MYCN Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog|This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] (NCBI Entrez Gene Database, 4613)
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Genes

349 genes differentially expressed following the MYCN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MAGEB1 melanoma antigen family B1 3.25429
TMEM176A transmembrane protein 176A 3.25429
EPPIN epididymal peptidase inhibitor 3.25429
EPB42 erythrocyte membrane protein band 4.2 3.25429
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.25429
SSTR5 somatostatin receptor 5 3.25429
LIM2 lens intrinsic membrane protein 2, 19kDa 3.25429
TRIM74 tripartite motif containing 74 3.25429
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.25429
TRPV2 transient receptor potential cation channel, subfamily V, member 2 3.25429
CD1C CD1c molecule 3.25429
CELF6 CUGBP, Elav-like family member 6 3.25429
ZSCAN5B zinc finger and SCAN domain containing 5B 3.25429
PCDHB12 protocadherin beta 12 3.25429
SLC35D3 solute carrier family 35, member D3 3.25429
IZUMO4 IZUMO family member 4 3.25429
ATP13A5 ATPase type 13A5 3.25429
FRMD7 FERM domain containing 7 3.25429
PRB1 proline-rich protein BstNI subfamily 1 3.25429
WEE2 WEE1 homolog 2 (S. pombe) 3.25429
ZACN zinc activated ligand-gated ion channel 3.25429
NAPSA napsin A aspartic peptidase 3.25429
NCKAP1L NCK-associated protein 1-like 3.25429
DRP2 dystrophin related protein 2 3.25429
MYO16 myosin XVI 3.25429
TSHZ1 teashirt zinc finger homeobox 1 3.25429
LDHC lactate dehydrogenase C 3.25429
STEAP4 STEAP family member 4 3.25429
FAM161B family with sequence similarity 161, member B 3.25429
BTBD18 BTB (POZ) domain containing 18 3.25429
PODN podocan 3.25429
SPDEF SAM pointed domain containing ETS transcription factor 3.25429
MEIG1 meiosis/spermiogenesis associated 1 3.25429
TRPC5OS TRPC5 opposite strand 3.25429
TAS2R13 taste receptor, type 2, member 13 3.25429
HBD hemoglobin, delta 3.25429
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3.25429
FBXW4 F-box and WD repeat domain containing 4 3.25429
MEIKIN meiotic kinetochore factor 3.25429
NEUROG2 neurogenin 2 3.25429
DLL4 delta-like 4 (Drosophila) 3.25429
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.25429
RFX6 regulatory factor X, 6 3.25429
SETSIP SET-like protein 3.25429
WWC1 WW and C2 domain containing 1 3.25429
RBP4 retinol binding protein 4, plasma 3.25429
TEX101 testis expressed 101 3.25429
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.25429
CCDC190 coiled-coil domain containing 190 3.25429
AJM1 apical junction component 1 homolog 3.25429
CBLIF cobalamin binding intrinsic factor 3.25429
TMEM275 transmembrane protein 275 3.25429
CFAP65 cilia and flagella associated protein 65 3.25429
SQOR sulfide quinone oxidoreductase 3.25429
PHF24 PHD finger protein 24 3.25429
ERVW-1 endogenous retrovirus group W, member 1 3.25429
GIPC3 GIPC PDZ domain containing family, member 3 3.25429
H2BC3 H2B clustered histone 3 3.25429
DUSP29 dual specificity phosphatase 29 3.25429
GARIN1A golgi associated RAB2 interactor 1A 3.25429
CIMAP1A ciliary microtubule associated protein 1A 3.25429
TEKTL1 tektin like 1 3.25429
SPDYE8 speedy/RINGO cell cycle regulator family member E8 3.25429
TBC1D3I TBC1 domain family member 3I 3.25429
C17ORF113 chromosome 17 open reading frame 113 3.25429
SMIM35 small integral membrane protein 35 3.25429
MINDY4B MINDY family member 4B 3.25429
CCDC197 coiled-coil domain containing 197 3.25429
CATSPERZ catsper channel auxiliary subunit zeta 3.25429
PCDHGA9 protocadherin gamma subfamily A, 9 3.25429
ACER1 alkaline ceramidase 1 3.25429
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.25429
S100G S100 calcium binding protein G 3.25429
SPDYC speedy/RINGO cell cycle regulator family member C 3.25429
CFAP45 cilia and flagella associated protein 45 3.25429
TFEC transcription factor EC 3.25429
TLR6 toll-like receptor 6 3.25429
LOC124901872 uncharacterized LOC124901872 3.25429
ANXA13 annexin A13 3.25429
HPR haptoglobin-related protein 3.25429
PGA3 pepsinogen 3, group I (pepsinogen A) 3.25429
IL1R2 interleukin 1 receptor, type II 3.25429
IL1R1 interleukin 1 receptor, type I 3.25429
RD3 retinal degeneration 3 3.25429
PKD2L1 polycystic kidney disease 2-like 1 3.25429
IQCF1 IQ motif containing F1 3.25429
SPATA22 spermatogenesis associated 22 3.25429
