHRM5 cholinergic receptor, muscarinic 5 -2.10214
SSH2 slingshot protein phosphatase 2 -2.10214
CEP170 centrosomal protein 170kDa -2.10214
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.10214
CRTC2 CREB regulated transcription coactivator 2 -2.10214
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.10214
PRC1 protein regulator of cytokinesis 1 -2.10214
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.10214
DGLUCY D-glutamate cyclase -2.10214
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -2.10214
STAT4 signal transducer and activator of transcription 4 -2.10214
HTRA2 HtrA serine peptidase 2 -2.10214
EMG1 EMG1 N1-specific pseudouridine methyltransferase -2.10214
SHROOM3 shroom family member 3 -2.10214
SYT10 synaptotagmin X -2.10214
RBM45 RNA binding motif protein 45 -2.10214
TM6SF1 transmembrane 6 superfamily member 1 -2.10214
SNRPF small nuclear ribonucleoprotein polypeptide F -2.10214
SLC16A14 solute carrier family 16, member 14 -2.10214
ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator -2.10214
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -2.10214
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.10214
VAMP3 vesicle-associated membrane protein 3 -2.10214
SMIM29 small integral membrane protein 29 -2.10214
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.10214
NPAT nuclear protein, ataxia-telangiectasia locus -2.10214
STK11IP serine/threonine kinase 11 interacting protein -2.10214
CTNS cystinosin, lysosomal cystine transporter -2.10214
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -2.10214
NSUN7 NOP2/Sun domain family, member 7 -2.10214
FCF1 FCF1 rRNA-processing protein -2.10214
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.10214
BCKDK branched chain ketoacid dehydrogenase kinase -2.10214
NPTXR neuronal pentraxin receptor -2.10214
SOS1 son of sevenless homolog 1 (Drosophila) -2.10214
CALCOCO1 calcium binding and coiled-coil domain 1 -2.10214
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -2.10176
ERP29 endoplasmic reticulum protein 29 -2.09976
LDB2 LIM domain binding 2 -2.09865
THOC7 THO complex 7 -2.09865
TRIM27 tripartite motif containing 27 -2.0788
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -2.07065
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -2.03389
SLIT1 slit homolog 1 (Drosophila) -2.01701
MAP10 microtubule-associated protein 10 -2.006
ZNF774 zinc finger protein 774 -2.00025
SIAE sialic acid acetylesterase -2.00025
MCMDC2 minichromosome maintenance domain containing 2 -2.00025
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.00025
PYGM phosphorylase, glycogen, muscle -2.00025
CSF1 colony stimulating factor 1 (macrophage) -2.00025
ZBBX zinc finger, B-box domain containing -2.00025
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.00025
LPAR5 lysophosphatidic acid receptor 5 -2.00025
ENDOD1 endonuclease domain containing 1 -2.00025
CMKLR1 chemerin chemokine-like receptor 1 -2.00025
SMIM45 small integral membrane protein 45 -2.00025
MINDY4B MINDY family member 4B -2.00025
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -2.00025
GRAMD2A GRAM domain containing 2A -2.00025
CCDC175 coiled-coil domain containing 175 -2.00025
EXD1 exonuclease 3'-5' domain containing 1 -2.00025
IQCC IQ motif containing C -2.00025
ANO1 anoctamin 1, calcium activated chloride channel -2.00025
SSC5D scavenger receptor cysteine rich family, 5 domains -2.00025
NKX3-1 NK3 homeobox 1 -2.00025
ECT2L epithelial cell transforming 2 like -2.00025
TBC1D10A TBC1 domain family, member 10A -2.00025
ZNF784 zinc finger protein 784 -2.00025
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) -2.00025
ZSCAN22 zinc finger and SCAN domain containing 22 -2.00025
ADGRA2 adhesion G protein-coupled receptor A2 -2.00025
C6ORF163 chromosome 6 open reading frame 163 -2.00025
ARRDC4 arrestin domain containing 4 -2.00025
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -2.00025
GYS2 glycogen synthase 2 (liver) -2.00025
SIRT3 sirtuin 3 -2.00025
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.00025
FAM209A family with sequence similarity 209, member A -2.00025
ZNF287 zinc finger protein 287 -2.00025
HSF2 heat shock transcription factor 2 -2.00025
KIRREL2 kin of IRRE like 2 (Drosophila) -2.00025
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 -2.00025
NRIP2 nuclear receptor interacting protein 2 -2.00025
SKAP1 src kinase associated phosphoprotein 1 -2.00025
MITF microphthalmia-associated transcription factor -2.00025
HARBI1 harbinger transposase derived 1 -2.00025
FREM2 FRAS1 related extracellular matrix protein 2 -2.00025
GMPPB GDP-mannose pyrophosphorylase B -2.00025