LY6H lymphocyte antigen 6 complex, locus H 3.25429
RNF186 ring finger protein 186 3.25429
ZNF683 zinc finger protein 683 3.25429
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.25429
SAMD15 sterile alpha motif domain containing 15 3.25429
MAG myelin associated glycoprotein 3.25429
PRR23A proline rich 23A 3.25429
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.25429
CST1 cystatin SN 3.25429
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.25429
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.25429
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.25429
MRLN myoregulin 3.25429
GAB4 GRB2-associated binding protein family, member 4 3.25429
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.25429
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.25429
FNDC1 fibronectin type III domain containing 1 3.25429
GPR62 G protein-coupled receptor 62 3.25429
NCR3 natural cytotoxicity triggering receptor 3 3.25429
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.25429
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.25429
BCL2L15 BCL2-like 15 3.25429
GAL3ST2 galactose-3-O-sulfotransferase 2 3.25429
PCDHGB4 protocadherin gamma subfamily B, 4 3.25429
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.25429
KLK2 kallikrein-related peptidase 2 3.25429
SHISA8 shisa family member 8 3.25429
VWA3B von Willebrand factor A domain containing 3B 3.25429
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.25429
KISS1 KiSS-1 metastasis-suppressor 3.25429
CLEC4E C-type lectin domain family 4, member E 3.25429
CLEC4D C-type lectin domain family 4, member D 3.25429
TNP1 transition protein 1 (during histone to protamine replacement) 3.25429
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.25429
HPX hemopexin 3.25429
ADAM2 ADAM metallopeptidase domain 2 3.25429
RAD21L1 RAD21-like 1 (S. pombe) 3.25429
CYSLTR1 cysteinyl leukotriene receptor 1 3.25429
KRT222 keratin 222, type II 3.25429
CXCR6 chemokine (C-X-C motif) receptor 6 3.25429
AQP7 aquaporin 7 3.25429
SST somatostatin 3.25429
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 3.25429
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.25429
PSG6 pregnancy specific beta-1-glycoprotein 6 3.25429
THEM5 thioesterase superfamily member 5 3.25429
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 3.25429
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.25429
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.25429
CETP cholesteryl ester transfer protein, plasma 3.25429
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.25429
TMEM156 transmembrane protein 156 3.25429
TMPRSS15 transmembrane protease, serine 15 3.25429
TGM4 transglutaminase 4 3.25429
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.25429
CFI complement factor I 3.25429
MMP10 matrix metallopeptidase 10 3.25429
ART1 ADP-ribosyltransferase 1 3.25429
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.25429
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.25429
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.25429
FRMPD2 FERM and PDZ domain containing 2 3.25429
CNGB1 cyclic nucleotide gated channel beta 1 3.25429
SLITRK1 SLIT and NTRK-like family, member 1 3.25429
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.25429
TRIM29 tripartite motif containing 29 3.25429
IHH indian hedgehog 3.25429
NKX6-1 NK6 homeobox 1 3.25429
HEMGN hemogen 3.25429
PHGR1 proline/histidine/glycine-rich 1 3.25429
ADGRF4 adhesion G protein-coupled receptor F4 3.25429
MEPE matrix extracellular phosphoglycoprotein 3.25429
MT1M metallothionein 1M 3.25429
LST1 leukocyte specific transcript 1 3.25429
GPN3 GPN-loop GTPase 3 3.18787
CLDN23 claudin 23 3.17714
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.17714
CCDC83 coiled-coil domain containing 83 3.08066
EGLN2 egl-9 family hypoxia-inducible factor 2 3.04802
CCDC60 coiled-coil domain containing 60 2.89514
CCND3 cyclin D3 2.83627
SF3B3 splicing factor 3b, subunit 3, 130kDa 2.81426
WRAP73 WD repeat containing, antisense to TP73 2.69112
HYPK huntingtin interacting protein K 2.66679
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.64823
TOMM34 translocase of outer mitochondrial membrane 34 2.62022
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.61065
TBCEL tubulin folding cofactor E-like 2.57578
ODF2 outer dense fiber of sperm tails 2 2.52333
COPS7A COP9 signalosome subunit 7A 2.50085
H3C7 H3 clustered histone 7 2.48398
TOX3 TOX high mobility group box family member 3 2.47479
HNMT histamine N-methyltransferase 2.46119
MYLK2 myosin light chain kinase 2 2.43923
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.43923
MDFIC MyoD family inhibitor domain containing 2.43923
NKX3-1 NK3 homeobox 1 2.43923
LHFPL2 lipoma HMGIC fusion partner-like 2 2.42144
ETNPPL ethanolamine-phosphate phospho-lyase 2.34059
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.34059
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 2.32642
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.31747
TMEM86A transmembrane protein 86A 2.30063
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 2.29418
ICA1L islet cell autoantigen 1,69kDa-like 2.28608
DORIP1 dopamine receptor interacting protein 1 2.27337
MARS1 methionyl-tRNA synthetase 1 2.24746
OXR1 oxidation resistance 1 2.24538
RFLNB refilin B 2.22456
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.22456
BET1 Bet1 golgi vesicular membrane trafficking protein 2.20899
HSF5 heat shock transcription factor family member 5 2.18332
DNAAF1 dynein, axonemal, assembly factor 1 2.18332
AADACL3 arylacetamide deacetylase-like 3 2.18332
CIPC CLOCK-interacting pacemaker 2.18231
PBK PDZ binding kinase 2.17844
ASCC2 activating signal cointegrator 1 complex subunit 2 2.16927
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 2.15258
CCDC136 coiled-coil domain containing 136 2.14124
POC1B-DUSP6 POC1B-DUSP6 readthrough 2.13621
TLN2 talin 2 2.13441
ANKMY1 ankyrin repeat and MYND domain containing 1 2.12907
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 2.10939
CLSTN3 calsyntenin 3 2.10508
TRIT1 tRNA isopentenyltransferase 1 2.0944
SENP5 SUMO1/sentrin specific peptidase 5 2.09437
PUM2 pumilio RNA-binding family member 2 2.0902
NUMBL numb homolog (Drosophila)-like 2.08073
PCDHB4 protocadherin beta 4 2.08027
N4BP3 NEDD4 binding protein 3 2.06598
COL6A2 collagen, type VI, alpha 2 2.06429
ERBB2 erb-b2 receptor tyrosine kinase 2 2.05581
DNPEP aspartyl aminopeptidase 2.05399
RELL1 RELT-like 1 2.04144
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.02311
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 2.01498
WRN Werner syndrome, RecQ helicase-like 2.00803
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 2.00657
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.00036

decreased expression

Symbol Name Standardized Value
CD86 CD86 molecule -3.25429
ARHGAP28 Rho GTPase activating protein 28 -3.25429
PADI1 peptidyl arginine deiminase, type I -3.25429
LIN52 lin-52 DREAM MuvB core complex component -3.25429
SPATS1 spermatogenesis associated, serine-rich 1 -3.25429
PLXNA3 plexin A3 -3.25429
SLC44A4 solute carrier family 44, member 4 -3.25429
DLX4 distal-less homeobox 4 -3.25429
KLF1 Kruppel-like factor 1 (erythroid) -3.25429
GLUD2 glutamate dehydrogenase 2 -3.25429
CCDC154 coiled-coil domain containing 154 -3.25429
RPA4 replication protein A4, 30kDa -3.25429
ZNF319 zinc finger protein 319 -3.25429
TBX10 T-box 10 -3.25429
DOK7 docking protein 7 -3.25429
POTEJ POTE ankyrin domain family, member J -3.25429
TMEM196 transmembrane protein 196 -3.25429
CARD6 caspase recruitment domain family, member 6 -3.25429
ACSL5 acyl-CoA synthetase long-chain family member 5 -3.25429
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled -3.25429
MAGEB17 melanoma antigen family B17 -3.25429
VN1R1 vomeronasal 1 receptor 1 -3.25429
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -3.25429
SHCBP1L SHC SH2-domain binding protein 1-like -3.25429
PVALEF parvalbumin like EF-hand containing -3.25429
IP6K3 inositol hexakisphosphate kinase 3 -3.25429
CD28 CD28 molecule -3.25429
CATSPERT catsper channel auxiliary subunit tau -3.25429
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -3.25429
OPTC opticin -3.25429
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -3.25429
SLC22A14 solute carrier family 22, member 14 -3.25429
TWIST1 twist family bHLH transcription factor 1 -3.25429
BEAN1 brain expressed, associated with NEDD4, 1 -3.25429
THTPA thiamine triphosphatase -3.25429
FGD2 FYVE, RhoGEF and PH domain containing 2 -3.25429
CCDC27 coiled-coil domain containing 27 -3.25429
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -3.25429
SH2D6 SH2 domain containing 6 -3.25429
TECPR1 tectonin beta-propeller repeat containing 1 -3.25429
SLC16A6 solute carrier family 16, member 6 -3.25429
IDO2 indoleamine 2,3-dioxygenase 2 -3.21682
LRRK2 leucine-rich repeat kinase 2 -3.21682
USP34 ubiquitin specific peptidase 34 -3.2142
SLC16A9 solute carrier family 16, member 9 -3.08904
NT5DC1 5'-nucleotidase domain containing 1 -3.07583
CDK5RAP3 CDK5 regulatory subunit associated protein 3 -3.06226
TRIM68 tripartite motif containing 68 -2.93526
KIF7 kinesin family member 7 -2.89319
RPL11 ribosomal protein L11 -2.87775
SIPA1L1 signal-induced proliferation-associated 1 like 1 -2.83508
VARS2 valyl-tRNA synthetase 2, mitochondrial -2.78983
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.7647
ZNF491 zinc finger protein 491 -2.76223
PYGM phosphorylase, glycogen, muscle -2.74683
DENND6B DENN/MADD domain containing 6B -2.74683
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.69989
FAM149B1 family with sequence similarity 149, member B1 -2.6557
PHF20L1 PHD finger protein 20-like 1 -2.6213
RPH3AL rabphilin 3A-like (without C2 domains) -2.61271
TMEM161B transmembrane protein 161B -2.59258
PAM peptidylglycine alpha-amidating monooxygenase -2.56878
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -2.56029
CFAP54 cilia and flagella associated 54 -2.55265
HMGA1 high mobility group AT-hook 1 -2.54908
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.54692
MRAS muscle RAS oncogene homolog -2.49907
TMEM221 transmembrane protein 221 -2.48398
PGLYRP1 peptidoglycan recognition protein 1 -2.47467
ATP5MGL ATP synthase membrane subunit g like -2.47467
ZNF540 zinc finger protein 540 -2.47192
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.43923
TOX thymocyte selection-associated high mobility group box -2.43923
CAV1 caveolin 1, caveolae protein, 22kDa -2.43923
PPCDC phosphopantothenoylcysteine decarboxylase -2.43923
MCM3 minichromosome maintenance complex component 3 -2.43923
SEC14L1 SEC14-like 1 (S. cerevisiae) -2.40765
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa -2.39594
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta -2.38959
RBBP6 retinoblastoma binding protein 6 -2.37116
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) -2.35305
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.3475
MINDY3 MINDY lysine 48 deubiquitinase 3 -2.32642
CHL1 cell adhesion molecule L1-like -2.30491
CALR3 calreticulin 3 -2.30491
MRAP2 melanocortin 2 receptor accessory protein 2 -2.29418
CERS4 ceramide synthase 4 -2.28608
PNRC2 proline-rich nuclear receptor coactivator 2 -2.27928
PYDC1 PYD (pyrin domain) containing 1 -2.27337
C1QTNF2 C1q and tumor necrosis factor related protein 2 -2.27337
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.27337
PPDPF pancreatic progenitor cell differentiation and proliferation factor -2.25833
WBP2NL WBP2 N-terminal like -2.24538
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.24538
TGDS TDP-glucose 4,6-dehydratase -2.24469
ESYT3 extended synaptotagmin-like protein 3 -2.22805
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B -2.21301
CHST13 carbohydrate (chondroitin 4) sulfotransferase 13 -2.19259
TSPO translocator protein (18kDa) -2.1913
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.1913
ATXN2 ataxin 2 -2.1913
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -2.18719
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.18231
GUCA1A guanylate cyclase activator 1A (retina) -2.1709
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) -2.1709
NECAB1 N-terminal EF-hand calcium binding protein 1 -2.16927
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 -2.1577
DALRD3 DALR anticodon binding domain containing 3 -2.15258
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -2.14907
CEP72 centrosomal protein 72kDa -2.14869
ETV1 ets variant 1 -2.1327
ZNF385D zinc finger protein 385D -2.12581
TSPYL2 TSPY-like 2 -2.12436
DCAF6 DDB1 and CUL4 associated factor 6 -2.12407
PAXBP1 PAX3 and PAX7 binding protein 1 -2.1229
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -2.10973
JAKMIP3 Janus kinase and microtubule interacting protein 3 -2.09373
OSTF1 osteoclast stimulating factor 1 -2.08309
B4GAT1-DT B4GAT1 divergent transcript -2.06429
NUP205 nucleoporin 205kDa -2.0328
SPRED1 sprouty-related, EVH1 domain containing 1 -2.02557
CNOT6L CCR4-NOT transcription complex, subunit 6-like -2.01498
METTL14 methyltransferase like 14 -2.01498